Research purpose:This study implemented somatosensory music therapy on patients with depressive disorders,and explored the effects of somatosensory music therapy on the degree of depression,positive and negative emoti...Research purpose:This study implemented somatosensory music therapy on patients with depressive disorders,and explored the effects of somatosensory music therapy on the degree of depression,positive and negative emotions,intuitive stress and autonomic nervous function of patients.Research method:We collected 66 patients diagnosed with depression from the Department of Psychological Medicine of Henan Provincial People’s Hospital,and divided them into a control group and an intervention group according to the random number table,with 33 people in each group.The control group received routine psychiatric treatment and nursing.On the basis of the control group,the intervention group received somatosensory music therapy 3 times a week,30 min each time,for 4 consecutive weeks.The Hamilton Depression Scale,Positive and Negative Emotion Scale,Perceived Stress Scale,and Heart Rate Variability Index were collected and analyzed at baseline(T0),2 weeks after treatment(T1)and 4 weeks after treatment(T2).Research results:After 4 weeks of treatment,the HAMD scores of the two groups decreased to varying degrees,and the difference between the groups was statistically significant(p<0.05).After 4 weeks of treatment,the scores of positive emotions in both groups increased to varying degrees,and the scores of negative emotions increased to varying degrees.The scores decreased to varying degrees,and there were statistically significant differences between the positive and negative emotion groups(p<0.05).After 4 weeks of treatment,the CPSS scores of the two groups decreased to varying degrees,and the difference between the two groups was statistically significant(p<0.05).Analyzing the main effect of intervention factors alone,after 4 weeks of treatment,SDNN and RMSSD indexes all increased to varying degrees,and the degree of increase in the intervention group was greater than that in the control group,and the difference between the groups was statistically significant(p<0.05).Research conclusion:assisting somatosensory music therapy for patients with depressive disorders can improve depressive symptoms,increase positive emotions,reduce negative emotions,and reduce perceived stress.These are beneficial to restore the balance of autonomic nervous system,and are effective for the treatment of depression.展开更多
Esophageal cancer is one of the common malignant tumors worldwide,and nutritional support during its treatment is of great significance for improving patients’quality of life and treatment outcomes.This paper aims to...Esophageal cancer is one of the common malignant tumors worldwide,and nutritional support during its treatment is of great significance for improving patients’quality of life and treatment outcomes.This paper aims to explore the application effect of full-course nutritional management in patients with esophageal cancer undergoing radiotherapy.Using a randomized controlled trial design,patients were randomly divided into an experimental group and a control group in a 1:1 ratio.The experimental group received full-course nutritional management,while the control group received routine care.Statistical analysis showed that the degree of weight loss in the experimental group after radiotherapy was significantly lower than that in the control group(P<0.05),the improvement in nutritional status was more obvious,and the incidence of radiotherapy-related adverse reactions was also significantly lower than that in the control group(P<0.05).It can be seen that full-course nutritional management can effectively improve the nutritional status of patients with esophageal cancer undergoing radiotherapy,reduce radiotherapy adverse reactions,and enhance patients’quality of life and treatment effects[1].It has important clinical application value and is worthy of promotion in clinical practice.展开更多
BACKGROUND In patients with liver failure(LF),the high rate of secondary infections,which are associated with poor prognosis,highlights the clinical significance of understanding the underlying risk factors and implem...BACKGROUND In patients with liver failure(LF),the high rate of secondary infections,which are associated with poor prognosis,highlights the clinical significance of understanding the underlying risk factors and implementing targeted intervention programs.AIM To investigate risk factors for secondary infections in patients with LF and evaluate the effectiveness of comprehensive nursing interventions.METHODS This retrospective study included 64 patients with LF,including 32 with and 32 without secondary infections.A questionnaire was used to collect data on age;laboratory parameters,including total and direct bilirubin,prothrombin time,blood ammonia,and other biochemical parameters;invasive procedures;and complications.Patients with secondary infections received comprehensive nursing intervention in addition to routine nursing care,whereas those without secondary infections received only routine nursing care to compare the effect of nursing intervention on outcomes.RESULTS The infection rate,which was not associated with age or complications,was significantly associated with biochemical parameters and invasive procedures(P<0.05).The infection rate was 61.6%in patients who had undergone invasive procedures and 32.1%in those who had not undergone invasive procedures during the hospital stay.The infection rate was also significantly associated with the type of LF(P<0.05),with the lowest rate observed in patients with acute LF and the highest rate observed in those with subacute LF.The nursing satisfaction rate was 58.3%in the uninfected group and 91.7%in the infected group,indicating significantly higher satisfaction in the infected group(P<0.05).CONCLUSION In patients with LF,the rate of secondary infections was high and associated with biochemical parameters and type of LF.Comprehensive nursing intervention can improve patient satisfaction.展开更多
High-intensity interval training(HIIT),a highly efficient and distinctive exercise format,has sparked growing academic interest in sports performance training.This article synthesizes theoretical and applied evidence ...High-intensity interval training(HIIT),a highly efficient and distinctive exercise format,has sparked growing academic interest in sports performance training.This article synthesizes theoretical and applied evidence to analyze mechanisms of HIIT in neuromuscular activation,hormonal responses,muscle fiber adaptation,and metabolic pathway effects.It focuses on its effectiveness in enhancing explosive power,maximum strength,and strength endurance,while also examining the integration of HIIT with traditional resistance training,periodized programming,and personalized prescription.Scientific implementation of HIIT can effectively diversify or even replace conventional strength training,not only offering positive directional changes for strength development but also introducing innovative approaches to sports performance training practices.展开更多
Objective: to apply global nursing intervention in interventional therapy of coronary heart disease and explore its nursing effect. Methods: 70 patients were included in this study, all of whom were coronary heart dis...Objective: to apply global nursing intervention in interventional therapy of coronary heart disease and explore its nursing effect. Methods: 70 patients were included in this study, all of whom were coronary heart disease patients undergoing interventional therapy in our hospital from January 2019 to December 2019. According to the principle of odd-even distribution, they were divided into 35 cases of nursing group A and 35 cases of nursing group B. The effect of nursing intervention was compared between the two groups. Results: compared with the nursing effect of the two groups, nursing group A was 82.86%, nursing group B was 94.29%, and the nursing effective rate of nursing group B was high (χ2=6.455, P < 0.05). Compared with the length of stay in bed and hospitalization, the nursing group B was shorter (t=27.288, 37.383, P<0.05). Conclusion: the application of global nursing intervention can improve the interventional treatment effect of coronary heart disease, shorten the hospitalization time of patients and reduce the medical burden of patients.展开更多
