BACKGROUND Paravalvular leak(PVL),also known as paravalvular prosthetic regurgitation,is not a rare complication after surgical valve replacement,and it may cause varying degrees of heart failure.The transcatheter clo...BACKGROUND Paravalvular leak(PVL),also known as paravalvular prosthetic regurgitation,is not a rare complication after surgical valve replacement,and it may cause varying degrees of heart failure.The transcatheter closure of PVL is technically demanding and challenging.CASE SUMMARY A 68-year-old man presented with degenerative mitral regurgitation with heart failure,New York Heart Association functional class 3.He received bioprosthetic mitral valve replacement in December 2019.PVL was noted at the location of the aorto-mitral curtain in transesophageal echocardiography without signs of endocarditis or dehiscence of the bioprosthetic valve.Transseptal transcatheter closure of the mitral PVL was performed efficiently using the EchoNavigator virtual marker and Agilis NxT steerable introducer.CONCLUSION This case highlights that the EchoNavigator virtual marker and Agilis NxT steerable introducer can facilitate transseptal transcatheter closure of mitral PVL by reducing the procedure time and contrast media.展开更多
Background: Turner syndrome (TS) affects approximately one in 2500 live births in females. Scoliosis is one of the skeletal manifestations of TS, but most cases only require observation or conservative treatment. We e...Background: Turner syndrome (TS) affects approximately one in 2500 live births in females. Scoliosis is one of the skeletal manifestations of TS, but most cases only require observation or conservative treatment. We experienced two adolescent TS cases in which progression of scoliosis required surgical intervention, which is very rare in TS. Case Presentation: Case 1: An 11-year-old female with TS had a single thoracic curve that rapidly progressed to a triple major curve with a 76˚ main thoracic curve at age 13.5 years. Case 2: A 14-year-old female with TS had a 59˚ single thoracic curve. In both cases, growth hormone and estrogen replacement therapy were administered preoperatively and planned postoperatively. Posterior correction and instrumented fusion using simultaneous translation on two rods technique and direct vertebral rotation with the use of multiple rod introducers were successfully performed in both cases. No crankshaft phenomenon or distal adding on were observed during those postoperative courses. Conclusions: Although curve pattern of the deformity is similar to adolescent idiopathic scoliosis (AIS), bone quality in patient with TS is lower. In the context of surgical interventions for scoliosis associated with TS, it is imperative to employ surgical techniques that take into account the suboptimal bone quality. If continuation of hormone replacement therapy is planned after corrective surgery for scoliosis in TS patients, it is essential to follow the patient closely postoperatively until bone maturation is complete.展开更多
The Qinghai-Tibet Plateau(QTP)is the highest and one of the most extensive plateaus in the world.Investigating naturalized non-native plant species composition,phylogenetic relationships among naturalized plant specie...The Qinghai-Tibet Plateau(QTP)is the highest and one of the most extensive plateaus in the world.Investigating naturalized non-native plant species composition,phylogenetic relationships among naturalized plant species,and phylogenetic relationships between native and naturalized plant species on the plateau is of great importance.Here,we analyze a comprehensive dataset including all species of native and naturalized vascular plants known to occur in the core part of the QTP.We use net relatedness index(NRI)and nearest taxon index(NTI),which reflect deep and shallow evolutionary histories,respectively,to quantify phylogenetic relatedness among angiosperm species.The QTP included in this study(1,448,815 km^(2))has 9086 and 314 species of native and naturalized non-native vascular plants,respectively.We find that the naturalized angiosperm species are phylogenetically clustered with respect to the species pool including all native and naturalized angiosperm species on the QTP included in this study,regardless of whether NRI or NTI is used.For the eight regions within the QTP included in this study,NRI and NTI of naturalized angiosperms are positive in seven regions with respect to their respective regional species pools,reflecting phylogenetic clustering.Thus,naturalized angiosperm species are a phylogenetically clustered subset of all angiosperm species on the QTP,regardless of whether the studied plateau as a whole or its constituent regions are considered.展开更多
1 People often think of musical memories as fixed images of the past,but a recent study suggests music may do more than just activate memories-it might even change how you remember them.2 The hypothesis(假说)was roote...1 People often think of musical memories as fixed images of the past,but a recent study suggests music may do more than just activate memories-it might even change how you remember them.2 The hypothesis(假说)was rooted in the idea that when you recall a memory,it becomes temporarily flexible,allowing new information to be integrated.To prove it,the researchers developed a three⁃day experiment to test whether music played during recall might introduce new emotional elements into the original memory.展开更多
