The composite structures/components made by friction stir lap welding(FSLW)of Mg alloy sheet and Al alloy sheet are of wide application potentials in the manufacturing sector of transportation vehicles.To further impr...The composite structures/components made by friction stir lap welding(FSLW)of Mg alloy sheet and Al alloy sheet are of wide application potentials in the manufacturing sector of transportation vehicles.To further improve the joint quality,the ultrasonic vibration(UV)is exerted in FSLW,and the UV enhanced FSLW(UVeFSLW)was developed for making Mg-to-Al dissimilar joints.The numerical analysis and experimental investigation were combined to study the process mechanism in Mg/Al UVeFSLW.An equation related to the temperature and strain rate was derived to calculate the grain size at different locations of the weld nugget zone,and the effect of grain size distribution on the threshold thermal stress was included,so that the prediction accuracy of flow stress was further improved.With such modified constitutive equation,the numerical simulation was conducted to compare the heat generation,temperature profiles and material flow behaviors in Mg/Al UVeFSLW/FSLW processes.It was found that the exerted UV decreased the temperature at two checking points on the tool/workpiece interface from 707/671 K in FSLW to 689/660 K in UVeFSLW,which suppressed the IMCs thickness at Mg-Al interface from 1.7μm in FSLW to 1.1μm in UVeFSLW.The exerted UV increased the horizontal materials flow ability,and decreased the upward flow ability,which resulted in the increase of effective sheet thickness/effective lap width from 2.01/3.70 mm in FSLW to 2.04/4.84 mm in UVeFSLW.Therefore,the ultrasonic vibration improved the tensile shear strength of Mg-to-Al lap joints by 18%.展开更多
Aquatic viruses are naturally present in the aquatic environment and the number of viruses is staggering.Various multicellular organisms in aquatic ecosystems may be infected,cross-species transmitted,manipulated,and ...Aquatic viruses are naturally present in the aquatic environment and the number of viruses is staggering.Various multicellular organisms in aquatic ecosystems may be infected,cross-species transmitted,manipulated,and killed by aquatic viruses,which can lead to cascading ecological effects.The viruses in unicellular aquatic organisms can alter interactions between host individuals,and are essential in effecting or maintaining the dynamics of aquatic microbial communities,horizontal gene transfer,biodiversity,and modulating ecological processes globally.Meanwhile,hosts also impact viral abundance and diversity.Microbial diversity drives multifunctionality in ecosystems,while viruses shape complex microbial communities and are crucial for ecosystem functioning.This review focuses on molecular,genetic,evolutionary,and ecosystemic advances related to emerging and reemerging aquatic viruses,presents the contexts,novel tools,and investigative approaches pertaining to the study of aquatic virology,and discusses the mechanisms by which viruses affect aquatic ecosystems.The paper provides an efficient and broadly-based blueprint for improving understanding of aquatic viruses.展开更多
Scientific and technological advancements are rapidly transforming underground engineering,shifting from labor-intensive,time-consuming methods to automated,real-time systems.This timely and comprehensive review cover...Scientific and technological advancements are rapidly transforming underground engineering,shifting from labor-intensive,time-consuming methods to automated,real-time systems.This timely and comprehensive review covers in-situ testing,intelligent monitoring,and geophysical testing methods,highlighting fundamental principles,testing apparatuses,data processing techniques,and engineering applications.The state-of-the-art summary emphasizes not only cutting-edge innovations for complex and harsh environments but also the transformative role of artificial intelligence and machine learning in data interpretations.The integration of big data and advanced algorithms is particularly impactful,enabling the identification,prediction,and mitigation of potential risks in underground projects.Key aspects of the discussion include detection capabilities,method integration,and data convergence of intelligent technologies to drive enhanced safety,operational efficiency,and predictive reliability.The review also examines future trends in intelligent technologies,emphasizing unified platforms that combine multiple methods,real-time data,and predictive analytics.These advancements are shaping the evolution of underground construction and maintenance,aiming for risk-free,high-efficiency underground engineering.展开更多
BACKGROUND Gestational diabetes mellitus(GDM)is a growing public health concern,particularly in regions with diverse ethnic populations.Understanding the incidence and risk factors of GDM is crucial for early preventi...BACKGROUND Gestational diabetes mellitus(GDM)is a growing public health concern,particularly in regions with diverse ethnic populations.Understanding the incidence and risk factors of GDM is crucial for early prevention and management,especially in underrepresented areas like Guizhou Province,China,where geographic and ethnic diversity may influence the disease’s prevalence and risk profiles.AIM To investigate the incidence of GDM and identify its associated risk and protective factors among different ethnic groups in Guizhou Province,providing essential data for early prevention strategies.METHODS A multi-center retrospective study was conducted,dividing participants into GDM and non-GDM groups according to standardized diagnostic criteria.Data were collected from 103629 deliveries across 40 hospitals in Guizhou.Various demographic,clinical,and laboratory parameters were analyzed using logistic regression to identify risk and protective factors for GDM.RESULTS Among the 103629 deliveries,18957 cases of GDM were identified,with an incidence of approximately 18.3%.The risk of GDM was higher in the Han ethnic group compared to minority ethnic groups.The Dong ethnic group had the lowest incidence among the minorities.Key risk factors identified included older age(especially>35 years),higher pre-pregnancy body mass index(BMI),light physical activity,gravidity,family history of diabetes,hemoglobin,aspartate aminotransferase,alanine aminotransferase,and direct bilirubin.Protective factors included higher education level,total protein,and albumin.There were also differences based on blood type,with type A associated with higher risk.CONCLUSION The incidence rate in Guizhou is 18.3%.Older age(especially>35 years),Han ethnicity,lower education level,higher pre-pregnancy BMI,light physical activity,and higher gravidity are the main risk factors for GDM.Laboratory findings indicate that higher hemoglobin,higher liver function parameters(alanine aminotransferase,aspartate aminotransferase,and direct bilirubin),and lower total protein and albumin are associated with a higher risk of GDM.Blood type A has a higher risk of GDM compared to blood types AB and O.展开更多
