It has been reported that electron-rotation coupling plays a significant role in diatomic nuclear dynamics induced by intense VUV pulses [Phys. Rev. A 102(2020) 033114;Phys. Rev. Res. 2(2020) 043348]. As a further ste...It has been reported that electron-rotation coupling plays a significant role in diatomic nuclear dynamics induced by intense VUV pulses [Phys. Rev. A 102(2020) 033114;Phys. Rev. Res. 2(2020) 043348]. As a further step, we present here investigations of the electron-rotation coupling effect in the presence of Auger decay channel for core-excited molecules, based on theoretical modeling of the total electron yield(TEY), resonant Auger scattering(RAS) and x-ray absorption spectra(XAS) for two showcases of CO and CH^(+) molecules excited by resonant intense x-ray pulses. The Wigner D-functions and the universal transition dipole operators are introduced to include the electron-rotation coupling for the core-excitation process. It is shown that with the pulse intensity up to 10^(16) W/cm^(2), no sufficient influence of the electron-rotation coupling on the TEY and RAS spectra can be observed. This can be explained by a suppression of the induced electron-rotation dynamics due to the fast Auger decay channel, which does not allow for effective Rabi cycling even at extreme field intensities,contrary to transitions in optical or VUV range. For the case of XAS, however, relative errors of about 10% and 30% are observed for the case of CO and CH^(+), respectively, when the electron-rotation coupling is neglected.It is concluded that conventional treatment of the photoexcitation, neglecting the electron-rotation coupling,can be safely and efficiently employed to study dynamics at the x-ray transitions by means of electron emission spectroscopy, yet the approximation breaks down for nonlinear processes as stimulated emission, especially for systems with light atoms.展开更多
This paper contrasts Military Power of the People＇s Republic of China from the year of 2000 to 2009 and Military and Security Developments Involving People＇s Republic of China from the year 2010 to 2013 with corpus ...This paper contrasts Military Power of the People＇s Republic of China from the year of 2000 to 2009 and Military and Security Developments Involving People＇s Republic of China from the year 2010 to 2013 with corpus analysis. It distinguishes the new reports＇ differences from the old ones and tries to explore American＇s discourse colonization and discourse hegemony through corpus software WordSmith 5.0-Keywords and Concordance analysis of high frequency words. The significance of the study is that it enlightens military texts which will influence audiences＇ viewpoints and provides a new perspective for strategies replying American media war.展开更多
In this paper, it is proved that the following boundary value problem [GRAPHICS] admits infinitely many solution for 0 < lambda < lambda-1, n greater-than-or-equal-to 5 and for ball regions OMEGA = B(R)(0).
A new type of Cope rearrangement involving carbon-carbon bond cleavage (or de-tbutylation) was found during the heating of 4-allyl-4-methyl-2, 6-di-t-butylsemiquinone,
Case 1 Protection of SINGERTrademark In November 1995,the Jiangsu NanjingBureau of Industry and Commerceinvestigated and dealt with a case in whichthe registered trademark SINGER for sewingmachines belonging to the Si...Case 1 Protection of SINGERTrademark In November 1995,the Jiangsu NanjingBureau of Industry and Commerceinvestigated and dealt with a case in whichthe registered trademark SINGER for sewingmachines belonging to the Singer Co.Ltdwas infringed upon. From the end of 1994 to early 1995,the Jiangsu New Time Industry and TradeCompany(hereinafter called New Time Co.for short),without permission from thetrademark proprietor,organized the productionof 9,600 sewing-machine heads with展开更多
Among various types of cervical spondylopathy, the one involving the vertebral arteries is frequently encountered in the middle-aged and the old people. It is often accompanied with arteriosclerosis and high blood... Among various types of cervical spondylopathy, the one involving the vertebral arteries is frequently encountered in the middle-aged and the old people. It is often accompanied with arteriosclerosis and high blood viscosity, and clinically it is difficult to be treated. From March 1996 to December 2000, the authors hadtreated 72 cases of cervical spondylopathy of this type and achieved satisfactory therapeutic effects shown by clinical symptoms and indicated by the trans-cranial Doppler ultrasonic examination (TCD). This is reported as follows.
