The therapeutic effects in treating the intermediate and late rheumatoid arthritis by supplementing the kidney and invigorating blood circulation were observed. In the 43 cases of the treatment group, No. 2 Qu Feng Sh...The therapeutic effects in treating the intermediate and late rheumatoid arthritis by supplementing the kidney and invigorating blood circulation were observed. In the 43 cases of the treatment group, No. 2 Qu Feng Shi Ling capsules (祛风湿灵胶囊2号) and Fenbid (芬必得) were prescribed, while in the 39 cases of the control group Lei Gong Teng Tablets (雷公藤总甙片) and Fenbid were given. The results showed that the total effective rate in the treatment group was more satisfactory than that in the control (P<0.05 or P<0.01). With less toxic effects, the former could better improve the local swelling and lower the blood viscosity.展开更多
Objective: to analyze the therapeutic effect of kidney-tonifying and blood-activating therapy in the treatment of senile Parkinson's disease. Methods: 60 senile patients with Parkinson's disease who were treat...Objective: to analyze the therapeutic effect of kidney-tonifying and blood-activating therapy in the treatment of senile Parkinson's disease. Methods: 60 senile patients with Parkinson's disease who were treated in our hospital from May 2014 to June 2019 were divided into the control group and the observation group equally, with 30 cases in each group (56 cases were completed in Shuijiang Central Hospital and 4 cases were completed in Zhongqiao Township Hospital due to the change of my own organizational relationship). The patients in the observation group were treated with conventional treatment, while the patients in the control group were treated with the method of tonifying kidney and promoting blood circulation in traditional Chinese medicine. The observation period of the two groups was 6 months, and the disease was directly treated with the help of the UPDRS scale. Results: during the treatment period, 16 cases in the observation group and 23 cases in the control group completed the observation. There were 2 cases of exfoliation in the observation group and 5 cases in the control group. However, due to the adoption of the PP principle, cases that have fallen off are not included in the therapeutic effect. After receiving treatment, the total score of UPDRS scale has been significantly improved (P<0.05), and the improvement of control group is more obvious than that of observation group. From Table 3, it can be seen that the overall effective rate of the observation group is 32.15% and that of the control group is 84%. It can be seen that the overall effective rate of the control group is higher. Before and after treatment, the blood routine, urine routine, liver function, kidney function and electrocardiogram of the two groups of patients did not show obvious changes. One adverse event occurred in the observation group, and the patient presented with symptoms of pneumonia. In the control group, there were 4 cases of adverse events, including 1 case of fever, 2 cases of dyskinesia and 1 case of cerebral infarction. Conclusion: the treatment of senile Parkinson's disease with the method of tonifying kidney and promoting blood circulation in TCM will have better effect.展开更多
Objective:Using network pharmacology to explore the mechanism of the'invigorating qi and promoting blood circulation'drug pair Ginseng-Danshen(Salvia miltiorrhiza)on treatment of ischemic heart disease(IHD).Me...Objective:Using network pharmacology to explore the mechanism of the'invigorating qi and promoting blood circulation'drug pair Ginseng-Danshen(Salvia miltiorrhiza)on treatment of ischemic heart disease(IHD).Methods:The chemical constituents of ginseng and Danshen drug pair were identified by searching the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and the potential targets of the pair were identified.The pharmacodynamics of the pair was analyzed using network pharmacology.The targets of IHD were identified by database screening.Using protein-protein interaction network,the interaction targets of Ginseng-Danshen on IHD were constructed.A"constituent-target-disease"interaction network was constructed using Cytoscape software,Gene Ontology(GO)term enrichment analysis and biological pathway enrichment analysis were carried out,and the mechanism of improving myocardial ischemia by the Ginseng-Danshen drug pair was investigated.Results:Seventeen active constituents and 53 targets were identified from ginseng,53 active constituents and 61 targets were identified from Danshen,and 32 protein targets were shared by ginseng and Danshen.Twenty GO terms were analyzed,including cytokine receptor binding,cytokine activity,heme binding,and antioxidant activity.Sixty Kyoto Encyclopedia of Genes and Genomes(KEGG)signaling pathways were analyzed,including phosphatidylinositol 3-kinase-serine-threonine kinase(PI3 K-AKT)signaling pathway,p53 signaling pathway,interleukin 17 signaling pathway,tumor necrosis factor signaling pathway,and the advanced glycation end product(AGE)-the receptor for AGE(RAGE)signaling pathway in diabetic complications.Conclusion:The specific mechanism of Ginseng-Danshen drug pair in treating IHD may be associated with improving the changes of metabolites inbody,inhibiting the production of peroxides,removing the endogenous oxygen free radicals,regulating the expression of inflammatory factors,reducing myocardial cell apoptosis and promoting vascular regeneration.展开更多
Twenty patients of chronic idiopathic thrombocytopenic purpura (ITP) were treated with suchkind of Chinese herbal medicine as invigorating Qi and promoting blood circulation for 4-8 weeks. The ther-apeutic effect was ...Twenty patients of chronic idiopathic thrombocytopenic purpura (ITP) were treated with suchkind of Chinese herbal medicine as invigorating Qi and promoting blood circulation for 4-8 weeks. The ther-apeutic effect was observed and compared with that of the two control groups treated with prednisone and co-enzyme A respectively. In the TCM group, the number of patients with marked effect, good effect and im-provement were 2, 4 and 7, the total effective rate being 65% . This efficacy was higher than that of the co-enzyme group and lower than that of the prednisone group. The changes of antiplatelet IgG antibody and hap-toglobin were also observed in the meantime, and results showed that after TOM treatment, both of themwere decreased as disease improved.展开更多
文摘The therapeutic effects in treating the intermediate and late rheumatoid arthritis by supplementing the kidney and invigorating blood circulation were observed. In the 43 cases of the treatment group, No. 2 Qu Feng Shi Ling capsules (祛风湿灵胶囊2号) and Fenbid (芬必得) were prescribed, while in the 39 cases of the control group Lei Gong Teng Tablets (雷公藤总甙片) and Fenbid were given. The results showed that the total effective rate in the treatment group was more satisfactory than that in the control (P<0.05 or P<0.01). With less toxic effects, the former could better improve the local swelling and lower the blood viscosity.