One of the detection objectives of the Chinese Asteroid Exploration mission is to investigate the space environment near the Main-belt Comet(MBC,Active Asteroid)311P/PANSTARRS.This paper outlines the scientific object...One of the detection objectives of the Chinese Asteroid Exploration mission is to investigate the space environment near the Main-belt Comet(MBC,Active Asteroid)311P/PANSTARRS.This paper outlines the scientific objectives,measurement targets,and measurement requirements for the proposed Gas and Ion Analyzer(GIA).The GIA is designed for in-situ mass spectrometry of neutral gases and low-energy ions,such as hydrogen,carbon,and oxygen,in the vicinity of 311P.Ion sampling techniques are essential for the GIA's Time-of-Flight(TOF)mass analysis capabilities.In this paper,we present an enhanced ion sampling technique through the development of an ion attraction model and an ion source model.The ion attraction model demonstrates that adjusting attraction grid voltage can enhance the detection efficiency of low-energy ions and mitigate the repulsive force of ions during sampling,which is influenced by the satellite's surface positive charging.The ion source model simulates the processes of gas ionization and ion multiplication.Simulation results indicate that the GIA can achieve a lower pressure limit below 10-13Pa and possess a dynamic range exceeding 10~9.These performances ensure the generation of ions with stable and consistent current,which is crucial for high-resolution and broad dynamic range mass spectrometer analysis.Preliminary testing experiments have verified GIA's capability to detect gas compositions such as H2O and N2.In-situ measurements near 311P using GIA are expected to significantly contribute to our understanding of asteroid activity mechanisms,the evolution of the atmospheric and ionized environments of main-belt comets,the interactions with solar wind,and the origin of Earth's water.展开更多
0 INTRODUCTION Geohazards in mountainous regions pose significant risks to the construction and safe operation of transportation,water conservancy,and other critical infrastructure projects.Engineering geological inve...0 INTRODUCTION Geohazards in mountainous regions pose significant risks to the construction and safe operation of transportation,water conservancy,and other critical infrastructure projects.Engineering geological investigations are crucial for disaster prevention and mitigation.展开更多
Polyploidization is a commonly employed strategy in crop breeding to augment genetic diversity,particularly leveraging the distinctive benefits of additional progressive heterosis or multi-generation heterosis unique ...Polyploidization is a commonly employed strategy in crop breeding to augment genetic diversity,particularly leveraging the distinctive benefits of additional progressive heterosis or multi-generation heterosis unique to polyploidy.Despite genetic disparities between polyploids and diploids,challenges stem from reproductive anomalies,complicating genetic investigations in polyploid systems.Through nearly two decades of intensive research,our team has effectively generated a series of fertile tetraploid lines known as neo-tetraploid rice(NTR),facilitating comparative genetic studies between diploid and tetraploid rice.In this study,we identified diploid counterparts(H3d and H8d)for two NTR lines[Huaduo 3(H3)and Huaduo 8(H8)]and utilized them to create diploid and tetraploid fertile F_(2) populations to assess genotype segregation ratios,recombination rates,and their impact on QTL mapping via bulked segregant analysis combined with sequencing(BSA-seq).Additionally,we assessed yield heterosis in F_(1) and F_(2) generations of two tetraploid populations(H3×H8 and T449×H1),revealing evidence of multi-generation heterosis in polyploid rice.These findings provide valuable insights into the advantages and challenges of polyploid rice breeding.展开更多
Investigative identification is a routine criminal investigative procedure,the results of which can be used as evidence in litigation.However,some suspects often deny their involvement in the case,and some witnesses m...Investigative identification is a routine criminal investigative procedure,the results of which can be used as evidence in litigation.However,some suspects often deny their involvement in the case,and some witnesses may withhold information or misrepresent it,all of which may lead to a miscarriage of justice.This study created a stressful environment and conducted a simulated crime experiment to explore whether eye movement data can be an effective feature for distinguishing perpetrators,innocents,and insiders.The eye movement features—such as the total fixation duration,number of fixations,and first fixation duration—within an area of interest were collected from 83 participants sorted into informed,involved,and innocent groups.The results revealed the following:(1)compared with the object and scene stimuli,subjects with different identities were more likely to exhibit significant differences in eye movement data for the involved and irrelevant portraits.The total fixation duration and the number of fixations can provide a reference for judging whether someone is involved in a case,and the first fixation duration effect was not obvious.(2)Using machine learning algorithms to predict subjects’identities through eye movement features,it was demonstrated that the involved portrait-object-scene model had the best predictive effect.(3)Multiple algorithmic models were used to distinguish subjects’identities,and the highest accuracy of 92.7%was achieved for the informed×innocent group,88%for the innocent×suspect group(including the informed and involved groups),and 84.5%for the involved group.The eye movement analysis method can provide a reference for criminal investigators to distinguish between the perpetrator,insider,and innocent,and offer a novel approach to determining the direction of further investigation and uncovering and verifying case clues.展开更多
Investigation and analysis of the current status of farmers'livelihood capital and promptly discovering and solving problems in farmers'livelihood development are of great practical significance for optimizing...Investigation and analysis of the current status of farmers'livelihood capital and promptly discovering and solving problems in farmers'livelihood development are of great practical significance for optimizing farmers'livelihood strategies and enhancing farmers'livelihood sustainable development capability.Based on the framework of sustainable livelihood analysis,taking Yangshan County as an example,this paper uses field surveys,questionnaires and interviews to summarize and analyze the current status and characteristics and main problems of local farmers'livelihood capitals on the basis of the data of 628 farmer samples.It proposes countermeasures for future development of farmers'livelihoods.Implementing these strategies will be helpful for improving the livelihoods capital structure of farmers'and enhancing their sustainable development capability.展开更多
The editor regrets that they inadvertently pasted the wrong figure during the production stage.The correct Fig.7 should be as below:The editor would like to apologise for any inconvenience caused.
