Objective: to analyze the difference of efficacy and safety between intravascular interventional therapy and microneurosurgery in the treatment of intracranial artery tumor (ICA), and to provide reference for the rati...Objective: to analyze the difference of efficacy and safety between intravascular interventional therapy and microneurosurgery in the treatment of intracranial artery tumor (ICA), and to provide reference for the rationality of surgical plan. Methods: a total of 96 ICA patients were selected from our hospital according to the purpose, procedure and requirements of the study. Forty-eight ICA patients were selected by the method of drawing lots. Forty-eight ICA patients were selected as the control group after intravascular interventional therapy, and forty-eight ICA patients were selected as the extra-nervous group after microneurosurgery. Results: the good recovery rate and mild disability rate of patients in shenshen group were significantly higher than those in control group (P <0.05), and the complication rate was significantly lower than that in control group (P <0.05). Conclusion: microneurosurgery can significantly improve the postoperative physical recovery of ICA patients and have a good effect on prevention of complications.展开更多
BACKGROUND： Cerebrovascular intervention is a medical strategy to diagnose and treat cerehrovascular disease by intravascular intervention techniques. With the continual developments of computer technology, imageolog...BACKGROUND： Cerebrovascular intervention is a medical strategy to diagnose and treat cerehrovascular disease by intravascular intervention techniques. With the continual developments of computer technology, imageology, and angiography, cerebrovascular intervention techniques have developed rapidly. OBJECTIVE： To summarize and to evaluate vascular imaging diagnostic techniques, vascular intra-arterial thrombolysis, vascular intra-arterial angioplasty, and vascular embolization in clinical applications. RETRIEVAL STRATEGY： An online search was conducted in PubMed for English language reports, published from January 2002 to January 2008, containing the key words： intervention therapy, cerebral vascular disease, endovascular intervention and angioplasty. A total of 57 publications were identified. Inclusion criteria： articles about cerebrovascular intervention for cerebrovascular disease; articles published either in high impact factor journals or in recent years. Exclusion criteria： duplicated articles. LITERATURE EVALUATION; 30 articles were identified concerning intravascular intervention techniques and arterial angioplasty. Of those, 7 articles were reviews and 23 were clinical or basic studies. DATA SYNTHESIS： Carotid artery and basilar artery stenosis were important etiological factors for ischemic cerebrovascular disease. The mechanism of stenosis induction included atherosclerotic plaque exfoliation and stenosis could cause hemodynamic changes to induce cerebral infarction. Therefore, the treatment of carotid artery and basilar artery stenosis played a key role in preventing ischemic cerebral infarction. The international organization for subarachnoid hemorrhage aneurysm has conclusively shown that both relative and absolute risk factors of intravascular embolotherapy were reduced compared to those of surgical occlusion, demonstrating the important role of vascular embolization for the treatment of intracranial aneurysm. Endovascular stents were placed into the intracavities of affected vessels to recover normal blood flow in the intravascular cavity. Percutaneous transluminal angioplasty and endovascular stent placement were frequently combined in clinical applications. CONCLUSION： Cerebrovascular intervention aims to diagnose and treat cerebrovascular disease by intravascular intervention techniques, which are a new set of techniques and which are widely applied for the treatment of cerebrovascular disease. Compared with traditional drug and surgical therapies, intravascular intervention techniques have the advantages of a simple and less traumatic method of operation, exact localization of the intervention, fewer complications, and positive effects; therefore, these techniques have considerable promise in clinical application.展开更多
Transarterial radioembolization(TARE)is a widely utilized therapeutic approach for hepatocellular carcinoma(HCC),however,the clinical implementation is constrained by the stringent preparation conditions of radioembol...Transarterial radioembolization(TARE)is a widely utilized therapeutic approach for hepatocellular carcinoma(HCC),however,the clinical implementation is constrained by the stringent preparation conditions of radioembolization agents.Herein,we incorporated the superstable homogeneous iodinated formulation technology(SHIFT),simultaneously utilizing an enhanced solvent form in a carbon dioxide supercritical fluid environment,to encapsulate radionuclides(such as^(131)I,^(177)Lu,or^(18)F)with lipiodol for the preparation of radiolipiodol.The resulting radiolipiodol exhibited exceptional stability and ultra-high labeling efficiency(≥99%)and displayed notable intratumoral radionuclide retention and in vivo stability more than 2 weeks following locoregional injection in subcutaneous tumors in mice and orthotopic liver tumors in rats and rabbits.Given these encouraging findings,^(18)F was authorized as a radiotracer in radiolipiodol for clinical trials in HCC patients,and showed a favorable tumor accumulation,with a tumor-to-liver uptake ratio of≥50 and minimal radionuclide leakage,confirming the feasibility of SHIFT for TARE applications.In the context of transforming from preclinical to clinical screening,the preparation of radiolipiodol by SHIFT represents an innovative physical strategy for radionuclide encapsulation.Hence,this work offers a reliable and efficient approach for TARE in HCC,showing considerable promise for clinical application(ChiCTR2400087731).展开更多
We have shown the value of intravascular ultrasound (IVUS) in the evaluation of myocardial bridging (MB). The purpose of the study was to elucidate the mechanism of inter-
文摘Objective: to analyze the difference of efficacy and safety between intravascular interventional therapy and microneurosurgery in the treatment of intracranial artery tumor (ICA), and to provide reference for the rationality of surgical plan. Methods: a total of 96 ICA patients were selected from our hospital according to the purpose, procedure and requirements of the study. Forty-eight ICA patients were selected by the method of drawing lots. Forty-eight ICA patients were selected as the control group after intravascular interventional therapy, and forty-eight ICA patients were selected as the extra-nervous group after microneurosurgery. Results: the good recovery rate and mild disability rate of patients in shenshen group were significantly higher than those in control group (P <0.05), and the complication rate was significantly lower than that in control group (P <0.05). Conclusion: microneurosurgery can significantly improve the postoperative physical recovery of ICA patients and have a good effect on prevention of complications.
