Nuclear masses play a crucial role in both nuclear physics and astrophysics,driving sustained efforts toward precise experi-mental determination and reliable theoretical predictions.In this study,we compiled the newly...Nuclear masses play a crucial role in both nuclear physics and astrophysics,driving sustained efforts toward precise experi-mental determination and reliable theoretical predictions.In this study,we compiled the newly measured masses for 296 nuclides from 40 references published between 2021 and 2024,subsequent to the release of the latest atomic mass evalu-ation.These data were used to benchmark the performance of several relativistic and nonrelativistic density functionals,including PC-PK1,TMA,SLy4,SV-min,UNEDF1,and the recently proposed PC-L3R.The results for PC-PK1 and PC-L3R were obtained using the state-of-the-art deformed relativistic Hartree-Bogoliubov theory in continuum(DRHBc),whereas the others were adopted from the existing literature.It was found that the DRHBc calculations with PC-PK1 and PC-L3R achieved an accuracy better than 1.5 MeV,outperforming the other functionals,which all exhibited root-mean-square devia-tions exceeding 2 MeV.The odd-even effects and isospin dependence in these theoretical descriptions were examined.The PC-PK1 and PC-L3R descriptions were qualitatively similar,exhibiting robust isospin dependence along the isotopic chains.Finally,a quantitative comparison between the PC-PK1 and PC-L3R results is presented,with the largest discrepancies analyzed in terms of the potential energy curves from the constrained DRHBc calculations.展开更多
Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM...Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM is critical to providing early treatment options.This commentary elaborates on the findings of Jiang et al.[2],who investigated the role of adipokine hormone,Adipsin,as a cardioprotective factor in DCM.We provide an exposition and alternative treatment considerations,like Fisetin,and discuss the potential of investigating other cellular targets implicated in cardiac dysfunction,like the interleukin-1 receptor-associated kinaselike 2(Irak2)protein[3]and protein kinase R[4].展开更多
Objective: To discuss some key points about nursing in the use of DDG-3300K liver reserve function analyzer in patients at the department of infectious diseases. Method: DDG-3300K liver reserve function analyzer was a...Objective: To discuss some key points about nursing in the use of DDG-3300K liver reserve function analyzer in patients at the department of infectious diseases. Method: DDG-3300K liver reserve function analyzer was applied to 5464 patients at the department of infectious diseases. The reasons for failed detection and complications related to the detection were analyzed, and the measures for improving the nursing procedures were proposed. Result: Among the 5464 patients, the detections were successful at the first attempt in 5458 patients;2 patients had leakage of liquid;2 patients were poorly prepared, and 1 case failed because of mistaken selection of CO mode, which led to adverse drug reactions;1 case did not finish the detection due to anaphylactic shock;8 patients had nausea and 6 patients had skin rash on the four limbs and torso during the detection. Conclusion: It is necessary to formulate the nursing procedures for the use of DDG-3300K liver reserve function analyzer. Moreover, preparatory work, health education, refined nursing procedures and skillful operations are closely related to the success rate and accuracy of the detection.展开更多
In this context, we mainly study the behavior in the neighborhood of finite singular points for k-regular functions in R1^n with values in R0、n. We get a Laurent expansion of them in an open set, prove its uniqueness...In this context, we mainly study the behavior in the neighborhood of finite singular points for k-regular functions in R1^n with values in R0、n. We get a Laurent expansion of them in an open set, prove its uniqueness, give the definitions of k-poles, isolated and essential singular points and removable singularity, discuss some properties, and further obtain the residue theorems.展开更多
African swine fever(ASF),caused by African swine fever virus(ASFV),is a highly contagious swine disease that has spread globally.Effective control strategies are not yet available.In this study,we prepared K205R mRNA,...African swine fever(ASF),caused by African swine fever virus(ASFV),is a highly contagious swine disease that has spread globally.Effective control strategies are not yet available.In this study,we prepared K205R mRNA,which was then formulated using Lipid Nanoparticle(LNP).The resulting K205R mRNA-LNP showed a particle size of approximately 86.27 nm and an mRNA encapsulation efficiency of 96.24%.Efficient expression of the K205R protein was confirmed in both HEK293T and PK15 cells.We further evaluated the immunogenicity of K205R mRNA-LNP in mice and pigs.All immunized animals developed significantly higher levels of IgG antibodies against K205R compared to the control group in the first week after the second immunization,with antibody titers reaching up to 105.Challenge experiments showed that K205R mRNA delayed the time of death.Our results suggested the successful implementation of the mRNA platform in the preparation and application of ASFV mRNA.展开更多
In this paper, we obtain the convexity of new general integral operator on some classes of k-uniformly p-valent a-convex functions of complex order. These results extend some known theorems.