Based on the site investigation of a lightning stroke accident in a coal mine in Weiyuan County during a strong thunderstorm process on the night of August 10,2024,combined with the investigation data of the accident ...Based on the site investigation of a lightning stroke accident in a coal mine in Weiyuan County during a strong thunderstorm process on the night of August 10,2024,combined with the investigation data of the accident site,the causes of the lightning stroke accident were analyzed,and the corresponding rectification suggestions were put forward.展开更多
BACKGROUND Postmenopausal women with osteoporosis are at high risk of developing depre-ssive symptoms,necessitating specialized psychological nursing interventions.AIM To investigate factors influencing depressive sym...BACKGROUND Postmenopausal women with osteoporosis are at high risk of developing depre-ssive symptoms,necessitating specialized psychological nursing interventions.AIM To investigate factors influencing depressive symptoms in postmenopausal women with osteoporosis and develop targeted psychological nursing interven-tions.METHODS A total of 180 postmenopausal women with osteoporosis admitted to the Depar-tment of Orthopedics at the First Affiliated Hospital of Soochow University between October 2021 and October 2024 were selected as research participants.Information on age,duration of menopause,body mass index,education level,marital status,activity intensity,bone density,presence of chronic diseases,calcium supplement intake,sex hormone levels,and depressive symptoms were collected.The 24-item Hamilton Depression Scale was used for assessment.RESULTS Forty-eight patients had no depressive symptoms,and 132 patients had depre-ssive symptoms.Comprehensive univariate and multivariate logistic regression analyses showed that low bone density in the lumbar spine(L2-L4)and femoral neck,presence of chronic diseases,and low 5-hydroxytryptamine levels were independent risk factors for depressive symptoms,whereas calcium supplement intake and moderate to high-intensity activity were independent protective factors.CONCLUSION By implementing specialized psychological nursing interventions,and providing rehabilitation guidance,the incidence of depressive symptoms can be effectively reduced,improving the psychological health status and patient quality of life.展开更多
Aim:To evaluate the impact of professional training on pediatric outpatient nurses’cognition and attitudes towards the use of clown therapy,and to assess its clinical applicability.Design:A pre-and post-training eval...Aim:To evaluate the impact of professional training on pediatric outpatient nurses’cognition and attitudes towards the use of clown therapy,and to assess its clinical applicability.Design:A pre-and post-training evaluation study.Methods:A total of 31 pediatric outpatient nurses participated in the study,completing a self-designed 15-item questionnaire focused on clown therapy.The questionnaires were administered both before and after a structured training program.The assessment aimed to measure changes in nurses’knowledge and attitudes toward clown therapy.Results:The results indicated a statistically significant improvement in the nurses’cognition following the training(mean score post-training:8.55 vs pre-training:7.71,p=0.003).Conclusion:Notably,the training also eliminated the age-related differences in cognition observed prior to the intervention.Furthermore,nurses expressed more positive attitudes toward the clinical implementation of clown therapy post-training.展开更多
SnS,a well-known van der Waals chalcogenide,is susceptible to oxidation in high-temperature or highhumidity environments,significantly impacting its functional performance and device stability.Conversely,oxidation can...SnS,a well-known van der Waals chalcogenide,is susceptible to oxidation in high-temperature or highhumidity environments,significantly impacting its functional performance and device stability.Conversely,oxidation can be used as an effective strategy for surface engineering,allowing for structure modulation or design,property tuning and application exploration.However,there is currently a gap in understanding the relationship between the oxidation behavior of SnS,the structure of its oxidized surface,and the dependence on oxidation temperature.In this study,we systematically investigated the evolution of SnS surfaces under thermal oxidation using electron microscopy.The microstructure evolution(e.g.,surface structures,phases,defects,and interface)of SnS during high-temperature oxidation has been fully characterized and studied based on cross-sectional samples.Various surface heterostructures were constructed,including SnO_(2)/SnS,SnO_(2)/SnS_(2)/SnS,and SnO_(2)/Sn_(2)S_(3)/SnS,offering significant potential for the surface functionalization of SnS-based systems.Accordingly,oxidation mechanisms at different stages were elucidated based on the detailed and clear picture of microstructures.This research not only deepens our understanding of the fundamental science of SnS oxidation but also provides valuable insights for preventing and developing surface oxidation engineering in SnS and other van der Waals chalcogenides/materials.展开更多
Commonly,the standards for the geometric design of roads refer to a given set of values for the friction coefficient(longitudinal and transverse friction).These"reference"values imply corresponding visibilit...Commonly,the standards for the geometric design of roads refer to a given set of values for the friction coefficient(longitudinal and transverse friction).These"reference"values imply corresponding visibility sights,curvature radii,and speed limits.Unfortunately,not only do these reference values not correspond to a given standard to measure them,but nothing is said about the decrease of the posted speed limit(variable speed limits)when roads become slippery and lanes for autonomous vehicle(AV)are concerned.Furthermore,the same assessment of the friction coefficient has plenty of uncertainties due to measurement device,temperature,location,time passed from the construction,alignment-related variables(e.g.,curve,tangent,transition curve,convexity/crests or concavity/sags,longitudinal slope,superelevation,and ruling gradient),and supplementary singularities such as joints and bridge approaches.All the issues above may harm road safety and the complexity of forensic investigations of pavements.Consequently,this study's objectives were confined to(1)carrying out friction measurements and analyzing the problem of friction decay over time;(2)setting up a method to lower the speed limits where friction decays are detected;(3)setting up a method to handle friction decays for autonomous vehicles.Results demonstrate that:(1)a power law describes how the speed limits are affected by friction;(2)for speeds up to 170 km/h,due to the lower reaction time,AV reaction distance is lower,which benefits AV traffic(lower stopping distance);(3)on the contrary,for higher values of friction and higher speeds,under the hypothesis of having the same reaction time law for non-AV(NAV)(i.e.,decreasing with the initial speed),AV speed limits become lower than NAV speed limits;(4)not only do comfort-based speed profiles for AVs bring higher braking distances,but also,in the median part(of the deceleration process),this could pose safety issues and reduce the distance between the available and the needed friction.展开更多
