In this editorial,a commentary on the article by Chang et al has been provided,the course of treatment of anorectal fistulas,especially complex and recurring ones,require accurate diagnostic procedures for determining...In this editorial,a commentary on the article by Chang et al has been provided,the course of treatment of anorectal fistulas,especially complex and recurring ones,require accurate diagnostic procedures for determining ideal surgical procedures.Conventional ways of imaging sometimes fall short,offering insufficient insights in aggravated instances.In this editorial,a novel application of hydrogen peroxide-enhanced magnetic resonance imaging(HP-MRI)that promises significant improvements in the imaging of anorectal fistula.Study is based on a retrospective investigation of 60 patients,contrasts the new HP-MRI with conventional diagnostic techniques such as physical examination,trans-perineal ultrasonography and poor spatial resolution MRI.The findings demonstrate HP-MRI's incredible diagnostic performance,with sensitivity and specificity rates of 96.08%and 90.91%,respectively,and unparalleled interobserver agreement(Kappa values ranging from 0.80 to 0.89).It has been a significant advancement for assessment of anorectal fistulas providing a better roadmap for surgical planning,lowering recurrence rates as well as reduced personal and financial burden on patients by reducing the need for repeated treatment and extended hospital stays.The remaining funds can be utilized for treatment of other medical need.Ultimately HP-MRI provides us a healthier&more efficient society by improvising patients well-being&optimized healthcare infrastructure.展开更多
<strong>Objective:</strong> To evaluate the role of invasive imaging in the identification and pre-surgical localization of endoductal breast lesions. <strong>Methods:</strong> We retrospective...<strong>Objective:</strong> To evaluate the role of invasive imaging in the identification and pre-surgical localization of endoductal breast lesions. <strong>Methods:</strong> We retrospectively evaluated cytological outcomes, non-invasive/invasive breast imaging obtained between January 2016 and December 2019 in women with pathological nipple discharge (PND). We analysed sensitivity, specificity, positive predictive value and negative predictive value. We also evaluated the advantages of a pre-surgical radiological study using an endoductal contrast medium (with 3D-technique, in young women with dense breasts). <strong>Results:</strong> A total of 286 women with PND underwent cytological examination, mammography and/or breast ultrasound. When the cytological outcome was reported as “negative” (66.78%) in agreement with negative noninvasive imaging, patients were sent to follow up. Patients with cytological outcomes defined as “bloody with papillary clusters” (29.37%) “bloody not associated to cytological modifications” (2.44%), or “atypical/suspected” for malignant (1.39%) underwent an invasive procedure. Sensitivity, specificity, positive predictive value and negative predictive value were, respectively: 92.63%, 100%, 100% and 96.46% for cytological examination;64.28%, 96.95%, 60% and 97.44% for mammography;41.11%, 97.44%, 88.09% and 78.27% for ultrasound;93.68%, 100%, 100% and 96.95% for invasive procedures. Post-surgical histological outcomes confirmed the diagnosis. <strong>Conclusion:</strong> In absence of a standard diagnostic algorithm, we recommend invasive procedures to identify intraductal breast lesions and for preoperative planning. Digital imaging and new technologies such as 3D-tomosynthesis lead to a renaissance of breast invasive imaging;they are confirmed to be an essential diagnostic modality for preoperative planning, to define localization and extension of multiple coexisting endoductal lesions.展开更多
Electrical impedance tomography(EIT)is a non-invasive imaging modality that generates real-time images by measuring tissue bioimpedance.It works by applying current and collecting voltage data to reconstruct images of...Electrical impedance tomography(EIT)is a non-invasive imaging modality that generates real-time images by measuring tissue bioimpedance.It works by applying current and collecting voltage data to reconstruct images of electrical conductivity,refl ecting tissue properties.[1]We aim to off er a comprehensive guide to the fundamental technology behind EIT and to explore its clinical applications across both pulmonary and extrapulmonary domains.展开更多
Scattering media pose a significant barrier to non-invasive biomedical imaging,as conventional wavefront shaping methods rely on invasive guide stars or costly nonlinear modalities.Here,we introduce an improved approa...Scattering media pose a significant barrier to non-invasive biomedical imaging,as conventional wavefront shaping methods rely on invasive guide stars or costly nonlinear modalities.Here,we introduce an improved approach that enables high-fidelity,non-invasive fluorescence imaging through scattering media by combining the linear fluorescence mechanism with efficient computational optimization.The method leverages a genetic algorithm guided by variance maximization to dynamically optimize speckle,non-invasively exciting an individual fluorescent bead by∼10-fold enhancement in target intensity ratio.This process generates a precise system point spread function(PSF),which drives a convex optimization-based deconvolution framework to reconstruct obscured targets.Remarkably,the technique eliminates the need for complex scanning systems,achieving rapid wide-field imaging with structural similarity(SSIM)indices exceeding 0.997(for beads).We demonstrate robust imaging of both discrete beads and continuous fibers behind scattering media,revealing resolution superior to that of conventional speckle cross-correlation methods.The method provides a pathway for non-invasively visualizing fluorescent objects behind scattering media.展开更多