Macrophages derived from the human THP-1 cell line have been widely used as substitutes for primary macrophages in various macrophage-related studies.However,difficulties still exist in establishing THP-I macrophage m...Macrophages derived from the human THP-1 cell line have been widely used as substitutes for primary macrophages in various macrophage-related studies.However,difficulties still exist in establishing THP-I macrophage models.This research presents techniques for generating different phenotypes of activated macrophages derived from THP-1 cells by introducing specific stimuli and provides some potential markers to confirm each type of activated macrophage.It is hoped to provide novel and useful methods for scientific research and to help researchers explore this field more intuitively and effectively.展开更多
Understanding how structural disorder affects phonon transport is critical for controlling thermal conduction in nanoscale materials.In this work,we investigate thermal transport in Si-like nanowires composed of layer...Understanding how structural disorder affects phonon transport is critical for controlling thermal conduction in nanoscale materials.In this work,we investigate thermal transport in Si-like nanowires composed of layered atoms with one-dimensional correlated disorder.Using the nonequilibrium Green’s function method,we reveal that introducing correlation among atomic layers induces phonon Anderson localization at low-frequencies,leading to a nonmonotonic length dependence of thermal conductivity:it increases at short lengths but decreases beyond a critical size,in sharp contrast to the monotonic trend observed in random disorder.Despite having fewer mass interfaces,the correlated nanowires exhibit lower thermal conductivity than their random disorder counterparts when the nanowire length exceeds 70 nm.Frequency-resolved analysis shows that spatial correlation suppresses the transmission of low-frequency phonons and promotes their localization,while concurrently extending the localization length of mid-and high-frequency modes.This selective reshaping of phonon localization is responsible for the anomalous transport behavior.Our findings provide new insights into heat transport engineering via tailored disorder in low-dimensional materials.展开更多
Electrocatalytic reduction of NO(NORR) is an effective method for NH_(3) synthesis, due to low bonding energy of N–O bond. In this work, we have investigated many CrS_(2)based catalysts, including pristine CrS_(2),Cr...Electrocatalytic reduction of NO(NORR) is an effective method for NH_(3) synthesis, due to low bonding energy of N–O bond. In this work, we have investigated many CrS_(2)based catalysts, including pristine CrS_(2),CrS_(2)with one S vacancy(v-CrS_(2)), and Ti doped CrS_(2)(Ti@CrS_(2)). The results have shown that the pristine CrS_(2)exhibits inert character for NO activation. However, v-CrS_(2)and Ti@CrS_(2)can exhibit enhanced interaction with NO, due to increased charge transfer between NO and substrates(0.52–0.75 e) and enhanced adsorption energies of NO on the catalysts(-0.96~-1.64 e V), compared to the situation of CrS_(2)(0.065 e/-0.30 e V). From the free energy profiles of NO electro-reduction to NH3, we can see that the v-CrS_(2)and Ti@CrS_(2)all exhibit ultralow limiting potentials of-0.03~-0.47 V, following both*NOH and*NHO mechanisms. Therefore, introducing vacancy and doping are all promising modification strategies for NORR catalysts. The results have provided a new idea for the search of catalysts for efficient electrocatalytic reduction of NO.展开更多
Molecular recognition of bioreceptors and enzymes relies on orthogonal interactions with small molecules within their cavity. To date, Chinese scientists have developed three types of strategies for introducing active...Molecular recognition of bioreceptors and enzymes relies on orthogonal interactions with small molecules within their cavity. To date, Chinese scientists have developed three types of strategies for introducing active sites inside the cavity of macrocyclic arenes to better mimic molecular recognition of bioreceptors and enzymes.The editorial aims to enlighten scientists in this field when they develop novel macrocycles for molecular recognition, supramolecular assembly, and applications.展开更多
Aerodigestive cancer, like esophageal cancer or head and neck cancer, is well known to have a poor prognosis. It is often diagnosed in the late stages, with dysphagia being the major symptom. Insufficient nutrition an...Aerodigestive cancer, like esophageal cancer or head and neck cancer, is well known to have a poor prognosis. It is often diagnosed in the late stages, with dysphagia being the major symptom. Insufficient nutrition and lack of stimulation of the intestinal mucosa may worsen immune compromise due to toxic side effects. A poor nutritional status is a significant prognostic factor for increased mortality. Therefore, it is most important to optimize enteral nutrition in patients with aerodigestive cancer before and during treatment, as well as during palliative treatment. Percutaneous endoscopic gastrostomy(PEG) may be useful for nutritional support. However, PEG tube placement is limited by digestive tract stenosis and is an invasive endoscopic procedure with a risk of complications. There are three PEG techniques. The pull/push and introducer methods have been established as standard techniques for PEG tube placement. The modified introducer method, namely the direct method, allows for direct placement of a larger button-bumper-type catheter device. PEG tube placement using the introducer method or the direct method may be a much safer alternative than the pull/push method. PEG may be recommended in patients with aerodigestive cancer because of the improved complication rate.展开更多