The gut microbiome is closely associated with human health and the development of diseases. Isolating, characterizing, and identifying gut microbes are crucial for research on the gut microbiome and essential for adva...The gut microbiome is closely associated with human health and the development of diseases. Isolating, characterizing, and identifying gut microbes are crucial for research on the gut microbiome and essential for advancing our understanding and utilization of it. Although culture-independent approaches have been developed, a pure culture is required for in-depth analysis of disease mechanisms and the development of biotherapy strategies. Currently, microbiome research faces the challenge of expanding the existing database of culturable gut microbiota and rapidly isolating target microorganisms. This review examines the advancements in gut microbe isolation and cultivation techniques, such as culturomics, droplet microfluidics, phenotypic and genomics selection, and membrane diffusion. Furthermore, we evaluate the progress made in technology for identifying gut microbes considering both non-targeted and targeted strategies. The focus of future research in gut microbial culturomics is expected to be on high-throughput, automation, and integration. Advancements in this field may facilitate strain-level investigation into the mechanisms underlying diseases related to gut microbiota.展开更多
Accurate determination of rockhead is crucial for underground construction.Traditionally,borehole data are mainly used for this purpose.However,borehole drilling is costly,time-consuming,and sparsely distributed.Non-i...Accurate determination of rockhead is crucial for underground construction.Traditionally,borehole data are mainly used for this purpose.However,borehole drilling is costly,time-consuming,and sparsely distributed.Non-invasive geophysical methods,particularly those using passive seismic surface waves,have emerged as viable alternatives for geological profiling and rockhead detection.This study proposes three interpretation methods for rockhead determination using passive seismic surface wave data from Microtremor Array Measurement(MAM)and Horizontal-to-Vertical Spectral Ratio(HVSR)tests.These are:(1)the Wavelength-Normalized phase velocity(WN)method in which a nonlinear relationship between rockhead depth and wavelength is established;(2)the Statistically Determined-shear wave velocity(SD-V_(s))method in which the representative V_(s) value for rockhead is automatically determined using a statistical method;and(3)the empirical HVSR method in which the rockhead is determined by interpreting resonant frequencies using a reliably calibrated empirical equation.These methods were implemented to determine rockhead depths at 28 locations across two distinct geological formations in Singapore,and the results were evaluated using borehole data.The WN method can determine rockhead depths accurately and reliably with minimal absolute errors(average RMSE=3.11 m),demonstrating robust performance across both geological formations.Its advantage lies in interpreting dispersion curves alone,without the need for the inversion process.The SD-V_(s) method is practical in engineering practice owing to its simplicity.The empirical HVSR method reasonably determines rockhead depths with moderate accuracy,benefiting from a reliably calibrated empirical equation.展开更多
Urban transportation systems are facing severe challenges due to the rapid growth of the urban population,especially in China.Suspended monorail system(SMS),as a sky rail transportation form,can effectively alleviate ...Urban transportation systems are facing severe challenges due to the rapid growth of the urban population,especially in China.Suspended monorail system(SMS),as a sky rail transportation form,can effectively alleviate urban traffic congestion due to its independent right-of-way and minimal ground footprint.However,the SMS possesses a special traveling system with unique vehicle structure and bridge configuration,which results in significant differences in both the mechanisms and dynamics problems associated with train–bridge interaction(TBI)when contrasted with those of traditional railway systems.Therefore,a thorough understanding of the SMS dynamics is essential for ensuring the operational safety of the system.This article presents a state-of-the-art review of the TBI modeling methodologies,critical dynamic features,field tests,and practice of the SMS in China.Firstly,the development history,technical features,and potential dynamics problems of the SMS are briefly described,followed by the mechanical characteristics and mechanisms of the train–bridge interactive systems.Then,the modeling methodology of the fundamental elements in the suspended monorail TBI is systematically reviewed,including the suspended train subsystem,bridge subsystem,train–bridge interaction relationships,system excitations,and solution method.Further,the typical dynamic features of the TBI under various operational scenarios are elaborated,including different train speeds,a variety of line sections,and a natural wind environment.Finally,the first new energy-based SMS test line in the world is systematically introduced,including the composition and functionality of the system,the details of the conducted field tests,and the measured results of the typical dynamic responses.At the end of the paper,both the guidance on further improvement of the SMS and future research topics are proposed.展开更多
The neem flower(Azadirachta indica),a well-known element of Ayurvedic medicine,has attracted considerable interest due to its abundance of bioactive compounds.This systematic review examines its pharmacological and im...The neem flower(Azadirachta indica),a well-known element of Ayurvedic medicine,has attracted considerable interest due to its abundance of bioactive compounds.This systematic review examines its pharmacological and immunomodulatory properties in detail,emphasizing its potential role in contemporary healthcare.Neem flowers are rich in various bioactive components,such as flavonoids,terpenoids,and glycosides,known for their antioxidant,anti-inflammatory,antimicrobial,and anticancer properties.Recent studies indicate that extracts from neem flowers can influence immune system activity by boosting both innate and adaptive immune functions while reducing excessive inflammation.These properties suggest that neem flowers could serve as valuable therapeutic agents for treating immune-related disorders.Additionally,neem flowers have demonstrated promise in addressing conditions such as diabetes,cardiovascular issues,and microbial infections through their ability to regulate metabolic functions and inhibit the growth of harmful pathogens.Preclinical research highlights their protective effects against oxidative damage and their capacity to induce apoptosis in cancer cells.However,challenges such as the lack of standardized extraction processes and limited clinical research hinder broader utilization.This review emphasizes the need for more robust studies to fully harness the pharmacological potential of neem flowers and facilitate their incorporation into evidence-based medicinal properties.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.52035005)the Key R&D Program of Shandong Province in China(Grant No.2021ZLGX01).
