We synthesized vinylieriazolyl ketone through Knoevenagel reaction of α-triazolylpinacolone with 4-chlorophenyl acetaldehyde using KF-Al2O3 as a catalyst. The effect of the reaction conditions, such as the amount of ...We synthesized vinylieriazolyl ketone through Knoevenagel reaction of α-triazolylpinacolone with 4-chlorophenyl acetaldehyde using KF-Al2O3 as a catalyst. The effect of the reaction conditions, such as the amount of catalyst, temperature, the molar ratio of 4-chlorophenyl acetaldehyde to α-triazolylpinacolone and different PEGs was investigated. The optimum reaction conditions are: the molar ratio of 4-chlorophenyl acetaldehyde to α-triazolylpinacolone is 1.2∶1, reaction time is 0.5 h, reaction temperature is 75～80℃, the phase transfer is PEG4000. Under these conditions, the yield of vinylieriazolyl ketone could reach up to 95.2%.展开更多
A new method of synthesis of 2 methyl 1 benzyl benzimidazole starting from 2 methyl benzimdazole and benzyl bromide was reported with KF Al 2O 3 as catlyst and DMF as solution.The influence of some reaction condition ...A new method of synthesis of 2 methyl 1 benzyl benzimidazole starting from 2 methyl benzimdazole and benzyl bromide was reported with KF Al 2O 3 as catlyst and DMF as solution.The influence of some reaction condition on yield was also tested,and the optimum conditions were obtained,the molecular ratio of catlyst and 2 methyl benzimdazole and benzyl bromide 1∶1∶1 05,the reaction temperature 20-25,and the yield 70 8%.展开更多
文摘We synthesized vinylieriazolyl ketone through Knoevenagel reaction of α-triazolylpinacolone with 4-chlorophenyl acetaldehyde using KF-Al2O3 as a catalyst. The effect of the reaction conditions, such as the amount of catalyst, temperature, the molar ratio of 4-chlorophenyl acetaldehyde to α-triazolylpinacolone and different PEGs was investigated. The optimum reaction conditions are: the molar ratio of 4-chlorophenyl acetaldehyde to α-triazolylpinacolone is 1.2∶1, reaction time is 0.5 h, reaction temperature is 75～80℃, the phase transfer is PEG4000. Under these conditions, the yield of vinylieriazolyl ketone could reach up to 95.2%.
文摘A new method of synthesis of 2 methyl 1 benzyl benzimidazole starting from 2 methyl benzimdazole and benzyl bromide was reported with KF Al 2O 3 as catlyst and DMF as solution.The influence of some reaction condition on yield was also tested,and the optimum conditions were obtained,the molecular ratio of catlyst and 2 methyl benzimdazole and benzyl bromide 1∶1∶1 05,the reaction temperature 20-25,and the yield 70 8%.
