A new method based on the iterative adaptive algorithm(IAA)and blocking matrix preprocessing(BMP)is proposed to study the suppression of multi-mainlobe interference.The algorithm is applied to precisely estimate the s...A new method based on the iterative adaptive algorithm(IAA)and blocking matrix preprocessing(BMP)is proposed to study the suppression of multi-mainlobe interference.The algorithm is applied to precisely estimate the spatial spectrum and the directions of arrival(DOA)of interferences to overcome the drawbacks associated with conventional adaptive beamforming(ABF)methods.The mainlobe interferences are identified by calculating the correlation coefficients between direction steering vectors(SVs)and rejected by the BMP pretreatment.Then,IAA is subsequently employed to reconstruct a sidelobe interference-plus-noise covariance matrix for the preferable ABF and residual interference suppression.Simulation results demonstrate the excellence of the proposed method over normal methods based on BMP and eigen-projection matrix perprocessing(EMP)under both uncorrelated and coherent circumstances.展开更多
The rising prevalence of multidrug-resistant pathogens poses a substantial threat to global healthcare systems,demanding urgent therapeutic interventions.Microorganisms exhibit diverse resistance mechanisms against va...The rising prevalence of multidrug-resistant pathogens poses a substantial threat to global healthcare systems,demanding urgent therapeutic interventions.Microorganisms exhibit diverse resistance mechanisms against various classes of antibiotics,highlighting the urgent need to discover novel antimicrobial agents for combating bacterial infections.Anti-virulence therapy has emerged as a promising therapeutic strategy that neutralizes pathogens by targeting their virulence determinants.The strategies for screening virulence arresting drugs(VADs)in bacteria represent a multifaceted approach that involves elucidating molecular pathogenesis mechanisms of bacterial pathogenicity,identifying evolutionarily conserved virulence factors across different pathogens,and employing integrated approaches combining in silico prediction with experimental validation.Recent technological advancements have established standardized protocols for effective identification and validation of anti-virulence compounds.This review systematically examines contemporary screening methodologies,primarily focusing on quorum-sensing disruption and biofilm suppression strategies,including in silico screening,activity-based screening with bioassays,in vitro and in vivo models.Additionally,we emphasize the imperative for standardized preclinical validation through physiologically relevant animal models,while proposing framework recommendations for developing next-generation VAD screening platforms.This synthesis not only outlines current best practices but also proposes innovative avenues for future antimicrobial discovery research.展开更多
A method for correlating thermal light over a wide spectral range is proposed.A multi-wavelength pseudothermal source,prepared by projecting laser beams of multiple wavelengths(650 nm,635 nm,532 nm,and 473 nm)onto a m...A method for correlating thermal light over a wide spectral range is proposed.A multi-wavelength pseudothermal source,prepared by projecting laser beams of multiple wavelengths(650 nm,635 nm,532 nm,and 473 nm)onto a moving thin ground glass plate,is employed in a double-slit interference experiment.The ground glass plate induces random phase differences between light beams of different wavelengths passing through it.This initial random phase difference significantly influences the high-order intensity correlation functions of multi-wavelength thermal beams.Experimentally,second-order correlated interference patterns,including subwavelength interference,of pseudothermal beams with different wavelengths are observed in the intensity correlation measurements.This method facilitates applications of correlated thermal photons in quantum information processing and quantum imaging.展开更多
With the rapid development of intelligent electronic and military equipment,multifunctional flexible materials that integrat electromagnetic interference(EMI)shielding,temperature sensing,and information encryption ar...With the rapid development of intelligent electronic and military equipment,multifunctional flexible materials that integrat electromagnetic interference(EMI)shielding,temperature sensing,and information encryption are urgently required.This study presents a bio-inspired hierarchical composite foam fabricated using supercritical nitrogen foaming technology.This material exhibits a honeycomb structure,with pore cell sizes controllable within a range of 30–92μm by regulating the filler.The carbon fiber