Objective: to explore the significance of medical nursing intervention in elderly patients with chronic heart failure during surgery. Methods: the subjects of this study were 72 elderly patients with chronic heart fai...Objective: to explore the significance of medical nursing intervention in elderly patients with chronic heart failure during surgery. Methods: the subjects of this study were 72 elderly patients with chronic heart failure who were hospitalized in our hospital from July 2020 to July 2021. After obtaining the consent of the subjects and their families, the subjects were divided into two groups, namely, the conventional group (36 cases, routine intervention) and the observation group (36 cases, comfort intervention), to observe the effect of intervention and the feelings of patients. Results: there was no significant difference in cardiac health score between the two groups before operation, and the P value was more than 0.05. After intervention, there was a significant difference in the heart health score of patients with heart failure between the two groups, and the hospitalization days of patients in the observation group were significantly less than those in the conventional group, with a significant difference in related indicators, and the P value was within 0.05. At the same time, patients in the observation group were more satisfied with the nursing services they received than those in the conventional group, with a significant difference, and the P value was within 0.05. Conclusion: comfort nursing intervention has important application significance during the implementation of nursing intervention for elderly patients with chronic heart failure, which can effectively improve the symptoms of patients and promote the recovery speed of patients, and is worth widely used in practice.展开更多
Objective: to explore the effect of multi-form psychological intervention on children in pediatric clinical nursing. Methods: 92 cases of pediatric patients admitted to our hospital from June to November 2021 were sel...Objective: to explore the effect of multi-form psychological intervention on children in pediatric clinical nursing. Methods: 92 cases of pediatric patients admitted to our hospital from June to November 2021 were selected for this study. According to the time of admission, 46 cases were divided into the control group (admitted from June to August 2021) and the combined group (admitted from September to November 2021). Both groups of children were given routine care. The former was given routine intervention while the latter was given multiple forms of psychological intervention on the basis of the former. The nursing compliance, SCARED (anxiety disorder) score, DSRSC (depression disorder) score and parents satisfaction with the nursing work were compared between the two groups. Results: compared the total score of nursing compliance between the two groups, the score of the control group (40.3±3.5) was lower than that of the combined group (55.2±2.1). Compared the SCARED and DSRSC scores of the two groups of children after nursing, the two scores of the control group were all higher than the two scores of the combined group;Compared with the total satisfaction of parents in the two groups, the control group was 76.09%(35/46) < the combined group was 91.30%(42/46). there were differences in the above three measurement indexes and one counting index between the two groups (p < 0.05). Conclusion: the adoption of various forms of psychological intervention for pediatric children can improve the childrens bad mood and mentality, and guide the gradual formation of their correct behavior, so as to improve the treatment coordination and nursing compliance, and win higher satisfaction from the parents of the children.展开更多
Through the use of a survey and statistical methods, this study explores the effects and interventions of handheld Tai Chi water resistance fitness balls on the elderly with Parkinson’s disease. Firstly, a questionna...Through the use of a survey and statistical methods, this study explores the effects and interventions of handheld Tai Chi water resistance fitness balls on the elderly with Parkinson’s disease. Firstly, a questionnaire on exercise compliance for patients with Parkinson’s disease was developed, and its reliability and validity were tested. Then, a survey was conducted to investigate the current status of exercise compliance among Parkinson’s disease patients, including general information, scoring status, and single and multiple factor analyses of influencing factors [1]. The results of the study show that through qualitative research, the dimensions and item pools of the questionnaire were initially constructed, and the reliability analysis of the questionnaire was conducted through Delphi expert consultation, with favorable results in terms of its reliability and validity [2]. Regarding the current status of exercise compliance among Parkinson’s disease patients, the study found that the level of exercise compliance needs improvement, and there are significant differences in exercise compliance levels among patients under different circumstances. Finally, the research results were discussed and conclusions were drawn. The innovation of this study lies in the development of a questionnaire on exercise compliance for patients with Parkinson’s disease and the preliminary qualitative research and Delphi expert consultation conducted on it, providing new ideas and methods for the study of exercise compliance. However, the study also has limitations as it did not examine the effects of other interventions on Parkinson’s disease, so further research should be conducted [3].展开更多
Objective: To investigate the effect of ginger slice acupoint application combined with moxibustion on chemotherapy-induced vomiting in postoperative breast cancer patients. Methods: Sixty postoperative breast cancer ...Objective: To investigate the effect of ginger slice acupoint application combined with moxibustion on chemotherapy-induced vomiting in postoperative breast cancer patients. Methods: Sixty postoperative breast cancer patients undergoing chemotherapy were randomly divided into an observation group and a control group, with 30 patients in each group. The control group received antiemetic treatment with dolasetron, while the observation group received ginger slice acupoint application combined with moxibustion in addition to antiemetic treatment to address chemotherapy-induced vomiting. The vomiting response on days 1-3 was compared between the two groups, along with R-INVR retching scores and patient satisfaction with the intervention methods. Results: On days 2 and 3 of chemotherapy, the observation group showed significantly less vomiting than the control group, with differences reaching a highly significant level (P < 0.001). On day 3, the R-INVR score in the observation group was significantly lower than that of the control group, with a highly significant difference (P < 0.001). The satisfaction score in the observation group was 8.38 ± 0.81, higher than the control group’s 7.65 ± 0.71, with a statistically significant difference (P < 0.05). Conclusion: Ginger slice acupoint application combined with moxibustion effectively alleviates chemotherapy-induced vomiting in postoperative breast cancer patients, improves quality of life, and is worth promoting clinically.展开更多
BACKGROUND： Phycocyanin can relieve decrease of mitochondrial membrane potential through reducing production of active oxygen so as to protect neurons after hypoxia/reoxygenation. OBJECTIVE： To observe the effect of...BACKGROUND： Phycocyanin can relieve decrease of mitochondrial membrane potential through reducing production of active oxygen so as to protect neurons after hypoxia/reoxygenation. OBJECTIVE： To observe the effect of phycocyanin on activity of PC12 cells and mitochondrial membrane potential after hypoxia/reoxygenation. DESIGN： Randomized controlled study SETTING ： Cerebrovascular Disease Institute of Affiliated Hospital, Medical College of Qingdao University MATERIALS： The experiment was carried out at the Key Laboratory of Prevention and Cure for cerebropathia in Shandong Province from October to December 2005. PC12 cells, rat chromaffin tumor cells, were provided by Storage Center of Wuhan University; phycocyanin was provided by Ocean Institute of Academia Sinica; Thiazoyl blue tetrazolium bromide （MTT） and rhodamine 123 were purchased from Sigma Company, USA; RPMI-1640 medium, fetal bovine serum and equine serum were purchased from Gibco Company, USA. METHODS： ① Culture of PC12 cells： PC12 cells were put into RPMI-1640 medium which contained 100 g/L heat inactivation equine serum and 0.05 volume fraction of fetal bovine serum and incubated in CO2 incubator at 37℃. Number of cells was regulated to 4 × 10^5 L 1, and cells were inoculated at 96-well culture plate. The final volume was 100μL. ② Model establishing and grouping： Cultured PC12 cells were randomly divided into three groups： phycocyanin group, model control group and non-hypoxia group. At 24 hours before hypoxia, culture solution in phycocyanin group was added with phycocyanin so as to make sure the final concentration of 3 g/L , but cells in model control group did not add with phycocyanin. Cells in non-hypoxia group were also randomly divided into adding phycocyanin group （the final concentration of 3 g/L） and non-adding phycocyanin group. Cells in model control group and phycocyanin group were cultured with hypoxia for 1 hour and reoxygenation for 1, 2 and 3 hours; meanwhile, cells in non-hypoxia group were cultured with oxygen and were measured at 1 hour after hypoxia/reoxygenation. ③ Detecting items： At 1, 2 and 3 hours after reoxygenation, absorbance （A value） of PC12 cells was measured with MTT technique so as to observe activity and quantity of cells. Fluorescence intensity of PC12 cells marked by rhodamine 123 was measured with confocal microscope in order to observe changes of mitochondrial membrane potential. MAEN OUTCOME MEASURES： Comparisons between quantity and activity of PC12 cells and mitochondria membrane potential at 1, 2 and 3 hours after reoxygenation. RESULTS： ① Effect of phycocyanin on quantity and activity of PC12 cells： A value was 0.924±0.027 in adding phycocyanin group and 0.924±0.033 in non-adding phycocyanin group. A value was lower in model control group and phycocyanin group than that in non-hypoxia group at 1, 2 and 3 hours after reoxygenation （0.817±0.053, 0.838±0.037, 0.875±0.029; 0.842±0.029, 0.872±0.025, 0.906±0.023, P 〈 0.05）. A value was higher in phycocyanin group than that in model control group at 1, 2 and 3 after culture （P 〈 0.05）. With culture time being longer, A value was increased gradually in phycocyanin group and model control group after reoxygenation （P 〈 0.05）. ~ Effect of phycocyanin on mitochondrial membrane potential of PC12 cells： Fluorescence intensity was 2.967±0.253 in adding phycocyanin group and 2.962±0.294 in non-adding phycocyanin group. Fluorescence intensity was lower in model control group and phycocyanin group than that in non-hypoxia group at 1, 2 and 3 hours after hypoxia/reoxygenation （1.899±0.397, 2.119±0.414, 2.287±0.402; 2.191±0.377, 2.264±0.359, 2.436±0.471, P 〈 0.05）; but it was higher in phycocyanin group than that in model control group at 1, 2 and 3 after reoxygenation （P 〈 0.05）. With culture time being longer, fluorescence intensity was increased gradually in phycocyanin group and model control group after reoxygenation （P 〈 0.05）. CONCLUSION： Phycocyanin and reoxygenation can protect PC12 cells after hypoxia injury through increasing mitochondrial membrane potential and cellular activity, and the effect is improved gradually with prolonging time of reoxygenation.展开更多
BACKGROUND： It is suspected that dissociation, destruction or synthetic disorder of microtubule-associated protein 2 （MAP-2） may participate in secondary injury of intracerebral hemorrhage （ICH）, and the reason m...BACKGROUND： It is suspected that dissociation, destruction or synthetic disorder of microtubule-associated protein 2 （MAP-2） may participate in secondary injury of intracerebral hemorrhage （ICH）, and the reason may be related to thrombin in high concentration after ICH; therefore, the mechanism should be studied further. OBJECTIVE： To explore the effect of hirudin on expression of MAP-2 in peripheral tissue of hematom after ICH and changes of water content in brain tissue and analyze pathogenesis of thrombin in secondary injury after ICH. DESIGN ： Completely randomized grouping design and controlled animal study SEn-ING ： Department of Neurology, the First Affiliated Hospital of Jilin University MATERIALS ： The experiment was carried out in the Neurological Laboratory of the First Affiliated Hospital of Jilin University from April 2003 to April 2004. A number of 80 healthy Wistar rats, of both genders, aged 3-4 months, weighing 250-350 g, were randomly divided into 8 groups： normal control group, 6-hour ICH group, 1-day ICH group, 2-day ICH group, 3-day ICH group, 7-day ICH group, 3-day hirudin group and 7-day hirudin group with 10 in each group. Five rats from each group were selected to measure their water content, and the others were undertaken immunohistochemical stain. Hirudin was produced by Sigma Company, USA, and MAP-2 rabbit-rat polyclonal antibody was provided by Fuzhou Maixin Biotechnology Company Limited. METHODS： ① Model establishing and grouping intervention： Rats in simple ICH group were collected their blood from tails and then inserted with 50 μL non-anticoagulant auto-arterial blood into the cauda of the putamen in right brain within 5 minutes. Rats in hirudin groups were inserted with 10 U hirudin （which was diluted with saline to 20 μL） into local hematom regions within 5 minutes, and the needle was pulled out after 10 minutes. Rats in normal control group were untouched. ② Water content in peripheral tissue of hematom： Based on the ratio between dry weight and wet weight, brain tissue at bleeding side and in right frontal lobe was selected to measure dry and wet weights so as to calculate the water content [（wet weight - dry weight） /wet weight] × 100%.③ Positive expression of MAP-2： Based on immunohistochemical stain, positive MAP-2 cells were regarded as neurons and they were buffy morphological. Positive rate of MAP-2 was calculated, i.e., percentage of positive cells in each sight to total cells in all sights. ④ Statistical analysis： Data among groups were compared with one-way analysis of variance, averages were compared with SNK-q test by each other, and relation between water content and MAP-2 was analyzed with linear regression technique. MAIN OUTCOME MEASURES： Changes of water content and MAP-2 expression in peripheral tissue of hematorn at various time points after ICH and intervention of hirudin. RESULTS： All 80 rats were involved in the final analysis. ①Water content： Water content was increased at day 1, reached peak at day 3 and decreased at day 7. It was （72.31±0.32）%, （77.42±0.53）%, （78.44±0.28）%, （74.10±0.13）%, （74.85±0.51）% and （70.07±0.36）%, respectively in 1-day, 2-day, 3-day and 7-day ICH groups and 3-day and 7-day hirudin groups, which was higher than that in normal control group （63.85±0.41, q=-4.684 3 to -7.262 0, P〈 0.05）; that in 2-day and 3-day ICH groups was higher than that in 7-day ICH group （q=-3.053 4, -3.727 0, P 〈 0.05）; and that in 3-day and 7-day ICH groups was higher than that in hirudin groups at the same time points （q=-2.965 6, -2.726 4, P 〈 0.05）. ②Positive expression of MAP-2： Positive expression of MAP-2 was decreased at 6 hours after ICH, reached the lowest value at day 3 and increased at day 7. Positive rate was （78.60±0.42）%, （60.56±0.74）%, （44.60±0.26）%, （25.45±0.85）%, （32.55±0.64）%, （37.69＋0.76）%, （41.75±0.68）%, respectively in 6-hour, 1-day, 2-day, 3-day and 7-day ICH groups and 3-day and 7-day hirudin groups, which was lower than that in normal control group [（96.50±0.33）%, q= -3.074 5 to -8.128 5, P 〈 0.05]. In addition, positive cells of MAP-2 disappeared plentifully at 3-7 days after ICH, stain of positive cells were light, and only stain of plasma was positive. That in 3-day and 7-day hirudin groups was higher than that in ICH groups at the same time points （q= -3.391 8, -2.967 9, P 〈 0.05）. Moreover, positive cells of MAP-2 was formed slightly but deeply stained. ③ Results of linear regression： Water content was negatively related to MAP-2 changes at 7 days after ICH （r= -0.894 9, P〈 0.01）, i.e., water content was increased with decrease of MAP-2 expression. CONCLUSION ： The deterioration of MAP-2 may be involved in the pathogenesis of thrombin within the first week after ICH, and the local administration of hirudin can protect neurons.展开更多
BACKGROUND： Central coordination disturbance is regarded as the early-stage symptom of brain injury-induced cerebral palsy. This disease manifests itself as motor disorder, abnormal attitudinal reflex and muscular te...BACKGROUND： Central coordination disturbance is regarded as the early-stage symptom of brain injury-induced cerebral palsy. This disease manifests itself as motor disorder, abnormal attitudinal reflex and muscular tension. Early intervention may improve its prognosis. OBJECTIVE： To observe the effects of intervention treatment from different stages on the prognosis of central coordination disturbance following brain injury in children patients. DESIGN： A contrast observation experiment SETTING： Department of Neurology and Rehabilitation, Urumqi Children＇s Hospital PARTICIPANTS ： Totally 151 children who were diagnosed as central coordination disturbance from January 2002 to December 2003 in the Department of Neurology and Rehabilitation of Urumqi Children＇s Hospital were recruited. All the children patients, including 101 male and 50 female, aged from 3 months to 1 year old, met the diagnosis criteria of central coordination disturbance from Vojta. They were divided into slight, moderate and severe abnormity according to Vojta attitudinal reflex. All 151 patients were divided into 2 groups according to their age at diagnosis： 3-6 months old group （n=74）, 62 severe, 10 moderate and 2 slight; 7-12 months old group （n=77）, 66 severe, 7 moderate and 4 slight. All the relatives of children patients were informed of the experiment. METHODS： ① Both groups received physical training （PT） as the main treatment; Hand training was given if necessary. All of the patients received additional hyperbaric oxygen therapy, bioelectric therapy, scalp acupuncture, drug treatment and family training. The importance of integration of hospital and family based rehabilitation was stressed. Those who did not catch up with the normal development or had abnormal reflexes continued to receive treatment. ② Around the age of 2 years old, all children did a final evaluation