Stroke,as an acute cerebrovascular disease,is characterized by high incidence,high mortality,and high disability rate,thus attracting great attention from the medical community.Medication literacy,on the other hand,is...Stroke,as an acute cerebrovascular disease,is characterized by high incidence,high mortality,and high disability rate,thus attracting great attention from the medical community.Medication literacy,on the other hand,is an active,comprehensive,and sustainable concept of health management,which includes the learning of health knowledge and the guidelines for healthy behaviors,and directly affects the treatment effect and health safety of patients.This paper conducts an in-depth study on the current research status of medication literacy in stroke patients,analyzes its influencing factors,and explores specific intervention strategies from multiple perspectives,aiming to provide a theoretical reference for improving patients’medication management ability and optimizing clinical prognosis.展开更多
This study aims to explore the characteristics of novice teachers’inappropriate behaviors in classroom teaching and their intervention strategies.With the continuous improvement of education quality,novice teachers f...This study aims to explore the characteristics of novice teachers’inappropriate behaviors in classroom teaching and their intervention strategies.With the continuous improvement of education quality,novice teachers face increasing challenges in teaching practice.Their inappropriate behaviors not only affect the classroom atmosphere but may also negatively impact students’learning outcomes.Therefore,researching the characteristics of novice teachers’inappropriate behaviors and their intervention strategies holds significant scientific and social value.This study employs a combination of quantitative and qualitative methods to analyze the behavioral patterns of novice teachers in classroom teaching and proposes corresponding intervention strategies.The results indicate that novice teachers’inappropriate behaviors mainly manifest as poor classroom management,monotonous teaching methods,and insufficient interaction with students.Based on these findings,the study proposes a series of effective intervention strategies,including enhancing teacher training,optimizing teaching design,and promoting positive interactions between teachers and students.The conclusions of the study not only provide practical guidance for educational practice but also point out directions for future research,emphasizing the crucial role of teacher professional development in improving teaching quality.展开更多
Thyroid cancer is a common endocrine malignancy with a rising incidence.Pa-tients often suffer from mental pain due to concerns about recurrence,treatment-related side-effect,and body image changes.Demographic factors...Thyroid cancer is a common endocrine malignancy with a rising incidence.Pa-tients often suffer from mental pain due to concerns about recurrence,treatment-related side-effect,and body image changes.Demographic factors like age,gender,physiological factors such as somatic symptoms and disease stage,co-gnitive-regulatory factors including negative and positive thinking,and social factors like work,economy,education level,and social support all influence their mental state.Existing interventions,including nursing,psychological,and tra-ditional Chinese medicine-based methods,have some benefits but face limitations like short-term effectiveness and lack of standardization.Future research should focus on creating better-defined,long-term,and widely applicable intervention programs and explore positive psychology-based approaches to improve patients'mental well-being and quality of life.展开更多
Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease.Clinical studies have shown that renal inflammation is a key factor dete...Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease.Clinical studies have shown that renal inflammation is a key factor determining kidney damage during diabetes.With the development of immunological technology,many studies have shown that diabetic nephropathy is an immune complex disease,and that most patients have immune dysfunction.However,the immune response associated with diabetic nephropathy and autoimmune kidney disease,or caused by ischemia or infection with acute renal injury,is different,and has a complicated pathological mechanism.In this review,we discuss the pathogenesis of diabetic nephropathy in immune disorders and the intervention mechanism,to provide guidance and advice for early intervention and treatment of diabetic nephropathy.展开更多
Objective This study was to evaluate the efficacy and safety of a short acting reduced dose fibrinolytic regimen to promote early infarct related artery (IRA) patency for acyute myocardial infarction (AMI) patients re...Objective This study was to evaluate the efficacy and safety of a short acting reduced dose fibrinolytic regimen to promote early infarct related artery (IRA) patency for acyute myocardial infarction (AMI) patients referred for percutaneous coronary intervention (PCI).Methods Following aspirin and heparin, 166 patients were randomized to a 50 mg bolus of recombinant tissue type plasminogen activator(rt PA) or to a same volume sodium chloride injection followed by immediate primary PCI. The end points included patency rates on catheterization laboratory (cath lab) arrival, revascularization results when PCI was performed, complication rates, left ventricular function and restored patency rate following PCI. Results Patency on cath lab arrival was 64% with rt PA (34% TIMI 3,30% TIMI 2), while 31% of placebo (13% TIMI 3, 18% TIMI 2). There was no difference in the restored TIMI 3 rates of IRA between the two groups (85% vs 87%). No difference were observed in stroke or major bleeding. Left ventricular function was similar in both groups (52±9% vs 50±8%), but left ventricular ejection fraction fraction (LVEF) was higher with patent IRA (TIMI 3) on cath lab arrival than that of others (56±12% vs 48±10%).Conclusions Strategy thrombolytic regimens were compatible with subsequent PCI lead to more frequenc early recanalization (before cath lab arrival), which facilitates greater left ventricular function preservation with no augmentation of adverse events.展开更多
