Objective: To explore the mechanism of action of Radix et Rhizoma Rhei (Dahuang)(RERR) and Semen Persicae (Taoren)(SP) on adhesive intestinal obstruction (AIO). Methods: The main targets of the active ingredients of R...Objective: To explore the mechanism of action of Radix et Rhizoma Rhei (Dahuang)(RERR) and Semen Persicae (Taoren)(SP) on adhesive intestinal obstruction (AIO). Methods: The main targets of the active ingredients of RERR and SP were filtered based on the traditional Chinese medicine system pharmacology analysis platform. Cytoscape 3.2.1 was applied to build the ingredient-target network of RERR and SP for AIO. Results: Fifteen active components were predicted from the RERR and SP herb pair, such as aloe-emodin, catechin, rhein, gibberellin (GA) 119, GA120 and GA121. These components were applied to 59 targets mainly involved in many biological processes such as signal transduction, anti-apoptosis, and inflammatory response involved in activating the immune effect. Conclusion: This study proposes the system pharmacology method and identifies the potent combination therapeutic mechanism of RERR and SP for AIO. This strategy will provide a new insight to the study of herb combinations.展开更多
TO THE EDITOR I have read with great interest the very recent article rifled ＂Intestinal Behcet＇s disease with pyoderma gangrenosum： A case report＂ of Nakamura T et al that was published in your journal. The autho...TO THE EDITOR I have read with great interest the very recent article rifled ＂Intestinal Behcet＇s disease with pyoderma gangrenosum： A case report＂ of Nakamura T et al that was published in your journal. The authors stated that they presented a very rare case of intestinal Behcet＇s disease with pyoderma gangrenosum in a 16-year old patient. However, I would like to make some important contributions and suggestions to the presented case and have a few questions to ask the authors.展开更多
目的:研究LT导致肠黏膜微血管内皮细胞(MEC)损伤的作用机制。方法:将所培养的肠黏膜MEC分为空白对照组和LT组,每组按时间分为4个亚组:3h、6h、9h、12h。空白对照组加维持培养液,LT组加50μg/m l LT培养液,静置培养。结果:NO分泌明显升高...目的:研究LT导致肠黏膜微血管内皮细胞(MEC)损伤的作用机制。方法:将所培养的肠黏膜MEC分为空白对照组和LT组,每组按时间分为4个亚组:3h、6h、9h、12h。空白对照组加维持培养液,LT组加50μg/m l LT培养液,静置培养。结果:NO分泌明显升高,并且3h后达到高峰,随后逐渐降低,而ET在6h前明显降低,随后逐渐升高到正常水平。结论:LT引起肠黏膜MEC损伤的主要机制可能是引起NO升高,ET降低,导致MEC通透性升高。展开更多
基金National Natural Science Foundation Youth Project (81804098)Jiangsu Natural Science Foundation Youth Project (BK20180219).
文摘Objective: To explore the mechanism of action of Radix et Rhizoma Rhei (Dahuang)(RERR) and Semen Persicae (Taoren)(SP) on adhesive intestinal obstruction (AIO). Methods: The main targets of the active ingredients of RERR and SP were filtered based on the traditional Chinese medicine system pharmacology analysis platform. Cytoscape 3.2.1 was applied to build the ingredient-target network of RERR and SP for AIO. Results: Fifteen active components were predicted from the RERR and SP herb pair, such as aloe-emodin, catechin, rhein, gibberellin (GA) 119, GA120 and GA121. These components were applied to 59 targets mainly involved in many biological processes such as signal transduction, anti-apoptosis, and inflammatory response involved in activating the immune effect. Conclusion: This study proposes the system pharmacology method and identifies the potent combination therapeutic mechanism of RERR and SP for AIO. This strategy will provide a new insight to the study of herb combinations.
文摘TO THE EDITOR I have read with great interest the very recent article rifled ＂Intestinal Behcet＇s disease with pyoderma gangrenosum： A case report＂ of Nakamura T et al that was published in your journal. The authors stated that they presented a very rare case of intestinal Behcet＇s disease with pyoderma gangrenosum in a 16-year old patient. However, I would like to make some important contributions and suggestions to the presented case and have a few questions to ask the authors.
文摘目的:研究LT导致肠黏膜微血管内皮细胞(MEC)损伤的作用机制。方法:将所培养的肠黏膜MEC分为空白对照组和LT组,每组按时间分为4个亚组:3h、6h、9h、12h。空白对照组加维持培养液,LT组加50μg/m l LT培养液,静置培养。结果:NO分泌明显升高,并且3h后达到高峰,随后逐渐降低,而ET在6h前明显降低,随后逐渐升高到正常水平。结论:LT引起肠黏膜MEC损伤的主要机制可能是引起NO升高,ET降低,导致MEC通透性升高。