using Bayley Scales of Infant Development （BSID）. Mental development index （MDI） and physical development index （PDI） were taken as evaluative criteria. Children with scores 80 and above on MDI and PDI were considered to have normal motor and mental development; 79 and below were considered delayers. The Diagnostic Criteria of Cerebral Palsy and Infantecondary School Social Adaptation Scale were used in the final evaluation[scores ≤5 was extremely severe （extremely severe cerebral palsy）, 6 was severe（severe cerebral palsy）, 7 was moderate（moderate cerebral palsy）, 8 was slight（slight cerebral palsy）, 9 was borderline（slight cerebral palsy）, 10 was normal, 11 was above average, 12 was excellent and ≥13 was extremely excellent]. ③ Final evaluative results of 2 groups were compared. And u test was used for the comparison of Bayley development index and Chi-square test for the comparison of normalization rate. MAIN OUTCOME MEASURES： BSID MDI and PDI as well as the normalization rate of motor function and mental behavior of children patients at 2 years old. RESULTS： Totally 151 children patients entered the stage of result analysis. ①Two groups of children patients were given integrated rehabilitation therapy , and evaluated at 2 years old . The 3-6 months old group had higher MDI and PDI than the 7-12 months old group （91.81＋19.99 vs 71.93＋18.98;91.55＋23.61 vs 68.95＋23.51, u=6.265,5.894,P 〈 0.01 ）.②After being given integrated rehabilitation therapy, children patients of 3-6 months old group had significantly higher normalization rate of motor function and mental behavior than 7-12 months old group （73% ,27%,X2=29.723 9,P 〈 0.01 ）. ③Six slight and 17 moderate central coordination disturbance children of 2 groups all completely recovered; After intervention treatment, among 128 severe central coordination disturbance children, 52 recovered and 76 were still abnormal, in which, 43 slight cerebral palsy, 18 moderate cerebral palsy, 5 severe cerebral palsy and 10 extremely severe cerebral palsy. CONCLUSION： To perform integrated intervention treatment before 6 months old can better improve and promote mental and physical development levels of children patients with central coordination disturbance after brain injury than 6 months later.展开更多
Objective: to observe the effect of cardiac rehabilitation nursing intervention in patients with coronary heart disease undergoing interventional therapy. Methods: 70 patients with coronary heart disease undergoing in...Objective: to observe the effect of cardiac rehabilitation nursing intervention in patients with coronary heart disease undergoing interventional therapy. Methods: 70 patients with coronary heart disease undergoing interventional therapy in our hospital from July 1, 2019 to January 1, 2022 were selected for cardiac rehabilitation nursing research. They were randomly divided into basic group (35 cases, basic nursing) and rehabilitation group (35 cases, basic nursing + cardiac rehabilitation nursing) by computer. The research indexes were cardiac function, psychological rehabilitation index, quality of life, complications, hospitalization and satisfaction. Results: after the intervention, the cardiac function of patients in rehabilitation group was better than that of patients in basic group (P < 0.05). After the intervention, the psychological condition of patients in rehabilitation group was better than that of patients in basic group (P < 0.05). After the intervention, the quality of life of patients in rehabilitation group was higher than that of patients in basic group (P < 0.05). After the intervention, the incidence of complications in the rehabilitation group was lower than that in the basic group (P < 0.05). After the intervention, the hospitalization time and medical expenses of the interventional therapy patients in the rehabilitation group were lower than those of the interventional therapy patients (P < 0.05). After the intervention, the satisfaction of patients in rehabilitation group was higher than that in basic group (p < 0.05). Conclusion: cardiac rehabilitation nursing can strengthen the rehabilitation effect of patients undergoing interventional therapy for coronary heart disease, help to improve cardiac function and mental health, improve nursing safety, optimize hospitalization index of patients undergoing interventional therapy, and patients are more satisfied with the effect of nursing intervention.展开更多
Objective:To explore the clinical method and effect of 3D printing in the treatment of cerebral aneurysms.Methods:The authors research work on the hospital,work time in February 2019-February 2020,this study selected ...Objective:To explore the clinical method and effect of 3D printing in the treatment of cerebral aneurysms.Methods:The authors research work on the hospital,work time in February 2019-February 2020,this study selected patients of cerebral aneurysms,this period are selected for treatment of 100 cases of patients,randomly divided into two groups,a group to give simple intervention,named as the control group,another group for the interventional therapy under the guidance of 3 D printing,named as experimental group,analyze the effect of two groups of patients with clinical intervention.Results:The length of hospital stay in the experimental group was shorter than that in the control group.Meanwhile,the incidence of complications and adverse reactions in the experimental group and the control group were 6.00%and 18.00%,the experimental group was better(P<0.05).Conclusion:3D printing technology can be applied in the treatment of patients with cerebral aneurysms to provide guidance for interventional surgical treatment.It has significant effect,can reduce the incidence complications in patients,has significant clinical effect,and can be popularized.展开更多
Objective: to study the effect of comprehensive nursing for patients with periodontitis who received teeth cleaning and treatment. Methods: a total of 80 patients with periodontitis who received treatment in our hospi...Objective: to study the effect of comprehensive nursing for patients with periodontitis who received teeth cleaning and treatment. Methods: a total of 80 patients with periodontitis who received treatment in our hospital from April 2020 to April 2021 were enrolled and analyzed. The conventional group received traditional nursing plan, and the experimental group received comprehensive nursing intervention measures. The gingival index and complication index were compared between the two groups. Results: the gingival index of the experimental group was significantly better than that of the conventional group, P < 0.05. The incidence of complications in experimental group was significantly higher than that in conventional group (P < 0.05). Conclusion: comprehensive nursing for patients with periodontitis who received dental cleaning can effectively improve their dental status, which is worth popularizing.展开更多
Objective: to observe the clinical effect of Mongolian medicine syndrome differentiation in the treatment of chronic nephritis. Methods: 89 patients with chronic glomerulonephritis admitted to our hospital in recent y...Objective: to observe the clinical effect of Mongolian medicine syndrome differentiation in the treatment of chronic nephritis. Methods: 89 patients with chronic glomerulonephritis admitted to our hospital in recent years were selected as the research object. According to the treatment and nursing methods, 44 patients with conventional treatment and nursing were selected as the control group. Forty-five patients were treated with dialectical Mongolian medicine in the observation group. SAS and SDS scores and clinical efficacy were compared between the two groups before and after treatment. Results: the total effective rate was 97.78% in the observation group and 70.45% in the control group (P<0.05). SAS and SDS scores were compared between the two groups after nursing (P<0.05). Conclusion: Mongolian medicine syndrome differentiation therapy can significantly improve the mental state of patients with chronic glomerulonephritis, worthy of in-depth clinical research.展开更多
Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature undersc...Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature underscores the significance of HA in maintaining tissue water balance, fostering cell proliferation, promoting rapid cell migration, influencing cell differentiation during organism development, and facilitating tissue regeneration. Notably, HA’s interactions with cell surface receptors contribute to the viscosity of synovial fluid, activate the immune system, and enhance cartilage elasticity. Beyond these established functions, HA has also been investigated for its potential involvement in determining and studying the hormetic effects of radon water, adding a novel dimension to its applications in dental research. A thorough exploration of existing studies reveals a nuanced understanding of how HA interventions impact the outcomes of dental procedures. The comprehensive scope of these investigations allows for a more accurate assessment of the potential effectiveness of specific interventions and provides valuable insights into post-procedural prognoses for individual patients. This synthesis of literature serves as the foundation for elucidating the intricate interplay between HA, radon exposure, and their relevance in modern dental practices.展开更多
