Investigations into the distribution of neutron and proton densities were conducted within the Skyrme-Hartree-Fock-Bogoliubov(SHFB)framework.It was observed that nucleon orbitals with lower angular quantum numbers are...Investigations into the distribution of neutron and proton densities were conducted within the Skyrme-Hartree-Fock-Bogoliubov(SHFB)framework.It was observed that nucleon orbitals with lower angular quantum numbers are predominantly located inside the nucleus,whereas those with higher angular quantum numbers tend to be distributed more towards the outer regions.Additionally,this study reveals that the difference in the neutron skins of Ru and Zr can be attributed to the distinct contributions of neutron and proton orbitals.Our findings may introduce a novel approach to studying the distribution of nucleon orbitals through relativistic isobaric collisions.展开更多
Isobaric molar heat capacity affected by pressures for non-ideal gases is calculated theoretically at specified temperatures by means of gaseous equations of state,i.e.Redlish-Kwong(RK)Equation,SoaveRedlich-Kwong(SRK)...Isobaric molar heat capacity affected by pressures for non-ideal gases is calculated theoretically at specified temperatures by means of gaseous equations of state,i.e.Redlish-Kwong(RK)Equation,SoaveRedlich-Kwong(SRK)Equation,Peng-Robinson(PR)Equation,Virial Equation,coupled with Romberg numeric integral via solving the key obstacle(δV/δT)_(p),and integral(δ^(2)V/δT^(2))_(p).As an example,methane's C_(p)is calculated at constant 300 K but 1 MPa&10 MPa.The calculation results show that less than 2%relative errors occur in comparison with literature values at any specified temperatures and pressures if no phase change survives at elevated pressure P_(2)and temperature T,or when specified temperatures are greater than critical temperatures in spite of elevated pressures.However,greater errors would be present if gases were considered to be ideal,or if temperatures are lower than critical temperatures at elevated pressures(>10 MPa),because C_(p)is the function of both temperature and pressure.In particular,elevated pressures have significant effect on C_(p).展开更多
Key words,： Two 1-D dynamical and isothermal models of cathode gas diffusion layer（GDL） with isobaric and non-isobaric operations for polymer electrolyte fuel cells（PEFCs） were developed and implemented in COMSOL...Key words,： Two 1-D dynamical and isothermal models of cathode gas diffusion layer（GDL） with isobaric and non-isobaric operations for polymer electrolyte fuel cells（PEFCs） were developed and implemented in COMSOL Multiphysics v3.5.The artificial diffusion coefficient was introduced as well to make the numerical computation be stable.In the non-isobaric model,the pressure of gas mixture was obtained by summing up the governing equations of gaseous components,instead of Navier-Stoks equation.Comparison of the two models were carried out with the steady-states and dynamical simulations under given conditions.The corresponding analysis based on the simulated results was also given simultaneously.This paper is contributed to finding the differences between the isobaric and non-isobaric operation in the two-phase model of cathode GDL.展开更多
Kai-Xin-San consists of Ginseng Radix, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria at a ratio of 3:3:2:2. Kai-Xin-San has been widely used for the treatment of emotional disorders in China. However, no studi...Kai-Xin-San consists of Ginseng Radix, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria at a ratio of 3:3:2:2. Kai-Xin-San has been widely used for the treatment of emotional disorders in China. However, no studies have identified the key proteins implicated in response to Kai-Xin-San treatment. In this study, rat models of chronic mild stress were established using different stress methods over 28 days. After 14 days of stress stimulation, rats received daily intragastric administrations of 600 mg/kg Kai-Xin-San. The sucrose preference test was used to determine depression-like behavior in rats, while isobaric tags were used for relative and absolute quantitation-based proteomics to identify altered proteins following Kai-Xin-San treatment. Kai-Xin-San treatment for 2 weeks noticeably improved depression-like behaviors in rats with chronic mild stress. We identified 33 differentially expressed proteins: 7 were upregulated and 26 were downregulated. Functional analysis showed that these differentially expressed proteins participate in synaptic plasticity, neurodevelopment, and neurogenesis. Our results indicate that Kai-Xin-San has an important role in regulating the key node proteins in the synaptic signaling network, and are helpful to better understand the mechanism of the antidepressive effects of Kai-Xin-San and to provide objective theoretical support for its clinical application. The study was approved by the Ethics Committee for Animal Research from the Chinese PLA General Hospital(approval No. X5-2016-07) on March 5, 2016.展开更多
Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a label...Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a labeling technique termed isobaric tags for relative and absolute quantitation to investigate the protein profiles of spinal nerve tissues from Sprague-Dawley rats. In response to Wallerian degeneration, a total of 626 proteins were screened in sensory nerves, of which 368 were upregulated and 258 were downregulated. In addition, 637 proteins were screened in motor nerves, of which 372 were upregulated and 265 were downregulated. All identified proteins were analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of bioinformatics, and the presence of several key proteins closely related to Wallerian degeneration were tested and verified using quantitative real-time polymerase chain reaction analyses. The differentially expressed proteins only identified in the sensory nerves were mainly relevant to various biological processes that included cell-cell adhesion, carbohydrate metabolic processes and cell adhesion, whereas differentially expressed proteins only identified in the motor nerves were mainly relevant to biological processes associated with the glycolytic process, cell redox homeostasis, and protein folding. In the aspect of the cellular component, the differentially expressed proteins in the sensory and motor nerves were commonly related to extracellular exosomes, the myelin sheath, and focal adhesion. According to the Kyoto Encyclopedia of Genes and Genomes, the differentially expressed proteins identified are primarily related to various types of metabolic pathways. In conclusion, the present study screened differentially expressed proteins to reveal more about the differences and similarities between sensory and motor nerves during Wallerian degeneration. The present findings could provide a reference point for a future investigation into the differences between sensory and motor nerves in Wallerian degeneration and the characteristics of peripheral nerve regeneration. The study was approved by the Ethics Committee of the Chinese PLA General Hospital, China(approval No. 2016-x9-07) in September 2016.展开更多
We systematically calculated the multinucleon transfer reactions of ^(208)Os,^(208)Pt,^(208)Hg,^(208)Pb,^(208)Po,^(208)Rn,^(208)Ra,and ^(132,136) Xe when bombarded on ^(232) Th and ^(248) Cm at Coulomb barrier energie...We systematically calculated the multinucleon transfer reactions of ^(208)Os,^(208)Pt,^(208)Hg,^(208)Pb,^(208)Po,^(208)Rn,^(208)Ra,and ^(132,136) Xe when bombarded on ^(232) Th and ^(248) Cm at Coulomb barrier energies within the dinuclear system model.These results are in good agreement with the available experimental data.The influence of Coulomb and shell effects on actinide production in these reactions has been rigorously studied.We calculated and analyzed the potential energy surface (PES) and total kinetic energy (TKE) mass distributions for the reactions involving ^(208)Hg,^(208)Pb,and ^(208) Po with ^(248) Cm and ^(232)Th.The PES and TKE spectra shed light on the fragment formation mechanisms in multinucleon transfer reactions,with clear indications of isospin and shell effects.The production cross sections for multinucleon transfer products show a strong dependence on isobar projectiles with a mass number A=208.Isobar projectiles with high N/Z ratios are advantageous for generating neutron-rich target-like fragments.Conversely,products induced by isobar projectiles with larger charge numbers tend to shift toward proton-rich regions.The intertwining of the Coulomb potential and shell effect is evident in the production cross sections of actinide isotopes.Drawing from reactions induced by radioactive projectiles,we anticipate the discovery of several new actinide isotopes near the nuclear drip lines,extending our reach into the superheavy nuclei domain.展开更多
文摘Investigations into the distribution of neutron and proton densities were conducted within the Skyrme-Hartree-Fock-Bogoliubov(SHFB)framework.It was observed that nucleon orbitals with lower angular quantum numbers are predominantly located inside the nucleus,whereas those with higher angular quantum numbers tend to be distributed more towards the outer regions.Additionally,this study reveals that the difference in the neutron skins of Ru and Zr can be attributed to the distinct contributions of neutron and proton orbitals.Our findings may introduce a novel approach to studying the distribution of nucleon orbitals through relativistic isobaric collisions.