For the first time,proteolysis-targeting chimeras(PROTAC)technology was utilized to achieve the isoform-selective degradation of class I phosphoinositide 3-kinases(PI3Ks)in this study.Through screening and optimizatio...For the first time,proteolysis-targeting chimeras(PROTAC)technology was utilized to achieve the isoform-selective degradation of class I phosphoinositide 3-kinases(PI3Ks)in this study.Through screening and optimization,the PROTAC molecule ZM-PI05 was identified as a selective degrader of p110αin multiple breast cancer cells.More importantly,the degrader can down-regulate p85 regulatory subunit simultaneously,thereby inhibiting the non-enzymatic functions of PI3K that are independent on p110catalytic subunits.Therefore,compared with PI3K inhibitor copanlisib,ZM-PI05 displayed the stronger anti-proliferative activity on breast cancer cells.In brief,a selective and efficient PROTAC molecule was developed to induce the degradation of p110αand concurrent reduction of p85 proteins,providing a tool compound for the biological study of PI3K-αby blocking its enzymatic and non-enzymatic functions.展开更多
The purpose of this paper is to present a general universal formula for <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;&...The purpose of this paper is to present a general universal formula for <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate survival functions for arbitrary <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 2, 3, <span style="font-family:;" "=""><span style="font-family:Verdana;">...<span style="font-family:Verdana;">, given all the univariate marginal survival functions. This universal form of <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate probability distributions was obtained by means of “dependence functions” named “joiners” in the text. These joiners determine all the involved stochastic dependencies between the underlying random variables. However, in order that the presented formula (the form) represents a legitimate survival function, some necessary and sufficient conditions for the joiners had to be found. Basically, finding those conditions is the main task of this paper. This task was successfully performed for the case <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 2 and the main results for the case <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 3 were formulated as Theorem 1 and Theorem 2 in Section 4. Nevertheless, the hypothetical conditions valid for the general <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> ≥ 4 case were also formulated in Section 3 as the (very convincing) Hypothesis. As for the sufficient conditions for both the <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:;" "=""><span style="font-family:Verdana;"> = 3 and <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> ≥ 4 cases, the full generality was not achieved since two restrictions were imposed. Firstly, we limited ourselves to the, defined in the text, “continuous cases” (when the corresponding joint density exists and is continuous), and secondly we consider positive stochastic dependencies only. Nevertheless, the class of the <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate distributions which can be constructed is very wide. The presented method of construction by means of joiners can be considered competitive to the <span style="font-family:Verdana;"><span style="font-family:Verdana;">copula<span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> methodology. As it is suggested in the paper the possibility of building a common theory of both copulae and joiners is quite possible, and the joiners may play the role of tools within the theory of copulae, and vice versa copulae may, for example, be used for finding proper joiners. Another independent feature of the joiners methodology is the possibility of constructing many new stochastic processes including stationary and Markovian.展开更多
基金supported by the National Natural Science Foundation of China(Nos.12265012 and 12305125)Guizhou Provincial Science and Technology Projects(No.ZK[2022]203)+2 种基金PhD fund of Guizhou Minzu University(No.GZMUZK[2024]QD76)the National Key Laboratory of Neutron Science and Technology(No.NST202401016)the Sichuan Science and Technology Program(No.2024NSFSC1356).