felt(CFf)provides efficient reflection of electromagnetic waves,while the chloroprene rubber/carbon fiber/carbon black foam facilitates both wave absorption and temperature monitoring through its optimized conductive network.This synergistic mechanism results in an EMI shielding effectiveness(SE)of 60.06 d B with excellent temperature sensing performance(The temperature coefficient of resistance(TCR)is-2.642%/℃)in the 24–70℃ range.Notably,the material has a thermal conductivity of up to 0.159 W/(m·K),and the bio-inspired layered design enables information encryption,demonstrating the material's potential for secure communication applications.The foam also has tensile properties of up to 5.13 MPa and a tear strength of 33.02 N/mm.This biomimetic design overcomes the traditional limitations of flexible materials and provides a transformative solution for next-generation applications such as flexible electronics,aerospace systems and military equipment,which urgently need integrated electromagnetic protection,thermal management and information security.展开更多
High-precision optical frequency measurement serves as a cornerstone of modern science and technology,enabling advancements in fields ranging from fundamental physics to quantum information technologies.Obtaining prec...High-precision optical frequency measurement serves as a cornerstone of modern science and technology,enabling advancements in fields ranging from fundamental physics to quantum information technologies.Obtaining precise photon frequencies,especially in the ultraviolet or even extreme ultraviolet regimes,is a key goal in both light–matter interaction experiments and engineering applications.High-order harmonic generation(HHG)is an ideal light source for producing such photons.In this work,we propose an optical temporal interference model(OTIM)that establishes an analogy with multi-slit Fraunhofer diffraction(MSFD)to manipulate fine-frequency photon generation by exploiting the temporal coherence of HHG processes.Our model provides a unified physical framework for three distinct non-integer HHG generation schemes:single-pulse,shaped-pulse,and laser pulse train approaches,which correspond to single-MSFD-like,double-MSFD-like,and multi-MSFD-like processes,respectively.Arbitrary non-integer HHG photons can be obtained using our scheme.Our approach provides a new perspective for accurately measuring and controlling photon frequencies in fields such as frequency comb technology,interferometry,and atomic clocks.展开更多
Brain lesions,such as those caused by stroke or traumatic brain injury(TBI),frequently result in persistent motor and cognitive impairments that significantly affect the individual patient's quality of life.Despit...Brain lesions,such as those caused by stroke or traumatic brain injury(TBI),frequently result in persistent motor and cognitive impairments that significantly affect the individual patient's quality of life.Despite differences in the mechanisms of injury,both conditions share a high prevalence of motor and cognitive impairments.These deficits show only limited natural recovery.展开更多
In dry-coupled ultrasonic thickness measurement,thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy.Existing methods struggle to resolve overlap-pin...In dry-coupled ultrasonic thickness measurement,thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy.Existing methods struggle to resolve overlap-ping echoes under variable coupling conditions and non-stationary noise.This study proposes a novel dual-criterion framework integrating energy contribution and statistical impulsivity metrics to isolate specimen re-flections from coupling-layer interference.By decomposing A-scan signals into Intrinsic Mode Functions(IMFs),the framework employs energy contribution thresholds(>85%)and kurtosis indices(>3)to autonomously select IMFs containing valid specimen echoes.Hybrid time-frequency thresholding further suppresses interference through amplitude filtering and spectral focusing.Experimental results demonstrate the framework’s robustness,achieving 92.3%thickness accuracy for 5 mm steel specimens with 5 mm rubber coupling,outperforming conventional methods by up to 18.7%.The dual-criterion approach reduces operator dependency by 37%and maintainsΔT<0.03 mm under surface roughness up to 6.3μm,offering a practical solution for industrial nondestructive testing with thick dry-coupled interfaces.展开更多