Objective:To examine insomnia in the modern young and middle-aged population and explore nursing intervention strategies using traditional Chinese and Western medicine.Methods:A total of 255 inpatients and outpatients...Objective:To examine insomnia in the modern young and middle-aged population and explore nursing intervention strategies using traditional Chinese and Western medicine.Methods:A total of 255 inpatients and outpatients were sampled from Shenzhen Hospital of Traditional Chinese Medicine.The Sleep Questionnaire for Young and Middle-aged People was used to assess insomnia,and a linear regression model was applied for data analysis.Results:A total of 251 valid questionnaires were collected.Correlation analysis revealed a high incidence of insomnia among respondents.Linear correlation analysis indicated that mental illness or other underlying diseases leading to pain had a significantly positive effect on symptom improvement through Chinese and Western medicine treatments(B=0.763,P<0.01).Conversely,work or life pressures(emotional or financial issues)had a significantly negative impact on treatment effectiveness(B=-0.503,P<0.01).Cross-analysis identified high life or work pressure as the primary cause of insomnia(70.1%).Conclusion:Insomnia is prevalent among the young and middle-aged in modern times,with high work or life pressure being the leading factor.展开更多
Teenagers are in the special stage of physical and mental development,and their psychological problems show complex and diverse characteristics.Depression is the most common mental disorder among teenagers.Literary re...Teenagers are in the special stage of physical and mental development,and their psychological problems show complex and diverse characteristics.Depression is the most common mental disorder among teenagers.Literary reading has a certain intervention effect on depression and can be used as an important strategy for psychological intervention.Reading literature works can help teenagers understand and discover themselves from different angles,and then realize the self-recognition and intervention of depression.This paper mainly discusses the causes of depression in teenagers and the intervention principles and strategies of literary reading on depression,aiming to alleviate and eliminate the depressive symptoms of teenagers through literary reading and promote their physical and mental health development.展开更多
Purpose:To compare the effectiveness of the interventional limb raising management strategy(ILRMS)to elastic bandage compression at radial vascular access sites following coronary angiographies(CAGs)and percutaneous c...Purpose:To compare the effectiveness of the interventional limb raising management strategy(ILRMS)to elastic bandage compression at radial vascular access sites following coronary angiographies(CAGs)and percutaneous coronary interventions(PCIs).Methods:Patients with ischemic coronary heart disease whose condition was stable over three months were enrolled in this clinical study(n=590;aged 25e80).All participants had just undergone CAG and PCI.Patients were randomized into either the ILRMS group(n=360)or standard post-intervention care with an elastic bandage(n=230).Overall comfort and wrist pain was assessed and the degree of index finger swelling and oxygen saturation was measured on the affected arm.All variables were measured prior to postintervention treatment and again at six hours after CAG and PCI.Results:We found that patients receiving ILRMS had significantly lower wrist pain scores and swelling around the index finger compared to the elastic bandage group(p<0.05).Oxygen saturation of the index finger was not statistically significant(p>0.05).We also found that 19.57%of the elastic bandage patients were comfortable,while ILRMS patients were significantly more comfortable(93.06%;p<0.05).Conclusions:We find that ILRMS alleviates swelling and pain of the wrist more effectively than current practices and improves the degree of overall comfort of patients who undergo CAG and PCI.展开更多
Objective:This study aims to investigate the impact of early intervention on neuropsychological development in children with autism and attention deficit hyperactivity disorder(ADHD),providing effective intervention s...Objective:This study aims to investigate the impact of early intervention on neuropsychological development in children with autism and attention deficit hyperactivity disorder(ADHD),providing effective intervention strategies for clinical practice.Methods:A total of 130 children with autism and ADHD who visited the hospital between June 2023 and June 2024 were selected as study subjects and randomly divided into an intervention group and a control group,with 65 children in each group.The intervention group received a one-year early comprehensive intervention,including behavioral therapy,cognitive training,and family guidance,while the control group only received routine medical care.The neuropsychological development assessment scale was used to evaluate both groups before and after the intervention to compare changes in their neuropsychological development levels.Results:Children in the intervention group showed significant improvements in cognitive function,social skills,language ability,and attention concentration,with an average improvement score of 23.5 points.Children in the control group did not show significant improvements in these areas,with an average improvement score of only 5.8 points.The difference between the two groups was statistically significant(P<0.05).Conclusion:Early comprehensive intervention has a significant promoting effect on the neuropsychological development of children with autism and ADHD.Targeted behavioral therapy,cognitive training,and family guidance can effectively enhance children’s cognitive,social,language,and attention abilities,laying a solid foundation for their future overall development.Therefore,it is recommended to actively promote and apply early intervention strategies in clinical practice.展开更多
This paper examines the bidirectional relationship between heart failure (HF) and cognitive impairment, underscoring the need for integrated intervention strategies to address these interconnected conditions effective...This paper examines the bidirectional relationship between heart failure (HF) and cognitive impairment, underscoring the need for integrated intervention strategies to address these interconnected conditions effectively. Cognitive deficits often hinder the effective management of HF, leading to poorer treatment adherence and health outcomes, while the physiological stress of HF can further impair cognitive function, creating a complex interplay that complicates patient care. This study highlights the effectiveness of angiotensin-converting enzyme (ACE) inhibitors and cardiac resynchronization therapy (CRT) in improving both cardiac and cognitive functions. By targeting the underlying physiological and neurobiological mechanisms of HF, these therapies enhance patient outcomes, leading to better adherence to treatment regimens and overall quality of life. Furthermore, the findings suggest that regular cognitive assessments should be integrated into HF management protocols, enabling early identification of cognitive impairment and timely intervention. Incorporating ACE inhibitors and CRT into standard care practices not only addresses the complexities of managing HF and cognitive decline but also fosters a holistic approach to patient health. Ultimately, this multifaceted strategy has the potential to significantly improve health outcomes, enhance the quality of care, and support sustainable management of patients with heart failure and cognitive impairment.展开更多
