Tight junctions(TJs)are structures between cells where cells appear in the closest possible contact.They are responsible for sealing compartments when epithelial sheets are generated.They regulate the permeability of ...Tight junctions(TJs)are structures between cells where cells appear in the closest possible contact.They are responsible for sealing compartments when epithelial sheets are generated.They regulate the permeability of ions,(macro)molecules and cells via the paracellular pathway.Their structure at the electron microscopic level has been well known since the 1970s;however,only recently has their macromolecular composition been revealed.This review first examines the major macromolecular components of the TJs(occludin,claudins,junctional adhesion molecule and tricellulin)and then the associated macromolecules at the intracellular plaque[zonula occludens(ZO)-1,ZO-2,ZO-3,AF-6,cingulin,7H6].Emphasis is given to their interactions in order to begin to understand the mode of assembly of TJs.The functional significance of TJs is detailed and several mechanisms and factors involved are discussed briefly.Emphasis is given to the role of intestinal TJs and the alterations observed or speculated in diverse disease states.Specifically,intestinal TJs may exert a pathogenetic role in intestinal(inflammatory bowel disease,celiac disease)and extraintestinal diseases (diabetes type 1,food allergies,autoimmune diseases).Additionally,intestinal TJs may be secondarily disrupted during the course of diverse diseases,subsequently allowing the bacterial translocation phenomenon and promoting the systemic inflammatory response,which is often associated with clinical deterioration.The major questions in the field are highlighted.展开更多
The global wall shear stress measurement tech- nique using shear-sensitive liquid crystal （SSLC） is extended to wind tunnel measurements. Simple and common every- day equipment is used in the measurement; in particu...The global wall shear stress measurement tech- nique using shear-sensitive liquid crystal （SSLC） is extended to wind tunnel measurements. Simple and common every- day equipment is used in the measurement; in particular a tungsten-halogen light bulb provides illumination and a saturation of SSLC coating color change with time is found. Spatial wall shear stress distributions of several typical flows are obtained using this technique, including wall-jet flow, vortex flow generated by a delta wing and junction flow behind a thin cylinder, although the magnitudes are not fully calibrated. The results demonstrate that SSLC technique can be extended to wind tunnel measurements with no complicated facilities used.展开更多
The general solution of stresses is derived for a T-shaped junction of two thin plates with an adhesion crack. The plates are orthotropic. A shear force is applied on the crack surface. The analysis is based on the su...The general solution of stresses is derived for a T-shaped junction of two thin plates with an adhesion crack. The plates are orthotropic. A shear force is applied on the crack surface. The analysis is based on the supposition that the stresses in each plate can be approximated by a plane stress condition. The results obtained are verified by numerical calculation of FEM.展开更多
文摘Tight junctions(TJs)are structures between cells where cells appear in the closest possible contact.They are responsible for sealing compartments when epithelial sheets are generated.They regulate the permeability of ions,(macro)molecules and cells via the paracellular pathway.Their structure at the electron microscopic level has been well known since the 1970s;however,only recently has their macromolecular composition been revealed.This review first examines the major macromolecular components of the TJs(occludin,claudins,junctional adhesion molecule and tricellulin)and then the associated macromolecules at the intracellular plaque[zonula occludens(ZO)-1,ZO-2,ZO-3,AF-6,cingulin,7H6].Emphasis is given to their interactions in order to begin to understand the mode of assembly of TJs.The functional significance of TJs is detailed and several mechanisms and factors involved are discussed briefly.Emphasis is given to the role of intestinal TJs and the alterations observed or speculated in diverse disease states.Specifically,intestinal TJs may exert a pathogenetic role in intestinal(inflammatory bowel disease,celiac disease)and extraintestinal diseases (diabetes type 1,food allergies,autoimmune diseases).Additionally,intestinal TJs may be secondarily disrupted during the course of diverse diseases,subsequently allowing the bacterial translocation phenomenon and promoting the systemic inflammatory response,which is often associated with clinical deterioration.The major questions in the field are highlighted.
基金the Doctorate Creation Foundation of Northwestern Polytechnical University (CX200902)
文摘The global wall shear stress measurement tech- nique using shear-sensitive liquid crystal （SSLC） is extended to wind tunnel measurements. Simple and common every- day equipment is used in the measurement; in particular a tungsten-halogen light bulb provides illumination and a saturation of SSLC coating color change with time is found. Spatial wall shear stress distributions of several typical flows are obtained using this technique, including wall-jet flow, vortex flow generated by a delta wing and junction flow behind a thin cylinder, although the magnitudes are not fully calibrated. The results demonstrate that SSLC technique can be extended to wind tunnel measurements with no complicated facilities used.
文摘The general solution of stresses is derived for a T-shaped junction of two thin plates with an adhesion crack. The plates are orthotropic. A shear force is applied on the crack surface. The analysis is based on the supposition that the stresses in each plate can be approximated by a plane stress condition. The results obtained are verified by numerical calculation of FEM.