Amplitude variations with offset or incident angle （AVO/AVA） inversion are typically combined with statistical methods, such as Bayesian inference or deterministic inversion. We propose a joint elastic inversion met...Amplitude variations with offset or incident angle （AVO/AVA） inversion are typically combined with statistical methods, such as Bayesian inference or deterministic inversion. We propose a joint elastic inversion method in the time and frequency domain based on Bayesian inversion theory to improve the resolution of the estimated P- and S-wave velocities and density. We initially construct the objective function using Bayesian inference by combining seismic data in the time and frequency domain. We use Cauchy and Gaussian probability distribution density functions to obtain the prior information for the model parameters and the likelihood function, respectively. We estimate the elastic parameters by solving the initial objective function with added model constraints to improve the inversion robustness. The results of the synthetic data suggest that the frequency spectra of the estimated parameters are wider than those obtained with conventional elastic inversion in the time domain. In addition, the proposed inversion approach offers stronger antinoising compared to the inversion approach in the frequency domain. Furthermore, results from synthetic examples with added Gaussian noise demonstrate the robustness of the proposed approach. From the real data, we infer that more model parameter details can be reproduced with the proposed joint elastic inversion.展开更多
Due to the strong electromagnetic interferences and human interference,traditional electromagnetic methods cannot obtain high quality resistivity data of mineral deposits in Chinese mines.The wide field electromagneti...Due to the strong electromagnetic interferences and human interference,traditional electromagnetic methods cannot obtain high quality resistivity data of mineral deposits in Chinese mines.The wide field electromagnetic method(WFEM),in which the pseudo-random signal is taken as the transmitter source,can extract high quality resistivity data in areas with sever interference by only measuring the electric field component.We use the WFEM to extract the resistivity information of the Dongguashan mine in southeast China.Compared with the audio magnetotelluric(AMT)method,and the controlled source audio-frequency magnetotelluric(CSAMT) method,the WFEM can obtain data with higher quality and simpler operations.The inversion results indicate that the WFEM can accurately identify the location of the main ore-body,which can be used for deep mine exploration in areas with strong interference.展开更多
A novel communication receiver which uses lapped transform(LT) incorporating modified median filter(MMF) algorithm was designed for narrow band interference(NBI) excision.Comparing to traditional Fourier Transform,LT ...A novel communication receiver which uses lapped transform(LT) incorporating modified median filter(MMF) algorithm was designed for narrow band interference(NBI) excision.Comparing to traditional Fourier Transform,LT has longer basis vectors,less spectral leakage,thus better frequency resolution.The LT domain MMF algorithm takes full advantages of the direct sequence spread spectrum signal,as well as the characteristics of LT,performs the transform domain filtering twice.The first filtering locates the position of interference and mitigates most of them.The second filtering is performed in a small neighborhood of the located interference.So LT domain MMF algorithm can completely mitigate the interference without distorting the desired signal.The simulation results demonstrate the improved BER(Bit Error Rate)performance and increased robustness of our receiver.展开更多
Robust, ultra-flexible, and multifunctional MXene-basedelectromagnetic interference (EMI) shielding nanocomposite filmsexhibit enormous potential for applications in artificial intelligence,wireless telecommunication,...Robust, ultra-flexible, and multifunctional MXene-basedelectromagnetic interference (EMI) shielding nanocomposite filmsexhibit enormous potential for applications in artificial intelligence,wireless telecommunication, and portable/wearable electronic equipment.In this work, a nacre-inspired multifunctional heterocyclic aramid(HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper withlarge-scale, high strength, super toughness, and excellent tolerance tocomplex conditions is fabricated through the strategy of HA/MXenehydrogel template-assisted in-situ assembly of PPy. Benefiting from the"brick-and-mortar" layered structure and the strong hydrogen-bondinginteractions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa),outstanding toughness (57.6 MJ m−3), exceptional foldability, and structural stability against ultrasonication. By using the template effect ofHA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly,the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dBat an ultra-thin thickness (25.4 μm) and a high specific EMI SE of 17,204.7 dB cm2g−1. In addition, the papers also have excellent applicationsin electromagnetic protection, electro-/photothermal de-icing, thermal therapy, and fire safety. These findings broaden the ideas for developinghigh-performance and multifunctional MXene-based films with enormous application potential in EMI shielding and thermal management.展开更多