This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various diseases.In recurrent colorectal polyps,the abundance...This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various diseases.In recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus decrease.This dysbiosis may promote the formation and recurrence of polyps.Similar microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these conditions.Regulating the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut health.This microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.展开更多
This literature review explores the complex relationship between loneliness and mortality,emphasizing its eff ects on physical and mental health across diff erent age groups.Drawing on studies from both Western and As...This literature review explores the complex relationship between loneliness and mortality,emphasizing its eff ects on physical and mental health across diff erent age groups.Drawing on studies from both Western and Asian contexts,the review highlights that loneliness contributes to increased risks of depression,cardiovascular diseases,substance abuse,and ultimately premature death,particularly among the elderly.It investigates how social relationships,living arrangements,cultural traditions,and institutional frameworks shape the experience of loneliness and its health outcomes.While some findings suggest a direct correlation between loneliness and mortality,others point to mediating factors such as health behavior and access to social or religious support.The paper also examines intervention strategies and proposes that targeted community-based programs and educational engagement may mitigate loneliness-related health risks.The fi ndings underscore the need for more cross-cultural,longitudinal studies and policy-level interventions.展开更多
The global prevalence of myopia is becoming increasingly severe,with epidemiological models predicting that by 2050,approximately 50%of the world’s population will be affected by myopia,and about 10%will suffer from ...The global prevalence of myopia is becoming increasingly severe,with epidemiological models predicting that by 2050,approximately 50%of the world’s population will be affected by myopia,and about 10%will suffer from high myopia.The incidence of high myopia is projected to increase fivefold,making it the leading cause of irreversible vision impairment.Myopia often leads to various complications and has been associated with other ocular diseases,including early-onset cataracts,age-related macular degeneration,and primary open angle glaucoma.As a result,the control and management of myopia have become ongoing and long-term research priorities.The pathogenesis of myopia involves complex multisystem interactions.Current mainstream theories focus primarily on choroidal hypoxia-induced scleral remodeling,with neurotransmitters such as acetylcholine and dopamine playing regulatory roles.However,recent studies have increasingly suggested that changes in nutritional intake,including proteins,fats,and cholesterol,may also be related to myopia development.The role of lipid metabolism in the onset and progression of myopia has gradually attracted growing attention.Therefore,this review aims to systematically elucidate the molecular mechanisms of lipid metabolism regulatory networks in axial myopia,integrating multidimensional factors to provide a theoretical foundation for precision intervention strategies.展开更多
Spillover of trypanosomiasis parasites from wildlife to domestic livestock and humans remains a major challenge world over.With the disease targeted for elimination by 2030,assessing the impact of control strategies i...Spillover of trypanosomiasis parasites from wildlife to domestic livestock and humans remains a major challenge world over.With the disease targeted for elimination by 2030,assessing the impact of control strategies in communities where there are human-cattle-wildlife interactions is therefore essential.A compartmental framework incorporating tsetse flies,humans,cattle,wildlife and various disease control strategies is developed and analyzed.The reproduction is derived and its sensitivity to different model parameters is investigated.Meanwhile,the optimal control theory is used to identify a combination of control strategies capable of minimizing the infected human and cattle population over time at minimal costs of implementation.The results indicates that tsetse fly mortality rate is strongly and negatively correlated to the reproduction number.It is also established that tsetse fly feeding rate in strongly and positively correlated to the reproduction number.Simulation results indicates that time dependent control strategies can significantly reduce the infections.Overall,the study shows that screening and treatment of humans may not lead to disease elimination.Combining this strategy with other strategies such as screening and treatment of cattle and vector control strategies will result in maximum reduction of tsetse fly population and disease elimination.展开更多
It is well known that the gut microbiota plays an extremely important role in modulating host physiological functions such as immunity and metabolic homeostasis.In recent years,accumulated evidence has revealed that t...It is well known that the gut microbiota plays an extremely important role in modulating host physiological functions such as immunity and metabolic homeostasis.In recent years,accumulated evidence has revealed that the gut microbiota can regulate the functions of the central nervous system(CNS)through the gut-brain axis,which provides a novel insight into the interactions between the gut and brain.This review focuses on the molecular mechanism of the crosstalk between the gut microbiota and the brain via the gut-brain axis,and on the onset and development of neurological disorders triggered by gut microbiota dysbiosis.These topics are followed by a critical analysis of potential intervention strategies targeting gut microbiota dysbiosis,including the use of probiotics,prebiotics,synbiotics,and diets.While research on the microbiota-gut-brain axis is still in its relative infancy,clarifying the molecular mechanism that underlies how the gut microbiota regulates neurological functions not only holds the promise of revealing potentially novel pathogeneses of neurological disorders,but also may lead to the development of potential diagnosis biomarkers and intervention strategies targeting microbiota dysbiosis for neurological disorders.展开更多
