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Physiological Variance of CD34 Marker’s Content in Twenty Tissues Determining Different Risks of Cardiovascular Diseases and Cancer in Them
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作者 Aleksey N. Shoutko Marat A. Karamullin 《Open Journal of Biophysics》 2025年第1期1-17,共17页
The decreasing of hazard ratio for cancer incidence (HRCVD) in the range of twenty native tissues (lung, liver, brain, hematologic, neuroendocrine renal, pancreas, lymphoid, bladder, colon, lip-oral-head-neck, leukocy... The decreasing of hazard ratio for cancer incidence (HRCVD) in the range of twenty native tissues (lung, liver, brain, hematologic, neuroendocrine renal, pancreas, lymphoid, bladder, colon, lip-oral-head-neck, leukocytic, rectum and anus, thyroid, soft tissue, prostate, skin, ovarian, breast, uterine) as much, as decreasing of the level of cardiovascular pathology (CVD) in the host before malignization, have been described by C.F. Bell et al. in 2023. Earlier, in 2022, the decreasing of 5-year mortality from cancer in similar range of tissues discussed by us as the inverse dependence from the content of stem CD34 markers in tissues before malignization, with example of population in England. In present article we investigate the interrelation between both data more thoroughly, using accessible and more representative populations level of the data. The analysis shows that high level of HRCVD is able to predicts only high cancer death for tissue sites in the beginning of the range, being applied to the referent data of cancer cases and deaths in estimated population of USA 2024. Along with this, an increasing the content of CD34 stem marker in the native tissues of the same range was favorite for increasing of cancer’s cases at the end of the range, diminishing, in parallel, the signs of vasculo-endothelial pathology, i.e. HR CVD. Thus, the cases (incidence) of cancer depend directly rather from content of CD34, which preexisted in native sites, than that from HRCVD. Further analysis shows that CD34 content averaged over twenty cites dominates over that CD2 marker of total T-cells more than 7 times, in oppose to their ratio in the blood. The enhancement of stem CD34 marker in the range of tissues is accompanied by unidirectional rising of its maturing derivatives, vasculo-endothelial CD31 and total T-cells CD2 markers, which contents relate positively to increasing of cancer death in US population 2024. The increase of CD34 decreases cancer mortality (death: cases) in sites, but indirectly, rather due to enhancement of the denominator. The high HRCVD (more than 1.0) in range of 20 tissues, concerns of those of them, which have had highest mitotic activity (by Ki67), but lowest “stemness” (by CD34), “vascularity” (by CD31), cancer’s incidence (cases) and the worse results of therapy. Oppositely, the normal tissue with lowest HRCVD (below 1.0) and Ki67, but highest CD34, CD31, and cancer incidence (cases) are more sensitive to treatment. Thus, the residential hematopoietic “stemness” in native tissues acts as natural protectors for cardio-vascular system and promoter for cancer incidence in them. The steady and irreversible exhaustion of current regenerative resource (CRR) of BM, which assumed by us as a product of CD34 number and average telomeres length, manifests itself in acceleration of non-malignant CVD and deceleration of malignancy in population +70 (in term the death per 105), according to data extracted from WHO Mortality Database. The similar deficit of CD34 arises artificially during cytotoxic treatment of cancer, when rapid waste of local CRR forces malignant cells to search more “stemness” cites. The competition between malignant and native tissues of the host for scanty CRR seems to be the most important factor for evaluation and prediction of prevalence, curability, and long-term results in oncology. 展开更多
关键词 Population Cardiovascular Pathology CANCERS Interrelation TISSUES CD Markers Prognostic Value Revision
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Dreaming Forward: Postidentity and the Generative Thresholds of Tourism
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作者 Keith Hollinshead Alfred B.Vellah 《Journal of Geographical Research》 2020年第4期8-21,共14页
This manuscript from Hollinshead and Vellah calls for researchers in Tourism Studies and related Fields to reflect upon their own role in refreshing the social imaginaries of“after-colonialism”under the nomadisms of... This manuscript from Hollinshead and Vellah calls for researchers in Tourism Studies and related Fields to reflect upon their own role in refreshing the social imaginaries of“after-colonialism”under the nomadisms of our time.Deleuzian in outlook,it positions the“post”of postcolonialism not as an end to colonialism’s imperatives but as a generative-portal through which new-seeds-of-”becoming”are discernable as the postidentities(rather than the“identities”)of populations are interpretable in multidirectional,non-hierarchical,and not easily-predictable ways.In provoking(after Deleuze)thought per rhizomatic processes(rather than via fixed concepts),the manuscript-critiquing these dynamic matters of“postidentity”-then harnesses the insights of(Leela)Ghandi’s on hybrid-nomadic-subjects,and of Venn on alternative-(com)possible-futures.Thereafter,these concerns of and about“after-colonialism”are critically contextualised within Aboriginal“Australia”,via the views of a pool of Indigenous intellectuals there,who synthesise the disruptive dialectics of belonging-cum-aspiration which they maintain that they and fellow Aboriginal people(of many sorts)face today.Throughout this manuscript,the agency and authority of tourism hovers in its sometimes-manifest/sometimes-latent generative power to project empowering postidentities for the world’s“host”or“visited”populations today. 展开更多
