The development of new strategy for environmentally friendly,cost-effective and large-scale electro-synthesis of anticancer drugs is highly desirable to replace high-cost traditional methods and realize high atomic ec...The development of new strategy for environmentally friendly,cost-effective and large-scale electro-synthesis of anticancer drugs is highly desirable to replace high-cost traditional methods and realize high atomic economy.GW 610,an antitumor agent with potent and selective anticancer activity against lung,colon,and breast cancer cell lines in real medical treatment processes,has a market price of~10……(7) USD/kg and calls for novel methods like electro-synthesis to reduce the cost.Here,for the first time,we design a solid-liquid-gas three-phase indirect electrolysis system based on a kind of microwave-synthesized polyoxometalate-based metal-organic framework(MW-POMOF)that can converse S-S bond substrates into valuable C-S bond products like anticancer drug molecules(e.g.,GW 610).Specifically,the solid-phase MW-POMOF as heterogeneous redox mediator exhibits the excellent electrocatalytic efficiency for the formation of liquid-phase C-S bond products(yields up to 95%)coupling with the generation of gas-phase H_(2) product(~402μmol·g^(-1)·h^(-1)),resulting in an interesting three-phase indirect electrolysis system.Remarkably,it enables the kilo-scale production(~1 kg in a batch experiment)of GW 610 at one thousandth of the market price(from~10^(7) to~3200 USD/kg).This work may inaugurate a new electrocatalytic avenue to explore porous crystalline materials in electrocatalysis field.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21871125,22475057,22171139 and 22201116)Natural Science Foundation of Guangdong Province(No.2023B1515020076)+1 种基金Natural Science Foundation of Shandong Province(No.ZR2022QB066 and ZR2023MB018)Foundation of State Key Laboratory of Coal Conversion(No.J24-25-902).
文摘The development of new strategy for environmentally friendly,cost-effective and large-scale electro-synthesis of anticancer drugs is highly desirable to replace high-cost traditional methods and realize high atomic economy.GW 610,an antitumor agent with potent and selective anticancer activity against lung,colon,and breast cancer cell lines in real medical treatment processes,has a market price of~10……(7) USD/kg and calls for novel methods like electro-synthesis to reduce the cost.Here,for the first time,we design a solid-liquid-gas three-phase indirect electrolysis system based on a kind of microwave-synthesized polyoxometalate-based metal-organic framework(MW-POMOF)that can converse S-S bond substrates into valuable C-S bond products like anticancer drug molecules(e.g.,GW 610).Specifically,the solid-phase MW-POMOF as heterogeneous redox mediator exhibits the excellent electrocatalytic efficiency for the formation of liquid-phase C-S bond products(yields up to 95%)coupling with the generation of gas-phase H_(2) product(~402μmol·g^(-1)·h^(-1)),resulting in an interesting three-phase indirect electrolysis system.Remarkably,it enables the kilo-scale production(~1 kg in a batch experiment)of GW 610 at one thousandth of the market price(from~10^(7) to~3200 USD/kg).This work may inaugurate a new electrocatalytic avenue to explore porous crystalline materials in electrocatalysis field.
