Structure, magnetic properties, and thermal stability of ternary Sm1-xTmxCo5 compounds were studied via X-ray diffraction（XRD）, thermal magnetic analysis（TMA）, and magnetic measurements. XRD results show that all ...Structure, magnetic properties, and thermal stability of ternary Sm1-xTmxCo5 compounds were studied via X-ray diffraction（XRD）, thermal magnetic analysis（TMA）, and magnetic measurements. XRD results show that all the compounds have a main phase of hexagonal CaCu5-type crystal structure with small amount of impurity phases; increasing Tm content is associated with contraction of the hexagonal unit cell in the direction of the c axis and expansion of the a and b parameters. TMA results indicate that the Curie temperature（TC） of Sm1-xTmxCo5 compounds gets higher with the increase in Tm content.Magnetic measurements show that both the magnetic anisotropy field（HA） and the magnetization at an applied field of 7 T（M7 T） decrease with the increase of Tm content. However, the thermal stability of both the HAand M7 Tof all the Tm doped compounds is remarkably improved compared with that of the pure SmCo5 compound, leading to the result that both the M7 Tand HAof Sm0.8Tm0.2Co5 .2are higher than those of SmCo5 compound at 473 K, which indicates the good potential of Tm doped compound in the practical applications at elevated temperature.展开更多
Platinum(Pt)-based single atoms and alloys represent reasonable structures to reduce the cost of electrocatalysts for the oxygen reduction reaction(ORR).However,the poor oxygen adsorption of single Pt atoms and the un...Platinum(Pt)-based single atoms and alloys represent reasonable structures to reduce the cost of electrocatalysts for the oxygen reduction reaction(ORR).However,the poor oxygen adsorption of single Pt atoms and the unfavorable surface microenvironment of alloy electrodes limit their practical applications.To address these issues,we have engineered a synergistic hybrid structure by anchoring PtNi alloys onto defective carbon(DC)modified with Pt and Ni single atoms,followed by surface modification with 2,6-diacetylpyridine(DAP)molecules.The mass activity(MA)of the optimized DAP-PtNi/Pt&Ni-SAC electrocatalyst reaches 1678.9 mA mg_(Pt)^(-1),which is 10.21 times that of commercial JM Pt/C(164.5 mA mg_(Pt)^(-1)).Moreover,after 20,000 accelerated durability tests(ADTs),DAP-PtNi/Pt&Ni-SAC shows only a 7.9%loss in MA,demonstrating its outstanding stability.Structural characterization and theoretical calculations reveal that the interaction of Ni single atoms and PtNi alloys enhances the adsorption stability of O_(2)molecules at Pt single atoms,facilitating a 4-electron ORR pathway.Meanwhile,DAP molecules adsorbed on Pt alloy sites associate with various oxygen-containing intermediates and protons through electrostatic interactions,promoting their combination.This synergistic effect between the intrinsic structure and the electrochemical microenvironment optimizes the ORR pathway in an overall manner,thus improving the kinetics of ORR.展开更多
The role of androgen receptor （AR） in the initiation and progression of prostate cancer （PCa） is well established. Competitive inhibition of the AR ligand-binding domain （LBD） has been the staple of antiandrogen...The role of androgen receptor （AR） in the initiation and progression of prostate cancer （PCa） is well established. Competitive inhibition of the AR ligand-binding domain （LBD） has been the staple of antiandrogen therapies employed to combat the disease in recent years. However, their efficacy has often been limited by the emergence of resistance, mediated through point mutations, and receptor truncations. As a result, the prognosis for patients with malignant castrate resistant disease remains poor. The amino-terminal domain （NTD） of the AR has been shown to be critical for AR function. Its modular activation function （AF-1） is important for both gene regulation and participation in protein-protein interactions. However, due to the intrinsically disordered structure of the domain, its potential as a candidate for therapeutic intervention has been dismissed in the past. The recent emergence of the small molecule EPI-O01 has provided evidence that AR-NTD can be targeted therapeutically, independent of the LBD. Targeting of AR-NTD has the potential to disrupt multiple intermolecular interactions between AR and its coregulatory binding partners, in addition to intramolecular cross-talk between the domains of the AR. Therapeutics targeting these protein-protein interactions or NTD directly should also have efficacy against emerging AR splice variants which may play a role in PCa progression. This review will discuss the role of intrinsic disorder in AR function and illustrate how emerging therapies might target NTD in PCa.展开更多
Transmission electron microscopy(TEM)is an indispensable tool for elucidating the intrinsic atomic structures of materials and provides deep insights into defect dynamics,phase transitions,and nanoscale structural det...Transmission electron microscopy(TEM)is an indispensable tool for elucidating the intrinsic atomic structures of materials and provides deep insights into defect dynamics,phase transitions,and nanoscale structural details.While numerous intriguing physical properties have been revealed in recently discovered two-dimensional(2D)quantummaterials,many exhibit significant sensitivity towater and oxygen under ambient conditions.This inherent instability complicates sample preparation for TEM analysis and hinders accurate property measurements.This review highlights recent technical advancements to preserve the intrinsic structures of water-and oxygen-sensitive 2D materials for atomic-scale characterizations.A critical development discussed in this review is implementing an inert gas-protected glovebox integrated system(GIS)designed specifically for TEM experiments.In addition,this review emphasizes air-sensitivematerials such as 2D transitionmetal dichalcogenides,transition metal dihalides and trihalides,and low-dimensional magnetic materials,demonstrating breakthroughs in overcoming their environmental sensitivity.Furthermore,the progress in TEM characterization enabled by the GIS is analyzed to provide a comprehensive overview of state-of-the-art methodologies in this rapidly advancing field.展开更多
基金financially supported by the State Key Development Program of Basic Research of China (No. 2010CB934600)State Key Laboratory of Advanced Metals and Materials (No. 2011-ZD02)the Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges under Beijing Municipality (No. 009000543113507)
文摘Structure, magnetic properties, and thermal stability of ternary Sm1-xTmxCo5 compounds were studied via X-ray diffraction（XRD）, thermal magnetic analysis（TMA）, and magnetic measurements. XRD results show that all the compounds have a main phase of hexagonal CaCu5-type crystal structure with small amount of impurity phases; increasing Tm content is associated with contraction of the hexagonal unit cell in the direction of the c axis and expansion of the a and b parameters. TMA results indicate that the Curie temperature（TC） of Sm1-xTmxCo5 compounds gets higher with the increase in Tm content.Magnetic measurements show that both the magnetic anisotropy field（HA） and the magnetization at an applied field of 7 T（M7 T） decrease with the increase of Tm content. However, the thermal stability of both the HAand M7 Tof all the Tm doped compounds is remarkably improved compared with that of the pure SmCo5 compound, leading to the result that both the M7 Tand HAof Sm0.8Tm0.2Co5 .2are higher than those of SmCo5 compound at 473 K, which indicates the good potential of Tm doped compound in the practical applications at elevated temperature.