文摘The composite structures/components made by friction stir lap welding(FSLW)of Mg alloy sheet and Al alloy sheet are of wide application potentials in the manufacturing sector of transportation vehicles.To further improve the joint quality,the ultrasonic vibration(UV)is exerted in FSLW,and the UV enhanced FSLW(UVeFSLW)was developed for making Mg-to-Al dissimilar joints.The numerical analysis and experimental investigation were combined to study the process mechanism in Mg/Al UVeFSLW.An equation related to the temperature and strain rate was derived to calculate the grain size at different locations of the weld nugget zone,and the effect of grain size distribution on the threshold thermal stress was included,so that the prediction accuracy of flow stress was further improved.With such modified constitutive equation,the numerical simulation was conducted to compare the heat generation,temperature profiles and material flow behaviors in Mg/Al UVeFSLW/FSLW processes.It was found that the exerted UV decreased the temperature at two checking points on the tool/workpiece interface from 707/671 K in FSLW to 689/660 K in UVeFSLW,which suppressed the IMCs thickness at Mg-Al interface from 1.7μm in FSLW to 1.1μm in UVeFSLW.The exerted UV increased the horizontal materials flow ability,and decreased the upward flow ability,which resulted in the increase of effective sheet thickness/effective lap width from 2.01/3.70 mm in FSLW to 2.04/4.84 mm in UVeFSLW.Therefore,the ultrasonic vibration improved the tensile shear strength of Mg-to-Al lap joints by 18%.
基金supported by the National Key R&D Plan of the Ministry of Science and Technology,China(2018YFA0903101,2018YFD0900302)the Key Program of Frontier Sciences of the Chinese Academy of Sciences(KJZD-SW-L11).
文摘Aquatic viruses are naturally present in the aquatic environment and the number of viruses is staggering.Various multicellular organisms in aquatic ecosystems may be infected,cross-species transmitted,manipulated,and killed by aquatic viruses,which can lead to cascading ecological effects.The viruses in unicellular aquatic organisms can alter interactions between host individuals,and are essential in effecting or maintaining the dynamics of aquatic microbial communities,horizontal gene transfer,biodiversity,and modulating ecological processes globally.Meanwhile,hosts also impact viral abundance and diversity.Microbial diversity drives multifunctionality in ecosystems,while viruses shape complex microbial communities and are crucial for ecosystem functioning.This review focuses on molecular,genetic,evolutionary,and ecosystemic advances related to emerging and reemerging aquatic viruses,presents the contexts,novel tools,and investigative approaches pertaining to the study of aquatic virology,and discusses the mechanisms by which viruses affect aquatic ecosystems.The paper provides an efficient and broadly-based blueprint for improving understanding of aquatic viruses.
基金supported by Ministry of Education of Singapore,under Academic Research Fund Tier 1(Grant Number RG143/23).
文摘Scientific and technological advancements are rapidly transforming underground engineering,shifting from labor-intensive,time-consuming methods to automated,real-time systems.This timely and comprehensive review covers in-situ testing,intelligent monitoring,and geophysical testing methods,highlighting fundamental principles,testing apparatuses,data processing techniques,and engineering applications.The state-of-the-art summary emphasizes not only cutting-edge innovations for complex and harsh environments but also the transformative role of artificial intelligence and machine learning in data interpretations.The integration of big data and advanced algorithms is particularly impactful,enabling the identification,prediction,and mitigation of potential risks in underground projects.Key aspects of the discussion include detection capabilities,method integration,and data convergence of intelligent technologies to drive enhanced safety,operational efficiency,and predictive reliability.The review also examines future trends in intelligent technologies,emphasizing unified platforms that combine multiple methods,real-time data,and predictive analytics.These advancements are shaping the evolution of underground construction and maintenance,aiming for risk-free,high-efficiency underground engineering.
基金National Natural Science Foundation of China,No.81960284Science and Technology Support Program of Science and Technology Department of Guizhou Province,No.Qian Ke He Zhi Cheng[2022]Yi Ban 183.
文摘BACKGROUND Gestational diabetes mellitus(GDM)is a growing public health concern,particularly in regions with diverse ethnic populations.Understanding the incidence and risk factors of GDM is crucial for early prevention and management,especially in underrepresented areas like Guizhou Province,China,where geographic and ethnic diversity may influence the disease’s prevalence and risk profiles.AIM To investigate the incidence of GDM and identify its associated risk and protective factors among different ethnic groups in Guizhou Province,providing essential data for early prevention strategies.METHODS A multi-center retrospective study was conducted,dividing participants into GDM and non-GDM groups according to standardized diagnostic criteria.Data were collected from 103629 deliveries across 40 hospitals in Guizhou.Various demographic,clinical,and laboratory parameters were analyzed using logistic regression to identify risk and protective factors for GDM.RESULTS Among the 103629 deliveries,18957 cases of GDM were identified,with an incidence of approximately 18.3%.The risk of GDM was higher in the Han ethnic group compared to minority ethnic groups.The Dong ethnic group had the lowest incidence among the minorities.Key risk factors identified included older age(especially>35 years),higher pre-pregnancy body mass index(BMI),light physical activity,gravidity,family history of diabetes,hemoglobin,aspartate aminotransferase,alanine aminotransferase,and direct bilirubin.Protective factors included higher education level,total protein,and albumin.There were also differences based on blood type,with type A associated with higher risk.CONCLUSION The incidence rate in Guizhou is 18.3%.Older age(especially>35 years),Han ethnicity,lower education level,higher pre-pregnancy BMI,light physical activity,and higher gravidity are the main risk factors for GDM.Laboratory findings indicate that higher hemoglobin,higher liver function parameters(alanine aminotransferase,aspartate aminotransferase,and direct bilirubin),and lower total protein and albumin are associated with a higher risk of GDM.Blood type A has a higher risk of GDM compared to blood types AB and O.
