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JOS OUR LATEST SPECIAL ISSUES
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《Journal of Semiconductors》 EI CAS CSCD 2019年第2期66-66,共1页
Semiconductor Materials Genome Initiative J.Semicond.2018,VoL39,Issue 7 vip Edited by Suhuai Wei(Beijing Computational Science Research Center,Beijing,China)Junwei Luo(Institute of Semiconductors,CAS,Beijing,China)B... Semiconductor Materials Genome Initiative J.Semicond.2018,VoL39,Issue 7 vip Edited by Suhuai Wei(Beijing Computational Science Research Center,Beijing,China)Junwei Luo(Institute of Semiconductors,CAS,Beijing,China)Bing Huang(Beijing Computational Science Research Center,Beijing,China)Advancedsem iconductingmaterialshavemanyapplications in information technology and clean energy,thus they are critical to sustained economic and environmental development.In recent years. 展开更多
关键词 SI CAS jos OUR LATEST SPECIAL ISSUES
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Delirium Severity and Correlates among Medical Inpatients Admitted through Accident and Emergency Unit of Jos University Teaching Hospital
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作者 Lubuola I. Bamidele Aishatu Y. Armiya’u +2 位作者 Yusufu T. Maigari Opeyemi F. Akinyemi Taiwo J. Obindo 《Open Journal of Emergency Medicine》 2018年第3期31-42,共12页
Background: Delirium is one of the most common medical emergencies and is associated with poor outcomes including: mortality, prolonged length of stay and poor functional outcome. The more severe delirium is the worst... Background: Delirium is one of the most common medical emergencies and is associated with poor outcomes including: mortality, prolonged length of stay and poor functional outcome. The more severe delirium is the worst the clinical outcomes of medical illness. Despite the obvious, not much has been documented on delirium severity and its associated factors among medical inpatients in low income countries including Nigeria. Objectives: This study was conducted to examine the severity of delirium among medical inpatients admitted through the Accident and Emergency unit of Jos University Teaching Hospital as well as to assess its associated Sociodemographic and Clinical characteristics. Method: This was a cross-sectional study that employed a consecutive sampling technique to select 290 eligible subjects from medical inpatients that presented to Accident and Emergency unit of Jos University Teaching Hospital. On admission, patients were assessed for delirium using Confusion Assessment Method and severity of delirium was evaluated using Delirium Rating Scale-Revised-98. Results: Of the 105 delirious medical inpatients, 48 (45.7%) had severe delirium, 41 (39.1%) developed less severe delirium while 16 (15.2) presented with no severe delirium. Sociodemographic characteristics found to be significantly associated with less to more severe delirium include male gender (P = 0.001), nonprofessionals (P = 0.003), income range of N20,000 - N49,000 (P Conclusion: This study demonstrates that delirium is often associated with higher severity in Accident and Emergency unit admission and there are strongly associated clinical characteristics to watch out for in high risk medical inpatients. 展开更多
关键词 DELIRIUM SEVERITY and CORRELATES AMONG Medical Inpatients Admitted through Accident and Emergency UNIT of jos UNIVERSITY Teaching Hospital
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Behavior of Surface Sediment from the JoséAntonio Alzate Dam in Mexico as a Deposit of Heavy Metals
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作者 Icela Dagmar Barceló-Quintal Hugo Eduardo Solís-Correa +2 位作者 Julisa García-Albortante Magdalena García-Martínez Luis Jesús Osornio-Berthet 《Journal of Environmental Protection》 2018年第10期1049-1065,共17页
The problem of contamination of Lerma River in the State of Mexico, México, has been studied in an integral way, since it is one of the rivers of importance due to its geographical situation in the country. Jos&#... The problem of contamination of Lerma River in the State of Mexico, México, has been studied in an integral way, since it is one of the rivers of importance due to its geographical situation in the country. José Antonio Dam is the main receiving body of this river that is being contaminated by, industrial wastewater, of which about 70% is inorganic, as well as discharges municipal and agricultural, driving a lot of material in suspension. This dam acts as a regulator of avenues and its water is used for agricultural irrigation and its sediments are used as sludge to improve agricultural soil in the surroundings. One of the studies that have been carried out is to determine the geochemical distribution of heavy metals in the sediments of this dam, as well as its adsorptive capacity towards different metals. It has been observed that these sediments acts as metal contaminants sequester. Knowing the composition and morphology of these sediments can provide information to understand the mobility of different heavy metals it contains, and potential health risk, which can finally lead to the establishment of purification capacity of this sludge. 展开更多
关键词 Lerma RIVER josé Antonio Alzate DAM SEDIMENT HEAVY Metal
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Estimation of Annual Effective Dose Due to Ingestion of Natural Radionuclides in Cattle in Tin Mining Areas of Jos Plateau, Nigeria: Are Large Mammals Really Affected?