……展开更多
Objective:To explore the curative effect of Carisolv,a minimally invasive caries removal technique and traditional mechanical caries removal treatment on children’s dental caries.Methods:A total of 97 children with d...Objective:To explore the curative effect of Carisolv,a minimally invasive caries removal technique and traditional mechanical caries removal treatment on children’s dental caries.Methods:A total of 97 children with dental caries who were treated in the Department of Stomatology in Affiliated Hospital of Chifeng University,Chifeng from September 2017 to May 2019 were selected and recruited as the research subjects.They were divided into two groups by random number table method.Forty-nine individuals were assigned in the control group while the remaining 48 individuals in the observation group.The control group was treated with traditional mechanical caries removal method,and the observation group was treated with minimally invasive caries removal technique,i.e.Carisolv.Both groups were followed up for six months.The degree of pain,recovery time of dental function and complications after six months of treatment were observed in the two groups of children.Results:During the treatment,compared with the control group,the children in the observation group experienced lower degree of pain and had shorter recovery time of dental function.After six months of treatment,the incidence of complications in the observation group was lower than that in the control group.The difference was statistically significant(P<0.05).Conclusion:Compared with traditional mechanical caries removal method,Carisolv,a minimally invasive caries removal technique could reduce the pain of children during the treatment process,shorten the time to restore dental function,reduce the occurrence of complications,and had a better therapeutic effect in treating children’s dental caries.展开更多
Objective:The aim of this study was to assess the feasibility and safety of implanting covered stents in cases of advanced head and neck squamous cell carcinoma(ASCCHN)where the carotid artery was involved.Methods:A t...Objective:The aim of this study was to assess the feasibility and safety of implanting covered stents in cases of advanced head and neck squamous cell carcinoma(ASCCHN)where the carotid artery was involved.Methods:A total of 30 patients(29 males and one female)were included in this study,with ages ranging from 40 to 79 years.Among these patients,28 patients had received radiotherapy and 17 received subsequent adjuvant therapy,while one was receiving treatment for the first time.Eighteen were treated with covered stent implantation in conjunction with surgery,and the remaining 12 received stent implantation alone.The study evaluated and compared the stent implantation's success rate,overall survival(OS),and associated complications.Results:Successful implantation of covered stents was achieved in all 30 cases.No instances of significant hemorrhage or thromboembolic cerebral infarction occurred during surgery.Of the patients in the salvage surgical group,15 underwent complete tumor resection with a success rate of 83.3%(15/18),of which four experienced tumor recurrence with a local recurrence rate of 26.7%(4/15).The OS rates at 6 months for all patients,the salvage surgical group,the 15 patients with complete tumor resection,and the nonsurgical group were 64.0%,66.8%,75.5%,and 58.6%,respectively.At 12 months,the OS rates were 21.4%,29.3%,43.2%,and 11.8%,respectively.Notably,the OS of the 15 patients who underwent complete tumor resection was significantly higher than that of the 12 patients who received stent implantation alone(p=0.044).All cerebrovascular accidents occurred in patients with radiotherapy history,and subsequent adjuvant therapy had no significant effect on the OS time in the salvage surgical and nonsurgical groups(p=0.935;p=0.526).Conclusion:In cases of ASCCHN involving the carotid artery,the implantation of covered stents is a safe and feasible procedure.展开更多
Motor vehicle crashes are the leading cause of the death of teenagers in the United States.Young drivers have shown a higher propensity to get involved in crashes due to using a cellphone while driving,breaking the sp...Motor vehicle crashes are the leading cause of the death of teenagers in the United States.Young drivers have shown a higher propensity to get involved in crashes due to using a cellphone while driving,breaking the speed limit,and reckless driving.This study analyzed motor vehicle crashes involving young drivers using New Jersey crash data.Specifically,four years of crash data(2016-2019)were gathered and analyzed.Different machine learning(ML)methods,such as Random Forest,Light GBM,Catboost,and XGBoost,were used to predict the injury severity.The performance of the models was evaluated using accuracy,precision,and recall scores.In addition,interpretable ML techniques like sensitivity analysis and Shapley values were conducted to assess the most influential factors’impacts on young driver-related crashes.The results revealed that XGBoost performed better than Random Forest,CatBoost,and LightGBM models in crash severity prediction.Results from the sensitivity analysis showed that multi-vehicle crashes,angular crashes,crashes at intersections,and dark-not-lit conditions had increased crash severity.A partial dependence plot of SHAP values revealed that speeding in clear weather had a higher likelihood of injury crashes,and multi-vehicle crashes at the intersection had more injury crashes.We expect that the results obtained from this study will help policymakers and practitioners take appropriate countermeasures to improve the safety of young drivers in New Jersey.展开更多