This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the at...This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the attacker and the capability to defend the GNSS during navigation countermeasures.Key evaluation indicators for the jamming effect of GNSS suppressive and deceptive jamming sources are first created,their evaluation models are built,and their detection procedures are sorted out,as the basis for determining the deployment principles.The principles for collaboratively deploying multi-jamming sources are developed to obtain the deployment structures(including the required number,structures in demand,and corresponding positions)of three single interference sources required by collaboratively deploying.Accordingly,simulation and hardware-in-loop testing results are presented to determine a rational configuration of the collaborative deployment of multi-jamming sources in the set situation and further realize the full-domain deployment of an interference network from ground,air to space.Varied evaluation indices for the deployment effect are finally developed to evaluate the deployment effect of the proposed configuration and further verify its reliability and rationality.展开更多
Electromagnetic interference(EMI)shielding materials with superior shielding efficiency and low-reflection properties hold promising potential for utilization across electronic components,precision instruments,and fif...Electromagnetic interference(EMI)shielding materials with superior shielding efficiency and low-reflection properties hold promising potential for utilization across electronic components,precision instruments,and fifth-generation communication equipment.In this study,multistage microcellular waterborne polyurethane(WPU)composites were constructed via gradient induction,layer-by-layer casting,and supercritical carbon dioxide foaming.The gradient-structured WPU/ironcobalt loaded reduced graphene oxide(FeCo@rGO)foam serves as an impedance-matched absorption layer,while the highly conductive WPU/silver loaded glass microspheres(Ag@GM)layer is employed as a reflection layer.Thanks to the incorporation of an asymmetric structure,as well as the introduction of gradient and porous configurations,the composite foam demonstrates excellent conductivity,outstanding EMI SE(74.9 dB),and minimal reflection characteristics(35.28%)in 8.2-12.4 GHz,implying that more than 99.99999%of electromagnetic(EM)waves were blocked and only 35.28%were reflected to the external environment.Interestingly,the reflectivity of the composite foam is reduced to 0.41%at 10.88 GHz due to the resonance for incident and reflected EM waves.Beyond that,the composite foam is characterized by low density(0.47 g/cm^(3))and great stability of EMI shielding properties.This work offers a viable approach for craft-ing lightweight,highly shielding,and minimally reflective EMI shielding composites.展开更多
The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use e...The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use efficiency and enhancing crop stress resistance.Nevertheless,the precise interaction between soil warming(SW)and SN remains unclear.In order to ascertain the impact of SW on maize growth and whether SN can improve the tolerance of maize to SW,a two-year field experiment was conducted(2022-2023).The aim was to examine the influence of two SW ranges(MT,warming 1.40℃;HT,warming 2.75℃)and two nitrogen application methods(N1,one-time basal application of nitrogen fertilizer;N2,one third of base nitrogen fertilizer+two thirds of jointing stage supplemental nitrogen fertilizer)on maize root growth,photosynthetic characteristics,nitrogen use efficiency,and yield.The results demonstrated that SW impeded root growth and precipitated the premature aging of maize leaves following anthesis,particularly in the HT,which led to a notable reduction in maize yield.In comparison to N1,SN has been shown to increase root length density by 8.54%,root bleeding rate by 8.57%,and enhance root distribution ratio in the middle soil layers(20-60 cm).The interaction between SW and SN had a notable impact on maize growth and yield.The SN improved the absorption and utilization efficiency of nitrogen by promoting root development and downward canopy growth,thus improving the tolerance of maize to SW at the later stage of growth.In particular,the N2HT resulted in a 14.51%increase in the photosynthetic rate,a 18.58%increase in nitrogen absorption efficiency,and a 18.32%increase in maize yield compared with N1HT.It can be posited that the SN represents a viable nitrogen management measure with the potential to enhance maize tolerance to soil high-temperature stress.展开更多
