Ten previously undescribed rearranged 4,9-friedodrimane merosesquiterpenoids,designated ircinrimanes A-J(1-10),were isolated from the marine sponge Ircinia sp.,collected from the South China Sea.Their structures and a...Ten previously undescribed rearranged 4,9-friedodrimane merosesquiterpenoids,designated ircinrimanes A-J(1-10),were isolated from the marine sponge Ircinia sp.,collected from the South China Sea.Their structures and absolute configurations were definitively elucidated through a combination of spectroscopic data analysis,DP4+probability assessments,electronic circular dichroism(ECD)calculations,and Mo2(OAc)4 experiment.Compounds 1-4contained benzene rings,with compound 1 featuring an unusual 2-carbonyl morpholin ring,while compound 2 possessed a benzoxazole ring.Compounds 5-9 comprised sesquiterpenoid quinones with distinct amino side chains at C-20,and compound 10 incorporated an ethoxy side chain.Notably,compounds 1-10 demonstrated an unusual rearrangement of 4,9-friedodrimane sesquiterpenes.Compounds 2,5-8 and 10 demonstrated cytotoxic activity,while compound 2 exhibited anti-inflammatory activity in zebrafish.展开更多
A new diterpene, irciniketene, was isolated from the marine sponge Ircinia selaginea(Lamark) collected from the sea around Baihai, Guangxi Province. Its structure was determined by spectroscopic methods. In the struct...A new diterpene, irciniketene, was isolated from the marine sponge Ircinia selaginea(Lamark) collected from the sea around Baihai, Guangxi Province. Its structure was determined by spectroscopic methods. In the structure, a ketene function is connected with a long conjugated system via an allene unit. Irciniketene shows a moderate inhibition toward MGC and HepG2 tumor cell lines.展开更多
基金supported by National Key R&D Program of China(No.2022YFC2804100)Qingdao Marine Science and Technology Center(No.2022QNLM030003-1)+2 种基金Qingdao postdoctoral project(No.QDBSH20240102034)Shandong Postdoctoral Science Foundation(No.SDCX-ZG-202400077)National Natural Science Foundation of China(No.U2006204)。
文摘Ten previously undescribed rearranged 4,9-friedodrimane merosesquiterpenoids,designated ircinrimanes A-J(1-10),were isolated from the marine sponge Ircinia sp.,collected from the South China Sea.Their structures and absolute configurations were definitively elucidated through a combination of spectroscopic data analysis,DP4+probability assessments,electronic circular dichroism(ECD)calculations,and Mo2(OAc)4 experiment.Compounds 1-4contained benzene rings,with compound 1 featuring an unusual 2-carbonyl morpholin ring,while compound 2 possessed a benzoxazole ring.Compounds 5-9 comprised sesquiterpenoid quinones with distinct amino side chains at C-20,and compound 10 incorporated an ethoxy side chain.Notably,compounds 1-10 demonstrated an unusual rearrangement of 4,9-friedodrimane sesquiterpenes.Compounds 2,5-8 and 10 demonstrated cytotoxic activity,while compound 2 exhibited anti-inflammatory activity in zebrafish.
文摘A new diterpene, irciniketene, was isolated from the marine sponge Ircinia selaginea(Lamark) collected from the sea around Baihai, Guangxi Province. Its structure was determined by spectroscopic methods. In the structure, a ketene function is connected with a long conjugated system via an allene unit. Irciniketene shows a moderate inhibition toward MGC and HepG2 tumor cell lines.