We have shown the value of intravascular ultrasound (IVUS) in the evaluation of myocardial bridging (MB). The purpose of the study was to elucidate the mechanism of inter-
Before vaccine development during the COVID-19 pandemic,Non-Pharmaceutical Interventions(NPIs)were the only solutions to mitigate COVID-19 infections.Governments continued to use them even after starting vaccine admin...Before vaccine development during the COVID-19 pandemic,Non-Pharmaceutical Interventions(NPIs)were the only solutions to mitigate COVID-19 infections.Governments continued to use them even after starting vaccine administration.In this research,we review different big data analytics models that assess and optimize the effectiveness of NPIs.These models are categorized into three big data analytics groups:descriptive,which measures the infection rate changes caused by NPIs;predictive,which predicts the future of the pandemic by implementing several NPIs;and data-driven prescriptive,which suggests optimal control policies.We further analyze each method’s basic assumptions,limitations,and applicability during different pandemic phases and under different scenarios.This review of COVID-19 NPI evaluation methods will be beneficial for decision-makers to know which model to select for policy-making in possible future pandemics,which are more likely recently due to globalization.Finally,we suggest some future research directions.展开更多
文摘Research purpose:This study implemented somatosensory music therapy on patients with depressive disorders,and explored the effects of somatosensory music therapy on the degree of depression,positive and negative emotions,intuitive stress and autonomic nervous function of patients.Research method:We collected 66 patients diagnosed with depression from the Department of Psychological Medicine of Henan Provincial People’s Hospital,and divided them into a control group and an intervention group according to the random number table,with 33 people in each group.The control group received routine psychiatric treatment and nursing.On the basis of the control group,the intervention group received somatosensory music therapy 3 times a week,30 min each time,for 4 consecutive weeks.The Hamilton Depression Scale,Positive and Negative Emotion Scale,Perceived Stress Scale,and Heart Rate Variability Index were collected and analyzed at baseline(T0),2 weeks after treatment(T1)and 4 weeks after treatment(T2).Research results:After 4 weeks of treatment,the HAMD scores of the two groups decreased to varying degrees,and the difference between the groups was statistically significant(p<0.05).After 4 weeks of treatment,the scores of positive emotions in both groups increased to varying degrees,and the scores of negative emotions increased to varying degrees.The scores decreased to varying degrees,and there were statistically significant differences between the positive and negative emotion groups(p<0.05).After 4 weeks of treatment,the CPSS scores of the two groups decreased to varying degrees,and the difference between the two groups was statistically significant(p<0.05).Analyzing the main effect of intervention factors alone,after 4 weeks of treatment,SDNN and RMSSD indexes all increased to varying degrees,and the degree of increase in the intervention group was greater than that in the control group,and the difference between the groups was statistically significant(p<0.05).Research conclusion:assisting somatosensory music therapy for patients with depressive disorders can improve depressive symptoms,increase positive emotions,reduce negative emotions,and reduce perceived stress.These are beneficial to restore the balance of autonomic nervous system,and are effective for the treatment of depression.
文摘Esophageal cancer is one of the common malignant tumors worldwide,and nutritional support during its treatment is of great significance for improving patients’quality of life and treatment outcomes.This paper aims to explore the application effect of full-course nutritional management in patients with esophageal cancer undergoing radiotherapy.Using a randomized controlled trial design,patients were randomly divided into an experimental group and a control group in a 1:1 ratio.The experimental group received full-course nutritional management,while the control group received routine care.Statistical analysis showed that the degree of weight loss in the experimental group after radiotherapy was significantly lower than that in the control group(P<0.05),the improvement in nutritional status was more obvious,and the incidence of radiotherapy-related adverse reactions was also significantly lower than that in the control group(P<0.05).It can be seen that full-course nutritional management can effectively improve the nutritional status of patients with esophageal cancer undergoing radiotherapy,reduce radiotherapy adverse reactions,and enhance patients’quality of life and treatment effects[1].It has important clinical application value and is worthy of promotion in clinical practice.
文摘BACKGROUND In patients with liver failure(LF),the high rate of secondary infections,which are associated with poor prognosis,highlights the clinical significance of understanding the underlying risk factors and implementing targeted intervention programs.AIM To investigate risk factors for secondary infections in patients with LF and evaluate the effectiveness of comprehensive nursing interventions.METHODS This retrospective study included 64 patients with LF,including 32 with and 32 without secondary infections.A questionnaire was used to collect data on age;laboratory parameters,including total and direct bilirubin,prothrombin time,blood ammonia,and other biochemical parameters;invasive procedures;and complications.Patients with secondary infections received comprehensive nursing intervention in addition to routine nursing care,whereas those without secondary infections received only routine nursing care to compare the effect of nursing intervention on outcomes.RESULTS The infection rate,which was not associated with age or complications,was significantly associated with biochemical parameters and invasive procedures(P<0.05).The infection rate was 61.6%in patients who had undergone invasive procedures and 32.1%in those who had not undergone invasive procedures during the hospital stay.The infection rate was also significantly associated with the type of LF(P<0.05),with the lowest rate observed in patients with acute LF and the highest rate observed in those with subacute LF.The nursing satisfaction rate was 58.3%in the uninfected group and 91.7%in the infected group,indicating significantly higher satisfaction in the infected group(P<0.05).CONCLUSION In patients with LF,the rate of secondary infections was high and associated with biochemical parameters and type of LF.Comprehensive nursing intervention can improve patient satisfaction.
文摘High-intensity interval training(HIIT),a highly efficient and distinctive exercise format,has sparked growing academic interest in sports performance training.This article synthesizes theoretical and applied evidence to analyze mechanisms of HIIT in neuromuscular activation,hormonal responses,muscle fiber adaptation,and metabolic pathway effects.It focuses on its effectiveness in enhancing explosive power,maximum strength,and strength endurance,while also examining the integration of HIIT with traditional resistance training,periodized programming,and personalized prescription.Scientific implementation of HIIT can effectively diversify or even replace conventional strength training,not only offering positive directional changes for strength development but also introducing innovative approaches to sports performance training practices.
文摘Objective: to apply global nursing intervention in interventional therapy of coronary heart disease and explore its nursing effect. Methods: 70 patients were included in this study, all of whom were coronary heart disease patients undergoing interventional therapy in our hospital from January 2019 to December 2019. According to the principle of odd-even distribution, they were divided into 35 cases of nursing group A and 35 cases of nursing group B. The effect of nursing intervention was compared between the two groups. Results: compared with the nursing effect of the two groups, nursing group A was 82.86%, nursing group B was 94.29%, and the nursing effective rate of nursing group B was high (χ2=6.455, P < 0.05). Compared with the length of stay in bed and hospitalization, the nursing group B was shorter (t=27.288, 37.383, P<0.05). Conclusion: the application of global nursing intervention can improve the interventional treatment effect of coronary heart disease, shorten the hospitalization time of patients and reduce the medical burden of patients.
