We present two schemes for preparing cluster states with atomic qubits in an ion-trap system. In the first scheme an auxiliary atomic level is needed. While in the second scheme an additional classical driven field is...We present two schemes for preparing cluster states with atomic qubits in an ion-trap system. In the first scheme an auxiliary atomic level is needed. While in the second scheme an additional classical driven field is used, and the multi-ion cluster states can be generated by one step. Both the schemes are insensitive to thermal motion of the ions, all the facilities used in them are well within state of the art.展开更多
We propose a scheme for generating a four-particle cluster state in an ion-trap system.The scheme isinsensitive to the thermal motion of the ions,and needs less operations than previous ones.With such a setup,we alsod...We propose a scheme for generating a four-particle cluster state in an ion-trap system.The scheme isinsensitive to the thermal motion of the ions,and needs less operations than previous ones.With such a setup,we alsodemonstrate a procedure for perfectly teleporting an arbitrary two-particle state via a single multipartite entanglementchannel,a four-particle cluster state.展开更多
We propose an ion-trap scheme for one-step generation of a special configuration of W-class state which has recently been shown to be better than canonical W states for several quantum-information processing tasks. We...We propose an ion-trap scheme for one-step generation of a special configuration of W-class state which has recently been shown to be better than canonical W states for several quantum-information processing tasks. We also present a method for one-step realization of a nontrivial collective operation which can transform a canonical W state into a fully separable state. Such a transformation plays a key role in recently proposed quantum protocols. The operation speed in our schemes increases with the number of qubits. This is contrary to usual entanglement generation and quantum manipulation schemes which take more and more time with the increase of the number of qubits.展开更多
We propose a scheme for the implementation of remote controlled-NOT gates and entanglement swapping via geometric phase gates in ion-trap systems. The proposed scheme uses the two ground states of the A-type ions as m...We propose a scheme for the implementation of remote controlled-NOT gates and entanglement swapping via geometric phase gates in ion-trap systems. The proposed scheme uses the two ground states of the A-type ions as memory instead of the vibrational mode. And the system is robust against the spontaneous radiation and the dephasing.展开更多
This paper proposes a scheme to generate, in an ion-trap, a type of multipartite maximally entangled state which was first introduced by Chen et al. [Chen P X, Zhu S Y and Guo G C 2006 Phys. Rev. A 74 032324]. The max...This paper proposes a scheme to generate, in an ion-trap, a type of multipartite maximally entangled state which was first introduced by Chen et al. [Chen P X, Zhu S Y and Guo G C 2006 Phys. Rev. A 74 032324]. The maximum entanglement property of these states is examined. It also demonstrates how to discriminate among these states in the ion-trap.展开更多
In order to identify the potential nephrotoxic compounds in traditional Chinese medicine Lithospermum erythrorhizon,it was separated into serial fractions according to their polarities.An in vitro method was utilized ...In order to identify the potential nephrotoxic compounds in traditional Chinese medicine Lithospermum erythrorhizon,it was separated into serial fractions according to their polarities.An in vitro method was utilized to determine the nephrotoxicity of these fractions with the help of fluorescence image analysis.As a result,the primary fraction A05 and its secondary fractions C06 ＂C09 and C12 ＂C14 were found to have significant toxicity to LLC-PK1 cell line,as determined by the survive rate less than 20% after they were treated with these fractions.These potential nephrotoxic fractions were further analyzed by multistage and high resolution mass spectrometry.The main compounds in these fractions were tentatively identified to be acetylshikonin,isobutyrylshikonin,β,β＇-dimethyla-cryloylshikonin,and isovalerylshikonin,which may bring nephrotoxicity.展开更多
Glycolysis-related lactic acid overproduction creates an“ion-trapping”barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy.Therefore,normalization of ...Glycolysis-related lactic acid overproduction creates an“ion-trapping”barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy.Therefore,normalization of tumor microenvironment via lactic acid neutralization can be a promising avenue for overcoming this therapeutic hurdle.In this study,the flexible liposomes loaded with sodium bicarbonate(NaHCO_(3)@Flip)were used as a nano-adjuvant to boost chemoimmunotherapy.Their effects on assisting DOXIL and anti-programmed cell death protein 1(PD-1)therapy were investigated.NaHCO_(3)@Flip achieved deep tumor penetration,with the ability to neutralize lactic acid and normalize the acidic tumor microenvironment.NaHCO_(3)@Flip is biosafe and can enhance cellular uptake efficiency of doxorubicin(DOX)by overcoming the ion-trapping barrier and amplify immunogenic cell death induced by DOX.The combination therapy of liposomal DOX and NaHCO_(3)@Flip demonstrated enhanced inhibition of tumor growth.NaHCO_(3)@Flip can also synergize with PD-1 antibody therapy.NaHCO_(3)@Flip has the potential to serve as a therapeutic adjuvant for boosting chemoimmunotherapy by overcoming the ion-trapping effect and normalizing the tumor microenvironment.展开更多
基金The project supported by the Scientific Research Fund of the Education Department of Hunan Province under Grant No.06C354the Natural Science Foundation of Hunan Province under Grant No.06JJ5015
文摘We present two schemes for preparing cluster states with atomic qubits in an ion-trap system. In the first scheme an auxiliary atomic level is needed. While in the second scheme an additional classical driven field is used, and the multi-ion cluster states can be generated by one step. Both the schemes are insensitive to thermal motion of the ions, all the facilities used in them are well within state of the art.