To keep open network more efficacious and secure, it is necessary that a nice trust model and method of trust management must be developed. The reason why traditional trust models are incomplete in their function to m...To keep open network more efficacious and secure, it is necessary that a nice trust model and method of trust management must be developed. The reason why traditional trust models are incomplete in their function to manage trust is explained, and a general model based on hybrid trust model and introducer protocol is provided. The hybrid model is more flexible and efficacious to manage trust compared with hierarchy model and Web model. The introducer protocol is a better solution to build, maintain and refresh the trust relationship in open network environment.展开更多
An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, clo...An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, cloud data de-noising optimization, construction, display and operation of three-dimensional model, model editing, profile generation, calculation of goaf volume and roof area, Boolean calculation among models and interaction with the third party soft ware. Concerning this system with a concise interface, plentiful data input/output interfaces, it is featured with high integration, simple and convenient operations of applications. According to practice, in addition to being well-adapted, this system is favorably reliable and stable.展开更多
This article is devoted to work aimed at normalizing the condition of degraded soils in open-pit mines as a result of anthropogenic influences through phytomass. By creating a biological cover from plants, it has been...This article is devoted to work aimed at normalizing the condition of degraded soils in open-pit mines as a result of anthropogenic influences through phytomass. By creating a biological cover from plants, it has been achieved to improve the composition of the soil. Plants such as Datura starmonium, Portuluca oleracea, Caspella bursa-pastoris, Chenopodium vulvaria, Chenopodium album, Plantago lanceolata, Vaccaria hispanica, Vicia angustifolia were used for the research. The effect of micronutrients on plants was studied.展开更多
Seven microsatellite markers were used to evaluate the genetic diversity and differentiation of seven stocks of Litopenaeus vannamei, which were introduced from Central and South America to China. All seven microsatel...Seven microsatellite markers were used to evaluate the genetic diversity and differentiation of seven stocks of Litopenaeus vannamei, which were introduced from Central and South America to China. All seven microsatellite loci were polymorphic, with polymorphism information content(PIC) values ranging from 0.593 to 0.952. Totally 92 alleles were identified, and the number of alleles(Na) and effective alleles(Ne) varied between 4 and 21 and 2.7 and 14.6, respectively. Observed heterozygosity(Ho) values were lower than the expected heterozygosity(He) values(0.526–0.754), which indicated that the seven stocks possessed a rich genetic diversity. Thirty-seven tests were detected for reasonable significant deviation from Hardy-Weinberg equilibrium. Fis values were positive at five loci, suggesting that there was a relatively high degree of inbreeding within stocks. Pairwise Fst values ranged from 0.0225 to 0.151, and most of the stock pairs were moderately differentiated. Genetic distance and cluster analysis using UPGMA revealed a close genetic relationship of L. vannamei between Pop2 and Pop3. AMOVA indicated that the genetic variation among stocks(11.3%) was much lower than that within stocks(88.7%). Although the seven stocks had a certain degree of genetic differentiation and a rich genetic diversity, there is an increasing risk of decreased performance due to inbreeding in subsequent generations.展开更多
文摘BACKGROUND Paravalvular leak(PVL),also known as paravalvular prosthetic regurgitation,is not a rare complication after surgical valve replacement,and it may cause varying degrees of heart failure.The transcatheter closure of PVL is technically demanding and challenging.CASE SUMMARY A 68-year-old man presented with degenerative mitral regurgitation with heart failure,New York Heart Association functional class 3.He received bioprosthetic mitral valve replacement in December 2019.PVL was noted at the location of the aorto-mitral curtain in transesophageal echocardiography without signs of endocarditis or dehiscence of the bioprosthetic valve.Transseptal transcatheter closure of the mitral PVL was performed efficiently using the EchoNavigator virtual marker and Agilis NxT steerable introducer.CONCLUSION This case highlights that the EchoNavigator virtual marker and Agilis NxT steerable introducer can facilitate transseptal transcatheter closure of mitral PVL by reducing the procedure time and contrast media.