<span style="font-family:Verdana;"><strong>Intro</strong></span><span style="font-family:Verdana;"><strong>duction:</strong></span><span style=&qu...<span style="font-family:Verdana;"><strong>Intro</strong></span><span style="font-family:Verdana;"><strong>duction:</strong></span><span style="font-family:Verdana;"> Excessive masturbation has for long been reported to affect youths with intervention strategies to intervene </span><span style="font-family:Verdana;">with </span><span style="font-family:Verdana;">this problem rema</span><span style="font-family:""><span style="font-family:Verdana;">ining unclear. This study aimed at determining the underlying factors for excessive masturbation, its effects and intervention strategies used. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a case study design for a youth aged 19 years;affected by excessive masturbation. Data were collected through individual counseling and intervention. It i</span><span style="font-family:Verdana;">nvolved 15 counseling sessions which w</span></span><span style="font-family:Verdana;">ere</span><span style="font-family:Verdana;"> run in nine month</span><span style="font-family:""><span style="font-family:Verdana;">s in a three weeks interval. The sessions involved narration and exploration of the causes and effects of masturbation. Counseling intervention was built in a vicious circle. </span><b><span style="font-family:Verdana;">R</span><span style="font-family:Verdana;">esults:</span></b><span style="font-family:Verdana;"> Several factors, effects and intervention strategies were identified, r</span><span style="font-family:Verdana;">e</span><span style="font-family:Verdana;">ported and discussed in this study. Main causes were such as stories fro</span><span style="font-family:Verdana;">m friends and pornographic videos. Effects were multiple risk behaviors and hea</span><span style="font-family:Verdana;">lth problems. Counseling model for individual was developed. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The study indicates that there are multiple causes and effects of excessive masturbation. Since masturbation is secretly done, the effects are not widely known to many people. Most of these effects are long-term which affects a person psychologically, physically, socially and morally.</span></span>展开更多
This editorial explores the significant challenge of intensive care unit-acquiredweakness(ICU-AW),a prevalent condition affecting critically ill patients,characterizedby profound muscle weakness and complicating patie...This editorial explores the significant challenge of intensive care unit-acquiredweakness(ICU-AW),a prevalent condition affecting critically ill patients,characterizedby profound muscle weakness and complicating patient recovery.Highlightingthe paradox of modern medical advances,it emphasizes the urgent needfor early identification and intervention to mitigate ICU-AW's impact.Innovatively,the study by Wang et al is showcased for employing a multilayer perceptronneural network model,achieving high accuracy in predicting ICU-AWrisk.This advancement underscores the potential of neural network models inenhancing patient care but also calls for continued research to address limitationsand improve model applicability.The editorial advocates for the developmentand validation of sophisticated predictive tools,aiming for personalized carestrategies to reduce ICU-AW incidence and severity,ultimately improving patientoutcomes in critical care settings.展开更多
Like rest of the world,the South Asian region is facing enormous challenges with the coronavirus disease 2019(COVID-19)pandemic.The socio-economic context of the eight South Asian countries is averse to any longterm l...Like rest of the world,the South Asian region is facing enormous challenges with the coronavirus disease 2019(COVID-19)pandemic.The socio-economic context of the eight South Asian countries is averse to any longterm lockdown program,but the region still observed stringent lockdown close to two months.This paper analyzed major measures in public health preparedness and responses in those countries in the pandemic.The research was based on a situation analysis to discuss appropriate plan for epidemic preparedness,strategies for prevention and control measures,and adequate response management mechanism.Based on the data from March 21 to June 26,2020,it appeared lockdown program along with other control measures were not as effective to arrest the exponential growth of fortnightly COVID-19 cases in Afghanistan,Bangladesh,India,Nepal and Pakistan.However,Bhutan,Maldives and Sri Lanka have been successfully limiting the spread of the disease.The in-depth analysis of prevention and control measures espoused densely populated context of South Asia needs community-led intervention strategy,such as case containment,in order to reverse the growing trend,and adopt the policy of mitigation instead of suppression to formulate COVID-19 action plan.On the other hand,mechanism for response management encompassed a four-tier approach of governance to weave community-led local bodies with state,national and international governance actors for enhancing the countries’emergency operation system.It is concluded resource-crunch countries in South Asia are unable to cope with the disproportionate demand of capital and skilled health care workforce at the time of the pandemic.Hence,response management needs an approach of governance maximization instead of resource maximization.The epidemiologic management of population coupled with suitable public health prevention and control measures may be a more appropriate strategy to strike a balance between economy and population health during the time of pandemic.展开更多
AIM To review impacts of interventions involving self-management education, health coaching, and motivational interviewing for type 2 diabetes. METHODS A thorough review of the scientific literature on diabetes care a...AIM To review impacts of interventions involving self-management education, health coaching, and motivational interviewing for type 2 diabetes. METHODS A thorough review of the scientific literature on diabetes care and management was executed by a research team. RESULTS This article summarizes important findings in regard to the validity of developing a comprehensive behavioral system as a framework for empirical investigation. The behavioral system framework consists of patients' knowledge(K), motivation(M), attitude(A), and practice(P) as predictor variables for diabetes care outcomes(O). Care management strategies or health education programs serve as the intervention variable that directly influences K, M, A, and P and then indirectly affects the variability in patient care outcomes of patients with type 2 diabetes. CONCLUSION This review contributes to the understanding of the KMAP-O framework and how it can guide the care management of patients with type 2 diabetes. It will allow the tailoring of interventions to be more effective through knowledge enhancement, increased motivation, attitudinal changes, and improved preventive practice to reduce the progression of type 2 diabetes and comorbidities. Furthermore, the use of health information technology for enhancing changes in KMAP and communications is advocated in health promotion and development.展开更多
