AIM:To investigate whether retinal nerve fiber layer defects(RNFLDs)is a potential risk factor for chronic kidney disease(CKD)in Chinese adults.METHODS:The Kailuan Eye Study was a populationbased study that included 1...AIM:To investigate whether retinal nerve fiber layer defects(RNFLDs)is a potential risk factor for chronic kidney disease(CKD)in Chinese adults.METHODS:The Kailuan Eye Study was a populationbased study that included 14440 participants.All participants underwent detailed assessments,RNFLDs were diagnosed using color fundus photographs.RESULTS:Overall,12507 participants[8533 males(68.23%)]had complete systemic examination data and at least one evaluable fundus photograph.RNFLDs were found in 621 participants[5.0%;95%confidence interval(CI):4.6%-5.34%],and 70 cases of multiple RNFLDs were found(11.27%).After adjusting multiple factors,RNFLDs was significantly associated with CKD severity,the ORs of CKD stage 3,stage 4 and stage 5 were 1.698,4.167,and 9.512,respectively.Multiple RNFLDs were also associated with CKD severity after adjusting multiple factors,the ORs of CKD stage 3 and stage 5 were 4.465 and 11.833 respectively.Furthermore,2294 participants had CKD(18.34%,95%CI:17.68%-18.99%).After adjusting for other factors,CKD presence was significantly correlated with the presence of RNFLDs.CONCLUSION:The strongest risk factors for RNFLDs are CKD and hypertension.Conversely,RNFLDs can be an ocular feature in patients with CKD.Fundoscopy can help detect systemic diseases,and assessment for RNFLDs should be considered in CKD patients.展开更多
BACKGROUND The American Heart Association defines cardiovascular health in terms of four behaviors(smoking,diet,physical activity,and body weight)and three factors(plasma glucose,cholesterol,and blood pressure).By thi...BACKGROUND The American Heart Association defines cardiovascular health in terms of four behaviors(smoking,diet,physical activity,and body weight)and three factors(plasma glucose,cholesterol,and blood pressure).By this definition,the preva-lence of ideal cardiovascular health behaviors and factors(ICHBF)is negatively correlated with all-cause mortality and risks of cardiovascular and cerebrovas-cular diseases and malignancy.AIM To investigate the changing trends of cardiovascular and cerebrovascular health scores in the Kailuan study population from 2006 to 2011.METHODS The Kailuan population data from three health checkups held in 2006-2007,2008-2009,and 2010-2011 were analyzed,and the constituent ratios of cardiovascular and cerebrovascular health behaviors and factors at ideal,intermediate,and poor levels were calculated by using Huffman and Capewell method.Simultaneously,the cardiovascular and cerebrovascular health behavior and factor scores were calculated.RESULTS From 2006 to 2007,the proportion of people with ideal physical exercise,low salt diet,ideal body mass index,ideal total cholesterol level,no smoking,ideal blood sugar,and ideal blood pressure was 13.12%,9.34%,49.17%,64.20%,49.27%,69.99%,and 20.55%,respectively,in men with a health score of 8.46,and 12.00%,9.13%,61.60%,64.28%,98.19%,78.90%and 36.92%in women,with a score of 10.02.From 2008 to 2009,the proportion was 16.09%,14.04%,51.94%,65.02%,40.18%,66.44%,and 17.04%in men,with a score of 8.18,and 16.860%,17.360%,64.010%,67.433%,98.220%,76.370%,and 42.340%in women,with a score of 10.12.From 2010 to 2011,the proportion was 12.22%,17.65%,49.40%,68.33%,48.17%,64.67%,and 14.68%in males,having a score of 8.21,while in females,the proportion was 11.83%,18.09%,49.40%,67.85%,98.82%,74.52%,and 37.78%,with a score of 9.90.Core Tip:The American Heart Association defines ideal cardiovascular health as the concurrent presence of ideal health parameters(blood glucose,total cholesterol,and blood pressure levels)and ideal