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作者 A. S. Aliyu T. A. Mousseau +2 位作者 N. N. Garba H. T. Abba A. T. Ramli 《Natural Science》 2015年第4期190-196,共7页
We have read with great interest the paper which was published in Natural Science, 2014 issue number 6 titled “Estimation of annual effective dose due to ingestion of natural radionuclides in cattle in tin mining are... We have read with great interest the paper which was published in Natural Science, 2014 issue number 6 titled “Estimation of annual effective dose due to ingestion of natural radionuclides in cattle in tin mining area of Jos Plateau, Nigeria” [1]. The paper motivated us to use state-of-the-art computational technique to investigate the risks of the tin mining activity in Jos-Plateau, Nigeria on large mammals (e.g. cattle). The Tier 2 Erica Tool assessment was used to estimate the total dose rate and risk quotients of these reference terrestrial animals. Our investigation revealed that the expected and conservative risk quotients of large mammals due to internal and external exposure to enhanced level of radioactivity are 0.05 and 0.16, respectively. Since the risk quotients are less than unity, this indicates that there is less than 5% probability that the screen dose rate (10 μGy&bull;h–1) is exceeded. The estimated total dose rate to large mammals is 0.52 μGy&bull;h–1 which is not statistically significant. A critical analysis of [1] is presented in the introductory part of this paper. 展开更多
关键词 TIN Mining RADIOECOLOGY BIOTA jos Dose Rate
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Determination of Hemobiochemical Profiles of Apparently Healthy Exotic Breed of Dogs in Jos, Plateau State, Nigeria
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作者 Kenneth I. Ogbu Kingsley U. Ezema +10 位作者 Ijeoma C. Adieme Rhoda I. Malgwi Jibreel A. Sabo Philip N. Ayuba Philip N. Ayuba Samuel A. Nguety Simone T. Atuna Francis O. Emeribe Johnson J. Shallmizhili Boniface M. Anene Boniface M. Anene 《Open Journal of Veterinary Medicine》 2021年第6期226-245,共20页
The hematological and serum biochemical profiles of apparently healthy exotic breed of dogs in Jos, Plateau state, Nigeria was studied in this research. One hundred and seven exotic breed of dogs were examined from Oc... The hematological and serum biochemical profiles of apparently healthy exotic breed of dogs in Jos, Plateau state, Nigeria was studied in this research. One hundred and seven exotic breed of dogs were examined from October</span><span style="font-family:""> - </span><span style="font-family:"">December, 2018. The results from physical, clinical examinations and parasitological examinations were used to determine ap</span><span style="font-family:Verdana;"></span><span style="font-family:"">parently healthy exotic breed of dogs which were used in this study. The parameters measured were rectal temperature, parasitaemia, hematology which included red blood cells count, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin and hemoglobin content;total white blood cell count, including eosinophils, neutrophils, lymphocytes, monocytes, granulocytes