文摘BACKGROUND： Cerebrovascular intervention is a medical strategy to diagnose and treat cerehrovascular disease by intravascular intervention techniques. With the continual developments of computer technology, imageology, and angiography, cerebrovascular intervention techniques have developed rapidly. OBJECTIVE： To summarize and to evaluate vascular imaging diagnostic techniques, vascular intra-arterial thrombolysis, vascular intra-arterial angioplasty, and vascular embolization in clinical applications. RETRIEVAL STRATEGY： An online search was conducted in PubMed for English language reports, published from January 2002 to January 2008, containing the key words： intervention therapy, cerebral vascular disease, endovascular intervention and angioplasty. A total of 57 publications were identified. Inclusion criteria： articles about cerebrovascular intervention for cerebrovascular disease; articles published either in high impact factor journals or in recent years. Exclusion criteria： duplicated articles. LITERATURE EVALUATION; 30 articles were identified concerning intravascular intervention techniques and arterial angioplasty. Of those, 7 articles were reviews and 23 were clinical or basic studies. DATA SYNTHESIS： Carotid artery and basilar artery stenosis were important etiological factors for ischemic cerebrovascular disease. The mechanism of stenosis induction included atherosclerotic plaque exfoliation and stenosis could cause hemodynamic changes to induce cerebral infarction. Therefore, the treatment of carotid artery and basilar artery stenosis played a key role in preventing ischemic cerebral infarction. The international organization for subarachnoid hemorrhage aneurysm has conclusively shown that both relative and absolute risk factors of intravascular embolotherapy were reduced compared to those of surgical occlusion, demonstrating the important role of vascular embolization for the treatment of intracranial aneurysm. Endovascular stents were placed into the intracavities of affected vessels to recover normal blood flow in the intravascular cavity. Percutaneous transluminal angioplasty and endovascular stent placement were frequently combined in clinical applications. CONCLUSION： Cerebrovascular intervention aims to diagnose and treat cerebrovascular disease by intravascular intervention techniques, which are a new set of techniques and which are widely applied for the treatment of cerebrovascular disease. Compared with traditional drug and surgical therapies, intravascular intervention techniques have the advantages of a simple and less traumatic method of operation, exact localization of the intervention, fewer complications, and positive effects; therefore, these techniques have considerable promise in clinical application.
基金supported by the Major State Basic Research Development Program of China(No.2023YFB3810000)the National Natural Science Foundation of China(NSFC)(Nos.82402501,81925019,81801817,82360360,U22A20333 and U24A20525)+3 种基金Natural Science Foundation of Guangxi(No.2023GXNSFAA026023,China)Central Government Guided Local Science and Technology Development Fund Projects(No.2023ZYZX1090,China)Nanchong Science and Technology Bureau basic research platform project(No.23JCYJPT0043,China)China Postdoctoral Science Foundation,(Nos.2023MD734156 and 2024M763915).
文摘Transarterial radioembolization(TARE)is a widely utilized therapeutic approach for hepatocellular carcinoma(HCC),however,the clinical implementation is constrained by the stringent preparation conditions of radioembolization agents.Herein,we incorporated the superstable homogeneous iodinated formulation technology(SHIFT),simultaneously utilizing an enhanced solvent form in a carbon dioxide supercritical fluid environment,to encapsulate radionuclides(such as^(131)I,^(177)Lu,or^(18)F)with lipiodol for the preparation of radiolipiodol.The resulting radiolipiodol exhibited exceptional stability and ultra-high labeling efficiency(≥99%)and displayed notable intratumoral radionuclide retention and in vivo stability more than 2 weeks following locoregional injection in subcutaneous tumors in mice and orthotopic liver tumors in rats and rabbits.Given these encouraging findings,^(18)F was authorized as a radiotracer in radiolipiodol for clinical trials in HCC patients,and showed a favorable tumor accumulation,with a tumor-to-liver uptake ratio of≥50 and minimal radionuclide leakage,confirming the feasibility of SHIFT for TARE applications.In the context of transforming from preclinical to clinical screening,the preparation of radiolipiodol by SHIFT represents an innovative physical strategy for radionuclide encapsulation.Hence,this work offers a reliable and efficient approach for TARE in HCC,showing considerable promise for clinical application(ChiCTR2400087731).
文摘We have shown the value of intravascular ultrasound (IVUS) in the evaluation of myocardial bridging (MB). The purpose of the study was to elucidate the mechanism of inter-