Objective:To determine the effects of Chinese medicine(CM)involving triple rehabilitation therapy on the progression of knee osteoarthritis(KOA).Methods:A total of 722 patients recruited from 38 community health servi...Objective:To determine the effects of Chinese medicine(CM)involving triple rehabilitation therapy on the progression of knee osteoarthritis(KOA).Methods:A total of 722 patients recruited from 38 community health service centers located in China from March 2013 to March 2017 were randomly divided into treatment and control groups equally,using a cluster randomization design.Health education combined with CM involving triple rehabilitation therapy for KOA(electro-acupuncture,Chinese medicinal herb fumigating-washing,and traditional exercises)was administered in the treatment group while conventional rehabilitation therapy(physical factor therapy,joint movement training,and muscle strength training)was administered in the control group.Patients with a visual analog scale(VAS)scores>A were treated with dispersible meloxicam tablets(7.5 mg,once daily).The Lequesne index scores,VAS scores,range of motion(ROM),lower limb muscle strength,knee joint circumference,quantitative scores of KOA symptoms,and the short-form 36 item health survey questionnaire(SF-36)scores were measured for each patient at 5 checkpoints(before treatment,at the 2nd week and the 4th week during the 4-week treatment period,at 1 month and 3 months after end of treatment),and adverse reactions were observed also.Results:A total of 696 patients completed the entire process,with 351 in the treatment group and 345 in the control group.At all treatment checkpoints,the treatment group demonstrated better outcomes than the control group with regard to the total Lequesne index scores,effective rate and improvement rate of the total Lequesne index scores,VAS scores,lower limb muscle strength,knee circumference,quantitative scores of KOA symptoms,and SF-36 scores as well(P<0.05 or P<0.01).No adverse reactions were encountered in this study.Conclusions:CM involving triple rehabilitation therapy can alleviate KOA-related pain and swelling,improve lower limb muscle strength,promote flexion and activity of the knee and improve the quality of life in patients undergoing KOA.It is suitable for patients with early or mid-stage KOA.(Registration No.ChiCTR-TRC-12002538)展开更多
We numerically demonstrate a novel ultra-broadband polarization-independent metamaterial perfect absorber in the visible and near-infrared region involving the phase-change material Ge_2Sb_2Te_5(GST).The novel perfect...We numerically demonstrate a novel ultra-broadband polarization-independent metamaterial perfect absorber in the visible and near-infrared region involving the phase-change material Ge_2Sb_2Te_5(GST).The novel perfect absorber scheme consists of an array of high-index strong-absorbance GST square resonators separated from a continuous Au substrate by a low-index lossless dielectric layer(silica)and a high-index GST planar cavity.Three absorption peaks with the maximal absorbance up to 99.94% are achieved,owing to the excitation of plasmon-like dipolar or quadrupole resonances from the high-index GST resonators and cavity resonances generated by the GST planar cavity.The intensities and positions of the absorption peaks show strong dependence on structural parameters.A heat transfer model is used to investigate the temporal variation of temperature within the GST region.The results show that the temperature of amorphous GST can reach up to 433 K of the phase transition temperature from room temperature in just 0.37 ns with a relatively low incident light intensity of 1.11×10~8W∕m^2,due to the enhanced ultra-broadband light absorbance through strong plasmon resonances and cavity resonance in the absorber.The study suggests a feasible means to lower the power requirements for photonic devices based on a thermal phase change via engineering ultra-broadband light absorbers.展开更多
Document Of World Medical AssociationWorld medical association declaration of Helsinki Ethical principles for medical research involving human subjects
Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal cord.While the typical clinical phenotype of ALS involves ...Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal cord.While the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of ALS.Although superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized therapies.Despite numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this subpopulation.In this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during SOD1-ALS.The multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.展开更多
Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives ...Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.展开更多