counts, and platelets;serum biochemical parameters also included Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total proteins, albumin, globulin, blood urea nitrogen, creatinine, cholesterol and triglyceride, using standard methods. Data generated from the study were statistically analyzed using students t</span><span style="font-family:"">-</span><span style="font-family:"">test one-way analysis of variance while the level of significance </span><span style="font-family:"">was </span><span style="font-family:"">measured at p < 0.05. From this study, hematological and serum biochemical values were comparable to and not different from those reported for dogs in available literature, but the upper and lower reference limits (minimum and maximum values) were different for most parameters. Sex-related significant difference (p < 0.05) occurred only in WBC and total protein while age-related significant difference occurred only in total protein and urea level. Breed affected the MCHC and total bilirubin level which was evident in higher MCHC level in Neapolitan mastiff than Alsatian breed while total bilirubin was higher in Alsatian breed than Bull mastiff (p < 0.05). The present study has presented preliminary information on the range of hematological and serum biochemistry profile of exotic breed of dogs in Jos, Plateau state, Nigeria which may be useful to biomedical researchers and veterinary clinicians. 展开更多
关键词 Hematology Serum Biochemical Profiles Apparently Healthy Exotic Breed DOGS jos Plateau State
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The Effect of the COVID 19 Pandemic on Elective Surgical Services in Jos, North Central, Nigeria
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作者 Michael Bundepuun Ode Andrew Shitta +2 位作者 Solomon Danjuma Peter Idumagbodi Amupitan Shem Bulus Yilleng 《Journal of Biosciences and Medicines》 2021年第7期29-37,共9页
<strong>Background. </strong>The COVID 19 pandemic affected healthcare delivery systems worldwide. There was a redistribution of health care resources in order to deal with the effects of the pandemic, wit... <strong>Background. </strong>The COVID 19 pandemic affected healthcare delivery systems worldwide. There was a redistribution of health care resources in order to deal with the effects of the pandemic, with a corresponding consequence on other clinical services rendered. The extent of this effect on other non COVID 19 related services has been reported in other centres worldwide. In our own setting, health care resources are limited with suboptimal access even in normal situations. <strong>Objective. </strong>We sought to evaluate the effects of the COVID 19 pandemic on elective surgical services in our hospital. <strong>Methods.</strong> This was a cross sectional comparative study carried out at the Jos University Teaching hospital, (North central, Nigeria) of the elective surgical services rendered during the first wave of the COVID 19 pandemic lockdown covering the period April to June 2020 with a corresponding period of the preceding year 2019. Data was obtained from the hospital records department, theatres and service areas for clinic attendance, elective surgeries and ward occupancy. The paired sample t-test was used to compare the assessed variables across the three months of both years with a level of significance of P < 0.05. <strong>Results.