文摘Objective: to analyze the therapeutic effect of kidney-tonifying and blood-activating therapy in the treatment of senile Parkinson's disease. Methods: 60 senile patients with Parkinson's disease who were treated in our hospital from May 2014 to June 2019 were divided into the control group and the observation group equally, with 30 cases in each group (56 cases were completed in Shuijiang Central Hospital and 4 cases were completed in Zhongqiao Township Hospital due to the change of my own organizational relationship). The patients in the observation group were treated with conventional treatment, while the patients in the control group were treated with the method of tonifying kidney and promoting blood circulation in traditional Chinese medicine. The observation period of the two groups was 6 months, and the disease was directly treated with the help of the UPDRS scale. Results: during the treatment period, 16 cases in the observation group and 23 cases in the control group completed the observation. There were 2 cases of exfoliation in the observation group and 5 cases in the control group. However, due to the adoption of the PP principle, cases that have fallen off are not included in the therapeutic effect. After receiving treatment, the total score of UPDRS scale has been significantly improved (P<0.05), and the improvement of control group is more obvious than that of observation group. From Table 3, it can be seen that the overall effective rate of the observation group is 32.15% and that of the control group is 84%. It can be seen that the overall effective rate of the control group is higher. Before and after treatment, the blood routine, urine routine, liver function, kidney function and electrocardiogram of the two groups of patients did not show obvious changes. One adverse event occurred in the observation group, and the patient presented with symptoms of pneumonia. In the control group, there were 4 cases of adverse events, including 1 case of fever, 2 cases of dyskinesia and 1 case of cerebral infarction. Conclusion: the treatment of senile Parkinson's disease with the method of tonifying kidney and promoting blood circulation in TCM will have better effect.
基金Supported by the National Natural Science Foundation of China(No.81774145)Youth Program of National Natural Science Foundation of China(No.81503292)National Key Basic Research and Development Program(No.2015cb554406)。
文摘Objective:Using network pharmacology to explore the mechanism of the'invigorating qi and promoting blood circulation'drug pair Ginseng-Danshen(Salvia miltiorrhiza)on treatment of ischemic heart disease(IHD).Methods:The chemical constituents of ginseng and Danshen drug pair were identified by searching the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and the potential targets of the pair were identified.The pharmacodynamics of the pair was analyzed using network pharmacology.The targets of IHD were identified by database screening.Using protein-protein interaction network,the interaction targets of Ginseng-Danshen on IHD were constructed.A"constituent-target-disease"interaction network was constructed using Cytoscape software,Gene Ontology(GO)term enrichment analysis and biological pathway enrichment analysis were carried out,and the mechanism of improving myocardial ischemia by the Ginseng-Danshen drug pair was investigated.Results:Seventeen active constituents and 53 targets were identified from ginseng,53 active constituents and 61 targets were identified from Danshen,and 32 protein targets were shared by ginseng and Danshen.Twenty GO terms were analyzed,including cytokine receptor binding,cytokine activity,heme binding,and antioxidant activity.Sixty Kyoto Encyclopedia of Genes and Genomes(KEGG)signaling pathways were analyzed,including phosphatidylinositol 3-kinase-serine-threonine kinase(PI3 K-AKT)signaling pathway,p53 signaling pathway,interleukin 17 signaling pathway,tumor necrosis factor signaling pathway,and the advanced glycation end product(AGE)-the receptor for AGE(RAGE)signaling pathway in diabetic complications.Conclusion:The specific mechanism of Ginseng-Danshen drug pair in treating IHD may be associated with improving the changes of metabolites inbody,inhibiting the production of peroxides,removing the endogenous oxygen free radicals,regulating the expression of inflammatory factors,reducing myocardial cell apoptosis and promoting vascular regeneration.
文摘Twenty patients of chronic idiopathic thrombocytopenic purpura (ITP) were treated with suchkind of Chinese herbal medicine as invigorating Qi and promoting blood circulation for 4-8 weeks. The ther-apeutic effect was observed and compared with that of the two control groups treated with prednisone and co-enzyme A respectively. In the TCM group, the number of patients with marked effect, good effect and im-provement were 2, 4 and 7, the total effective rate being 65% . This efficacy was higher than that of the co-enzyme group and lower than that of the prednisone group. The changes of antiplatelet IgG antibody and hap-toglobin were also observed in the meantime, and results showed that after TOM treatment, both of themwere decreased as disease improved.