A modification of the transbasal approach of Dorome called extensive subfrontal approach and the surgical results with this approach in 22 cases are presented. Bilateral frontal craniotomies incorporated with the remo...A modification of the transbasal approach of Dorome called extensive subfrontal approach and the surgical results with this approach in 22 cases are presented. Bilateral frontal craniotomies incorporated with the removal of orbital ridges and part of the orbital roofs were fashioned en bloc. It may give rise to good exposure of the midline lesions of the anterior, middle and posterior skull base, minimizing the need for the retraction of frontal lobes. There was no surgical mortality in this series of cases. Of the 20 cases with tumors, total resections were achieved in 11 cases, subtotal or large resections in 4 cases and partial resection in one case. Two patients with spontaneous rhinorrhea were successively treated surgically, 21 patients had a follow-up with a time ranging from 1-11 years (a mean of 3 years). 15 patients resumed their jobs with no evidence of recurrence of the original disease, and 5 patients able to live self-care. One patient with an olfactory neuroblastoma died 3 years after the operation owing to relapse of the tumor.展开更多
An African student in Hangzhou is furthering the cause of intercultural dialogue through community involvement.During the 19th Asian Games held in east China’s Hangzhou,McCleary Gondo,a 27-year-old Zimbabwean student...An African student in Hangzhou is furthering the cause of intercultural dialogue through community involvement.During the 19th Asian Games held in east China’s Hangzhou,McCleary Gondo,a 27-year-old Zimbabwean student living in Hangzhou,Zhejiang Province,caught people’s attention.展开更多
Objective:Pediatric patients undergoing day surgery often experience significant anxiety,which can negatively impact both the child and their parents.Addressing this anxiety is crucial to ensure a smooth surgical expe...Objective:Pediatric patients undergoing day surgery often experience significant anxiety,which can negatively impact both the child and their parents.Addressing this anxiety is crucial to ensure a smooth surgical experience and recovery.This mini review aims to evaluate the impact of preoperative anxiety in children,identify contributing factors,and explore effective strategies to manage this anxiety during day surgery.Methods:A literature review was conducted,focusing on studies that assess anxiety levels in pediatric patients before day surgery and the interventions designed to alleviate this anxiety.The review included both psychological and procedural strategies.Results:Preoperative anxiety in children can be influenced by a variety of factors,including age,previous medical experiences,parental anxiety,and the hospital environment.Untreated anxiety may lead to increased postoperative pain,behavioral changes,and extended recovery times.Several strategies,including psychological preparation,family centered approaches,and the involvement of child life specialists,have been shown to effectively reduce anxiety.Conclusions:Managing anxiety in pediatric day surgery is vital to improving both surgical outcomes and the overall experience for children and their families.Healthcare professionals can play a key role in reducing anxiety through targeted interventions and supportive care.展开更多
基金Supported by the National Natural Science Foundation of China (Grant Nos.11934004,11974230,and 11904192)the Education of Russian Federation (Grant No.FSRZ-2020-0008)。
文摘It has been reported that electron-rotation coupling plays a significant role in diatomic nuclear dynamics induced by intense VUV pulses [Phys. Rev. A 102(2020) 033114;Phys. Rev. Res. 2(2020) 043348]. As a further step, we present here investigations of the electron-rotation coupling effect in the presence of Auger decay channel for core-excited molecules, based on theoretical modeling of the total electron yield(TEY), resonant Auger scattering(RAS) and x-ray absorption spectra(XAS) for two showcases of CO and CH^(+) molecules excited by resonant intense x-ray pulses. The Wigner D-functions and the universal transition dipole operators are introduced to include the electron-rotation coupling for the core-excitation process. It is shown that with the pulse intensity up to 10^(16) W/cm^(2), no sufficient influence of the electron-rotation coupling on the TEY and RAS spectra can be observed. This can be explained by a suppression of the induced electron-rotation dynamics due to the fast Auger decay channel, which does not allow for effective Rabi cycling even at extreme field intensities,contrary to transitions in optical or VUV range. For the case of XAS, however, relative errors of about 10% and 30% are observed for the case of CO and CH^(+), respectively, when the electron-rotation coupling is neglected.It is concluded that conventional treatment of the photoexcitation, neglecting the electron-rotation coupling,can be safely and efficiently employed to study dynamics at the x-ray transitions by means of electron emission spectroscopy, yet the approximation breaks down for nonlinear processes as stimulated emission, especially for systems with light atoms.