文摘Background: Turner syndrome (TS) affects approximately one in 2500 live births in females. Scoliosis is one of the skeletal manifestations of TS, but most cases only require observation or conservative treatment. We experienced two adolescent TS cases in which progression of scoliosis required surgical intervention, which is very rare in TS. Case Presentation: Case 1: An 11-year-old female with TS had a single thoracic curve that rapidly progressed to a triple major curve with a 76˚ main thoracic curve at age 13.5 years. Case 2: A 14-year-old female with TS had a 59˚ single thoracic curve. In both cases, growth hormone and estrogen replacement therapy were administered preoperatively and planned postoperatively. Posterior correction and instrumented fusion using simultaneous translation on two rods technique and direct vertebral rotation with the use of multiple rod introducers were successfully performed in both cases. No crankshaft phenomenon or distal adding on were observed during those postoperative courses. Conclusions: Although curve pattern of the deformity is similar to adolescent idiopathic scoliosis (AIS), bone quality in patient with TS is lower. In the context of surgical interventions for scoliosis associated with TS, it is imperative to employ surgical techniques that take into account the suboptimal bone quality. If continuation of hormone replacement therapy is planned after corrective surgery for scoliosis in TS patients, it is essential to follow the patient closely postoperatively until bone maturation is complete.
基金supported by grants from the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502)the Strategic Priority Research Program of Chinese Academy of Sciences(XDA20050203)+4 种基金the National Natural Science Foundation of China-Yunnan joint fund to support key projects(U1802232)the Major Program for Basic Research Project of Yunnan Province(202101BC070002)the Yunnan Young&Elite Talents Project(YNWR-QNBJ-2019-033)the Ten Thousand Talents Program of Yunnan Province(202005AB160005)the Chinese Academy of Sciences“Light of West China”Program.
文摘The Qinghai-Tibet Plateau(QTP)is the highest and one of the most extensive plateaus in the world.Investigating naturalized non-native plant species composition,phylogenetic relationships among naturalized plant species,and phylogenetic relationships between native and naturalized plant species on the plateau is of great importance.Here,we analyze a comprehensive dataset including all species of native and naturalized vascular plants known to occur in the core part of the QTP.We use net relatedness index(NRI)and nearest taxon index(NTI),which reflect deep and shallow evolutionary histories,respectively,to quantify phylogenetic relatedness among angiosperm species.The QTP included in this study(1,448,815 km^(2))has 9086 and 314 species of native and naturalized non-native vascular plants,respectively.We find that the naturalized angiosperm species are phylogenetically clustered with respect to the species pool including all native and naturalized angiosperm species on the QTP included in this study,regardless of whether NRI or NTI is used.For the eight regions within the QTP included in this study,NRI and NTI of naturalized angiosperms are positive in seven regions with respect to their respective regional species pools,reflecting phylogenetic clustering.Thus,naturalized angiosperm species are a phylogenetically clustered subset of all angiosperm species on the QTP,regardless of whether the studied plateau as a whole or its constituent regions are considered.
