AIM: The aim of this study was to observe the effect of a Chinese medicine compound Changtong oral liquid (CT) on tissue plasminogen activity (t-PA), plasminogen activator inhibitor (PAI), TGF-β1 and hydroxyproline (...AIM: The aim of this study was to observe the effect of a Chinese medicine compound Changtong oral liquid (CT) on tissue plasminogen activity (t-PA), plasminogen activator inhibitor (PAI), TGF-β1 and hydroxyproline (OHP). METHODS: Two sets of animal experiments were performed in the present study. Forty New Zealand rabbits and 48 Sprague-Dawley (SD) rats were assigned randomly to one of the five groups: sham adhesion, adhesion with saline, adhesion with low dosage of the CT, adhesion with middle dosage of the CT and adhesion with high dosage of the CT. t-PA and PAI activity in plasma, OHP and TGF-β1 expression in adhesion were investigated. Analysis of variance was used to test differences among groups. RESULTS: CT treatment increased plasma t-PA activity in rabbits but decreased TGF-β1 activity in rats. The data were expressed from low to high dose respectively as follows: t-PA, 46.1±8.6 μkat/L, 59.6±10.1 μkat/L, 64.0±11.5 μkat/L; TGF-β1 28±7.23%, 31±3.05%, 30±4.04%. There were significant differences compared with saline-treated animals (t-PA 26.4±5.1 μkat/L, TGF-β1 54±5.51%). OHP content in cecum of rabbits from middle and high but not low dose of CT lowered significantly as compared with saline-treated rabbits, 0.3641±0.1373, 0.3348±0.0321, 0.2757±0.0497 mg/g vs 0.4183±0.0883 mg/g of protein, P>0.05, P<0.05, P<0.05 respectively. The rabbit plasma PAI activity and OHP content in abdominal wall had no difference in all groups. CONCLUSION: CT treatment significantly enhanced t-PA activity in rabbits, but decreased TGF-β1 content in rats, OHP content in cecum of rabbits, and failed to affect the activity of PAI and OHP content in abdominal wall in rabbits, compared with saline group. The result suggests that CT could effectively prevent adhesions without interfering wound healina.展开更多
Objective: To study the clinical effect of Taozhi Zhipu Mixture(桃蛭枳朴合剂, TZM) in preventing postoperative intestinal adhesion. Methods: The total of 396 patients who had received abdominal operation were randomly...Objective: To study the clinical effect of Taozhi Zhipu Mixture(桃蛭枳朴合剂, TZM) in preventing postoperative intestinal adhesion. Methods: The total of 396 patients who had received abdominal operation were randomly divided into the treated group (188 cases) and the control group (208 cases). Same treatment was given to both groups except that the treated group received TZM orally or via nasogastric tube. The time of borborygmus recovering and first passing of flatus defecation after operation was recorded. Patients’ gastro intestinal motility was observed by isotope tracing with I 131 capsule. The frequency and intensity of borborygmus were measured by a tracer. All patients had been followed up for 2-3 years. Results: The recovery of borborygmus, the first passing of flatus defecation were much earlier, the I 131 capsule passed gastro intestinal tract more quickly, and the tracer showed higher frequency and intensity of borborygmus in the treated group than those in the control group. Follow up study also showed the treated group was better than the control group in the non adhesion rate and the total effective rate ( P <0.05). Conclusion: TZM has good effect on stimulating postoperational gastro intestinal peristalsis and preventing the occurrence of postoperational intestinal adhesion.展开更多
Objective: To evaluate the therapeutic effect of infantile massage on intestinal adhesions after abdominal operation and its influence on the recovery of intestinal function. Methods: 60 children with intestinal adhes...Objective: To evaluate the therapeutic effect of infantile massage on intestinal adhesions after abdominal operation and its influence on the recovery of intestinal function. Methods: 60 children with intestinal adhesions after abdominal operation in our hospital from October 2019 to June 2020 were selected and divided into two groups according to different treatment schemes, study group (n = 30) and control group (n = 30). The former was given infantile massage, while the latter was not treated after operation. The incidence of postoperative intestinal adhesion was compared between the two groups, and the results of anal exhaust, defecation time and abdominal pain disappearance time of the two groups were compared. Results: the incidence of postoperative intestinal adhesion in the study group was lower than that in the control group (P < 0.05);compared with the control group, the average time of anal exhaust and defecation, appetite recovery and abdominal pain disappearance in the study group was shorter than that in the control group (P < 0.05). Conclusion: infantile massage after abdominal operation can reduce the incidence of postoperative intestinal adhesion, shorten the time of anal exhaust and defecation, appetite recovery and abdominal pain disappearance, and promote the rapid recovery of intestinal function.展开更多