文摘This paper contrasts Military Power of the People＇s Republic of China from the year of 2000 to 2009 and Military and Security Developments Involving People＇s Republic of China from the year 2010 to 2013 with corpus analysis. It distinguishes the new reports＇ differences from the old ones and tries to explore American＇s discourse colonization and discourse hegemony through corpus software WordSmith 5.0-Keywords and Concordance analysis of high frequency words. The significance of the study is that it enlightens military texts which will influence audiences＇ viewpoints and provides a new perspective for strategies replying American media war.
文摘In this paper, it is proved that the following boundary value problem [GRAPHICS] admits infinitely many solution for 0 < lambda < lambda-1, n greater-than-or-equal-to 5 and for ball regions OMEGA = B(R)(0).
文摘A new type of Cope rearrangement involving carbon-carbon bond cleavage (or de-tbutylation) was found during the heating of 4-allyl-4-methyl-2, 6-di-t-butylsemiquinone,
文摘Case 1 Protection of SINGERTrademark In November 1995,the Jiangsu NanjingBureau of Industry and Commerceinvestigated and dealt with a case in whichthe registered trademark SINGER for sewingmachines belonging to the Singer Co.Ltdwas infringed upon. From the end of 1994 to early 1995,the Jiangsu New Time Industry and TradeCompany(hereinafter called New Time Co.for short),without permission from thetrademark proprietor,organized the productionof 9,600 sewing-machine heads with
文摘 Among various types of cervical spondylopathy, the one involving the vertebral arteries is frequently encountered in the middle-aged and the old people. It is often accompanied with arteriosclerosis and high blood viscosity, and clinically it is difficult to be treated. From March 1996 to December 2000, the authors hadtreated 72 cases of cervical spondylopathy of this type and achieved satisfactory therapeutic effects shown by clinical symptoms and indicated by the trans-cranial Doppler ultrasonic examination (TCD). This is reported as follows.
……
文摘Objective:To explore the curative effect of Carisolv,a minimally invasive caries removal technique and traditional mechanical caries removal treatment on children’s dental caries.Methods:A total of 97 children with dental caries who were treated in the Department of Stomatology in Affiliated Hospital of Chifeng University,Chifeng from September 2017 to May 2019 were selected and recruited as the research subjects.They were divided into two groups by random number table method.Forty-nine individuals were assigned in the control group while the remaining 48 individuals in the observation group.The control group was treated with traditional mechanical caries removal method,and the observation group was treated with minimally invasive caries removal technique,i.e.Carisolv.Both groups were followed up for six months.The degree of pain,recovery time of dental function and complications after six months of treatment were observed in the two groups of children.Results:During the treatment,compared with the control group,the children in the observation group experienced lower degree of pain and had shorter recovery time of dental function.After six months of treatment,the incidence of complications in the observation group was lower than that in the control group.The difference was statistically significant(P<0.05).Conclusion:Compared with traditional mechanical caries removal method,Carisolv,a minimally invasive caries removal technique could reduce the pain of children during the treatment process,shorten the time to restore dental function,reduce the occurrence of complications,and had a better therapeutic effect in treating children’s dental caries.
基金supported by the Project of Nanjing Municipal Health Commission grant number YKK22249,2022.