文摘Objective: to explore the significance of medical nursing intervention in elderly patients with chronic heart failure during surgery. Methods: the subjects of this study were 72 elderly patients with chronic heart failure who were hospitalized in our hospital from July 2020 to July 2021. After obtaining the consent of the subjects and their families, the subjects were divided into two groups, namely, the conventional group (36 cases, routine intervention) and the observation group (36 cases, comfort intervention), to observe the effect of intervention and the feelings of patients. Results: there was no significant difference in cardiac health score between the two groups before operation, and the P value was more than 0.05. After intervention, there was a significant difference in the heart health score of patients with heart failure between the two groups, and the hospitalization days of patients in the observation group were significantly less than those in the conventional group, with a significant difference in related indicators, and the P value was within 0.05. At the same time, patients in the observation group were more satisfied with the nursing services they received than those in the conventional group, with a significant difference, and the P value was within 0.05. Conclusion: comfort nursing intervention has important application significance during the implementation of nursing intervention for elderly patients with chronic heart failure, which can effectively improve the symptoms of patients and promote the recovery speed of patients, and is worth widely used in practice.
文摘Objective: to explore the effect of multi-form psychological intervention on children in pediatric clinical nursing. Methods: 92 cases of pediatric patients admitted to our hospital from June to November 2021 were selected for this study. According to the time of admission, 46 cases were divided into the control group (admitted from June to August 2021) and the combined group (admitted from September to November 2021). Both groups of children were given routine care. The former was given routine intervention while the latter was given multiple forms of psychological intervention on the basis of the former. The nursing compliance, SCARED (anxiety disorder) score, DSRSC (depression disorder) score and parents satisfaction with the nursing work were compared between the two groups. Results: compared the total score of nursing compliance between the two groups, the score of the control group (40.3±3.5) was lower than that of the combined group (55.2±2.1). Compared the SCARED and DSRSC scores of the two groups of children after nursing, the two scores of the control group were all higher than the two scores of the combined group;Compared with the total satisfaction of parents in the two groups, the control group was 76.09%(35/46) < the combined group was 91.30%(42/46). there were differences in the above three measurement indexes and one counting index between the two groups (p < 0.05). Conclusion: the adoption of various forms of psychological intervention for pediatric children can improve the childrens bad mood and mentality, and guide the gradual formation of their correct behavior, so as to improve the treatment coordination and nursing compliance, and win higher satisfaction from the parents of the children.
文摘Through the use of a survey and statistical methods, this study explores the effects and interventions of handheld Tai Chi water resistance fitness balls on the elderly with Parkinson’s disease. Firstly, a questionnaire on exercise compliance for patients with Parkinson’s disease was developed, and its reliability and validity were tested. Then, a survey was conducted to investigate the current status of exercise compliance among Parkinson’s disease patients, including general information, scoring status, and single and multiple factor analyses of influencing factors [1]. The results of the study show that through qualitative research, the dimensions and item pools of the questionnaire were initially constructed, and the reliability analysis of the questionnaire was conducted through Delphi expert consultation, with favorable results in terms of its reliability and validity [2]. Regarding the current status of exercise compliance among Parkinson’s disease patients, the study found that the level of exercise compliance needs improvement, and there are significant differences in exercise compliance levels among patients under different circumstances. Finally, the research results were discussed and conclusions were drawn. The innovation of this study lies in the development of a questionnaire on exercise compliance for patients with Parkinson’s disease and the preliminary qualitative research and Delphi expert consultation conducted on it, providing new ideas and methods for the study of exercise compliance. However, the study also has limitations as it did not examine the effects of other interventions on Parkinson’s disease, so further research should be conducted [3].
文摘Objective: To investigate the effect of ginger slice acupoint application combined with moxibustion on chemotherapy-induced vomiting in postoperative breast cancer patients. Methods: Sixty postoperative breast cancer patients undergoing chemotherapy were randomly divided into an observation group and a control group, with 30 patients in each group. The control group received antiemetic treatment with dolasetron, while the observation group received ginger slice acupoint application combined with moxibustion in addition to antiemetic treatment to address chemotherapy-induced vomiting. The vomiting response on days 1-3 was compared between the two groups, along with R-INVR retching scores and patient satisfaction with the intervention methods. Results: On days 2 and 3 of chemotherapy, the observation group showed significantly less vomiting than the control group, with differences reaching a highly significant level (P < 0.001). On day 3, the R-INVR score in the observation group was significantly lower than that of the control group, with a highly significant difference (P < 0.001). The satisfaction score in the observation group was 8.38 ± 0.81, higher than the control group’s 7.65 ± 0.71, with a statistically significant difference (P < 0.05). Conclusion: Ginger slice acupoint application combined with moxibustion effectively alleviates chemotherapy-induced vomiting in postoperative breast cancer patients, improves quality of life, and is worth promoting clinically.
基金the Natural Science Foundation of Shandong Province, No. Y2004C04
文摘BACKGROUND： Phycocyanin can relieve decrease of mitochondrial membrane potential through reducing production of active oxygen so as to protect neurons after hypoxia/reoxygenation. OBJECTIVE： To observe the effect of phycocyanin on activity of PC12 cells and mitochondrial membrane potential after hypoxia/reoxygenation. DESIGN： Randomized controlled study SETTING ： Cerebrovascular Disease Institute of Affiliated Hospital, Medical College of Qingdao University MATERIALS： The experiment was carried out at the Key Laboratory of Prevention and Cure for cerebropathia in Shandong Province from October to December 2005. PC12 cells, rat chromaffin tumor cells, were provided by Storage Center of Wuhan University; phycocyanin was provided by Ocean Institute of Academia Sinica; Thiazoyl blue tetrazolium bromide （MTT） and rhodamine 123 were purchased from Sigma Company, USA; RPMI-1640 medium, fetal bovine serum and equine serum were purchased from Gibco Company, USA. METHODS： ① Culture of PC12 cells： PC12 cells were put into RPMI-1640 medium which contained 100 g/L heat inactivation equine serum and 0.05 volume fraction of fetal bovine serum and incubated in CO2 incubator at 37℃. Number of cells was regulated to 4 × 10^5 L 1, and cells were inoculated at 96-well culture plate. The final volume was 100μL. ② Model establishing and grouping： Cultured PC12 cells were randomly divided into three groups： phycocyanin group, model control group and non-hypoxia group. At 24 hours before hypoxia, culture solution in phycocyanin group was added with phycocyanin so as to make sure the final concentration of 3 g/L , but cells in model control group did not add with phycocyanin. Cells in non-hypoxia group were also randomly divided into adding phycocyanin group （the final concentration of 3 g/L） and non-adding phycocyanin group. Cells in model control group and phycocyanin group were cultured with hypoxia for 1 hour and reoxygenation for 1, 2 and 3 hours; meanwhile, cells in non-hypoxia group were cultured with oxygen and were measured at 1 hour after hypoxia/reoxygenation. ③ Detecting items： At 1, 2 and 3 hours after reoxygenation, absorbance （A value） of PC12 cells was measured with MTT technique so as to observe activity and quantity of cells. Fluorescence intensity of PC12 cells marked by rhodamine 123 was measured with confocal microscope in order to observe changes of mitochondrial membrane potential. MAEN OUTCOME MEASURES： Comparisons between quantity and activity of PC12 cells and mitochondria membrane potential at 1, 2 and 3 hours after reoxygenation. RESULTS： ① Effect of phycocyanin on quantity and activity of PC12 cells： A value was 0.924±0.027 in adding phycocyanin group and 0.924±0.033 in non-adding phycocyanin group. A value was lower in model control group and phycocyanin group than that in non-hypoxia group at 1, 2 and 3 hours after reoxygenation （0.817±0.053, 0.838±0.037, 0.875±0.029; 0.842±0.029, 0.872±0.025, 0.906±0.023, P 〈 0.05）. A value was higher in phycocyanin group than that in model control group at 1, 2 and 3 after culture （P 〈 0.05）. With culture time being longer, A value was increased gradually in phycocyanin group and model control group after reoxygenation （P 〈 0.05）. ~ Effect of phycocyanin on mitochondrial membrane potential of PC12 cells： Fluorescence intensity was 2.967±0.253 in adding phycocyanin group and 2.962±0.294 in non-adding phycocyanin group. Fluorescence intensity was lower in model control group and phycocyanin group than that in non-hypoxia group at 1, 2 and 3 hours after hypoxia/reoxygenation （1.899±0.397, 2.119±0.414, 2.287±0.402; 2.191±0.377, 2.264±0.359, 2.436±0.471, P 〈 0.05）; but it was higher in phycocyanin group than that in model control group at 1, 2 and 3 after reoxygenation （P 〈 0.05）. With culture time being longer, fluorescence intensity was increased gradually in phycocyanin group and model control group after reoxygenation （P 〈 0.05）. CONCLUSION： Phycocyanin and reoxygenation can protect PC12 cells after hypoxia injury through increasing mitochondrial membrane potential and cellular activity, and the effect is improved gradually with prolonging time of reoxygenation.