</strong> There was mean clinic attendance of 2859.33 ± 223.36 covering the three months in 2019 as against a mean attendance of 648.67 ± 578.24 covering a similar period in 2020, P = 0.037. The elective surgical procedures carried out across the surgical specialties over the period in 2019 gave a mean of 352.33 ± 44.60 as opposed to 64.001 ± 7.32 over the corresponding period in 2020, P = 0.018. Ward occupancy over April to June 2019 was a mean 297.33 ± 18.58 across the various surgical wards and 158.33 ± 25.70 in the same period in 2020, P = 0.007. <strong>Conclusion.</strong> There was a significant reduction in the elective surgical services rendered in the hospital during the first wave of the COVID 19 pandemic compared to a corresponding period in the preceding year. This decline in elective surgical services would have negatively affected the access to health care. Thus measures to clear the backlog of elective surgical procedures would be required. 展开更多
关键词 COVID 19 Lockdown Elective Surgery Clinic Attendance Ward Occupancy jos
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Substance Use Pattern among Nursing Students in Jos, North Central Nigeria
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作者 Nwoga Charles Ndak Zuhumnan +3 位作者 Danboyi Mafai Dakwak Samuel Piwuna Christopher Armiyau Aishetu 《Open Journal of Psychiatry》 2021年第2期80-90,共11页
<strong>Aim</strong>: To establish the substance use pattern and psychological distress among the in-coming nursing students of the College with a view towards recommending ways to prevent or reduce compli... <strong>Aim</strong>: To establish the substance use pattern and psychological distress among the in-coming nursing students of the College with a view towards recommending ways to prevent or reduce complications of substance use disorder in the college. <strong>Study design</strong>: A cross-sectional design was used. <strong>Place and duration</strong>: The study took place at the College of Nursing and Midwifery, Jos, Plateau state between the 3<sup>rd</sup> and 14<sup>th</sup> of February, 2020. <strong>Methodology</strong>: The study was carried out during the orientation program of the 206 first-year students of the college. Following approval, a health talk and explanation of the aims and objectives, their consent was obtained in writing. Two-staged sampling with a sociodemographic questionnaire and Hopkins Symptom Checklist-25 followed by urine drug testing was done. The participants were debriefed on the findings while maintaining strict confidentiality. There were 65 males and 141 females. <strong>Results</strong>: Lifetime prevalence rate of any substance use was 21.8%. More females 33 (23.4%) than males 12 (18.5%) used substances. Only 9 (4.5%) volunteered their substance use, the rest was revealed by the urine testing. Prevalence of alcohol was 23 (11.2%), ketamine 13 (6.3%), nicotine 3 (1.5%), benzodiazepines 3 (1.5%), cannabis 2 (1.0%) and opiods 1 (0.5%). Symptoms of psychological distress were high as 118 (57.3%) and 82 (38.8%) were symptomatic for anxiety and depression respectively. Alcohol use was significantly related with having symptomatic anxiety (<i>P = 0.02</i>) and depression (<span style="white-space:normal;"><i></span>P = 0.00<span style="white-space:normal;"></i></span>) in the study. <strong>Conclusion</strong>: Considering the high prevalence of substance use among the participants, educational intervention and policies should be designed to prevent substance dependence with its complications within the students. 展开更多
关键词 Substance Use STUDENTS jos NIGERIA
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Concentration of Heavy Metals in Respirable Dust in Jos Metropolitan Area, Nigeria
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作者 Godwin M. Mafuyai Ishaq S. Eneji Rufus Sha’Ato 《Open Journal of Air Pollution》 2014年第1期10-19,共10页
The concentration of respirable dust at seven sampling stations in Jos metropolitan area, was measured weekly for three consecutive months (October 2012 to December 2012). Characterization of the dust particles shows ... The concentration of respirable dust at seven sampling stations in Jos metropolitan area, was measured weekly for three consecutive months (October 2012 to December 2012). Characterization of the dust particles shows that the concentration of fine dust ( μm) ranged from 55.0 - 124.9 μg/m3 while the coarse dust (2.5 - 10 μm) varied from 20.0 - 124.4 μg/m3. FAAS analysis of the respirable dust shows that the concentrations of heavy metals ranged from 0.121 - 0.832 mg/kg Pb, 0.019 - 0.111 mg/kg Cr, 0.171 - 1.081 mg/kg Fe, 0.002 - 0.056 mg/kg Mn, 0.002 - 0.438 mg/kg Cd, 0.696 - 1.712 mg/kg Zn, 0.025 - 0.571 mg/kg Cu, and 0.021 - 0. 478 mg/kg Ni, across the sites studied. The main sources of these heavy metals in the sampled area could be attributed to anthropogenic activities like open incineration of waste and vehicular traffic. The concentrations of Cd, Mn and Ni were found to be far above the standard limits prescribed by the WHO for respirable dust. These results convey the health risk the inhabitants in the study area are exposed to. We therefore recommend that measures be taken to regulate these anthropogenic 展开更多
关键词 Mass CONCENTRATION Respirable DUST HEAVY METALS jos Air Quality
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HIV Prevalence amongst Pregnant Women Clients Attending Antenatal Clinic at the Faith Alive Foundation and PMTCT Centre, Jos Plateau State
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作者 Anyaka Charles Oyebode Tinuade +3 位作者 Musa Jonah Isichei Mercy Anyaka Ifechi Isichei Christian 《World Journal of AIDS》 2016年第2期59-64,共6页
