Intervertebral disc degeneration(IvDD)is a complex mechanobiological process driven by abnormal mechanical loading,resulting in structural failure,inflammatory activation,and cellular dysfunction.Understanding these m...Intervertebral disc degeneration(IvDD)is a complex mechanobiological process driven by abnormal mechanical loading,resulting in structural failure,inflammatory activation,and cellular dysfunction.Understanding these mechanobiological interactions offers novel therapeutic targets to interrupt the degenerative cascade and improve clinical outcomes in IVDD treatment.This review summarizes the fundamental characteristics of the mechanobiological microenvironment in IVDD,detailing mechanosensitive spinal components and providing evidence for mechanobiology-based therapies.By enhancing insight into disc degeneration from a mechano-biological perspective,researchers can develop innovative therapeutic strategies to restore a healthy disc microenvironment and spinal stability clinically,offering a promising outlook for patients with IvDD.However,current studies primarily focus on in vitro models and in vivo animal studies,limiting clinical translation.Therefore,effectively translating these research findings into practical clinical treatments remains a notable future challenge.展开更多
基金supported by the National Natural Science Founda-tion of China(NSFC)(No.82130073)Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System+1 种基金Shanghai Science and Technology Committee(Nos.24410710600 and 23ZR1447400)Biomaterials and Regenerative Medicine Institute Cooperative Research Project,Shanghai Jiao Tong University School of Medicine(No.2022LHA01).
文摘Intervertebral disc degeneration(IvDD)is a complex mechanobiological process driven by abnormal mechanical loading,resulting in structural failure,inflammatory activation,and cellular dysfunction.Understanding these mechanobiological interactions offers novel therapeutic targets to interrupt the degenerative cascade and improve clinical outcomes in IVDD treatment.This review summarizes the fundamental characteristics of the mechanobiological microenvironment in IVDD,detailing mechanosensitive spinal components and providing evidence for mechanobiology-based therapies.By enhancing insight into disc degeneration from a mechano-biological perspective,researchers can develop innovative therapeutic strategies to restore a healthy disc microenvironment and spinal stability clinically,offering a promising outlook for patients with IvDD.However,current studies primarily focus on in vitro models and in vivo animal studies,limiting clinical translation.Therefore,effectively translating these research findings into practical clinical treatments remains a notable future challenge.