基金the Clinical KeyFoundation of Public HealthMinistry, No. 20013144
文摘BACKGROUND： It is suspected that dissociation, destruction or synthetic disorder of microtubule-associated protein 2 （MAP-2） may participate in secondary injury of intracerebral hemorrhage （ICH）, and the reason may be related to thrombin in high concentration after ICH; therefore, the mechanism should be studied further. OBJECTIVE： To explore the effect of hirudin on expression of MAP-2 in peripheral tissue of hematom after ICH and changes of water content in brain tissue and analyze pathogenesis of thrombin in secondary injury after ICH. DESIGN ： Completely randomized grouping design and controlled animal study SEn-ING ： Department of Neurology, the First Affiliated Hospital of Jilin University MATERIALS ： The experiment was carried out in the Neurological Laboratory of the First Affiliated Hospital of Jilin University from April 2003 to April 2004. A number of 80 healthy Wistar rats, of both genders, aged 3-4 months, weighing 250-350 g, were randomly divided into 8 groups： normal control group, 6-hour ICH group, 1-day ICH group, 2-day ICH group, 3-day ICH group, 7-day ICH group, 3-day hirudin group and 7-day hirudin group with 10 in each group. Five rats from each group were selected to measure their water content, and the others were undertaken immunohistochemical stain. Hirudin was produced by Sigma Company, USA, and MAP-2 rabbit-rat polyclonal antibody was provided by Fuzhou Maixin Biotechnology Company Limited. METHODS： ① Model establishing and grouping intervention： Rats in simple ICH group were collected their blood from tails and then inserted with 50 μL non-anticoagulant auto-arterial blood into the cauda of the putamen in right brain within 5 minutes. Rats in hirudin groups were inserted with 10 U hirudin （which was diluted with saline to 20 μL） into local hematom regions within 5 minutes, and the needle was pulled out after 10 minutes. Rats in normal control group were untouched. ② Water content in peripheral tissue of hematom： Based on the ratio between dry weight and wet weight, brain tissue at bleeding side and in right frontal lobe was selected to measure dry and wet weights so as to calculate the water content [（wet weight - dry weight） /wet weight] × 100%.③ Positive expression of MAP-2： Based on immunohistochemical stain, positive MAP-2 cells were regarded as neurons and they were buffy morphological. Positive rate of MAP-2 was calculated, i.e., percentage of positive cells in each sight to total cells in all sights. ④ Statistical analysis： Data among groups were compared with one-way analysis of variance, averages were compared with SNK-q test by each other, and relation between water content and MAP-2 was analyzed with linear regression technique. MAIN OUTCOME MEASURES： Changes of water content and MAP-2 expression in peripheral tissue of hematorn at various time points after ICH and intervention of hirudin. RESULTS： All 80 rats were involved in the final analysis. ①Water content： Water content was increased at day 1, reached peak at day 3 and decreased at day 7. It was （72.31±0.32）%, （77.42±0.53）%, （78.44±0.28）%, （74.10±0.13）%, （74.85±0.51）% and （70.07±0.36）%, respectively in 1-day, 2-day, 3-day and 7-day ICH groups and 3-day and 7-day hirudin groups, which was higher than that in normal control group （63.85±0.41, q=-4.684 3 to -7.262 0, P〈 0.05）; that in 2-day and 3-day ICH groups was higher than that in 7-day ICH group （q=-3.053 4, -3.727 0, P 〈 0.05）; and that in 3-day and 7-day ICH groups was higher than that in hirudin groups at the same time points （q=-2.965 6, -2.726 4, P 〈 0.05）. ②Positive expression of MAP-2： Positive expression of MAP-2 was decreased at 6 hours after ICH, reached the lowest value at day 3 and increased at day 7. Positive rate was （78.60±0.42）%, （60.56±0.74）%, （44.60±0.26）%, （25.45±0.85）%, （32.55±0.64）%, （37.69＋0.76）%, （41.75±0.68）%, respectively in 6-hour, 1-day, 2-day, 3-day and 7-day ICH groups and 3-day and 7-day hirudin groups, which was lower than that in normal control group [（96.50±0.33）%, q= -3.074 5 to -8.128 5, P 〈 0.05]. In addition, positive cells of MAP-2 disappeared plentifully at 3-7 days after ICH, stain of positive cells were light, and only stain of plasma was positive. That in 3-day and 7-day hirudin groups was higher than that in ICH groups at the same time points （q= -3.391 8, -2.967 9, P 〈 0.05）. Moreover, positive cells of MAP-2 was formed slightly but deeply stained. ③ Results of linear regression： Water content was negatively related to MAP-2 changes at 7 days after ICH （r= -0.894 9, P〈 0.01）, i.e., water content was increased with decrease of MAP-2 expression. CONCLUSION ： The deterioration of MAP-2 may be involved in the pathogenesis of thrombin within the first week after ICH, and the local administration of hirudin can protect neurons.
文摘BACKGROUND： Central coordination disturbance is regarded as the early-stage symptom of brain injury-induced cerebral palsy. This disease manifests itself as motor disorder, abnormal attitudinal reflex and muscular tension. Early intervention may improve its prognosis. OBJECTIVE： To observe the effects of intervention treatment from different stages on the prognosis of central coordination disturbance following brain injury in children patients. DESIGN： A contrast observation experiment SETTING： Department of Neurology and Rehabilitation, Urumqi Children＇s Hospital PARTICIPANTS ： Totally 151 children who were diagnosed as central coordination disturbance from January 2002 to December 2003 in the Department of Neurology and Rehabilitation of Urumqi Children＇s Hospital were recruited. All the children patients, including 101 male and 50 female, aged from 3 months to 1 year old, met the diagnosis criteria of central coordination disturbance from Vojta. They were divided into slight, moderate and severe abnormity according to Vojta attitudinal reflex. All 151 patients were divided into 2 groups according to their age at diagnosis： 3-6 months old group （n=74）, 62 severe, 10 moderate and 2 slight; 7-12 months old group （n=77）, 66 severe, 7 moderate and 4 slight. All the relatives of children patients were informed of the experiment. METHODS： ① Both groups received physical training （PT） as the main treatment; Hand training was given if necessary. All of the patients received additional hyperbaric oxygen therapy, bioelectric therapy, scalp acupuncture, drug treatment and family training. The importance of integration of hospital and family based rehabilitation was stressed. Those who did not catch up with the normal development or had abnormal reflexes continued to receive treatment. ② Around the age of 2 years old, all children did a final evaluation using Bayley Scales of Infant Development （BSID）. Mental development index （MDI） and physical development index （PDI） were taken as evaluative criteria. Children with scores 80 and above on MDI and PDI were considered to have normal motor and mental development; 79 and below were considered delayers. The Diagnostic Criteria of Cerebral Palsy and Infantecondary School Social Adaptation Scale were used in the final evaluation[scores ≤5 was extremely severe （extremely severe cerebral palsy）, 6 was severe（severe cerebral palsy）, 7 was moderate（moderate cerebral palsy）, 8 was slight（slight cerebral palsy）, 9 was borderline（slight cerebral palsy）, 10 was normal, 11 was above average, 12 was excellent and ≥13 was extremely excellent]. ③ Final evaluative results of 2 groups were compared. And u test was used for the comparison of Bayley development index and Chi-square test for the comparison of normalization rate. MAIN OUTCOME MEASURES： BSID MDI and PDI as well as the normalization rate of motor function and mental behavior of children patients at 2 years old. RESULTS： Totally 151 children patients entered the stage of result analysis. ①Two groups of children patients were given integrated rehabilitation therapy , and evaluated at 2 years old . The 3-6 months old group had higher MDI and PDI than the 7-12 months old group （91.81＋19.99 vs 71.93＋18.98;91.55＋23.61 vs 68.95＋23.51, u=6.265,5.894,P 〈 0.01 ）.②After being given integrated rehabilitation therapy, children patients of 3-6 months old group had significantly higher normalization rate of motor function and mental behavior than 7-12 months old group （73% ,27%,X2=29.723 9,P 〈 0.01 ）. ③Six slight and 17 moderate central coordination disturbance children of 2 groups all completely recovered; After intervention treatment, among 128 severe central coordination disturbance children, 52 recovered and 76 were still abnormal, in which, 43 slight cerebral palsy, 18 moderate cerebral palsy, 5 severe cerebral palsy and 10 extremely severe cerebral palsy. CONCLUSION： To perform integrated intervention treatment before 6 months old can better improve and promote mental and physical development levels of children patients with central coordination disturbance after brain injury than 6 months later.