基金Supported by the National Natural Science Foundation of China(42474239,41204128)China National Space Administration(Pre-research project on Civil Aerospace Technologies No.D010301)Strategic Priority Research Program of the Chinese Academy of Sciences(XDA17010303)。
文摘One of the detection objectives of the Chinese Asteroid Exploration mission is to investigate the space environment near the Main-belt Comet(MBC,Active Asteroid)311P/PANSTARRS.This paper outlines the scientific objectives,measurement targets,and measurement requirements for the proposed Gas and Ion Analyzer(GIA).The GIA is designed for in-situ mass spectrometry of neutral gases and low-energy ions,such as hydrogen,carbon,and oxygen,in the vicinity of 311P.Ion sampling techniques are essential for the GIA's Time-of-Flight(TOF)mass analysis capabilities.In this paper,we present an enhanced ion sampling technique through the development of an ion attraction model and an ion source model.The ion attraction model demonstrates that adjusting attraction grid voltage can enhance the detection efficiency of low-energy ions and mitigate the repulsive force of ions during sampling,which is influenced by the satellite's surface positive charging.The ion source model simulates the processes of gas ionization and ion multiplication.Simulation results indicate that the GIA can achieve a lower pressure limit below 10-13Pa and possess a dynamic range exceeding 10~9.These performances ensure the generation of ions with stable and consistent current,which is crucial for high-resolution and broad dynamic range mass spectrometer analysis.Preliminary testing experiments have verified GIA's capability to detect gas compositions such as H2O and N2.In-situ measurements near 311P using GIA are expected to significantly contribute to our understanding of asteroid activity mechanisms,the evolution of the atmospheric and ionized environments of main-belt comets,the interactions with solar wind,and the origin of Earth's water.
基金financially supported by the National Key R&D Program of China(No.2022YFC3080200)。
文摘0 INTRODUCTION Geohazards in mountainous regions pose significant risks to the construction and safe operation of transportation,water conservancy,and other critical infrastructure projects.Engineering geological investigations are crucial for disaster prevention and mitigation.
基金supported by the National Key Resarch and Development Program of China(Grant No.2023YFD1200802)the Base Bank of Lingnan Rice Germplasm Resources Project,China(Grant No.2024B1212060009).
文摘Polyploidization is a commonly employed strategy in crop breeding to augment genetic diversity,particularly leveraging the distinctive benefits of additional progressive heterosis or multi-generation heterosis unique to polyploidy.Despite genetic disparities between polyploids and diploids,challenges stem from reproductive anomalies,complicating genetic investigations in polyploid systems.Through nearly two decades of intensive research,our team has effectively generated a series of fertile tetraploid lines known as neo-tetraploid rice(NTR),facilitating comparative genetic studies between diploid and tetraploid rice.In this study,we identified diploid counterparts(H3d and H8d)for two NTR lines[Huaduo 3(H3)and Huaduo 8(H8)]and utilized them to create diploid and tetraploid fertile F_(2) populations to assess genotype segregation ratios,recombination rates,and their impact on QTL mapping via bulked segregant analysis combined with sequencing(BSA-seq).Additionally,we assessed yield heterosis in F_(1) and F_(2) generations of two tetraploid populations(H3×H8 and T449×H1),revealing evidence of multi-generation heterosis in polyploid rice.These findings provide valuable insights into the advantages and challenges of polyploid rice breeding.
基金This work is supported by the Public Security First-class Discipline Cultivation and Public Safety Behavioral Science Lab Project(No.2023ZB02)the National Natural Science Foundation of China(72274208).
文摘Investigative identification is a routine criminal investigative procedure,the results of which can be used as evidence in litigation.However,some suspects often deny their involvement in the case,and some witnesses may withhold information or misrepresent it,all of which may lead to a miscarriage of justice.This study created a stressful environment and conducted a simulated crime experiment to explore whether eye movement data can be an effective feature for distinguishing perpetrators,innocents,and insiders.The eye movement features—such as the total fixation duration,number of fixations,and first fixation duration—within an area of interest were collected from 83 participants sorted into informed,involved,and innocent groups.The results revealed the following:(1)compared with the object and scene stimuli,subjects with different identities were more likely to exhibit significant differences in eye movement data for the involved and irrelevant portraits.The total fixation duration and the number of fixations can provide a reference for judging whether someone is involved in a case,and the first fixation duration effect was not obvious.(2)Using machine learning algorithms to predict subjects’identities through eye movement features,it was demonstrated that the involved portrait-object-scene model had the best predictive effect.(3)Multiple algorithmic models were used to distinguish subjects’identities,and the highest accuracy of 92.7%was achieved for the informed×innocent group,88%for the innocent×suspect group(including the informed and involved groups),and 84.5%for the involved group.The eye movement analysis method can provide a reference for criminal investigators to distinguish between the perpetrator,insider,and innocent,and offer a novel approach to determining the direction of further investigation and uncovering and verifying case clues.
基金Supported by Guangdong Province Philosophy and Social Science Planning Project(GD24CGL18&GD23CGL02).