文摘Objective:The aim of this study was to assess the feasibility and safety of implanting covered stents in cases of advanced head and neck squamous cell carcinoma(ASCCHN)where the carotid artery was involved.Methods:A total of 30 patients(29 males and one female)were included in this study,with ages ranging from 40 to 79 years.Among these patients,28 patients had received radiotherapy and 17 received subsequent adjuvant therapy,while one was receiving treatment for the first time.Eighteen were treated with covered stent implantation in conjunction with surgery,and the remaining 12 received stent implantation alone.The study evaluated and compared the stent implantation's success rate,overall survival(OS),and associated complications.Results:Successful implantation of covered stents was achieved in all 30 cases.No instances of significant hemorrhage or thromboembolic cerebral infarction occurred during surgery.Of the patients in the salvage surgical group,15 underwent complete tumor resection with a success rate of 83.3%(15/18),of which four experienced tumor recurrence with a local recurrence rate of 26.7%(4/15).The OS rates at 6 months for all patients,the salvage surgical group,the 15 patients with complete tumor resection,and the nonsurgical group were 64.0%,66.8%,75.5%,and 58.6%,respectively.At 12 months,the OS rates were 21.4%,29.3%,43.2%,and 11.8%,respectively.Notably,the OS of the 15 patients who underwent complete tumor resection was significantly higher than that of the 12 patients who received stent implantation alone(p=0.044).All cerebrovascular accidents occurred in patients with radiotherapy history,and subsequent adjuvant therapy had no significant effect on the OS time in the salvage surgical and nonsurgical groups(p=0.935;p=0.526).Conclusion:In cases of ASCCHN involving the carotid artery,the implantation of covered stents is a safe and feasible procedure.
文摘Motor vehicle crashes are the leading cause of the death of teenagers in the United States.Young drivers have shown a higher propensity to get involved in crashes due to using a cellphone while driving,breaking the speed limit,and reckless driving.This study analyzed motor vehicle crashes involving young drivers using New Jersey crash data.Specifically,four years of crash data(2016-2019)were gathered and analyzed.Different machine learning(ML)methods,such as Random Forest,Light GBM,Catboost,and XGBoost,were used to predict the injury severity.The performance of the models was evaluated using accuracy,precision,and recall scores.In addition,interpretable ML techniques like sensitivity analysis and Shapley values were conducted to assess the most influential factors’impacts on young driver-related crashes.The results revealed that XGBoost performed better than Random Forest,CatBoost,and LightGBM models in crash severity prediction.Results from the sensitivity analysis showed that multi-vehicle crashes,angular crashes,crashes at intersections,and dark-not-lit conditions had increased crash severity.A partial dependence plot of SHAP values revealed that speeding in clear weather had a higher likelihood of injury crashes,and multi-vehicle crashes at the intersection had more injury crashes.We expect that the results obtained from this study will help policymakers and practitioners take appropriate countermeasures to improve the safety of young drivers in New Jersey.
基金the State Administration of Traditional Chinese Medicine(No.201307004)。
文摘Objective:To determine the effects of Chinese medicine(CM)involving triple rehabilitation therapy on the progression of knee osteoarthritis(KOA).Methods:A total of 722 patients recruited from 38 community health service centers located in China from March 2013 to March 2017 were randomly divided into treatment and control groups equally,using a cluster randomization design.Health education combined with CM involving triple rehabilitation therapy for KOA(electro-acupuncture,Chinese medicinal herb fumigating-washing,and traditional exercises)was administered in the treatment group while conventional rehabilitation therapy(physical factor therapy,joint movement training,and muscle strength training)was administered in the control group.Patients with a visual analog scale(VAS)scores>A were treated with dispersible meloxicam tablets(7.5 mg,once daily).The Lequesne index scores,VAS scores,range of motion(ROM),lower limb muscle strength,knee joint circumference,quantitative scores of KOA symptoms,and the short-form 36 item health survey questionnaire(SF-36)scores were measured for each patient at 5 checkpoints(before treatment,at the 2nd week and the 4th week during the 4-week treatment period,at 1 month and 3 months after end of treatment),and adverse reactions were observed also.Results:A total of 696 patients completed the entire process,with 351 in the treatment group and 345 in the control group.At all treatment checkpoints,the treatment group demonstrated better outcomes than the control group with regard to the total Lequesne index scores,effective rate and improvement rate of the total Lequesne index scores,VAS scores,lower limb muscle strength,knee circumference,quantitative scores of KOA symptoms,and SF-36 scores as well(P<0.05 or P<0.01).No adverse reactions were encountered in this study.Conclusions:CM involving triple rehabilitation therapy can alleviate KOA-related pain and swelling,improve lower limb muscle strength,promote flexion and activity of the knee and improve the quality of life in patients undergoing KOA.It is suitable for patients with early or mid-stage KOA.(Registration No.ChiCTR-TRC-12002538)
