The gastrointestinal tract is the key interface between the ingesta and the human body.There is wide recognition that the gastrointestinal response to nutrients or bioactive compounds,particularly the secretion of num...The gastrointestinal tract is the key interface between the ingesta and the human body.There is wide recognition that the gastrointestinal response to nutrients or bioactive compounds,particularly the secretion of numerous hormones,is critical to the regulation of appetite,body weight and blood glucose.This concept has led to an increasing focus on“gut-based”strategies for the management of metabolic disorders,including type 2 diabetes and obesity.Understanding the underlying mechanisms and downstream effects of nutrient-gut interactions is fundamental to effective translation of this knowledge to clinical practice.To this end,an array of research tools and platforms have been developed to better understand the mechanisms of gut hormone secretion from enteroendocrine cells.This review discusses the evolution of in vitro and in vivo models and the integration of innovative techniques that will ultimately enable the development of novel therapies for metabolic diseases.展开更多
Organs-on-chips are microphysiological systems that allow to replicate the key functions of human organs and accel-erate the innovation in life sciences including disease modeling,drug development,and precision medici...Organs-on-chips are microphysiological systems that allow to replicate the key functions of human organs and accel-erate the innovation in life sciences including disease modeling,drug development,and precision medicine.How-ever,due to the lack of standards in their definition,structural design,cell source,model construction,and functional validation,a wide range of translational application of organs-on-chips remains a challenging.“Organs-on-chips:Intestine”is the first group standard on human intestine-on-a-chip in China,jointly agreed and released by the experts from the Chinese Society of Biotechnology on 29th April 2024.This standard specifies the scope,terminology,definitions,technical requirements,detection methods,and quality control in building the human intestinal model on a chip.The publication of this group standard will guide the institutional establishment,acceptance and execution of proper practical protocols and accelerate the international standardization of intestine-on-a-chip for translational applications.展开更多
基金Supported by the National Health and Medical Research Council(NHMRC)of Australia,No.APP1147333the National Nature Science Foundation of China,No.81870561+1 种基金the Hospital Research Foundation of Australiathe Australian Research Council Centre of Excellence for Nanoscale BioPhotonics,No.CE140100003.
文摘The gastrointestinal tract is the key interface between the ingesta and the human body.There is wide recognition that the gastrointestinal response to nutrients or bioactive compounds,particularly the secretion of numerous hormones,is critical to the regulation of appetite,body weight and blood glucose.This concept has led to an increasing focus on“gut-based”strategies for the management of metabolic disorders,including type 2 diabetes and obesity.Understanding the underlying mechanisms and downstream effects of nutrient-gut interactions is fundamental to effective translation of this knowledge to clinical practice.To this end,an array of research tools and platforms have been developed to better understand the mechanisms of gut hormone secretion from enteroendocrine cells.This review discusses the evolution of in vitro and in vivo models and the integration of innovative techniques that will ultimately enable the development of novel therapies for metabolic diseases.
基金National Key R&D Program of China(No.2022YFA1104700)to Zhang XNational Natural Science Foundation of China(No.32171406)to Qin JInnovation Program of Science and Research from the DICP,CAS(DICP I202435)to Qin J.
文摘Organs-on-chips are microphysiological systems that allow to replicate the key functions of human organs and accel-erate the innovation in life sciences including disease modeling,drug development,and precision medicine.How-ever,due to the lack of standards in their definition,structural design,cell source,model construction,and functional validation,a wide range of translational application of organs-on-chips remains a challenging.“Organs-on-chips:Intestine”is the first group standard on human intestine-on-a-chip in China,jointly agreed and released by the experts from the Chinese Society of Biotechnology on 29th April 2024.This standard specifies the scope,terminology,definitions,technical requirements,detection methods,and quality control in building the human intestinal model on a chip.The publication of this group standard will guide the institutional establishment,acceptance and execution of proper practical protocols and accelerate the international standardization of intestine-on-a-chip for translational applications.