Introduction: HIV infection and AIDS is a public health problem worldwide, particularly affecting the populace in resource challenged setting like sub-saharan Africa. Women of reproductive age are mostly affected and ... Introduction: HIV infection and AIDS is a public health problem worldwide, particularly affecting the populace in resource challenged setting like sub-saharan Africa. Women of reproductive age are mostly affected and infected with the HIV disease. Methodology: A cross-sectional study of 216 randomly selected women that booked for antenatal care at the Faith Alive Foundation and PMTCT centre Jos between 1st July to 31st December, 2014 was carried out. Information regarding age, parity, gestational age at booking, educational status and HIV sero-status of the clients was analysed. Screening test was conducted in a serial two step approval using determine and UNIGOLD as the confirmatory test, while STAT-PAK was the tie-beaker with discordant result as per the national algorithm. Positive samples were confirmed by western blot method. Result: A total of 18 women out of the 216 women studied were positive giving a sero-prevalence rate of 8.3%. The highest sero-prevalent rate was amongst 25 - 29 years age group (31.5%). Women of parity 1 - 4 constituted the highest group of 62.9%. Majority of the women 65.7% booked in the second trimester while 26.9% booked in the 3rd trimester. Most of the women 47.2% had secondary school education while only 5.6% of them had no form of education. Conclusion: HIV infection prevalence rate among antenatal attendants at Faith Alive Foundation and PMTCT centre Jos is still high. Multisectorial approach and intervention strategies should be further scaled up for the prevention of vertical transmission of the virus. However, it is worth noting that it is mainly an HIV/AIDS hospital which should have affected the outcome. 展开更多
关键词 HIV Prevalence Antenatal Clinic Faith Alive Foundation and PMTCT Centre jos Plateau State
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Jos Berry and Her New Avant-garde Film
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作者 Xue Peng 《China Textile》 2009年第8期32-34,共3页
As the lingerie’s top trend spotter,Ms Jos Berry directs an international team of designers based in Paris-Concepts Paris-and provides the latest trends for worldwide lingerie professionals. This Paris consultancy co... As the lingerie’s top trend spotter,Ms Jos Berry directs an international team of designers based in Paris-Concepts Paris-and provides the latest trends for worldwide lingerie professionals. This Paris consultancy company is devoted to a unique mix of services,such as trend book,online trend & news updates,color cards and design projects. 展开更多
关键词 jos Berry and Her New Avant-garde Film very more ASIA
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The“Dragging Foot”of Jose Garcia Villa’s Performative“Comma Poems”
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作者 Katie Bradshaw 《Journal of Foreign Languages and Cultures》 2022年第2期121-131,共11页
