Polymethoxy-substituted phenanthrene-9-carboxylic acids or their methylate are key intermediates for the synthesis of tylophora alkaloids and their analogs. An intramolecular oxidative coupling reaction of unfunctiona...Polymethoxy-substituted phenanthrene-9-carboxylic acids or their methylate are key intermediates for the synthesis of tylophora alkaloids and their analogs. An intramolecular oxidative coupling reaction of unfunctionalized 2,3-disubstituted phenyl acrylic acids and derivatives promoted by di-tert-butylper- oxide gave above intermediates in high yields. The mild reaction conditions and easy purification procedures of this method provide a new approach for the synthesis of phenanthrenes.展开更多
Two new lignans with dibenzocycloheptadiene skelectons have been synthesized by intramolecular nonphenolic oxidative coupling and rearrangement. The structures of these products have been identified by MS, UV, IR and ...Two new lignans with dibenzocycloheptadiene skelectons have been synthesized by intramolecular nonphenolic oxidative coupling and rearrangement. The structures of these products have been identified by MS, UV, IR and NMR spectra.展开更多
基金Sichuan Provincial Education Department(No.12ZA141)Key Laboratory of Advanced Functional Materials of Sichuan Province Higher Education System (No.KFKT2013-01)Sichuan Normal University(No.XYZ201314-37)for financial support
文摘Polymethoxy-substituted phenanthrene-9-carboxylic acids or their methylate are key intermediates for the synthesis of tylophora alkaloids and their analogs. An intramolecular oxidative coupling reaction of unfunctionalized 2,3-disubstituted phenyl acrylic acids and derivatives promoted by di-tert-butylper- oxide gave above intermediates in high yields. The mild reaction conditions and easy purification procedures of this method provide a new approach for the synthesis of phenanthrenes.
文摘Two new lignans with dibenzocycloheptadiene skelectons have been synthesized by intramolecular nonphenolic oxidative coupling and rearrangement. The structures of these products have been identified by MS, UV, IR and NMR spectra.