Point-cloud-projection-based stereo vision technology is widely applied in 3D reconstruction, robotic vision, and virtual reality. A metasurface, known for its exceptional light-field manipulation capabilities and com...Point-cloud-projection-based stereo vision technology is widely applied in 3D reconstruction, robotic vision, and virtual reality. A metasurface, known for its exceptional light-field manipulation capabilities and compact integration, offers a promising approach to reducing system size while enhancing functionality. In this work, we propose and implement a short-wave infrared 3D structured light detection system based on a metasurface supporting a bound state in the continuum(BIC). The designed BIC metasurface exhibits wavelength selectivity, generating a point cloud projection array exclusively under 1350 nm laser illumination, effectively minimizing interference from environmental light and enabling penetration through certain packaging materials opaque to visible light. Using this system, we successfully demonstrate 3D detection and reconstruction of concealed objects, such as lenses and workpieces, within opaque packaging. Our design provides a non-contact,penetrating 3D reconstruction approach for industrial inspection, offering potential applications in nondestructive quality control.展开更多
文摘In this editorial,a commentary on the article by Chang et al has been provided,the course of treatment of anorectal fistulas,especially complex and recurring ones,require accurate diagnostic procedures for determining ideal surgical procedures.Conventional ways of imaging sometimes fall short,offering insufficient insights in aggravated instances.In this editorial,a novel application of hydrogen peroxide-enhanced magnetic resonance imaging(HP-MRI)that promises significant improvements in the imaging of anorectal fistula.Study is based on a retrospective investigation of 60 patients,contrasts the new HP-MRI with conventional diagnostic techniques such as physical examination,trans-perineal ultrasonography and poor spatial resolution MRI.The findings demonstrate HP-MRI's incredible diagnostic performance,with sensitivity and specificity rates of 96.08%and 90.91%,respectively,and unparalleled interobserver agreement(Kappa values ranging from 0.80 to 0.89).It has been a significant advancement for assessment of anorectal fistulas providing a better roadmap for surgical planning,lowering recurrence rates as well as reduced personal and financial burden on patients by reducing the need for repeated treatment and extended hospital stays.The remaining funds can be utilized for treatment of other medical need.Ultimately HP-MRI provides us a healthier&more efficient society by improvising patients well-being&optimized healthcare infrastructure.
文摘<strong>Objective:</strong> To evaluate the role of invasive imaging in the identification and pre-surgical localization of endoductal breast lesions. <strong>Methods:</strong> We retrospectively evaluated cytological outcomes, non-invasive/invasive breast imaging obtained between January 2016 and December 2019 in women with pathological nipple discharge (PND). We analysed sensitivity, specificity, positive predictive value and negative predictive value. We also evaluated the advantages of a pre-surgical radiological study using an endoductal contrast medium (with 3D-technique, in young women with dense breasts). <strong>Results:</strong> A total of 286 women with PND underwent cytological examination, mammography and/or breast ultrasound. When the cytological outcome was reported as “negative” (66.78%) in agreement with negative noninvasive imaging, patients were sent to follow up. Patients with cytological outcomes defined as “bloody with papillary clusters” (29.37%) “bloody not associated to cytological modifications” (2.44%), or “atypical/suspected” for malignant (1.39%) underwent an invasive procedure. Sensitivity, specificity, positive predictive value and negative predictive value were, respectively: 92.63%, 100%, 100% and 96.46% for cytological examination;64.28%, 96.95%, 60% and 97.44% for mammography;41.11%, 97.44%, 88.09% and 78.27% for ultrasound;93.68%, 100%, 100% and 96.95% for invasive procedures. Post-surgical histological outcomes confirmed the diagnosis. <strong>Conclusion:</strong> In absence of a standard diagnostic algorithm, we recommend invasive procedures to identify intraductal breast lesions and for preoperative planning. Digital imaging and new technologies such as 3D-tomosynthesis lead to a renaissance of breast invasive imaging;they are confirmed to be an essential diagnostic modality for preoperative planning, to define localization and extension of multiple coexisting endoductal lesions.