文摘Investigation and analysis of the current status of farmers'livelihood capital and promptly discovering and solving problems in farmers'livelihood development are of great practical significance for optimizing farmers'livelihood strategies and enhancing farmers'livelihood sustainable development capability.Based on the framework of sustainable livelihood analysis,taking Yangshan County as an example,this paper uses field surveys,questionnaires and interviews to summarize and analyze the current status and characteristics and main problems of local farmers'livelihood capitals on the basis of the data of 628 farmer samples.It proposes countermeasures for future development of farmers'livelihoods.Implementing these strategies will be helpful for improving the livelihoods capital structure of farmers'and enhancing their sustainable development capability.
文摘The editor regrets that they inadvertently pasted the wrong figure during the production stage.The correct Fig.7 should be as below:The editor would like to apologise for any inconvenience caused.
文摘Based on the site investigation of a lightning stroke accident in a coal mine in Weiyuan County during a strong thunderstorm process on the night of August 10,2024,combined with the investigation data of the accident site,the causes of the lightning stroke accident were analyzed,and the corresponding rectification suggestions were put forward.
文摘BACKGROUND Postmenopausal women with osteoporosis are at high risk of developing depre-ssive symptoms,necessitating specialized psychological nursing interventions.AIM To investigate factors influencing depressive symptoms in postmenopausal women with osteoporosis and develop targeted psychological nursing interven-tions.METHODS A total of 180 postmenopausal women with osteoporosis admitted to the Depar-tment of Orthopedics at the First Affiliated Hospital of Soochow University between October 2021 and October 2024 were selected as research participants.Information on age,duration of menopause,body mass index,education level,marital status,activity intensity,bone density,presence of chronic diseases,calcium supplement intake,sex hormone levels,and depressive symptoms were collected.The 24-item Hamilton Depression Scale was used for assessment.RESULTS Forty-eight patients had no depressive symptoms,and 132 patients had depre-ssive symptoms.Comprehensive univariate and multivariate logistic regression analyses showed that low bone density in the lumbar spine(L2-L4)and femoral neck,presence of chronic diseases,and low 5-hydroxytryptamine levels were independent risk factors for depressive symptoms,whereas calcium supplement intake and moderate to high-intensity activity were independent protective factors.CONCLUSION By implementing specialized psychological nursing interventions,and providing rehabilitation guidance,the incidence of depressive symptoms can be effectively reduced,improving the psychological health status and patient quality of life.
文摘Aim:To evaluate the impact of professional training on pediatric outpatient nurses’cognition and attitudes towards the use of clown therapy,and to assess its clinical applicability.Design:A pre-and post-training evaluation study.Methods:A total of 31 pediatric outpatient nurses participated in the study,completing a self-designed 15-item questionnaire focused on clown therapy.The questionnaires were administered both before and after a structured training program.The assessment aimed to measure changes in nurses’knowledge and attitudes toward clown therapy.Results:The results indicated a statistically significant improvement in the nurses’cognition following the training(mean score post-training:8.55 vs pre-training:7.71,p=0.003).Conclusion:Notably,the training also eliminated the age-related differences in cognition observed prior to the intervention.Furthermore,nurses expressed more positive attitudes toward the clinical implementation of clown therapy post-training.
基金financially supported by the National Natural Science Foundation of China(Nos.11904039,52125103,52071041,U21A2054 and 12104071)。
文摘SnS,a well-known van der Waals chalcogenide,is susceptible to oxidation in high-temperature or highhumidity environments,significantly impacting its functional performance and device stability.Conversely,oxidation can be used as an effective strategy for surface engineering,allowing for structure modulation or design,property tuning and application exploration.However,there is currently a gap in understanding the relationship between the oxidation behavior of SnS,the structure of its oxidized surface,and the dependence on oxidation temperature.In this study,we systematically investigated the evolution of SnS surfaces under thermal oxidation using electron microscopy.The microstructure evolution(e.g.,surface structures,phases,defects,and interface)of SnS during high-temperature oxidation has been fully characterized and studied based on cross-sectional samples.Various surface heterostructures were constructed,including SnO_(2)/SnS,SnO_(2)/SnS_(2)/SnS,and SnO_(2)/Sn_(2)S_(3)/SnS,offering significant potential for the surface functionalization of SnS-based systems.Accordingly,oxidation mechanisms at different stages were elucidated based on the detailed and clear picture of microstructures.This research not only deepens our understanding of the fundamental science of SnS oxidation but also provides valuable insights for preventing and developing surface oxidation engineering in SnS and other van der Waals chalcogenides/materials.
文摘Commonly,the standards for the geometric design of roads refer to a given set of values for the friction coefficient(longitudinal and transverse friction).These"reference"values imply corresponding visibility sights,curvature radii,and speed limits.Unfortunately,not only do these reference values not correspond to a given standard to measure them,but nothing is said about the decrease of the posted speed limit(variable speed limits)when roads become slippery and lanes for autonomous vehicle(AV)are concerned.Furthermore,the same assessment of the friction coefficient has plenty of uncertainties due to measurement device,temperature,location,time passed from the construction,alignment-related variables(e.g.,curve,tangent,transition curve,convexity/crests or concavity/sags,longitudinal slope,superelevation,and ruling gradient),and supplementary singularities such as joints and bridge approaches.All the issues above may harm road safety and the complexity of forensic investigations of pavements.Consequently,this study's objectives were confined to(1)carrying out friction measurements and analyzing the problem of friction decay over time;(2)setting up a method to lower the speed limits where friction decays are detected;(3)setting up a method to handle friction decays for autonomous vehicles.Results demonstrate that:(1)a power law describes how the speed limits are affected by friction;(2)for speeds up to 170 km/h,due to the lower reaction time,AV reaction distance is lower,which benefits AV traffic(lower stopping distance);(3)on the contrary,for higher values of friction and higher speeds,under the hypothesis of having the same reaction time law for non-AV(NAV)(i.e.,decreasing with the initial speed),AV speed limits become lower than NAV speed limits;(4)not only do comfort-based speed profiles for AVs bring higher braking distances,but also,in the median part(of the deceleration process),this could pose safety issues and reduce the distance between the available and the needed friction.