Objective: To explore and analyze the effective nursing measures during the operation of adhesive intestinal obstruction and evaluate the nursing effect. Methods: 58 patients with adhesive intestinal obstruction who r...Objective: To explore and analyze the effective nursing measures during the operation of adhesive intestinal obstruction and evaluate the nursing effect. Methods: 58 patients with adhesive intestinal obstruction who received surgical treatment in our department were selected as subjects of the study. Divide into two groups by convenient sampling method to ensure the equal number of cases, namely the control group and the observation group. Routine nursing and high-quality nursing were adopted respectively to compare the nursing effect. Results: the incidence of complications in the observation group was lower than that in the control group. The recovery time of gastrointestinal function in the observation group was lower than that in the control group, P < 0.05. Conclusion: for patients with adhesive intestinal obstruction, implementing high-quality nursing measures has an exact effect on promoting the recovery of gastrointestinal function in patients, and can effectively reduce the incidence of complications, which is worthy of reference and promotion.展开更多
BACKGROUND Although minimally invasive surgery is becoming more commonly applied for ileostomy reversal(IR),there have been relatively few studies of IR for patients with Crohn's disease(CD).It is therefore import...BACKGROUND Although minimally invasive surgery is becoming more commonly applied for ileostomy reversal(IR),there have been relatively few studies of IR for patients with Crohn's disease(CD).It is therefore important to evaluate the potential benefits and risks of laparoscopy for patients with CD.AIM To compare the safety,feasibility,and short-term and long-term outcomes of laparoscopic IR(LIR)vs open IR(OIR)for the treatment of CD.METHODS The baseline characteristics,operative data,and short-term(30-d)and long-term outcomes of patients with CD who underwent LIR and OIR at our institution between January 2017 and January 2020 were retrieved from an electronic database and retrospectively reviewed.RESULTS Of the 60 patients enrolled in this study,LIR was performed for 48 and OIR for 12.There were no statistically significant differences in baseline characteristics,operation time,intraoperative blood loss,days to flatus and soft diet,postoperative complications,hospitalization time,readmission rate within 30 d,length of hospitalization,hospitalization costs,or reoperation rate after IR between the two groups.However,patients in the LIR group more frequently required lysis of adhesions as compared to those in the OIR group(87.5%vs 41.7%,respectively,P<0.05).Notably,following exclusion of patients who underwent enterectomy plus IR,OIR was more advantageous in terms of postoperative recovery of gastrointestinal function and hospitalization costs.CONCLUSION The safety and feasibility of LIR for the treatment of CD are comparable to those of OIR with no increase in intraoperative or postoperative complications.展开更多
基金Supported by the National New Drug Foundation of China, No.96-901-05-245
文摘AIM: The aim of this study was to observe the effect of a Chinese medicine compound Changtong oral liquid (CT) on tissue plasminogen activity (t-PA), plasminogen activator inhibitor (PAI), TGF-β1 and hydroxyproline (OHP). METHODS: Two sets of animal experiments were performed in the present study. Forty New Zealand rabbits and 48 Sprague-Dawley (SD) rats were assigned randomly to one of the five groups: sham adhesion, adhesion with saline, adhesion with low dosage of the CT, adhesion with middle dosage of the CT and adhesion with high dosage of the CT. t-PA and PAI activity in plasma, OHP and TGF-β1 expression in adhesion were investigated. Analysis of variance was used to test differences among groups. RESULTS: CT treatment increased plasma t-PA activity in rabbits but decreased TGF-β1 activity in rats. The data were expressed from low to high dose respectively as follows: t-PA, 46.1±8.6 μkat/L, 59.6±10.1 μkat/L, 64.0±11.5 μkat/L; TGF-β1 28±7.23%, 31±3.05%, 30±4.04%. There were significant differences compared with saline-treated animals (t-PA 26.4±5.1 μkat/L, TGF-β1 54±5.51%). OHP content in cecum of rabbits from middle and high but not low dose of CT lowered significantly as compared with saline-treated rabbits, 0.3641±0.1373, 0.3348±0.0321, 0.2757±0.0497 mg/g vs 0.4183±0.0883 mg/g of protein, P>0.05, P<0.05, P<0.05 respectively. The rabbit plasma PAI activity and OHP content in abdominal wall had no difference in all groups. CONCLUSION: CT treatment significantly enhanced t-PA activity in rabbits, but decreased TGF-β1 content in rats, OHP content in cecum of rabbits, and failed to affect the activity of PAI and OHP content in abdominal wall in rabbits, compared with saline group. The result suggests that CT could effectively prevent adhesions without interfering wound healina.
