One of the most profound goals of modern organic chemistry is to enrich synthetic method and compound library serving as the foundation of pharmaceutical and material sciences.Meanwhile,the synthesis of structurally c...One of the most profound goals of modern organic chemistry is to enrich synthetic method and compound library serving as the foundation of pharmaceutical and material sciences.Meanwhile,the synthesis of structurally complex compounds necessitates tedious multistep procedures.This is certainly not in line with the requirements of green chemistry.Therefore,there is a strong impetus for the development of more concise and sustainable approaches to obtaining such compounds.So far,a number of state-of-the-art strategies for this purpose have been developed.展开更多
As a part of our continuing work to discover bioactive leading molecules from marine microorganism, ethyl acetate fraction of organic extract of the train Stachybotrys longispora FG216 showed fibrinolytic activity in ...As a part of our continuing work to discover bioactive leading molecules from marine microorganism, ethyl acetate fraction of organic extract of the train Stachybotrys longispora FG216 showed fibrinolytic activity in our primary screen. The bioassay-guided purification of the active fractions resulted in isolation of a new isoindolone, FGFC2 （1） （FGFC2, Fungi fibrinolytic compound 2）, together with two known compounds, LL-Zl272β （2） and ergosterol （3）. The structure of compound 1 was elucidated by the spectral analysis of 1D （^1H, ^13C） NMR, 2D （COSY, HSQC, and HMBC） and ESI-MS. Three compounds were evaluated for fibrinolytic activities in vitro. Compared to FGFC1 （EC50=47 μmol/L） as a reference drug, compound 1 and ergosterol （3） showed moderate fibrinolytic activities in vitro with EC50 values of 108.16 and 156.30 μmol/L, respectively. LL-Z127213 （2） had no fibrinolytic activity.展开更多
基金the National Natural Science Foundation of China(U2004189)the Program for Science&Technology Innovation Talents in Universities of Henan Province(24HASTIT069)+1 种基金NMPA Key Laboratory for Research and Evaluation of Innovative Drug,Henan Key Laboratory of Organic Functional Molecules and Drug Innovation111 Project(D17007)for financial support.
文摘One of the most profound goals of modern organic chemistry is to enrich synthetic method and compound library serving as the foundation of pharmaceutical and material sciences.Meanwhile,the synthesis of structurally complex compounds necessitates tedious multistep procedures.This is certainly not in line with the requirements of green chemistry.Therefore,there is a strong impetus for the development of more concise and sustainable approaches to obtaining such compounds.So far,a number of state-of-the-art strategies for this purpose have been developed.
基金The work was supported by the National Natural Science Foundation of China （No. 81502955）, the Doctoral Scientific Research Foundation of Shanghai Ocean University （No. A2030214300077）, the Young Teachers Training Program of Shanghai （No. A12056160002）, and the Project Funded by Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening.
文摘As a part of our continuing work to discover bioactive leading molecules from marine microorganism, ethyl acetate fraction of organic extract of the train Stachybotrys longispora FG216 showed fibrinolytic activity in our primary screen. The bioassay-guided purification of the active fractions resulted in isolation of a new isoindolone, FGFC2 （1） （FGFC2, Fungi fibrinolytic compound 2）, together with two known compounds, LL-Zl272β （2） and ergosterol （3）. The structure of compound 1 was elucidated by the spectral analysis of 1D （^1H, ^13C） NMR, 2D （COSY, HSQC, and HMBC） and ESI-MS. Three compounds were evaluated for fibrinolytic activities in vitro. Compared to FGFC1 （EC50=47 μmol/L） as a reference drug, compound 1 and ergosterol （3） showed moderate fibrinolytic activities in vitro with EC50 values of 108.16 and 156.30 μmol/L, respectively. LL-Z127213 （2） had no fibrinolytic activity.