关键词 Postcolonialism DELEUZE Becoming PALPATION interrelationality Aboriginality the governmentality of tourism The positive inscriptions(of tourism) The flows of possibility(of tourism)
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Profile, spectrum and significance of hepatitisB virus genotypes in chronic HBV-infected patients in Yunnan, China 被引量:9
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作者 Hutcha Sriplung Virasakdi Chongsuvivatwong Alan Geater 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS 2008年第3期271-279,共9页
BACKGROUND: There are significant variations in the geographical distribution of hepatitis B virus (HBV) genotypes throughout the world, and some genotypes are associated with different clinical outcomes. Eight genoty... BACKGROUND: There are significant variations in the geographical distribution of hepatitis B virus (HBV) genotypes throughout the world, and some genotypes are associated with different clinical outcomes. Eight genotypes of human HBV (designated A-H) have been reported. The present study was designed to examine the distribution of HBV genotypes among patients at various stages of chronic type B liver disease in Yunnan Province, China, and to explore its significance and the relationship of HBV genotype with gender and age, clinical spectrum of chronic HBV infection, and viral replicative activity. METHODS: Serum samples from 126 patients with chronic HBV infection from Yunnan Province, including 26 chronic asymptomatic HBV carriers (ASC), 61 patients with chronic hepatitis B (CHB) (21 mild, 30 moderate and 10 severe), 20 patients with chronic fulminant hepatic failure (CFHF), 12 patients with HBV-related liver cirrhosis (LC) and 7 patients with HBV-related hepatocellular carcinoma (HCC) were analyzed using reverse dot blot (RDB) methodology, which is based on the reverse hybridization principle for HBV genotyping. The relations of HBV genotype with gender and age, clinical patterns, and serological data of the patients were analyzed. RESULTS: In this series, genotypes A, B, C, and D were found. 38.1% patients (48/126) belonged to B, 54.8% (69/126) to C, 0.8% (1/126) to D, 1.6% (2/126) to a mixture of B and C, and 1.6% (2/126) to a mixture of A and C. 3.2% patients (4/126) had unknown genotypes. No other genotypes (E, F, G, and H) were found. Genotypes B and C were predominant. There was a statistically significant difference in the distributions of genotypes C and B (chi(2)=7.04, P=0.008), and C was the dominant genotype in all patient categories. The rate of genotype B in the mild CHB group was significantly higher than that in the moderate and severe groups (chi(2)=12.16, P=0.0001; chi(2)=11.98, P=0.001, respectively), the ASC group (chi(2)=5.46, P=0.02), the CFHF group (chi(2)=5.53, P=0.019), and the LC/HCC group (chi(2)=12.13, P=0.001). The rate of genotype C in the LC/HCC group and the severe CHB group were significantly higher than that in the mild group (chi(2)=9.95, P=0.002; chi(2)=8.78, P=0.003, respectively). HBV DNA positivity and HBeAg positivity were higher in genotype C than in genotype B (chi(2)=9.81, P=0.002; chi(2)=3.85, P=0.05, respectively). The prevalence of genotype C showed an increasing trend in lowest-, middle- and highest-level groups of HBV replication (25.0%, 70.0%, and 55.6%, respectively); in contrast, the prevalence of genotype B showed an opposite trend in the same order (62.5%, 30.0%, and 37.0%, respectively). The rate of genotype C in the highest-level group of HBV replication was higher than genotype B (chi(2)=7.45, P=0.006). The rate of genotype C in the over-30 age group was higher than that in the below-30 age group (chi(2)=3.7, P=0.05). There was no difference between the sexes (P>0.05). More severe liver damage was found in genotype C than in genotype B (P<0.05). CONCLUSIONS: The predominant HBV genotypes in chronic HBV-infected patients are B and C, and C is the most prevalent genotype in Yunnan Province, China. HBV genotype C is associated with the development of more severe liver disease and a higher level of HBV viral replication, and genotype B has a relatively good progress. 展开更多
关键词 hepatitis B virus GENOTYPE reverse dot blot distribution clinical interrelation
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Experimental study on the interrelation of multiple mechanical parameters in overburden rock caving process during coal mining in longwall panel 被引量:1
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作者 Daixin Deng Hongwei Wang +2 位作者 Lili Xie Zeliang Wang Jiaqi Song 《International Journal of Coal Science & Technology》 EI CAS CSCD 2023年第4期265-289,共25页