Job burnout is an important factor affecting the work attitude and professional behavior of family doctors.This paper reviews the measurement tools,influencing factors and intervention strategies of job burnout,it is ...Job burnout is an important factor affecting the work attitude and professional behavior of family doctors.This paper reviews the measurement tools,influencing factors and intervention strategies of job burnout,it is suggested that improving job burnout can improve job satisfaction,work efficiency and reduce turnover intention of family doctors,and it is of great significance to the construction of family doctor team and the improvement of work quality.展开更多
基金2023 PSM Guangdong Pharmaceutical Science Popularization Research Fund"Drug Management Ability in Elderly Stroke Patients Based onAI-Predicted Pharmaceutical Science Popularization Interventions"(Project No.:2023KP65)。
文摘Stroke,as an acute cerebrovascular disease,is characterized by high incidence,high mortality,and high disability rate,thus attracting great attention from the medical community.Medication literacy,on the other hand,is an active,comprehensive,and sustainable concept of health management,which includes the learning of health knowledge and the guidelines for healthy behaviors,and directly affects the treatment effect and health safety of patients.This paper conducts an in-depth study on the current research status of medication literacy in stroke patients,analyzes its influencing factors,and explores specific intervention strategies from multiple perspectives,aiming to provide a theoretical reference for improving patients’medication management ability and optimizing clinical prognosis.
文摘This study aims to explore the characteristics of novice teachers’inappropriate behaviors in classroom teaching and their intervention strategies.With the continuous improvement of education quality,novice teachers face increasing challenges in teaching practice.Their inappropriate behaviors not only affect the classroom atmosphere but may also negatively impact students’learning outcomes.Therefore,researching the characteristics of novice teachers’inappropriate behaviors and their intervention strategies holds significant scientific and social value.This study employs a combination of quantitative and qualitative methods to analyze the behavioral patterns of novice teachers in classroom teaching and proposes corresponding intervention strategies.The results indicate that novice teachers’inappropriate behaviors mainly manifest as poor classroom management,monotonous teaching methods,and insufficient interaction with students.Based on these findings,the study proposes a series of effective intervention strategies,including enhancing teacher training,optimizing teaching design,and promoting positive interactions between teachers and students.The conclusions of the study not only provide practical guidance for educational practice but also point out directions for future research,emphasizing the crucial role of teacher professional development in improving teaching quality.
文摘Thyroid cancer is a common endocrine malignancy with a rising incidence.Pa-tients often suffer from mental pain due to concerns about recurrence,treatment-related side-effect,and body image changes.Demographic factors like age,gender,physiological factors such as somatic symptoms and disease stage,co-gnitive-regulatory factors including negative and positive thinking,and social factors like work,economy,education level,and social support all influence their mental state.Existing interventions,including nursing,psychological,and tra-ditional Chinese medicine-based methods,have some benefits but face limitations like short-term effectiveness and lack of standardization.Future research should focus on creating better-defined,long-term,and widely applicable intervention programs and explore positive psychology-based approaches to improve patients'mental well-being and quality of life.
基金Supported by the National Natural Science Foundation of China,No.82100883the Research Project of Educational Commission of Jilin Province of China,No.JJKH20231214KJ.
文摘Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease.Clinical studies have shown that renal inflammation is a key factor determining kidney damage during diabetes.With the development of immunological technology,many studies have shown that diabetic nephropathy is an immune complex disease,and that most patients have immune dysfunction.However,the immune response associated with diabetic nephropathy and autoimmune kidney disease,or caused by ischemia or infection with acute renal injury,is different,and has a complicated pathological mechanism.In this review,we discuss the pathogenesis of diabetic nephropathy in immune disorders and the intervention mechanism,to provide guidance and advice for early intervention and treatment of diabetic nephropathy.
文摘Objective This study was to evaluate the efficacy and safety of a short acting reduced dose fibrinolytic regimen to promote early infarct related artery (IRA) patency for acyute myocardial infarction (AMI) patients referred for percutaneous coronary intervention (PCI).Methods Following aspirin and heparin, 166 patients were randomized to a 50 mg bolus of recombinant tissue type plasminogen activator(rt PA) or to a same volume sodium chloride injection followed by immediate primary PCI. The end points included patency rates on catheterization laboratory (cath lab) arrival, revascularization results when PCI was performed, complication rates, left ventricular function and restored patency rate following PCI. Results Patency on cath lab arrival was 64% with rt PA (34% TIMI 3,30% TIMI 2), while 31% of placebo (13% TIMI 3, 18% TIMI 2). There was no difference in the restored TIMI 3 rates of IRA between the two groups (85% vs 87%). No difference were observed in stroke or major bleeding. Left ventricular function was similar in both groups (52±9% vs 50±8%), but left ventricular ejection fraction fraction (LVEF) was higher with patent IRA (TIMI 3) on cath lab arrival than that of others (56±12% vs 48±10%).Conclusions Strategy thrombolytic regimens were compatible with subsequent PCI lead to more frequenc early recanalization (before cath lab arrival), which facilitates greater left ventricular function preservation with no augmentation of adverse events.
