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Deep phenotyping detects a pathological CD4^(+) T-cell complosome signature in systemic sclerosis
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作者 Giuseppina Arbore Voon H.Ong +12 位作者 Benedetta Costantini Christopher P.Denton David Abraham Leo Placais Kevin Blighe Lynne Mitchell Richard Ellis Susanne Heck Paola Nocerino Trent M.Woodruff Shahram Kordasti Claudia Kemper Dennis E.Hourcade 《Cellular & Molecular Immunology》 CSCD 2020年第9期1010-1013,共4页
CD4^(+)T-helper 1 cell(Th1)function is closely regulated by an intrinsic developmental program in which activation/induction and proinflammatory interferon(IFN)-γ secretion are followed by a deactivation/contraction ... CD4^(+)T-helper 1 cell(Th1)function is closely regulated by an intrinsic developmental program in which activation/induction and proinflammatory interferon(IFN)-γ secretion are followed by a deactivation/contraction period characterized by a switch into cosecretion of immunoregulatory interleukin(IL)-10. 展开更多
关键词 switch cosecretion CD T helper cell TH intrinsic developmental program pathological CD T cell complosome signature deep phenotyping interleukin IL systemic sclerosis interferon IFN
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