Fusarium ear rot(FER),caused by Fusarium verticillioides,is a destructive fungal disease of maize.FER resistance is a complex,quantitatively inherited trait controlled by multiple minor-effect genes.In this study,we e...Fusarium ear rot(FER),caused by Fusarium verticillioides,is a destructive fungal disease of maize.FER resistance is a complex,quantitatively inherited trait controlled by multiple minor-effect genes.In this study,we employed two recombinant inbred line(RIL)populations with the common resistant parental line CML304 to identify FER-resistance loci.Initial QTL analysis identified 23 FER-resistance QTL,each explaining 5.21%-30.51%of the total phenotypic variation.Notably,one major QTL,qRfv2,on chromosome 2 was repeatedly detected,accounting for 11.92%-30.51%of the total phenotypic variation.qRfv2 was fine mapped to an interval of 1.01 Mb,flanked by the markers IDP8 and IDP10.qRfv2 is a semidominant resistance gene that could reduce the disease severity index(DSI)by 12.4%-20%,suggesting its potential for enhancing FER resistance in maize.Transcriptome analysis showed that 22 of the 28 annotated functional genes in the qRfv2 region displayed differential expression between parental lines in response to FER.One of the candidate genes,ZmLOX6,was validated to presumably provide a positive effect on FER resistance.Our study provides a basis for the potential cloning and application of FER resistance genes in maize breeding.展开更多
Interference significantly impacts the performance of the Global Navigation Satellite Systems(GNSS),highlighting the need for advanced interference localization technology to bolster anti-interference and defense capa...Interference significantly impacts the performance of the Global Navigation Satellite Systems(GNSS),highlighting the need for advanced interference localization technology to bolster anti-interference and defense capabilities.The Uniform Circular Array(UCA)enables concurrent estimation of the Direction of Arrival(DOA)in both azimuth and elevation.Given the paramount importance of stability and real-time performance in interference localization,this work proposes an innovative approach to reduce the complexity and increase the robustness of the DOA estimation.The proposed method reduces computational complexity by selecting a reduced number of array elements to reconstruct a non-uniform sparse array from a UCA.To ensure DOA estimation accuracy,minimizing the Cramér-Rao Bound(CRB)is the objective,and the Spatial Correlation Coefficient(SCC)is incorporated as a constraint to mitigate side-lobe.The optimization model is a quadratic fractional model,which is solved by Semi-Definite Relaxation(SDR).When the array has perturbations,the mathematical expressions for CRB and SCC are re-derived to enhance the robustness of the reconstructed array.Simulation and hardware experiments validate the effectiveness of the proposed method in estimating interference DOA,showing high robustness and reductions in hardware and computational costs associated with DOA estimation.展开更多
With the boom in maritime activities,the need for highly reliable maritime communication is becoming urgent,which is an important component of 5G/6G communication networks.However,the bandwidth reuse characteristic of...With the boom in maritime activities,the need for highly reliable maritime communication is becoming urgent,which is an important component of 5G/6G communication networks.However,the bandwidth reuse characteristic of 5G/6G networks will inevitably lead to severe interference,resulting in degradation in the communication performance of maritime users.In this paper,we propose a safe deep reinforcement learning based interference coordination scheme to jointly optimize the power control and bandwidth allocation in maritime communication systems,and exploit the quality-of-service requirements of users as the risk value references to evaluate the communication policies.In particular,this scheme designs a deep neural network to select the communication policies through the evaluation network and update the parameters using the target network,which improves the communication performance and speeds up the convergence rate.Moreover,the Nash equilibrium of the interference coordination game and the computational complexity of the proposed scheme are analyzed.Simulation and experimental results verify the performance gain of the proposed scheme compared with benchmarks.展开更多