基金973 Program of China(2013CB632704)National Natural Science Foundation of China(NSFC)(11374357,11434017)
文摘We numerically demonstrate a novel ultra-broadband polarization-independent metamaterial perfect absorber in the visible and near-infrared region involving the phase-change material Ge_2Sb_2Te_5(GST).The novel perfect absorber scheme consists of an array of high-index strong-absorbance GST square resonators separated from a continuous Au substrate by a low-index lossless dielectric layer(silica)and a high-index GST planar cavity.Three absorption peaks with the maximal absorbance up to 99.94% are achieved,owing to the excitation of plasmon-like dipolar or quadrupole resonances from the high-index GST resonators and cavity resonances generated by the GST planar cavity.The intensities and positions of the absorption peaks show strong dependence on structural parameters.A heat transfer model is used to investigate the temporal variation of temperature within the GST region.The results show that the temperature of amorphous GST can reach up to 433 K of the phase transition temperature from room temperature in just 0.37 ns with a relatively low incident light intensity of 1.11×10~8W∕m^2,due to the enhanced ultra-broadband light absorbance through strong plasmon resonances and cavity resonance in the absorber.The study suggests a feasible means to lower the power requirements for photonic devices based on a thermal phase change via engineering ultra-broadband light absorbers.
文摘Document Of World Medical AssociationWorld medical association declaration of Helsinki Ethical principles for medical research involving human subjects
文摘Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal cord.While the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of ALS.Although superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized therapies.Despite numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this subpopulation.In this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during SOD1-ALS.The multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.
基金supported by the National Natural Science Foundation of China,Nos.82071426,81873784Clinical Cohort Construction Program of Peking University Third Hospital,No.BYSYDL2019002(all to DF)。
文摘Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.
文摘A modification of the transbasal approach of Dorome called extensive subfrontal approach and the surgical results with this approach in 22 cases are presented. Bilateral frontal craniotomies incorporated with the removal of orbital ridges and part of the orbital roofs were fashioned en bloc. It may give rise to good exposure of the midline lesions of the anterior, middle and posterior skull base, minimizing the need for the retraction of frontal lobes. There was no surgical mortality in this series of cases. Of the 20 cases with tumors, total resections were achieved in 11 cases, subtotal or large resections in 4 cases and partial resection in one case. Two patients with spontaneous rhinorrhea were successively treated surgically, 21 patients had a follow-up with a time ranging from 1-11 years (a mean of 3 years). 15 patients resumed their jobs with no evidence of recurrence of the original disease, and 5 patients able to live self-care. One patient with an olfactory neuroblastoma died 3 years after the operation owing to relapse of the tumor.
文摘An African student in Hangzhou is furthering the cause of intercultural dialogue through community involvement.During the 19th Asian Games held in east China’s Hangzhou,McCleary Gondo,a 27-year-old Zimbabwean student living in Hangzhou,Zhejiang Province,caught people’s attention.
文摘Objective:Pediatric patients undergoing day surgery often experience significant anxiety,which can negatively impact both the child and their parents.Addressing this anxiety is crucial to ensure a smooth surgical experience and recovery.This mini review aims to evaluate the impact of preoperative anxiety in children,identify contributing factors,and explore effective strategies to manage this anxiety during day surgery.Methods:A literature review was conducted,focusing on studies that assess anxiety levels in pediatric patients before day surgery and the interventions designed to alleviate this anxiety.The review included both psychological and procedural strategies.Results:Preoperative anxiety in children can be influenced by a variety of factors,including age,previous medical experiences,parental anxiety,and the hospital environment.Untreated anxiety may lead to increased postoperative pain,behavioral changes,and extended recovery times.Several strategies,including psychological preparation,family centered approaches,and the involvement of child life specialists,have been shown to effectively reduce anxiety.Conclusions:Managing anxiety in pediatric day surgery is vital to improving both surgical outcomes and the overall experience for children and their families.Healthcare professionals can play a key role in reducing anxiety through targeted interventions and supportive care.