文摘Nuclear masses play a crucial role in both nuclear physics and astrophysics,driving sustained efforts toward precise experi-mental determination and reliable theoretical predictions.In this study,we compiled the newly measured masses for 296 nuclides from 40 references published between 2021 and 2024,subsequent to the release of the latest atomic mass evalu-ation.These data were used to benchmark the performance of several relativistic and nonrelativistic density functionals,including PC-PK1,TMA,SLy4,SV-min,UNEDF1,and the recently proposed PC-L3R.The results for PC-PK1 and PC-L3R were obtained using the state-of-the-art deformed relativistic Hartree-Bogoliubov theory in continuum(DRHBc),whereas the others were adopted from the existing literature.It was found that the DRHBc calculations with PC-PK1 and PC-L3R achieved an accuracy better than 1.5 MeV,outperforming the other functionals,which all exhibited root-mean-square devia-tions exceeding 2 MeV.The odd-even effects and isospin dependence in these theoretical descriptions were examined.The PC-PK1 and PC-L3R descriptions were qualitatively similar,exhibiting robust isospin dependence along the isotopic chains.Finally,a quantitative comparison between the PC-PK1 and PC-L3R results is presented,with the largest discrepancies analyzed in terms of the potential energy curves from the constrained DRHBc calculations.
基金supported by the Office of Naval Research Grant(N00014-22-1-2184)。
文摘Diabetic cardiomyopathy(DCM)is a major cause of heart failure in diabetic patients.It progresses asymptomatically prior to the onset of severe cardiac symptoms[1];therefore,elucidating the underlying mechanisms of DCM is critical to providing early treatment options.This commentary elaborates on the findings of Jiang et al.[2],who investigated the role of adipokine hormone,Adipsin,as a cardioprotective factor in DCM.We provide an exposition and alternative treatment considerations,like Fisetin,and discuss the potential of investigating other cellular targets implicated in cardiac dysfunction,like the interleukin-1 receptor-associated kinaselike 2(Irak2)protein[3]and protein kinase R[4].
文摘Objective: To discuss some key points about nursing in the use of DDG-3300K liver reserve function analyzer in patients at the department of infectious diseases. Method: DDG-3300K liver reserve function analyzer was applied to 5464 patients at the department of infectious diseases. The reasons for failed detection and complications related to the detection were analyzed, and the measures for improving the nursing procedures were proposed. Result: Among the 5464 patients, the detections were successful at the first attempt in 5458 patients;2 patients had leakage of liquid;2 patients were poorly prepared, and 1 case failed because of mistaken selection of CO mode, which led to adverse drug reactions;1 case did not finish the detection due to anaphylactic shock;8 patients had nausea and 6 patients had skin rash on the four limbs and torso during the detection. Conclusion: It is necessary to formulate the nursing procedures for the use of DDG-3300K liver reserve function analyzer. Moreover, preparatory work, health education, refined nursing procedures and skillful operations are closely related to the success rate and accuracy of the detection.
基金Supported by the National Natural Science Foundation of China (10471107)the Specialized Research Fund for the Doctoral Program of Higher Education of China (20060486001)
文摘In this context, we mainly study the behavior in the neighborhood of finite singular points for k-regular functions in R1^n with values in R0、n. We get a Laurent expansion of them in an open set, prove its uniqueness, give the definitions of k-poles, isolated and essential singular points and removable singularity, discuss some properties, and further obtain the residue theorems.
基金funded by the National Key Research and Development Program of China(2022YFD1800500,2021YFD1801401,2023YFD1802600)the Central Public-interest Scientific Institution Basal Research Fund,China(Y2022PT11)the Shanghai Sailing Program,China(23YF1457400).