As modern communication and detection technologies advance at a swift pace,multifunctional electromagnetic interference(EMI)shielding materials with active/positive infrared stealth,hydrophobicity,and electric-thermal...As modern communication and detection technologies advance at a swift pace,multifunctional electromagnetic interference(EMI)shielding materials with active/positive infrared stealth,hydrophobicity,and electric-thermal conversion ability have received extensive attention.Meeting the aforesaid requirements simultaneously remains a huge challenge.In this research,the melamine foam(MF)/polypyrrole(PPy)nanowire arrays(MF@PPy)were fabricated via one-step electrochemical polymerization.The hierarchical MF@PPy foam was composed of three-dimensional PPy micro-skeleton and ordered PPy nanowire arrays.Due to the upwardly grown PPy nanowire arrays,the MF@PPy foam possessed good hydrophobicity ability with a water contact angle of 142.00°and outstanding stability under various harsh environments.Meanwhile,the MF@PPy foam showed excellent thermal insulation property on account of the low thermal conductivity and elongated ligament characteristic of PPy nanowire arrays.Furthermore,taking advantage of the high conductivity(128.2 S m^(-1)),the MF@PPy foam exhibited rapid Joule heating under 3 V,resulting in dynamic infrared stealth and thermal camouflage effects.More importantly,the MF@PPy foam exhibited remarkable EMI shielding effectiveness values of 55.77 dB and 19,928.57 dB cm^(2)g^(-1).Strong EMI shielding was put down to the hierarchically porous PPy structure,which offered outstanding impedance matching,conduction loss,and multiple attenuations.This innovative approach provides significant insights to the development of advanced multifunctional EMI shielding foams by constructing PPy nanowire arrays,showing great applications in both military and civilian fields.展开更多
Flexible multifunctional polymer-based electromagnetic interference(EMI)shielding composite films play a pivotal role in 5 G communication technology,smart wearables,automotive electronics,and aerospace.In this work,(...Flexible multifunctional polymer-based electromagnetic interference(EMI)shielding composite films play a pivotal role in 5 G communication technology,smart wearables,automotive electronics,and aerospace.In this work,(Ti_(3)C_(2)T_(x) MXene/cellulose nanofibers(CNF)-(hydroxy‑functionalized BNNS(BNNS-OH)/CNF)composite films(TBCF)with Janus structure are prepared via vacuum-assisted filtration of BNNS-OH/CNF and Ti_(3)C_(2)T_(x)/CNF suspension by one after another.Then ionic bonding-strengthened TBCF(ITBCF)is obtained by Ca^(2+)ion infiltration and cold-pressing technique.The Janus structure endows ITBCF with the unique“conductive on one side and insulating on the other”property.When the mass ratio of Ti_(3)C_(2)T_(x) and BNNS is 1:1 and the total mass fraction is 70 wt.%,the electrical conductivity(σ)of the Ti_(3)C_(2)T_(x)/CNF side of ITBCF reaches 166.7 S/cm,while the surface resistivity of the BNNS-OH/CNF side is as high as 304 MΩ.After Ca^(2+)ion infiltration,the mechanical properties of ITBCF are significantly enhanced.The tensile strength and modulus of ITBCF are 73.5 MPa and 15.6 GPa,which are increased by 75.9%and 46.2%compared with those of TBCF,respectively.Moreover,ITBCF exhibits outstanding EMI shielding effectiveness(SE)of 57 dB and thermal conductivity(λ)of 9.49 W/(m K).In addition,ITBCF also presents excellent photothermal and photoelectric energy conversion performance.Under simulated solar irradiation with a power density of 120 mW/cm^(2),the surface stabilization temperature reaches up to 65.3°C and the maximum steady state voltage reaches up to 58.2 mV.展开更多
Temporal interference(TI)is a form of stimulation that epitomizes an innovative and non-invasive approach for profound neuromodulation of the brain,a technique that has been validated in mice.Yet,the thin cranial bone...Temporal interference(TI)is a form of stimulation that epitomizes an innovative and non-invasive approach for profound neuromodulation of the brain,a technique that has been validated in mice.Yet,the thin cranial bone structure of mice has a marginal influence on the effect of the TI technique and may not effectively showcase its effectiveness in larger animals.Based on this,we carried out TI stimulation experiments on rats.Following the TI intervention,analysis of electrophysiological data and immunofluorescence staining indicated the generation of a stimulation focus within the nucleus accumbens(depth,8.5 mm)in rats.Our findings affirm the viability of the TI methodology in the presence of thick cranial bones,furnishing efficacious parameters for profound stimulation with TI administered under such conditions.This experiment not only sheds light on the intervention effects of TI deep in the brain but also furnishes robust evidence in support of its prospective clinical utility.展开更多
基金The National Natural Science Foundation of China(No.U19B2031).