In order to comprehend the dynamic disaster mechanism induced by overburden rock caving during the advancement of a coal mining face, a physical simulation model is constructed basing on the geological condition of th... In order to comprehend the dynamic disaster mechanism induced by overburden rock caving during the advancement of a coal mining face, a physical simulation model is constructed basing on the geological condition of the 21221 mining face at Qianqiu coal mine in Henan Province, China. This study established, a comprehensive monitoring system to investigate the interrelations and evolutionary characteristics among multiple mechanical parameters, including mining-induced stress, displacement, temperature, and acoustic emission events during overburden rock caving. It is suggested that, despite the uniformity of the overburden rock caving interval, the main characteristic of overburden rock lies in its uneven caving strength. The mining-induced stress exhibits a reasonable interrelation with the displacement, temperature, and acoustic emission events of the rock strata. With the advancement of the coal seam, the mining-induced stress undergoes four successive stages: gentle stability, gradual accumulation, high-level mutation, and a return to stability. The variations in other mechanical parameters does not synchronize with the signifcant changes in mining-induced stress. Before the collapse of overburden rock occurs, rock strata temperature increment decreases and the acoustic emission ringing counts surges with the increase of rock strata displacement and mining-induced stress. Therefore, the collaborative characteristics of mining-induced stress, displacement, temperature, and acoustic emission ringing counts can be identifed as the precursor information or overburden rock caving. These results are in good consistent with on-site situation in the coal mine. 展开更多
关键词 Overburden rock caving Multiple mechanical parameters Interrelation characterization Precursor information
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Interrelation among several important links in seismic risk analysis
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作者 黄玮琼 吴宣 《Acta Seismologica Sinica(English Edition)》 EI CSCD 2006年第3期284-291,共8页
In order to further reveal the interrelation among division of seismic statistical regions, delimitation of potential seismic sources and estimation of seismicity parameters, we select 21 representative sites located ... In order to further reveal the interrelation among division of seismic statistical regions, delimitation of potential seismic sources and estimation of seismicity parameters, we select 21 representative sites located in different places within the range of 100°-120°E, 29°-42°N to study the influences of seismicity parameter uncertainties of statistical regions on seismic risk estimations of these sites in the inhomogeneous and homogeneous distribution models. Combining the results from this study and previous ones, we can see that different schemes for dividing seismic statistical regions can change the seismic data in a statistical region. The uncertain data and additional uncertainty in selecting time intervals for seismic statistics will result in uncertainty of seismicity parameters estimation in a statistical region. For the homogeneous model, the larger the variation of this uncertainty is, the greater the uncertain influence on the seismic risk estimation of a site will be, which means that the division of seismic statistical regions makes a major contribution. In a seismic statistical region, the delimitation of potential sources and variant weight assignment of spatial distribution functions can raise the estimated values of ground motion parameters in the place where great earthquake might occur and its vicinity. In these places, the influence of uncertainty in potential source delimitation is very obvious, especially on the absolute magnitude of ground motion parameters (e.g., intensity), which means that the link of potential source delimitation makes a major effect. Generally speaking, the link of potential source delimitation affects mainly the sites located in the potential sources with the highest and second-high upper-limit earthquake magnitudes or in the vicinity of those with the highest upper-limit magnitude. While for the sites located in the potential sources with low upper-imit magnitudes, the uncertainty influence of statistical region division is larger than that of potential source delimitation. 展开更多
关键词 seismic statistical region seismicity parameter potential seismic source homogeneous distribution inhomogeneous distribution uncertainty interrelation
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Grey Interrelation Analysis for the Use of Rare Earths and the Elements in Soil in Growing Cotton
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作者 张殿香 孙立德 牛殿礼 《Journal of Rare Earths》 SCIE EI CAS CSCD 1995年第4期290-294,共5页
The method of grey interrelation analysis is adopted for the analysis of the relationship between the amount of rare earths applied and the factors of the soil in increasing cotton production in Kazuo County, Liaonin... The method of grey interrelation analysis is adopted for the analysis of the relationship between the amount of rare earths applied and the factors of the soil in increasing cotton production in Kazuo County, Liaoning Province. The results show that there is an intimate relation between the use of the RE and the elements in the soil. The pH value, total K, and total P are the main factors influencing the relation, and the total N, hydrolytable N, organic matter, K2O and P2O5 are the secondary factors. This provides a scientific basis for the use of the RE. 展开更多
关键词 COTTON Rare Earth (RE) Elements in soil Grey interrelation analysis (GIA)
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Dynamic Variation and Correlation of Pericarp Tenderness and Component Contents of Super Sweet Corn(sh_(2))in Kernel Development
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作者 Shilong ZHANG Xiaoqin LI +1 位作者 Zhenghua HE Yiqin HUANG 《Agricultural Biotechnology》 CAS 2022年第4期26-31,35,共7页