health behaviors(weight status,diet,physical activity,and smoking).Our study design was retrospective and based on the Kailuan study.This prospective study was initiated in July 2006 to evaluate the risk factors and interventions for cardiovascular diseases and cerebrovascular diseases in the Kailuan community population,with several articles having been published on such chronic non-communicable diseases.A fixed population was constituted from these 57659 participants,and their cerebrovascular and cardiovascular health parameters and behaviors were surveyed from 2006 to 2011.Furthermore,the distributions of cardiovascular health parameters and behaviors were portrayed,and their health scores were estimated.cholesterol level,no smoking,ideal blood sugar,and ideal blood pressure was 16.09%,14.04%,51.94%,65.02%,40.18%,66.44%,and 17.04%,and it was 16.86%,17.36%,64.01%,67.433%,98.22%,76.37%,and 42.34%for women.From 2010-2011,the proportion of men with ideal physical exercise,low salt diet,ideal body mass index,and ideal total cholesterol level,no smoking,ideal blood sugar,and ideal blood pressure was 12.22%,17.65%,49.40%,68.33%,48.17%,64.67%,and 14.68%,and it was 11.83%,18.09%,49.40%,67.85%,98.82%,74.52%,and 37.78%in women.The prevalence of ideal cardiovascular and cerebrovascular health behaviors and factors of different genders from 2006 to 2011 is shown in Table 1 and Table 2.The prevalence of poor and intermediate cardiovascular and cerebrovascular health behaviors and factors of different genders from 2006 to 2011 was described in our previous research[11].The health scores of men and women in 2006,2008,and 2010 were 8.46 and 10.02,8.18 and 10.12,as well as 8.21 and 9.90,respectively;the distribution of cardiovascular and cerebrovascular health behaviors and factor scores of different genders from 2006 to 2011 are shown in Table 3 and Table 4.The mean±SD of body mass index,blood pressure,fasting blood glucose,and total cholesterol levels of different genders from 2006 to 2011 are shown in Table 5 and Table 6.展开更多
基金Supported by the National Natural Science Foundation of China(No.82220108017,No.82141128)the Capital Health Research and Development of Special(No.2020-1-2052)Science&Technology Project of Beijing Municipal Science&Technology Commission(No.Z201100005520045,No.Z181100001818003).
文摘AIM:To investigate whether retinal nerve fiber layer defects(RNFLDs)is a potential risk factor for chronic kidney disease(CKD)in Chinese adults.METHODS:The Kailuan Eye Study was a populationbased study that included 14440 participants.All participants underwent detailed assessments,RNFLDs were diagnosed using color fundus photographs.RESULTS:Overall,12507 participants[8533 males(68.23%)]had complete systemic examination data and at least one evaluable fundus photograph.RNFLDs were found in 621 participants[5.0%;95%confidence interval(CI):4.6%-5.34%],and 70 cases of multiple RNFLDs were found(11.27%).After adjusting multiple factors,RNFLDs was significantly associated with CKD severity,the ORs of CKD stage 3,stage 4 and stage 5 were 1.698,4.167,and 9.512,respectively.Multiple RNFLDs were also associated with CKD severity after adjusting multiple factors,the ORs of CKD stage 3 and stage 5 were 4.465 and 11.833 respectively.Furthermore,2294 participants had CKD(18.34%,95%CI:17.68%-18.99%).After adjusting for other factors,CKD presence was significantly correlated with the presence of RNFLDs.CONCLUSION:The strongest risk factors for RNFLDs are CKD and hypertension.Conversely,RNFLDs can be an ocular feature in patients with CKD.Fundoscopy can help detect systemic diseases,and assessment for RNFLDs should be considered in CKD patients.
基金Supported by the Peking University People’s Hospital Talent Introduction Scientific Research Launch Fund,No.2022-T-02.