文摘Objective: To study the clinical effect of Taozhi Zhipu Mixture(桃蛭枳朴合剂, TZM) in preventing postoperative intestinal adhesion. Methods: The total of 396 patients who had received abdominal operation were randomly divided into the treated group (188 cases) and the control group (208 cases). Same treatment was given to both groups except that the treated group received TZM orally or via nasogastric tube. The time of borborygmus recovering and first passing of flatus defecation after operation was recorded. Patients’ gastro intestinal motility was observed by isotope tracing with I 131 capsule. The frequency and intensity of borborygmus were measured by a tracer. All patients had been followed up for 2-3 years. Results: The recovery of borborygmus, the first passing of flatus defecation were much earlier, the I 131 capsule passed gastro intestinal tract more quickly, and the tracer showed higher frequency and intensity of borborygmus in the treated group than those in the control group. Follow up study also showed the treated group was better than the control group in the non adhesion rate and the total effective rate ( P <0.05). Conclusion: TZM has good effect on stimulating postoperational gastro intestinal peristalsis and preventing the occurrence of postoperational intestinal adhesion.
文摘Objective: To evaluate the therapeutic effect of infantile massage on intestinal adhesions after abdominal operation and its influence on the recovery of intestinal function. Methods: 60 children with intestinal adhesions after abdominal operation in our hospital from October 2019 to June 2020 were selected and divided into two groups according to different treatment schemes, study group (n = 30) and control group (n = 30). The former was given infantile massage, while the latter was not treated after operation. The incidence of postoperative intestinal adhesion was compared between the two groups, and the results of anal exhaust, defecation time and abdominal pain disappearance time of the two groups were compared. Results: the incidence of postoperative intestinal adhesion in the study group was lower than that in the control group (P < 0.05);compared with the control group, the average time of anal exhaust and defecation, appetite recovery and abdominal pain disappearance in the study group was shorter than that in the control group (P < 0.05). Conclusion: infantile massage after abdominal operation can reduce the incidence of postoperative intestinal adhesion, shorten the time of anal exhaust and defecation, appetite recovery and abdominal pain disappearance, and promote the rapid recovery of intestinal function.
文摘Objective: To explore and analyze the effective nursing measures during the operation of adhesive intestinal obstruction and evaluate the nursing effect. Methods: 58 patients with adhesive intestinal obstruction who received surgical treatment in our department were selected as subjects of the study. Divide into two groups by convenient sampling method to ensure the equal number of cases, namely the control group and the observation group. Routine nursing and high-quality nursing were adopted respectively to compare the nursing effect. Results: the incidence of complications in the observation group was lower than that in the control group. The recovery time of gastrointestinal function in the observation group was lower than that in the control group, P < 0.05. Conclusion: for patients with adhesive intestinal obstruction, implementing high-quality nursing measures has an exact effect on promoting the recovery of gastrointestinal function in patients, and can effectively reduce the incidence of complications, which is worthy of reference and promotion.
基金The study protocol was approved by the Ethics Committee of the Shanghai Tenth People’s Hospital Affiliated to the Tongji University School of Medicine(approval No.21K53).
文摘BACKGROUND Although minimally invasive surgery is becoming more commonly applied for ileostomy reversal(IR),there have been relatively few studies of IR for patients with Crohn's disease(CD).It is therefore important to evaluate the potential benefits and risks of laparoscopy for patients with CD.AIM To compare the safety,feasibility,and short-term and long-term outcomes of laparoscopic IR(LIR)vs open IR(OIR)for the treatment of CD.METHODS The baseline characteristics,operative data,and short-term(30-d)and long-term outcomes of patients with CD who underwent LIR and OIR at our institution between January 2017 and January 2020 were retrieved from an electronic database and retrospectively reviewed.RESULTS Of the 60 patients enrolled in this study,LIR was performed for 48 and OIR for 12.There were no statistically significant differences in baseline characteristics,operation time,intraoperative blood loss,days to flatus and soft diet,postoperative complications,hospitalization time,readmission rate within 30 d,length of hospitalization,hospitalization costs,or reoperation rate after IR between the two groups.However,patients in the LIR group more frequently required lysis of adhesions as compared to those in the OIR group(87.5%vs 41.7%,respectively,P<0.05).Notably,following exclusion of patients who underwent enterectomy plus IR,OIR was more advantageous in terms of postoperative recovery of gastrointestinal function and hospitalization costs.CONCLUSION The safety and feasibility of LIR for the treatment of CD are comparable to those of OIR with no increase in intraoperative or postoperative complications.