基金2024 China Mainland-Hong Kong-Macao University Teachers and Students Exchange Program(Project No.202311060001)。
文摘Objective:To examine insomnia in the modern young and middle-aged population and explore nursing intervention strategies using traditional Chinese and Western medicine.Methods:A total of 255 inpatients and outpatients were sampled from Shenzhen Hospital of Traditional Chinese Medicine.The Sleep Questionnaire for Young and Middle-aged People was used to assess insomnia,and a linear regression model was applied for data analysis.Results:A total of 251 valid questionnaires were collected.Correlation analysis revealed a high incidence of insomnia among respondents.Linear correlation analysis indicated that mental illness or other underlying diseases leading to pain had a significantly positive effect on symptom improvement through Chinese and Western medicine treatments(B=0.763,P<0.01).Conversely,work or life pressures(emotional or financial issues)had a significantly negative impact on treatment effectiveness(B=-0.503,P<0.01).Cross-analysis identified high life or work pressure as the primary cause of insomnia(70.1%).Conclusion:Insomnia is prevalent among the young and middle-aged in modern times,with high work or life pressure being the leading factor.
文摘Teenagers are in the special stage of physical and mental development,and their psychological problems show complex and diverse characteristics.Depression is the most common mental disorder among teenagers.Literary reading has a certain intervention effect on depression and can be used as an important strategy for psychological intervention.Reading literature works can help teenagers understand and discover themselves from different angles,and then realize the self-recognition and intervention of depression.This paper mainly discusses the causes of depression in teenagers and the intervention principles and strategies of literary reading on depression,aiming to alleviate and eliminate the depressive symptoms of teenagers through literary reading and promote their physical and mental health development.
基金This work was supported by the National Natural Science Foundation of China(GrantNos.81170279,81370408,81370409)the Social Development Projects of Jiangsu Province(WS074,LJ201116,Q201308)the Projects from Social Development of Zhenjiang(SS2012002,SH2013023,SH2013024).
文摘Purpose:To compare the effectiveness of the interventional limb raising management strategy(ILRMS)to elastic bandage compression at radial vascular access sites following coronary angiographies(CAGs)and percutaneous coronary interventions(PCIs).Methods:Patients with ischemic coronary heart disease whose condition was stable over three months were enrolled in this clinical study(n=590;aged 25e80).All participants had just undergone CAG and PCI.Patients were randomized into either the ILRMS group(n=360)or standard post-intervention care with an elastic bandage(n=230).Overall comfort and wrist pain was assessed and the degree of index finger swelling and oxygen saturation was measured on the affected arm.All variables were measured prior to postintervention treatment and again at six hours after CAG and PCI.Results:We found that patients receiving ILRMS had significantly lower wrist pain scores and swelling around the index finger compared to the elastic bandage group(p<0.05).Oxygen saturation of the index finger was not statistically significant(p>0.05).We also found that 19.57%of the elastic bandage patients were comfortable,while ILRMS patients were significantly more comfortable(93.06%;p<0.05).Conclusions:We find that ILRMS alleviates swelling and pain of the wrist more effectively than current practices and improves the degree of overall comfort of patients who undergo CAG and PCI.
文摘Objective:This study aims to investigate the impact of early intervention on neuropsychological development in children with autism and attention deficit hyperactivity disorder(ADHD),providing effective intervention strategies for clinical practice.Methods:A total of 130 children with autism and ADHD who visited the hospital between June 2023 and June 2024 were selected as study subjects and randomly divided into an intervention group and a control group,with 65 children in each group.The intervention group received a one-year early comprehensive intervention,including behavioral therapy,cognitive training,and family guidance,while the control group only received routine medical care.The neuropsychological development assessment scale was used to evaluate both groups before and after the intervention to compare changes in their neuropsychological development levels.Results:Children in the intervention group showed significant improvements in cognitive function,social skills,language ability,and attention concentration,with an average improvement score of 23.5 points.Children in the control group did not show significant improvements in these areas,with an average improvement score of only 5.8 points.The difference between the two groups was statistically significant(P<0.05).Conclusion:Early comprehensive intervention has a significant promoting effect on the neuropsychological development of children with autism and ADHD.Targeted behavioral therapy,cognitive training,and family guidance can effectively enhance children’s cognitive,social,language,and attention abilities,laying a solid foundation for their future overall development.Therefore,it is recommended to actively promote and apply early intervention strategies in clinical practice.
