Let us call a ring R (without identity) to be right symmetric if for any triple a,b,c,∈R?abc = 0 then acb = 0. Such rings are neither symmetric nor reversible (in general) but are semicommutative. With an idempotent ...Let us call a ring R (without identity) to be right symmetric if for any triple a,b,c,∈R?abc = 0 then acb = 0. Such rings are neither symmetric nor reversible (in general) but are semicommutative. With an idempotent they take care of the sheaf representation as obtained by Lambek. Klein 4-rings and their several generalizations and extensions are proved to be members of such class of rings. An extension obtained is a McCoy ring and its power series ring is also proved to be a McCoy ring.展开更多
Targeted protein degradation(TPD)technology mainly utilizes the natural degradation systems within cells to specific and efficient degradation of disease-related proteins1.The ubiquitin-proteasome system(UPS)is the mo...Targeted protein degradation(TPD)technology mainly utilizes the natural degradation systems within cells to specific and efficient degradation of disease-related proteins1.The ubiquitin-proteasome system(UPS)is the most important way of protein degradation in eukaryotic cells,which is involved in more than 80%of degradation processes2.Molecular glues are mostly small molecules to stabilize existing interactions between two proteins or induce new protein-protein interactions3.In the case of molecular glues between the target protein and an E3 ligase.展开更多
文摘Let us call a ring R (without identity) to be right symmetric if for any triple a,b,c,∈R?abc = 0 then acb = 0. Such rings are neither symmetric nor reversible (in general) but are semicommutative. With an idempotent they take care of the sheaf representation as obtained by Lambek. Klein 4-rings and their several generalizations and extensions are proved to be members of such class of rings. An extension obtained is a McCoy ring and its power series ring is also proved to be a McCoy ring.
文摘Targeted protein degradation(TPD)technology mainly utilizes the natural degradation systems within cells to specific and efficient degradation of disease-related proteins1.The ubiquitin-proteasome system(UPS)is the most important way of protein degradation in eukaryotic cells,which is involved in more than 80%of degradation processes2.Molecular glues are mostly small molecules to stabilize existing interactions between two proteins or induce new protein-protein interactions3.In the case of molecular glues between the target protein and an E3 ligase.