Jose Garcia Villa’s "comma poem,"in which he introduces“a new,special and poetic use”for the comma,is arguably the poet's most contentious innovation.Starting from an appropriation of Leonard Caspar’... Jose Garcia Villa’s "comma poem,"in which he introduces“a new,special and poetic use”for the comma,is arguably the poet's most contentious innovation.Starting from an appropriation of Leonard Caspar’s description of the comma poems as "demonstrably malfunctional as a dragging foot,"this essay argues that the comma poem was a visual performance whereby Villa dis-oriented and de-naturalized poetic“flows”through a quccr/crip aesthetic of hesitation and brokenness.Read as footsteps and/or footnotes,the comma’s minor mark interrupts and dis-ablcs normative flow,forcing the reader to adopt a nonnormative“gait.”Utilizing Sara Ahmed’s phenomenological theory of "queer orientation,"I examine how the comma poems’specific incongruity extends beyond modem grammars:anticipating readings of his“foreignness”and"insensitivity"to the English language.Villa performs the essentiality of the“minor mark”through linguistic experimentation.In doing so,he queers not only the“direction”of modem poetry and its canonicity,but also a contemporary politics of recuperation. 展开更多
关键词 joséGarcia Villa modernist poetry commas Sara Ahmed queer/erip theory
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Jos Berry女士详解内衣最新潮流
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《国际纺织品流行趋势》 2009年第4期32-32,共1页
作为顶级内衣潮流观察家.JOS BERRY女士领导着位于巴黎的《巴黎概念》这一国际化内衣设计团队,为全球内衣界专业人士提供最新的内衣风尚指标。
关键词 内衣设计 jos BERRY 潮流 详解 专业人士 国际化 巴黎
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Chaumet Joséphine约瑟芬经典新传奇
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作者 吴婷 《芭莎珠宝》 2015年第5期272-273,共2页
两个多世纪以前,拿破仑大帝在加冕大礼上把自己对约瑟芬皇后的爱浓缩在一顶华贵柔美的皇冠钻冕中。2015年,尚美巴黎Chaumet将皇后昔日的钻冕重新演绎,以Chaumet Joséphine加冕·爱全新臻品延续品牌传奇。想了解品牌背后的美丽... 两个多世纪以前,拿破仑大帝在加冕大礼上把自己对约瑟芬皇后的爱浓缩在一顶华贵柔美的皇冠钻冕中。2015年,尚美巴黎Chaumet将皇后昔日的钻冕重新演绎,以Chaumet Joséphine加冕·爱全新臻品延续品牌传奇。想了解品牌背后的美丽故事。 展开更多
关键词 约瑟芬 Chaumet jos phine 法兰西第一帝国 钻石戒指 尼铎 大幕 月光下 行业精英 黄钻
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JOS和他的女人
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《都市生活》 2006年第3期76-76,共1页
LOEWE背后的创意总监JOSE ENRIQUE ONA SELFA所塑造的女人是充满妩媚气质、刚柔并蓄的现代女性。爱婷专访。来自西班牙马德里的Loewe,在2005年欢庆品牌的星级手袋Amazona30周年。月前,该品牌也在上海展出2006年春夏季时装系列,并为Amaz... LOEWE背后的创意总监JOSE ENRIQUE ONA SELFA所塑造的女人是充满妩媚气质、刚柔并蓄的现代女性。爱婷专访。来自西班牙马德里的Loewe,在2005年欢庆品牌的星级手袋Amazona30周年。月前,该品牌也在上海展出2006年春夏季时装系列,并为Amazona系列手袋的30周年举行了欢庆派对。Loewe的创意总监—— 展开更多
关键词 jos 创意总监 西班牙马德里 设计灵感 水泥森林 金属色 皮肤色 城市女性 尚店 连锁式
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HMX基散粒体与其代用材料的准静态力学等效性
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作者 邵广雨 王小贺 +6 位作者 郝嘎子 肖磊 段若飞 冯晓军 郭锐 姜炜 杨俊清 《含能材料》 北大核心 2025年第12期1439-1447,共9页
为研究奥克托今(HMX)基散粒体(JO‑8)与其代用材料(硝酸钡基散粒体与硫酸钠基散粒体)的准静态力学等效性,采用自研的微型压缩破碎仪对三种药柱试样开展准静态压缩实验,基于混凝土本构模型对实验获得的应力‑应变曲线进行参数拟合。为进一... 为研究奥克托今(HMX)基散粒体(JO‑8)与其代用材料(硝酸钡基散粒体与硫酸钠基散粒体)的准静态力学等效性,采用自研的微型压缩破碎仪对三种药柱试样开展准静态压缩实验,基于混凝土本构模型对实验获得的应力‑应变曲线进行参数拟合。为进一步评估JO‑8炸药与代用材料在力学性能上的等效性,对其内部晶体单颗粒HMX、Ba(NO_(3))_(2)及Na_(2)SO_(4)开展准静态压缩实验。结果表明:JO‑8药柱的准静态力学行为宜采用真实应力‑应变曲线表征;本构模型的拟合数据与实验结果的良好吻合验证了本构模型的有效性;综合三种药柱与其内部晶体单颗粒实验结果,以及本构模型的数据分析,发现与硫酸钠基散粒体相比,硝酸钡基散粒体在准静态压缩条件下表现出与JO‑8炸药相当的力学性能。 展开更多
关键词 HMX基散粒体(JO‑8) 硝酸钡基散粒体 硫酸钠基散粒体 准静态压缩 力学等效性 本构模型
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浅谈美国久益JNA顺槽系统的电气原理 被引量:2
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作者 乔永军 孙国栋 孙丽霞 《科技与企业》 2014年第11期144-144,147,共2页
结合神华集团神东煤炭公司广泛使用的美国久益JNA顺槽系统,本文阐述顺槽系统的概况及系统基本框架,详细介绍了该系统关键部件的功能及如何与外设的通讯,举例说明外部反馈如何调节采煤机的牵引速度。