基金Supported by the National Natural Science Foundation of China under Grant No.10674018the National Fundamental Research Program of China under Grant No.2004CB719903
文摘We propose a scheme for generating a four-particle cluster state in an ion-trap system.The scheme isinsensitive to the thermal motion of the ions,and needs less operations than previous ones.With such a setup,we alsodemonstrate a procedure for perfectly teleporting an arbitrary two-particle state via a single multipartite entanglementchannel,a four-particle cluster state.
基金Supported by the Natural Science Foundation of Hunan Province under Grant No.06JJ50015
文摘We propose an ion-trap scheme for one-step generation of a special configuration of W-class state which has recently been shown to be better than canonical W states for several quantum-information processing tasks. We also present a method for one-step realization of a nontrivial collective operation which can transform a canonical W state into a fully separable state. Such a transformation plays a key role in recently proposed quantum protocols. The operation speed in our schemes increases with the number of qubits. This is contrary to usual entanglement generation and quantum manipulation schemes which take more and more time with the increase of the number of qubits.
基金Project supported by the National Natural Science Foundation (Grant Nos 10574022 and 10575022)the Funds of the Natural Science of Fujian Province, China (Grant No Z0512006)
文摘We propose a scheme for the implementation of remote controlled-NOT gates and entanglement swapping via geometric phase gates in ion-trap systems. The proposed scheme uses the two ground states of the A-type ions as memory instead of the vibrational mode. And the system is robust against the spontaneous radiation and the dephasing.
基金Project supported by the Special Funds of the National Natural Science Foundation of China (Grant No. 10947017/A05)
文摘This paper proposes a scheme to generate, in an ion-trap, a type of multipartite maximally entangled state which was first introduced by Chen et al. [Chen P X, Zhu S Y and Guo G C 2006 Phys. Rev. A 74 032324]. The maximum entanglement property of these states is examined. It also demonstrates how to discriminate among these states in the ion-trap.
基金Supported by the National Key Scientific and Technological Project of China(No.2009ZX09502-012)the Research Fund for the Doctoral Program of Higher Education of China(No.20090101110126)the Zhejiang Province Science and Technology Plan Project,China(No.2008C23065)
文摘In order to identify the potential nephrotoxic compounds in traditional Chinese medicine Lithospermum erythrorhizon,it was separated into serial fractions according to their polarities.An in vitro method was utilized to determine the nephrotoxicity of these fractions with the help of fluorescence image analysis.As a result,the primary fraction A05 and its secondary fractions C06 ＂C09 and C12 ＂C14 were found to have significant toxicity to LLC-PK1 cell line,as determined by the survive rate less than 20% after they were treated with these fractions.These potential nephrotoxic fractions were further analyzed by multistage and high resolution mass spectrometry.The main compounds in these fractions were tentatively identified to be acetylshikonin,isobutyrylshikonin,β,β＇-dimethyla-cryloylshikonin,and isovalerylshikonin,which may bring nephrotoxicity.
基金the National Key Research and Development Program of China(2021YFC400600,2022YFE0203600)the National Natural Science Foundation of China(81925035 and 82341232)+4 种基金the Future Network(083GJHZ2023012FN)Grand Challenges(083GJHZ2023021GC)of the International Partnership Program of the Chinese Academyof Sciences,CAS President’s International Fellowship Initiative(2024VBB0004)High-level Innovative Research Institute(2021B0909050003)from Department of ScienceTechnology of Guangdong ProvinceZhongshan Municipal Bureau of Science and Technology(LJ2021001 and CXTD2022011).
文摘Glycolysis-related lactic acid overproduction creates an“ion-trapping”barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy.Therefore,normalization of tumor microenvironment via lactic acid neutralization can be a promising avenue for overcoming this therapeutic hurdle.In this study,the flexible liposomes loaded with sodium bicarbonate(NaHCO_(3)@Flip)were used as a nano-adjuvant to boost chemoimmunotherapy.Their effects on assisting DOXIL and anti-programmed cell death protein 1(PD-1)therapy were investigated.NaHCO_(3)@Flip achieved deep tumor penetration,with the ability to neutralize lactic acid and normalize the acidic tumor microenvironment.NaHCO_(3)@Flip is biosafe and can enhance cellular uptake efficiency of doxorubicin(DOX)by overcoming the ion-trapping barrier and amplify immunogenic cell death induced by DOX.The combination therapy of liposomal DOX and NaHCO_(3)@Flip demonstrated enhanced inhibition of tumor growth.NaHCO_(3)@Flip can also synergize with PD-1 antibody therapy.NaHCO_(3)@Flip has the potential to serve as a therapeutic adjuvant for boosting chemoimmunotherapy by overcoming the ion-trapping effect and normalizing the tumor microenvironment.