文摘1 People often think of musical memories as fixed images of the past,but a recent study suggests music may do more than just activate memories-it might even change how you remember them.2 The hypothesis(假说)was rooted in the idea that when you recall a memory,it becomes temporarily flexible,allowing new information to be integrated.To prove it,the researchers developed a three⁃day experiment to test whether music played during recall might introduce new emotional elements into the original memory.
基金supported by the Shaanxi University of Chinese Medicine-National Natural Science Foundation Cultivation Project(No.2023GP16)the Shaanxi Key Laboratory of Research on TCM Physical Constitution and Diseases Prevention and Treatment(No.KF202311)the Graduate Student Innovative Practical Ability Improvement Project(No.CXSJ202302),China.
文摘Macrophages derived from the human THP-1 cell line have been widely used as substitutes for primary macrophages in various macrophage-related studies.However,difficulties still exist in establishing THP-I macrophage models.This research presents techniques for generating different phenotypes of activated macrophages derived from THP-1 cells by introducing specific stimuli and provides some potential markers to confirm each type of activated macrophage.It is hoped to provide novel and useful methods for scientific research and to help researchers explore this field more intuitively and effectively.
基金supported by the National Natural Science Foundation of China(Grant Nos.U22A20210,52576070 for H.Y.and 12174276 for S.X.)+1 种基金the Basic and Applied Basic Research Foundation of Guangdong Province(Grant No.2024A1515010521 for S.X.)the China Scholarship Council(CSC)(Grant No.202406120152 for W.Z.)。
文摘Understanding how structural disorder affects phonon transport is critical for controlling thermal conduction in nanoscale materials.In this work,we investigate thermal transport in Si-like nanowires composed of layered atoms with one-dimensional correlated disorder.Using the nonequilibrium Green’s function method,we reveal that introducing correlation among atomic layers induces phonon Anderson localization at low-frequencies,leading to a nonmonotonic length dependence of thermal conductivity:it increases at short lengths but decreases beyond a critical size,in sharp contrast to the monotonic trend observed in random disorder.Despite having fewer mass interfaces,the correlated nanowires exhibit lower thermal conductivity than their random disorder counterparts when the nanowire length exceeds 70 nm.Frequency-resolved analysis shows that spatial correlation suppresses the transmission of low-frequency phonons and promotes their localization,while concurrently extending the localization length of mid-and high-frequency modes.This selective reshaping of phonon localization is responsible for the anomalous transport behavior.Our findings provide new insights into heat transport engineering via tailored disorder in low-dimensional materials.
基金funded by the Natural Science Foundation of China (No. 21603109)the Henan Joint Fund of the National Natural Science Foundation of China (No. U1404216)+1 种基金the Scientific Research Program Funded by Shaanxi Provincial Education Department (No. 20JK0676)supported by Natural Science Basic Research Program of Shanxi (Nos. 2022JQ-108, 2022JQ096)。
文摘Electrocatalytic reduction of NO(NORR) is an effective method for NH_(3) synthesis, due to low bonding energy of N–O bond. In this work, we have investigated many CrS_(2)based catalysts, including pristine CrS_(2),CrS_(2)with one S vacancy(v-CrS_(2)), and Ti doped CrS_(2)(Ti@CrS_(2)). The results have shown that the pristine CrS_(2)exhibits inert character for NO activation. However, v-CrS_(2)and Ti@CrS_(2)can exhibit enhanced interaction with NO, due to increased charge transfer between NO and substrates(0.52–0.75 e) and enhanced adsorption energies of NO on the catalysts(-0.96~-1.64 e V), compared to the situation of CrS_(2)(0.065 e/-0.30 e V). From the free energy profiles of NO electro-reduction to NH3, we can see that the v-CrS_(2)and Ti@CrS_(2)all exhibit ultralow limiting potentials of-0.03~-0.47 V, following both*NOH and*NHO mechanisms. Therefore, introducing vacancy and doping are all promising modification strategies for NORR catalysts. The results have provided a new idea for the search of catalysts for efficient electrocatalytic reduction of NO.
文摘Molecular recognition of bioreceptors and enzymes relies on orthogonal interactions with small molecules within their cavity. To date, Chinese scientists have developed three types of strategies for introducing active sites inside the cavity of macrocyclic arenes to better mimic molecular recognition of bioreceptors and enzymes.The editorial aims to enlighten scientists in this field when they develop novel macrocycles for molecular recognition, supramolecular assembly, and applications.