基金supported partially by grants from the National Natural Science Foundation of China(82470068,82270086,GS Zhang82372185,BP Tian)+2 种基金the Natural Science Foundation of Zhejiang Province(Key Project)(LZ25H150001,GS Zhang)the National Health Commission Scientifi c Research Fund Zhejiang Provincial Health Major Science and Technology Plan Project(co-construction project of National Health Commission Committee and Zhejiang Province)(WKJ-ZJ-2526,GS Zhang)the Medical and Health Research Program of Zhejiang Province(2023572679).
文摘Electrical impedance tomography(EIT)is a non-invasive imaging modality that generates real-time images by measuring tissue bioimpedance.It works by applying current and collecting voltage data to reconstruct images of electrical conductivity,refl ecting tissue properties.[1]We aim to off er a comprehensive guide to the fundamental technology behind EIT and to explore its clinical applications across both pulmonary and extrapulmonary domains.
基金National Natural Science Foundation of China(62175198,62335018,12127805,62005309,61991452,U22A2092)Open Science Foundation of the Key Laboratory of Hepatobiliary Technology of Mengchao(2024ZDSY1001)Youth Innovation Promotion Association of the Chinese Academy of Sciences。
文摘Scattering media pose a significant barrier to non-invasive biomedical imaging,as conventional wavefront shaping methods rely on invasive guide stars or costly nonlinear modalities.Here,we introduce an improved approach that enables high-fidelity,non-invasive fluorescence imaging through scattering media by combining the linear fluorescence mechanism with efficient computational optimization.The method leverages a genetic algorithm guided by variance maximization to dynamically optimize speckle,non-invasively exciting an individual fluorescent bead by∼10-fold enhancement in target intensity ratio.This process generates a precise system point spread function(PSF),which drives a convex optimization-based deconvolution framework to reconstruct obscured targets.Remarkably,the technique eliminates the need for complex scanning systems,achieving rapid wide-field imaging with structural similarity(SSIM)indices exceeding 0.997(for beads).We demonstrate robust imaging of both discrete beads and continuous fibers behind scattering media,revealing resolution superior to that of conventional speckle cross-correlation methods.The method provides a pathway for non-invasively visualizing fluorescent objects behind scattering media.
基金National Key Researchand Development Program of China(2022YFB4600204)Beijing Outstanding Young Scientist Program(BJJWZYJH01201910007022)+1 种基金National Natural Science Foundation of China(12104046,62105024,61775019,62475018,U21A20140)Natural Science Foundation of Beijing Municipality(JQ24028).
文摘Point-cloud-projection-based stereo vision technology is widely applied in 3D reconstruction, robotic vision, and virtual reality. A metasurface, known for its exceptional light-field manipulation capabilities and compact integration, offers a promising approach to reducing system size while enhancing functionality. In this work, we propose and implement a short-wave infrared 3D structured light detection system based on a metasurface supporting a bound state in the continuum(BIC). The designed BIC metasurface exhibits wavelength selectivity, generating a point cloud projection array exclusively under 1350 nm laser illumination, effectively minimizing interference from environmental light and enabling penetration through certain packaging materials opaque to visible light. Using this system, we successfully demonstrate 3D detection and reconstruction of concealed objects, such as lenses and workpieces, within opaque packaging. Our design provides a non-contact,penetrating 3D reconstruction approach for industrial inspection, offering potential applications in nondestructive quality control.