文摘Isobaric molar heat capacity affected by pressures for non-ideal gases is calculated theoretically at specified temperatures by means of gaseous equations of state,i.e.Redlish-Kwong(RK)Equation,SoaveRedlich-Kwong(SRK)Equation,Peng-Robinson(PR)Equation,Virial Equation,coupled with Romberg numeric integral via solving the key obstacle(δV/δT)_(p),and integral(δ^(2)V/δT^(2))_(p).As an example,methane's C_(p)is calculated at constant 300 K but 1 MPa&10 MPa.The calculation results show that less than 2%relative errors occur in comparison with literature values at any specified temperatures and pressures if no phase change survives at elevated pressure P_(2)and temperature T,or when specified temperatures are greater than critical temperatures in spite of elevated pressures.However,greater errors would be present if gases were considered to be ideal,or if temperatures are lower than critical temperatures at elevated pressures(>10 MPa),because C_(p)is the function of both temperature and pressure.In particular,elevated pressures have significant effect on C_(p).
基金National High Technology Reseach & Development Program of High Temperature PEM Fuel Cell,China (863 Program,No. 2008AA050403)Shanghai Pujiang Talent Plan,China (No. 08PJ1409)Chinese 111-Program for Energy-Saving and Environment-Friendly Automotives (No. B08019)
文摘Key words,： Two 1-D dynamical and isothermal models of cathode gas diffusion layer（GDL） with isobaric and non-isobaric operations for polymer electrolyte fuel cells（PEFCs） were developed and implemented in COMSOL Multiphysics v3.5.The artificial diffusion coefficient was introduced as well to make the numerical computation be stable.In the non-isobaric model,the pressure of gas mixture was obtained by summing up the governing equations of gaseous components,instead of Navier-Stoks equation.Comparison of the two models were carried out with the steady-states and dynamical simulations under given conditions.The corresponding analysis based on the simulated results was also given simultaneously.This paper is contributed to finding the differences between the isobaric and non-isobaric operation in the two-phase model of cathode GDL.
基金supported by the National Natural Science Foundation of China,No.81573876(to YH)
文摘Kai-Xin-San consists of Ginseng Radix, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria at a ratio of 3:3:2:2. Kai-Xin-San has been widely used for the treatment of emotional disorders in China. However, no studies have identified the key proteins implicated in response to Kai-Xin-San treatment. In this study, rat models of chronic mild stress were established using different stress methods over 28 days. After 14 days of stress stimulation, rats received daily intragastric administrations of 600 mg/kg Kai-Xin-San. The sucrose preference test was used to determine depression-like behavior in rats, while isobaric tags were used for relative and absolute quantitation-based proteomics to identify altered proteins following Kai-Xin-San treatment. Kai-Xin-San treatment for 2 weeks noticeably improved depression-like behaviors in rats with chronic mild stress. We identified 33 differentially expressed proteins: 7 were upregulated and 26 were downregulated. Functional analysis showed that these differentially expressed proteins participate in synaptic plasticity, neurodevelopment, and neurogenesis. Our results indicate that Kai-Xin-San has an important role in regulating the key node proteins in the synaptic signaling network, and are helpful to better understand the mechanism of the antidepressive effects of Kai-Xin-San and to provide objective theoretical support for its clinical application. The study was approved by the Ethics Committee for Animal Research from the Chinese PLA General Hospital(approval No. X5-2016-07) on March 5, 2016.