文摘This paper examines the bidirectional relationship between heart failure (HF) and cognitive impairment, underscoring the need for integrated intervention strategies to address these interconnected conditions effectively. Cognitive deficits often hinder the effective management of HF, leading to poorer treatment adherence and health outcomes, while the physiological stress of HF can further impair cognitive function, creating a complex interplay that complicates patient care. This study highlights the effectiveness of angiotensin-converting enzyme (ACE) inhibitors and cardiac resynchronization therapy (CRT) in improving both cardiac and cognitive functions. By targeting the underlying physiological and neurobiological mechanisms of HF, these therapies enhance patient outcomes, leading to better adherence to treatment regimens and overall quality of life. Furthermore, the findings suggest that regular cognitive assessments should be integrated into HF management protocols, enabling early identification of cognitive impairment and timely intervention. Incorporating ACE inhibitors and CRT into standard care practices not only addresses the complexities of managing HF and cognitive decline but also fosters a holistic approach to patient health. Ultimately, this multifaceted strategy has the potential to significantly improve health outcomes, enhance the quality of care, and support sustainable management of patients with heart failure and cognitive impairment.
文摘This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various diseases.In recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus decrease.This dysbiosis may promote the formation and recurrence of polyps.Similar microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these conditions.Regulating the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut health.This microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.
文摘This literature review explores the complex relationship between loneliness and mortality,emphasizing its eff ects on physical and mental health across diff erent age groups.Drawing on studies from both Western and Asian contexts,the review highlights that loneliness contributes to increased risks of depression,cardiovascular diseases,substance abuse,and ultimately premature death,particularly among the elderly.It investigates how social relationships,living arrangements,cultural traditions,and institutional frameworks shape the experience of loneliness and its health outcomes.While some findings suggest a direct correlation between loneliness and mortality,others point to mediating factors such as health behavior and access to social or religious support.The paper also examines intervention strategies and proposes that targeted community-based programs and educational engagement may mitigate loneliness-related health risks.The fi ndings underscore the need for more cross-cultural,longitudinal studies and policy-level interventions.
基金Supported by the National Natural Science Foundation of China(No.82000922,No.81870647).
文摘The global prevalence of myopia is becoming increasingly severe,with epidemiological models predicting that by 2050,approximately 50%of the world’s population will be affected by myopia,and about 10%will suffer from high myopia.The incidence of high myopia is projected to increase fivefold,making it the leading cause of irreversible vision impairment.Myopia often leads to various complications and has been associated with other ocular diseases,including early-onset cataracts,age-related macular degeneration,and primary open angle glaucoma.As a result,the control and management of myopia have become ongoing and long-term research priorities.The pathogenesis of myopia involves complex multisystem interactions.Current mainstream theories focus primarily on choroidal hypoxia-induced scleral remodeling,with neurotransmitters such as acetylcholine and dopamine playing regulatory roles.However,recent studies have increasingly suggested that changes in nutritional intake,including proteins,fats,and cholesterol,may also be related to myopia development.The role of lipid metabolism in the onset and progression of myopia has gradually attracted growing attention.Therefore,this review aims to systematically elucidate the molecular mechanisms of lipid metabolism regulatory networks in axial myopia,integrating multidimensional factors to provide a theoretical foundation for precision intervention strategies.
文摘Spillover of trypanosomiasis parasites from wildlife to domestic livestock and humans remains a major challenge world over.With the disease targeted for elimination by 2030,assessing the impact of control strategies in communities where there are human-cattle-wildlife interactions is therefore essential.A compartmental framework incorporating tsetse flies,humans,cattle,wildlife and various disease control strategies is developed and analyzed.The reproduction is derived and its sensitivity to different model parameters is investigated.Meanwhile,the optimal control theory is used to identify a combination of control strategies capable of minimizing the infected human and cattle population over time at minimal costs of implementation.The results indicates that tsetse fly mortality rate is strongly and negatively correlated to the reproduction number.It is also established that tsetse fly feeding rate in strongly and positively correlated to the reproduction number.Simulation results indicates that time dependent control strategies can significantly reduce the infections.Overall,the study shows that screening and treatment of humans may not lead to disease elimination.Combining this strategy with other strategies such as screening and treatment of cattle and vector control strategies will result in maximum reduction of tsetse fly population and disease elimination.
基金supported by the State Key Program of National Natural Science Foundation of China(31530056)the National First-class Discipline Program of Food Science and Technology(JUFSTR20180102)the Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province,China.
文摘It is well known that the gut microbiota plays an extremely important role in modulating host physiological functions such as immunity and metabolic homeostasis.In recent years,accumulated evidence has revealed that the gut microbiota can regulate the functions of the central nervous system(CNS)through the gut-brain axis,which provides a novel insight into the interactions between the gut and brain.This review focuses on the molecular mechanism of the crosstalk between the gut microbiota and the brain via the gut-brain axis,and on the onset and development of neurological disorders triggered by gut microbiota dysbiosis.These topics are followed by a critical analysis of potential intervention strategies targeting gut microbiota dysbiosis,including the use of probiotics,prebiotics,synbiotics,and diets.While research on the microbiota-gut-brain axis is still in its relative infancy,clarifying the molecular mechanism that underlies how the gut microbiota regulates neurological functions not only holds the promise of revealing potentially novel pathogeneses of neurological disorders,but also may lead to the development of potential diagnosis biomarkers and intervention strategies targeting microbiota dysbiosis for neurological disorders.