文摘BACKGROUND The American Heart Association defines cardiovascular health in terms of four behaviors(smoking,diet,physical activity,and body weight)and three factors(plasma glucose,cholesterol,and blood pressure).By this definition,the preva-lence of ideal cardiovascular health behaviors and factors(ICHBF)is negatively correlated with all-cause mortality and risks of cardiovascular and cerebrovas-cular diseases and malignancy.AIM To investigate the changing trends of cardiovascular and cerebrovascular health scores in the Kailuan study population from 2006 to 2011.METHODS The Kailuan population data from three health checkups held in 2006-2007,2008-2009,and 2010-2011 were analyzed,and the constituent ratios of cardiovascular and cerebrovascular health behaviors and factors at ideal,intermediate,and poor levels were calculated by using Huffman and Capewell method.Simultaneously,the cardiovascular and cerebrovascular health behavior and factor scores were calculated.RESULTS From 2006 to 2007,the proportion of people with ideal physical exercise,low salt diet,ideal body mass index,ideal total cholesterol level,no smoking,ideal blood sugar,and ideal blood pressure was 13.12%,9.34%,49.17%,64.20%,49.27%,69.99%,and 20.55%,respectively,in men with a health score of 8.46,and 12.00%,9.13%,61.60%,64.28%,98.19%,78.90%and 36.92%in women,with a score of 10.02.From 2008 to 2009,the proportion was 16.09%,14.04%,51.94%,65.02%,40.18%,66.44%,and 17.04%in men,with a score of 8.18,and 16.860%,17.360%,64.010%,67.433%,98.220%,76.370%,and 42.340%in women,with a score of 10.12.From 2010 to 2011,the proportion was 12.22%,17.65%,49.40%,68.33%,48.17%,64.67%,and 14.68%in males,having a score of 8.21,while in females,the proportion was 11.83%,18.09%,49.40%,67.85%,98.82%,74.52%,and 37.78%,with a score of 9.90.Core Tip:The American Heart Association defines ideal cardiovascular health as the concurrent presence of ideal health parameters(blood glucose,total cholesterol,and blood pressure levels)and ideal health behaviors(weight status,diet,physical activity,and smoking).Our study design was retrospective and based on the Kailuan study.This prospective study was initiated in July 2006 to evaluate the risk factors and interventions for cardiovascular diseases and cerebrovascular diseases in the Kailuan community population,with several articles having been published on such chronic non-communicable diseases.A fixed population was constituted from these 57659 participants,and their cerebrovascular and cardiovascular health parameters and behaviors were surveyed from 2006 to 2011.Furthermore,the distributions of cardiovascular health parameters and behaviors were portrayed,and their health scores were estimated.cholesterol level,no smoking,ideal blood sugar,and ideal blood pressure was 16.09%,14.04%,51.94%,65.02%,40.18%,66.44%,and 17.04%,and it was 16.86%,17.36%,64.01%,67.433%,98.22%,76.37%,and 42.34%for women.From 2010-2011,the proportion of men with ideal physical exercise,low salt diet,ideal body mass index,and ideal total cholesterol level,no smoking,ideal blood sugar,and ideal blood pressure was 12.22%,17.65%,49.40%,68.33%,48.17%,64.67%,and 14.68%,and it was 11.83%,18.09%,49.40%,67.85%,98.82%,74.52%,and 37.78%in women.The prevalence of ideal cardiovascular and cerebrovascular health behaviors and factors of different genders from 2006 to 2011 is shown in Table 1 and Table 2.The prevalence of poor and intermediate cardiovascular and cerebrovascular health behaviors and factors of different genders from 2006 to 2011 was described in our previous research[11].The health scores of men and women in 2006,2008,and 2010 were 8.46 and 10.02,8.18 and 10.12,as well as 8.21 and 9.90,respectively;the distribution of cardiovascular and cerebrovascular health behaviors and factor scores of different genders from 2006 to 2011 are shown in Table 3 and Table 4.The mean±SD of body mass index,blood pressure,fasting blood glucose,and total cholesterol levels of different genders from 2006 to 2011 are shown in Table 5 and Table 6.