文摘African swine fever(ASF),caused by African swine fever virus(ASFV),is a highly contagious swine disease that has spread globally.Effective control strategies are not yet available.In this study,we prepared K205R mRNA,which was then formulated using Lipid Nanoparticle(LNP).The resulting K205R mRNA-LNP showed a particle size of approximately 86.27 nm and an mRNA encapsulation efficiency of 96.24%.Efficient expression of the K205R protein was confirmed in both HEK293T and PK15 cells.We further evaluated the immunogenicity of K205R mRNA-LNP in mice and pigs.All immunized animals developed significantly higher levels of IgG antibodies against K205R compared to the control group in the first week after the second immunization,with antibody titers reaching up to 105.Challenge experiments showed that K205R mRNA delayed the time of death.Our results suggested the successful implementation of the mRNA platform in the preparation and application of ASFV mRNA.
基金Foundation item： Supported by the Natural Science Foundation of Inner Mongolia（2009MS0113） Sup- ported by the Higher School Research Foundation of Inner Mongolia（NJzy08150）
文摘In this paper, we obtain the convexity of new general integral operator on some classes of k-uniformly p-valent a-convex functions of complex order. These results extend some known theorems.
基金supported by National Key R&D Program of China(Nos.2021YFA1302100,2021YFA1300200,2020YFE0202200)National Natural Science Foundation of China(Nos.82125034,82330115)。
文摘For the first time,proteolysis-targeting chimeras(PROTAC)technology was utilized to achieve the isoform-selective degradation of class I phosphoinositide 3-kinases(PI3Ks)in this study.Through screening and optimization,the PROTAC molecule ZM-PI05 was identified as a selective degrader of p110αin multiple breast cancer cells.More importantly,the degrader can down-regulate p85 regulatory subunit simultaneously,thereby inhibiting the non-enzymatic functions of PI3K that are independent on p110catalytic subunits.Therefore,compared with PI3K inhibitor copanlisib,ZM-PI05 displayed the stronger anti-proliferative activity on breast cancer cells.In brief,a selective and efficient PROTAC molecule was developed to induce the degradation of p110αand concurrent reduction of p85 proteins,providing a tool compound for the biological study of PI3K-αby blocking its enzymatic and non-enzymatic functions.
文摘The purpose of this paper is to present a general universal formula for <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate survival functions for arbitrary <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 2, 3, <span style="font-family:;" "=""><span style="font-family:Verdana;">...<span style="font-family:Verdana;">, given all the univariate marginal survival functions. This universal form of <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate probability distributions was obtained by means of “dependence functions” named “joiners” in the text. These joiners determine all the involved stochastic dependencies between the underlying random variables. However, in order that the presented formula (the form) represents a legitimate survival function, some necessary and sufficient conditions for the joiners had to be found. Basically, finding those conditions is the main task of this paper. This task was successfully performed for the case <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 2 and the main results for the case <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> = 3 were formulated as Theorem 1 and Theorem 2 in Section 4. Nevertheless, the hypothetical conditions valid for the general <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> ≥ 4 case were also formulated in Section 3 as the (very convincing) Hypothesis. As for the sufficient conditions for both the <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:;" "=""><span style="font-family:Verdana;"> = 3 and <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;"> ≥ 4 cases, the full generality was not achieved since two restrictions were imposed. Firstly, we limited ourselves to the, defined in the text, “continuous cases” (when the corresponding joint density exists and is continuous), and secondly we consider positive stochastic dependencies only. Nevertheless, the class of the <span style="font-family:Verdana;"><span style="font-family:Verdana;">k<span style="font-family:Verdana;"><span style="font-family:Verdana;">-variate distributions which can be constructed is very wide. The presented method of construction by means of joiners can be considered competitive to the <span style="font-family:Verdana;"><span style="font-family:Verdana;">copula<span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> methodology. As it is suggested in the paper the possibility of building a common theory of both copulae and joiners is quite possible, and the joiners may play the role of tools within the theory of copulae, and vice versa copulae may, for example, be used for finding proper joiners. Another independent feature of the joiners methodology is the possibility of constructing many new stochastic processes including stationary and Markovian.