基金supported by the National Natural Science Foundation of China under Grant No.22262018the Lanzhou Youth Science and Technology Talent Innovation Project under Grant No.2024-QN-96+1 种基金the Gansu Key Research and Development Program(Industry Field)under Grant No.23YFGA0056Hongliu Outstanding Youth Talents Support Project。
文摘Platinum(Pt)-based single atoms and alloys represent reasonable structures to reduce the cost of electrocatalysts for the oxygen reduction reaction(ORR).However,the poor oxygen adsorption of single Pt atoms and the unfavorable surface microenvironment of alloy electrodes limit their practical applications.To address these issues,we have engineered a synergistic hybrid structure by anchoring PtNi alloys onto defective carbon(DC)modified with Pt and Ni single atoms,followed by surface modification with 2,6-diacetylpyridine(DAP)molecules.The mass activity(MA)of the optimized DAP-PtNi/Pt&Ni-SAC electrocatalyst reaches 1678.9 mA mg_(Pt)^(-1),which is 10.21 times that of commercial JM Pt/C(164.5 mA mg_(Pt)^(-1)).Moreover,after 20,000 accelerated durability tests(ADTs),DAP-PtNi/Pt&Ni-SAC shows only a 7.9%loss in MA,demonstrating its outstanding stability.Structural characterization and theoretical calculations reveal that the interaction of Ni single atoms and PtNi alloys enhances the adsorption stability of O_(2)molecules at Pt single atoms,facilitating a 4-electron ORR pathway.Meanwhile,DAP molecules adsorbed on Pt alloy sites associate with various oxygen-containing intermediates and protons through electrostatic interactions,promoting their combination.This synergistic effect between the intrinsic structure and the electrochemical microenvironment optimizes the ORR pathway in an overall manner,thus improving the kinetics of ORR.
文摘The role of androgen receptor （AR） in the initiation and progression of prostate cancer （PCa） is well established. Competitive inhibition of the AR ligand-binding domain （LBD） has been the staple of antiandrogen therapies employed to combat the disease in recent years. However, their efficacy has often been limited by the emergence of resistance, mediated through point mutations, and receptor truncations. As a result, the prognosis for patients with malignant castrate resistant disease remains poor. The amino-terminal domain （NTD） of the AR has been shown to be critical for AR function. Its modular activation function （AF-1） is important for both gene regulation and participation in protein-protein interactions. However, due to the intrinsically disordered structure of the domain, its potential as a candidate for therapeutic intervention has been dismissed in the past. The recent emergence of the small molecule EPI-O01 has provided evidence that AR-NTD can be targeted therapeutically, independent of the LBD. Targeting of AR-NTD has the potential to disrupt multiple intermolecular interactions between AR and its coregulatory binding partners, in addition to intramolecular cross-talk between the domains of the AR. Therapeutics targeting these protein-protein interactions or NTD directly should also have efficacy against emerging AR splice variants which may play a role in PCa progression. This review will discuss the role of intrinsic disorder in AR function and illustrate how emerging therapies might target NTD in PCa.
基金supported by the National Key Basic Research and Development Program of China,China(No.2024YFA1409100)support by the National Natural Science Foundation of China,China(Nos.52473302 and 12461160252)+4 种基金Guangdong Innovative and Entrepreneurial Research Team Program,China(No.2019ZT08C044)Guangdong Basic Science Foundation,China(2023B1515120039)Shenzhen Science and Technology Program,China(No.20200925161102001)the Science,Technology and Innovation Commission of Shenzhen Municipality,China(No.ZDSYS20190902092905285)Quantum Science Strategic Special Project from the Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area,China(No.GDZX2301006).
文摘Transmission electron microscopy(TEM)is an indispensable tool for elucidating the intrinsic atomic structures of materials and provides deep insights into defect dynamics,phase transitions,and nanoscale structural details.While numerous intriguing physical properties have been revealed in recently discovered two-dimensional(2D)quantummaterials,many exhibit significant sensitivity towater and oxygen under ambient conditions.This inherent instability complicates sample preparation for TEM analysis and hinders accurate property measurements.This review highlights recent technical advancements to preserve the intrinsic structures of water-and oxygen-sensitive 2D materials for atomic-scale characterizations.A critical development discussed in this review is implementing an inert gas-protected glovebox integrated system(GIS)designed specifically for TEM experiments.In addition,this review emphasizes air-sensitivematerials such as 2D transitionmetal dichalcogenides,transition metal dihalides and trihalides,and low-dimensional magnetic materials,demonstrating breakthroughs in overcoming their environmental sensitivity.Furthermore,the progress in TEM characterization enabled by the GIS is analyzed to provide a comprehensive overview of state-of-the-art methodologies in this rapidly advancing field.