关键词 jos系统框架 通讯 外部信号反馈
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Tm^(3+)掺杂的MFT玻璃材料的升频转换发光及光学性质的JO计算 被引量:13
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作者 陈宝玖 吕少哲 +3 位作者 秦伟平 王海宇 许武 黄世华 《光子学报》 EI CAS CSCD 1999年第7期667-671,共5页
本文报道了Tm3+离子在MFT玻璃材料中的光学性质.测量了吸收光谱,利用JO理论计算了不同能级的寿命、跃迁分支比及跃迁几率,计算了一些能级的辐射跃迁振子强度.测量了650nm激发下蓝色升频转换发光,讨论了升频转换发光... 本文报道了Tm3+离子在MFT玻璃材料中的光学性质.测量了吸收光谱,利用JO理论计算了不同能级的寿命、跃迁分支比及跃迁几率,计算了一些能级的辐射跃迁振子强度.测量了650nm激发下蓝色升频转换发光,讨论了升频转换发光强度与激发光功率的关系,计算了1D2→3H4和1G4→3H6两个蓝色跃迁的发射截面. 展开更多
关键词 MFT玻璃 JO理论 升频转换发光 铥离子掺杂
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HepaRG细胞移植治疗鼠特异性Fas抗体诱导的小鼠急性肝衰竭 被引量:2
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作者 蒋黎 兰林 +2 位作者 李俊刚 王宇明 刘国栋 《第三军医大学学报》 CAS CSCD 北大核心 2009年第18期1724-1727,共4页
目的探讨HepaRG细胞移植对鼠特异性Fas抗体诱导的急性肝衰竭小鼠的治疗作用和人肝细胞异种移植的策略。方法利用特异性鼠抗Fas抗体(Jo2mAb)腹腔注射,剂量为0.3mg/kg,诱导20只SCID小鼠制备急性肝衰竭模型,24h内按照实验动物随机数字表分... 目的探讨HepaRG细胞移植对鼠特异性Fas抗体诱导的急性肝衰竭小鼠的治疗作用和人肝细胞异种移植的策略。方法利用特异性鼠抗Fas抗体(Jo2mAb)腹腔注射,剂量为0.3mg/kg,诱导20只SCID小鼠制备急性肝衰竭模型,24h内按照实验动物随机数字表分组方法,经脾移植2×106HepaRG细胞的小鼠为实验组(10只),未经HepaRG细胞移植的小鼠为对照组(10只)。观察小鼠的存活率、肝脏功能、肝组织变化情况。实验组移植4周免疫组化检测肝组织人白蛋白、人CK18、人HepPar1的表达,免疫荧光检测人白蛋白的表达。结果实验组小鼠有9只存活超过4周,而对照组小鼠3d内先后死亡9只,实验组血清ALT和AST趋于正常,显著低于对照组(P<0.01),且存活时间显著高于对照组(P<0.01)。实验组经HepaRG细胞移植能避免Jo2mAb所致肝组织出血、坏死,移植后4周免疫组化可见人白蛋白、CK18、HepPar1阳性表达细胞,肝组织免疫荧光可见人白蛋白阳性细胞的表达。结论移植HepaRG细胞可治疗Jo2mAb腹腔注射小鼠诱导的急性肝衰竭,HepaRG细胞不仅在小鼠肝内存活,且得以增殖。 展开更多
关键词 肝细胞移植 Fas抗体/Jo2 MAB 急性肝衰竭 动物模型/鼠
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利用bcl-2抗Fas凋亡特性联合Fas抗体促进人鼠嵌合肝中人肝细胞的增殖 被引量:1
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作者 蒋黎 兰林 +2 位作者 李俊刚 王宇明 刘国栋 《重庆医学》 CAS CSCD 北大核心 2009年第19期2445-2447,2450,I0003,共5页
目的移植bcl-2转基因HepaRG细胞到小鼠体内,并联合使用Jo2抗体诱导鼠肝细胞凋亡策略,促进人鼠嵌合肝中人肝细胞的增殖。方法SCID鼠经脾移植2×106bcl-2转基因HepaRG细胞,移植后1d始腹腔注射0.2mg/kgJo2抗体,每周1次,持续10周为实验... 目的移植bcl-2转基因HepaRG细胞到小鼠体内,并联合使用Jo2抗体诱导鼠肝细胞凋亡策略,促进人鼠嵌合肝中人肝细胞的增殖。方法SCID鼠经脾移植2×106bcl-2转基因HepaRG细胞,移植后1d始腹腔注射0.2mg/kgJo2抗体,每周1次,持续10周为实验组;移植未转染bcl-2基因的HepaRG细胞,同样给予Jo2抗体腹腔注射为对照1组,移植未转染bcl-2基因的HepaRG细胞,未腹腔注射Jo2抗体为对照2组,建立人鼠嵌合肝动物模型。从2周开始,后4、8、12、16、20、24周,分别采用免疫组化、免疫荧光和逆转录聚合酶链反应(RT-PCR)检测不同时相点实验组和对照组嵌合肝中肝组织人清蛋白以及人清蛋白mRNA,并用酶联免疫法(ELISA)定量检测鼠血清人清蛋白的含量。结果实验组和对照组小鼠均能存活至24周,鼠肝组织和血清中均能检测到清蛋白的表达。实验组肝组织和血清人清蛋白的表达均可持续到24周,人血清清蛋白高峰值为95.32ng/mL,出现在16周;而对照1组肝组织和血清人清蛋白的表达可持续到20周,人血清清蛋白高峰值为42.37ng/mL,出现在12周;对照2组肝组织和血清人清蛋白的表达可持续到12周,人血清清蛋白高峰值为22.91ng/mL,出现在8周。结论利用bcl-2抗Fas凋亡特性,转染bcl-2基因的HepaRG细胞移植并联合小剂量Jo2抗体腹腔注射SCID鼠,有利于人鼠嵌合肝中人肝细胞的增殖和存活。 展开更多
关键词 BCL-2 HepaRG细胞 Fas抗体/Jo2 MAB 移植 人鼠嵌合肝/动物模型
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12.7mm弹丸侵彻炸药的数值计算与试验研究 被引量:2
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作者 席鹏 张举华 +4 位作者 李媛媛 郑亚峰 南海 孙培培 张建雄 《四川兵工学报》 CAS 2014年第3期58-61,共4页
采用拉格朗日有限元算法对弹丸侵彻JO-H炸药实验进行数值计算,得到弹丸侵彻装药的侵彻过程及反应度。为验证数值计算结果,进行API验证试验,参考美军标MIL-STD-2105C评价反应等级。结果表明:在侵彻过程、轴向、径向尺寸效应等方面,验证... 采用拉格朗日有限元算法对弹丸侵彻JO-H炸药实验进行数值计算,得到弹丸侵彻装药的侵彻过程及反应度。为验证数值计算结果,进行API验证试验,参考美军标MIL-STD-2105C评价反应等级。结果表明:在侵彻过程、轴向、径向尺寸效应等方面,验证试验与数值计算结果吻合良好;Ф100×300 mm尺寸的JO-H炸药在弹丸侵彻作用下发生爆轰作用;Ф400×200 mm装药反应剧烈性低于Ф100×200 mm装药,反应级别相同,为爆炸反应。 展开更多
关键词 爆炸力学 数值计算 尺度效应 弹丸侵彻 JO—H
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