文摘Objective: to observe the effect of cardiac rehabilitation nursing intervention in patients with coronary heart disease undergoing interventional therapy. Methods: 70 patients with coronary heart disease undergoing interventional therapy in our hospital from July 1, 2019 to January 1, 2022 were selected for cardiac rehabilitation nursing research. They were randomly divided into basic group (35 cases, basic nursing) and rehabilitation group (35 cases, basic nursing + cardiac rehabilitation nursing) by computer. The research indexes were cardiac function, psychological rehabilitation index, quality of life, complications, hospitalization and satisfaction. Results: after the intervention, the cardiac function of patients in rehabilitation group was better than that of patients in basic group (P < 0.05). After the intervention, the psychological condition of patients in rehabilitation group was better than that of patients in basic group (P < 0.05). After the intervention, the quality of life of patients in rehabilitation group was higher than that of patients in basic group (P < 0.05). After the intervention, the incidence of complications in the rehabilitation group was lower than that in the basic group (P < 0.05). After the intervention, the hospitalization time and medical expenses of the interventional therapy patients in the rehabilitation group were lower than those of the interventional therapy patients (P < 0.05). After the intervention, the satisfaction of patients in rehabilitation group was higher than that in basic group (p < 0.05). Conclusion: cardiac rehabilitation nursing can strengthen the rehabilitation effect of patients undergoing interventional therapy for coronary heart disease, help to improve cardiac function and mental health, improve nursing safety, optimize hospitalization index of patients undergoing interventional therapy, and patients are more satisfied with the effect of nursing intervention.
文摘Objective:To explore the clinical method and effect of 3D printing in the treatment of cerebral aneurysms.Methods:The authors research work on the hospital,work time in February 2019-February 2020,this study selected patients of cerebral aneurysms,this period are selected for treatment of 100 cases of patients,randomly divided into two groups,a group to give simple intervention,named as the control group,another group for the interventional therapy under the guidance of 3 D printing,named as experimental group,analyze the effect of two groups of patients with clinical intervention.Results:The length of hospital stay in the experimental group was shorter than that in the control group.Meanwhile,the incidence of complications and adverse reactions in the experimental group and the control group were 6.00%and 18.00%,the experimental group was better(P<0.05).Conclusion:3D printing technology can be applied in the treatment of patients with cerebral aneurysms to provide guidance for interventional surgical treatment.It has significant effect,can reduce the incidence complications in patients,has significant clinical effect,and can be popularized.
文摘Objective: to study the effect of comprehensive nursing for patients with periodontitis who received teeth cleaning and treatment. Methods: a total of 80 patients with periodontitis who received treatment in our hospital from April 2020 to April 2021 were enrolled and analyzed. The conventional group received traditional nursing plan, and the experimental group received comprehensive nursing intervention measures. The gingival index and complication index were compared between the two groups. Results: the gingival index of the experimental group was significantly better than that of the conventional group, P < 0.05. The incidence of complications in experimental group was significantly higher than that in conventional group (P < 0.05). Conclusion: comprehensive nursing for patients with periodontitis who received dental cleaning can effectively improve their dental status, which is worth popularizing.
文摘Objective: to observe the clinical effect of Mongolian medicine syndrome differentiation in the treatment of chronic nephritis. Methods: 89 patients with chronic glomerulonephritis admitted to our hospital in recent years were selected as the research object. According to the treatment and nursing methods, 44 patients with conventional treatment and nursing were selected as the control group. Forty-five patients were treated with dialectical Mongolian medicine in the observation group. SAS and SDS scores and clinical efficacy were compared between the two groups before and after treatment. Results: the total effective rate was 97.78% in the observation group and 70.45% in the control group (P<0.05). SAS and SDS scores were compared between the two groups after nursing (P<0.05). Conclusion: Mongolian medicine syndrome differentiation therapy can significantly improve the mental state of patients with chronic glomerulonephritis, worthy of in-depth clinical research.
文摘Hyaluronic acid (HA) preparations have emerged as pivotal components in contemporary dentistry, gaining widespread recognition for their multifaceted roles in various biological functions. Extensive literature underscores the significance of HA in maintaining tissue water balance, fostering cell proliferation, promoting rapid cell migration, influencing cell differentiation during organism development, and facilitating tissue regeneration. Notably, HA’s interactions with cell surface receptors contribute to the viscosity of synovial fluid, activate the immune system, and enhance cartilage elasticity. Beyond these established functions, HA has also been investigated for its potential involvement in determining and studying the hormetic effects of radon water, adding a novel dimension to its applications in dental research. A thorough exploration of existing studies reveals a nuanced understanding of how HA interventions impact the outcomes of dental procedures. The comprehensive scope of these investigations allows for a more accurate assessment of the potential effectiveness of specific interventions and provides valuable insights into post-procedural prognoses for individual patients. This synthesis of literature serves as the foundation for elucidating the intricate interplay between HA, radon exposure, and their relevance in modern dental practices.
文摘We have shown the value of intravascular ultrasound (IVUS) in the evaluation of myocardial bridging (MB). The purpose of the study was to elucidate the mechanism of inter-
文摘Before vaccine development during the COVID-19 pandemic,Non-Pharmaceutical Interventions(NPIs)were the only solutions to mitigate COVID-19 infections.Governments continued to use them even after starting vaccine administration.In this research,we review different big data analytics models that assess and optimize the effectiveness of NPIs.These models are categorized into three big data analytics groups:descriptive,which measures the infection rate changes caused by NPIs;predictive,which predicts the future of the pandemic by implementing several NPIs;and data-driven prescriptive,which suggests optimal control policies.We further analyze each method’s basic assumptions,limitations,and applicability during different pandemic phases and under different scenarios.This review of COVID-19 NPI evaluation methods will be beneficial for decision-makers to know which model to select for policy-making in possible future pandemics,which are more likely recently due to globalization.Finally,we suggest some future research directions.