基金supported by National Key Research&Development Program of China,No.2016YFC11011601,2017YFA0104701the Youth Cultivation Project of Military Medical Science,China,No.15QNP091(to YW)People’s Liberation Army Youth Training Project for Medical Science of China,No.16QNP144(to YW)
文摘Sensory and motor nerve fibers of peripheral nerves have different anatomies and regeneration functions after injury. To gain a clear understanding of the biological processes behind these differences, we used a labeling technique termed isobaric tags for relative and absolute quantitation to investigate the protein profiles of spinal nerve tissues from Sprague-Dawley rats. In response to Wallerian degeneration, a total of 626 proteins were screened in sensory nerves, of which 368 were upregulated and 258 were downregulated. In addition, 637 proteins were screened in motor nerves, of which 372 were upregulated and 265 were downregulated. All identified proteins were analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of bioinformatics, and the presence of several key proteins closely related to Wallerian degeneration were tested and verified using quantitative real-time polymerase chain reaction analyses. The differentially expressed proteins only identified in the sensory nerves were mainly relevant to various biological processes that included cell-cell adhesion, carbohydrate metabolic processes and cell adhesion, whereas differentially expressed proteins only identified in the motor nerves were mainly relevant to biological processes associated with the glycolytic process, cell redox homeostasis, and protein folding. In the aspect of the cellular component, the differentially expressed proteins in the sensory and motor nerves were commonly related to extracellular exosomes, the myelin sheath, and focal adhesion. According to the Kyoto Encyclopedia of Genes and Genomes, the differentially expressed proteins identified are primarily related to various types of metabolic pathways. In conclusion, the present study screened differentially expressed proteins to reveal more about the differences and similarities between sensory and motor nerves during Wallerian degeneration. The present findings could provide a reference point for a future investigation into the differences between sensory and motor nerves in Wallerian degeneration and the characteristics of peripheral nerve regeneration. The study was approved by the Ethics Committee of the Chinese PLA General Hospital, China(approval No. 2016-x9-07) in September 2016.
基金supported by National Natural Science Foundation of China (Nos. 12105241, 12175072)Natural Science Foundation of Jiangsu Province (No. BK20210788)+3 种基金Jiangsu Provincial Double-Innovation Doctoral Program (No. JSSCBS20211013)University Science Research Project of Jiangsu Province (No. 21KJB140026)Lv Yang Jin Feng (No. YZLYJFJH2021YXBS130)Key Laboratory of High-Precision Nuclear Spectroscopy,Institute of Modern Physics,Chinese Academy of Sciences (No. IMPKFKT2021001)。
文摘We systematically calculated the multinucleon transfer reactions of ^(208)Os,^(208)Pt,^(208)Hg,^(208)Pb,^(208)Po,^(208)Rn,^(208)Ra,and ^(132,136) Xe when bombarded on ^(232) Th and ^(248) Cm at Coulomb barrier energies within the dinuclear system model.These results are in good agreement with the available experimental data.The influence of Coulomb and shell effects on actinide production in these reactions has been rigorously studied.We calculated and analyzed the potential energy surface (PES) and total kinetic energy (TKE) mass distributions for the reactions involving ^(208)Hg,^(208)Pb,and ^(208) Po with ^(248) Cm and ^(232)Th.The PES and TKE spectra shed light on the fragment formation mechanisms in multinucleon transfer reactions,with clear indications of isospin and shell effects.The production cross sections for multinucleon transfer products show a strong dependence on isobar projectiles with a mass number A=208.Isobar projectiles with high N/Z ratios are advantageous for generating neutron-rich target-like fragments.Conversely,products induced by isobar projectiles with larger charge numbers tend to shift toward proton-rich regions.The intertwining of the Coulomb potential and shell effect is evident in the production cross sections of actinide isotopes.Drawing from reactions induced by radioactive projectiles,we anticipate the discovery of several new actinide isotopes near the nuclear drip lines,extending our reach into the superheavy nuclei domain.