文摘Aerodigestive cancer, like esophageal cancer or head and neck cancer, is well known to have a poor prognosis. It is often diagnosed in the late stages, with dysphagia being the major symptom. Insufficient nutrition and lack of stimulation of the intestinal mucosa may worsen immune compromise due to toxic side effects. A poor nutritional status is a significant prognostic factor for increased mortality. Therefore, it is most important to optimize enteral nutrition in patients with aerodigestive cancer before and during treatment, as well as during palliative treatment. Percutaneous endoscopic gastrostomy(PEG) may be useful for nutritional support. However, PEG tube placement is limited by digestive tract stenosis and is an invasive endoscopic procedure with a risk of complications. There are three PEG techniques. The pull/push and introducer methods have been established as standard techniques for PEG tube placement. The modified introducer method, namely the direct method, allows for direct placement of a larger button-bumper-type catheter device. PEG tube placement using the introducer method or the direct method may be a much safer alternative than the pull/push method. PEG may be recommended in patients with aerodigestive cancer because of the improved complication rate.
文摘To keep open network more efficacious and secure, it is necessary that a nice trust model and method of trust management must be developed. The reason why traditional trust models are incomplete in their function to manage trust is explained, and a general model based on hybrid trust model and introducer protocol is provided. The hybrid model is more flexible and efficacious to manage trust compared with hierarchy model and Web model. The introducer protocol is a better solution to build, maintain and refresh the trust relationship in open network environment.
基金Project(51274250)supported by the National Natural Science Foundation of ChinaProject(2012BAK09B02-05)supported by the National Key Technology R&D Program during the 12th Five-year Plan of China
文摘An integration processing system of three-dimensional laser scanning information visualization in goaf was developed. It is provided with multiple functions, such as laser scanning information management for goaf, cloud data de-noising optimization, construction, display and operation of three-dimensional model, model editing, profile generation, calculation of goaf volume and roof area, Boolean calculation among models and interaction with the third party soft ware. Concerning this system with a concise interface, plentiful data input/output interfaces, it is featured with high integration, simple and convenient operations of applications. According to practice, in addition to being well-adapted, this system is favorably reliable and stable.
文摘This article is devoted to work aimed at normalizing the condition of degraded soils in open-pit mines as a result of anthropogenic influences through phytomass. By creating a biological cover from plants, it has been achieved to improve the composition of the soil. Plants such as Datura starmonium, Portuluca oleracea, Caspella bursa-pastoris, Chenopodium vulvaria, Chenopodium album, Plantago lanceolata, Vaccaria hispanica, Vicia angustifolia were used for the research. The effect of micronutrients on plants was studied.
基金supported by the National High Technology Development Project of China under contract No. 2012AA10A404the Recommended International Advanced Agricultural Science and Technology Project of China under contract No. 2012-S5
文摘Seven microsatellite markers were used to evaluate the genetic diversity and differentiation of seven stocks of Litopenaeus vannamei, which were introduced from Central and South America to China. All seven microsatellite loci were polymorphic, with polymorphism information content(PIC) values ranging from 0.593 to 0.952. Totally 92 alleles were identified, and the number of alleles(Na) and effective alleles(Ne) varied between 4 and 21 and 2.7 and 14.6, respectively. Observed heterozygosity(Ho) values were lower than the expected heterozygosity(He) values(0.526–0.754), which indicated that the seven stocks possessed a rich genetic diversity. Thirty-seven tests were detected for reasonable significant deviation from Hardy-Weinberg equilibrium. Fis values were positive at five loci, suggesting that there was a relatively high degree of inbreeding within stocks. Pairwise Fst values ranged from 0.0225 to 0.151, and most of the stock pairs were moderately differentiated. Genetic distance and cluster analysis using UPGMA revealed a close genetic relationship of L. vannamei between Pop2 and Pop3. AMOVA indicated that the genetic variation among stocks(11.3%) was much lower than that within stocks(88.7%). Although the seven stocks had a certain degree of genetic differentiation and a rich genetic diversity, there is an increasing risk of decreased performance due to inbreeding in subsequent generations.