文摘The gut microbiome is closely associated with human health and the development of diseases. Isolating, characterizing, and identifying gut microbes are crucial for research on the gut microbiome and essential for advancing our understanding and utilization of it. Although culture-independent approaches have been developed, a pure culture is required for in-depth analysis of disease mechanisms and the development of biotherapy strategies. Currently, microbiome research faces the challenge of expanding the existing database of culturable gut microbiota and rapidly isolating target microorganisms. This review examines the advancements in gut microbe isolation and cultivation techniques, such as culturomics, droplet microfluidics, phenotypic and genomics selection, and membrane diffusion. Furthermore, we evaluate the progress made in technology for identifying gut microbes considering both non-targeted and targeted strategies. The focus of future research in gut microbial culturomics is expected to be on high-throughput, automation, and integration. Advancements in this field may facilitate strain-level investigation into the mechanisms underlying diseases related to gut microbiota.
基金partially supported by the Singapore Ministry of National Development and the National Research Foundation,Prime Minister’s Office,Singapore,under the Land and Liveability National Innovation Challenge(L2 NIC)Research Program(Grant No.L2NICCFP2-2015-1)by the National Research Foundation(NRF)of Singapore,under the Virtual Singapore program(Grant No.NRF2019VSG-GMS-001).
文摘Accurate determination of rockhead is crucial for underground construction.Traditionally,borehole data are mainly used for this purpose.However,borehole drilling is costly,time-consuming,and sparsely distributed.Non-invasive geophysical methods,particularly those using passive seismic surface waves,have emerged as viable alternatives for geological profiling and rockhead detection.This study proposes three interpretation methods for rockhead determination using passive seismic surface wave data from Microtremor Array Measurement(MAM)and Horizontal-to-Vertical Spectral Ratio(HVSR)tests.These are:(1)the Wavelength-Normalized phase velocity(WN)method in which a nonlinear relationship between rockhead depth and wavelength is established;(2)the Statistically Determined-shear wave velocity(SD-V_(s))method in which the representative V_(s) value for rockhead is automatically determined using a statistical method;and(3)the empirical HVSR method in which the rockhead is determined by interpreting resonant frequencies using a reliably calibrated empirical equation.These methods were implemented to determine rockhead depths at 28 locations across two distinct geological formations in Singapore,and the results were evaluated using borehole data.The WN method can determine rockhead depths accurately and reliably with minimal absolute errors(average RMSE=3.11 m),demonstrating robust performance across both geological formations.Its advantage lies in interpreting dispersion curves alone,without the need for the inversion process.The SD-V_(s) method is practical in engineering practice owing to its simplicity.The empirical HVSR method reasonably determines rockhead depths with moderate accuracy,benefiting from a reliably calibrated empirical equation.
基金supported by the National Natural Science Foundation of China(Grant Nos.52202483,52108476,and 52388102)。
文摘Urban transportation systems are facing severe challenges due to the rapid growth of the urban population,especially in China.Suspended monorail system(SMS),as a sky rail transportation form,can effectively alleviate urban traffic congestion due to its independent right-of-way and minimal ground footprint.However,the SMS possesses a special traveling system with unique vehicle structure and bridge configuration,which results in significant differences in both the mechanisms and dynamics problems associated with train–bridge interaction(TBI)when contrasted with those of traditional railway systems.Therefore,a thorough understanding of the SMS dynamics is essential for ensuring the operational safety of the system.This article presents a state-of-the-art review of the TBI modeling methodologies,critical dynamic features,field tests,and practice of the SMS in China.Firstly,the development history,technical features,and potential dynamics problems of the SMS are briefly described,followed by the mechanical characteristics and mechanisms of the train–bridge interactive systems.Then,the modeling methodology of the fundamental elements in the suspended monorail TBI is systematically reviewed,including the suspended train subsystem,bridge subsystem,train–bridge interaction relationships,system excitations,and solution method.Further,the typical dynamic features of the TBI under various operational scenarios are elaborated,including different train speeds,a variety of line sections,and a natural wind environment.Finally,the first new energy-based SMS test line in the world is systematically introduced,including the composition and functionality of the system,the details of the conducted field tests,and the measured results of the typical dynamic responses.At the end of the paper,both the guidance on further improvement of the SMS and future research topics are proposed.
文摘The neem flower(Azadirachta indica),a well-known element of Ayurvedic medicine,has attracted considerable interest due to its abundance of bioactive compounds.This systematic review examines its pharmacological and immunomodulatory properties in detail,emphasizing its potential role in contemporary healthcare.Neem flowers are rich in various bioactive components,such as flavonoids,terpenoids,and glycosides,known for their antioxidant,anti-inflammatory,antimicrobial,and anticancer properties.Recent studies indicate that extracts from neem flowers can influence immune system activity by boosting both innate and adaptive immune functions while reducing excessive inflammation.These properties suggest that neem flowers could serve as valuable therapeutic agents for treating immune-related disorders.Additionally,neem flowers have demonstrated promise in addressing conditions such as diabetes,cardiovascular issues,and microbial infections through their ability to regulate metabolic functions and inhibit the growth of harmful pathogens.Preclinical research highlights their protective effects against oxidative damage and their capacity to induce apoptosis in cancer cells.However,challenges such as the lack of standardized extraction processes and limited clinical research hinder broader utilization.This review emphasizes the need for more robust studies to fully harness the pharmacological potential of neem flowers and facilitate their incorporation into evidence-based medicinal properties.