Data on the mechanism of how pericarp components in fresh sweet corn affect pericarp tenderness are scarce.This study explored variation and correlation of pericarp tenderness and components over time in three inbred ... Data on the mechanism of how pericarp components in fresh sweet corn affect pericarp tenderness are scarce.This study explored variation and correlation of pericarp tenderness and components over time in three inbred lines of sweet corn that were selected for their differences in pericarp tenderness.The three lines presented a curvilinear increase in pericarp tenderness(puncture reading)from 12 to 24 d after pollination(DAP)across two environments,with the means at each time point always in the same order:S33205>T105>PE10.Pericarp tenderness difference at each same time point in two environments over time varied similarly in each of the three inbred lines:increasing first,then dropping after peak,and insignificant at the end.Of the main pericarp components,mean contents were in the order:hemicellulose>cellulose>lignin in both environments at each time point for the three inbred lines.As the pericarp developed,hemicellulose content increased gradually,lignin content varied along a single-peak curve,cellulose content fluctuated around 24%,and pectin and ash contents changed slightly and irregularly.The pericarp of PE10,with the most tender pericarp,accumulated hemicellulose faster than other two lines.Hemicellulose and lignin contents were significantly correlated with pericarp tenderness,and the main components affected pericarp tenderness. 展开更多
关键词 Super sweet corn Pericarp tenderness Main ingredients Growth curve Interrelation
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中外优秀男子体操运动员全能成绩的结构特征
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《浙江体育科学》 北大核心 1999年第4期65-69,共5页
关键词 MEN GYMNASTICS all-round individual EVENT interrelation
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Fan‐hinged shear instead of frictional stick–slip as the main and most dangerous mechanism of natural,induced,and volcanic earthquakes in the earth's crust
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作者 Boris G.Tarasov 《Deep Underground Science and Engineering》 2023年第4期305-336,共32页
Frictional stick–slip instability along pre‐existing faults has been accepted as the main mechanism of earthquakes for about 60 years,since it is believed that fracture of intact rocks cannot reflect such features in... Frictional stick–slip instability along pre‐existing faults has been accepted as the main mechanism of earthquakes for about 60 years,since it is believed that fracture of intact rocks cannot reflect such features inherent in earthquakes as low shear stresses activating instability,low stress drop,repetitive dynamic instability,and connection with pre‐existing faults.This paper demonstrates that all these features can be induced by a recently discovered shear rupture mechanism(fan‐hinged),which creates dynamic ruptures in intact rocks under stress conditions corresponding to seismogenic depths.The key element of this mechanism is the fan‐shaped structure of the head of extreme ruptures,which is formed as a result of an intense tensile cracking process,with the creation of inter‐crack slabs that act as hinges between the shearing rupture faces.The preference of the fan mechanism over the stick–slip mechanism is clear due to the extraordinary properties of the fan structure,which include the ability to generate new faults in intact dry rocks even at shear stresses that are an order of magnitude lower than the frictional strength;to provide shear resistance close to zero and abnormally large energy release;to cause a low stress drop;to use a new physics of energy supply to the rupture tip,providing supersonic rupture velocity;and to provide a previously unknown interrelation between earthquakes and volcanoes.All these properties make the fan mechanism the most dangerous rupture mechanism at the seismogenic depths of the earth's crust,generating the vast majority of earthquakes.The detailed analysis of the fan mechanism is presented in the companion paper“New physics of supersonic ruptures”published in DUSE.Further study of this subject is a major challenge for deep underground science,earthquake and fracture mechanics,volcanoes,physics,and tribology. 展开更多
关键词 earthquake and rockburst mechanisms interrelation of earthquakes and volcanoes physics of supersonic ruptures postpeak rock properties rock rupture mechanism rupture energy budget
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ANALYSIS OF REGIONAL ECONOMY GROWTH WITH THE THEORY OF DIFFERENTIAL SYSTEM DYNAMICS 被引量:1
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作者 XU Jiuping LIU Jicheng (School of Business and Administration, Sichuan University, Chengdu 610065, China) 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2003年第4期541-549,共9页
In order to describe the interrelation forces among different regions during the economic growth, this paper introduces and analyzes the dynamical system model with the theory of differential systems dynamics. A pract... In order to describe the interrelation forces among different regions during the economic growth, this paper introduces and analyzes the dynamical system model with the theory of differential systems dynamics. A practical example based on a simplified model is given to analyze the dynamical process of Sichuan economy growth. 展开更多
关键词 differential systems dynamics interrelation population migration
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