文摘<span style="font-family:Verdana;"><strong>Intro</strong></span><span style="font-family:Verdana;"><strong>duction:</strong></span><span style="font-family:Verdana;"> Excessive masturbation has for long been reported to affect youths with intervention strategies to intervene </span><span style="font-family:Verdana;">with </span><span style="font-family:Verdana;">this problem rema</span><span style="font-family:""><span style="font-family:Verdana;">ining unclear. This study aimed at determining the underlying factors for excessive masturbation, its effects and intervention strategies used. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a case study design for a youth aged 19 years;affected by excessive masturbation. Data were collected through individual counseling and intervention. It i</span><span style="font-family:Verdana;">nvolved 15 counseling sessions which w</span></span><span style="font-family:Verdana;">ere</span><span style="font-family:Verdana;"> run in nine month</span><span style="font-family:""><span style="font-family:Verdana;">s in a three weeks interval. The sessions involved narration and exploration of the causes and effects of masturbation. Counseling intervention was built in a vicious circle. </span><b><span style="font-family:Verdana;">R</span><span style="font-family:Verdana;">esults:</span></b><span style="font-family:Verdana;"> Several factors, effects and intervention strategies were identified, r</span><span style="font-family:Verdana;">e</span><span style="font-family:Verdana;">ported and discussed in this study. Main causes were such as stories fro</span><span style="font-family:Verdana;">m friends and pornographic videos. Effects were multiple risk behaviors and hea</span><span style="font-family:Verdana;">lth problems. Counseling model for individual was developed. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The study indicates that there are multiple causes and effects of excessive masturbation. Since masturbation is secretly done, the effects are not widely known to many people. Most of these effects are long-term which affects a person psychologically, physically, socially and morally.</span></span>
文摘This editorial explores the significant challenge of intensive care unit-acquiredweakness(ICU-AW),a prevalent condition affecting critically ill patients,characterizedby profound muscle weakness and complicating patient recovery.Highlightingthe paradox of modern medical advances,it emphasizes the urgent needfor early identification and intervention to mitigate ICU-AW's impact.Innovatively,the study by Wang et al is showcased for employing a multilayer perceptronneural network model,achieving high accuracy in predicting ICU-AWrisk.This advancement underscores the potential of neural network models inenhancing patient care but also calls for continued research to address limitationsand improve model applicability.The editorial advocates for the developmentand validation of sophisticated predictive tools,aiming for personalized carestrategies to reduce ICU-AW incidence and severity,ultimately improving patientoutcomes in critical care settings.
基金supported by the National Natural Science Foundation of China(No.72042014).
文摘Like rest of the world,the South Asian region is facing enormous challenges with the coronavirus disease 2019(COVID-19)pandemic.The socio-economic context of the eight South Asian countries is averse to any longterm lockdown program,but the region still observed stringent lockdown close to two months.This paper analyzed major measures in public health preparedness and responses in those countries in the pandemic.The research was based on a situation analysis to discuss appropriate plan for epidemic preparedness,strategies for prevention and control measures,and adequate response management mechanism.Based on the data from March 21 to June 26,2020,it appeared lockdown program along with other control measures were not as effective to arrest the exponential growth of fortnightly COVID-19 cases in Afghanistan,Bangladesh,India,Nepal and Pakistan.However,Bhutan,Maldives and Sri Lanka have been successfully limiting the spread of the disease.The in-depth analysis of prevention and control measures espoused densely populated context of South Asia needs community-led intervention strategy,such as case containment,in order to reverse the growing trend,and adopt the policy of mitigation instead of suppression to formulate COVID-19 action plan.On the other hand,mechanism for response management encompassed a four-tier approach of governance to weave community-led local bodies with state,national and international governance actors for enhancing the countries’emergency operation system.It is concluded resource-crunch countries in South Asia are unable to cope with the disproportionate demand of capital and skilled health care workforce at the time of the pandemic.Hence,response management needs an approach of governance maximization instead of resource maximization.The epidemiologic management of population coupled with suitable public health prevention and control measures may be a more appropriate strategy to strike a balance between economy and population health during the time of pandemic.
文摘AIM To review impacts of interventions involving self-management education, health coaching, and motivational interviewing for type 2 diabetes. METHODS A thorough review of the scientific literature on diabetes care and management was executed by a research team. RESULTS This article summarizes important findings in regard to the validity of developing a comprehensive behavioral system as a framework for empirical investigation. The behavioral system framework consists of patients' knowledge(K), motivation(M), attitude(A), and practice(P) as predictor variables for diabetes care outcomes(O). Care management strategies or health education programs serve as the intervention variable that directly influences K, M, A, and P and then indirectly affects the variability in patient care outcomes of patients with type 2 diabetes. CONCLUSION This review contributes to the understanding of the KMAP-O framework and how it can guide the care management of patients with type 2 diabetes. It will allow the tailoring of interventions to be more effective through knowledge enhancement, increased motivation, attitudinal changes, and improved preventive practice to reduce the progression of type 2 diabetes and comorbidities. Furthermore, the use of health information technology for enhancing changes in KMAP and communications is advocated in health promotion and development.
文摘Job burnout is an important factor affecting the work attitude and professional behavior of family doctors.This paper reviews the measurement tools,influencing factors and intervention strategies of job burnout,it is suggested that improving job burnout can improve job satisfaction,work efficiency and reduce turnover intention of family doctors,and it is of great significance to the construction of family doctor team and the improvement of work quality.