文摘A new method based on the iterative adaptive algorithm(IAA)and blocking matrix preprocessing(BMP)is proposed to study the suppression of multi-mainlobe interference.The algorithm is applied to precisely estimate the spatial spectrum and the directions of arrival(DOA)of interferences to overcome the drawbacks associated with conventional adaptive beamforming(ABF)methods.The mainlobe interferences are identified by calculating the correlation coefficients between direction steering vectors(SVs)and rejected by the BMP pretreatment.Then,IAA is subsequently employed to reconstruct a sidelobe interference-plus-noise covariance matrix for the preferable ABF and residual interference suppression.Simulation results demonstrate the excellence of the proposed method over normal methods based on BMP and eigen-projection matrix perprocessing(EMP)under both uncorrelated and coherent circumstances.
基金supported by the National Natural Science Foundation of China(Grant No:82474158)the Natural Science Foundation of Sichuan Province,China(Grant No.:2024NSFSC0708).
文摘The rising prevalence of multidrug-resistant pathogens poses a substantial threat to global healthcare systems,demanding urgent therapeutic interventions.Microorganisms exhibit diverse resistance mechanisms against various classes of antibiotics,highlighting the urgent need to discover novel antimicrobial agents for combating bacterial infections.Anti-virulence therapy has emerged as a promising therapeutic strategy that neutralizes pathogens by targeting their virulence determinants.The strategies for screening virulence arresting drugs(VADs)in bacteria represent a multifaceted approach that involves elucidating molecular pathogenesis mechanisms of bacterial pathogenicity,identifying evolutionarily conserved virulence factors across different pathogens,and employing integrated approaches combining in silico prediction with experimental validation.Recent technological advancements have established standardized protocols for effective identification and validation of anti-virulence compounds.This review systematically examines contemporary screening methodologies,primarily focusing on quorum-sensing disruption and biofilm suppression strategies,including in silico screening,activity-based screening with bioassays,in vitro and in vivo models.Additionally,we emphasize the imperative for standardized preclinical validation through physiologically relevant animal models,while proposing framework recommendations for developing next-generation VAD screening platforms.This synthesis not only outlines current best practices but also proposes innovative avenues for future antimicrobial discovery research.
基金supported by the National Natural Science Foundation of China(Grant Nos.62105278 and 11674273)the Natural Science Foundation of Shandong Province(Grant No.ZR2023MA015)。
文摘A method for correlating thermal light over a wide spectral range is proposed.A multi-wavelength pseudothermal source,prepared by projecting laser beams of multiple wavelengths(650 nm,635 nm,532 nm,and 473 nm)onto a moving thin ground glass plate,is employed in a double-slit interference experiment.The ground glass plate induces random phase differences between light beams of different wavelengths passing through it.This initial random phase difference significantly influences the high-order intensity correlation functions of multi-wavelength thermal beams.Experimentally,second-order correlated interference patterns,including subwavelength interference,of pseudothermal beams with different wavelengths are observed in the intensity correlation measurements.This method facilitates applications of correlated thermal photons in quantum information processing and quantum imaging.
基金financially supported by the Natural Science Foundation of Shandong Province(No.ZR2024QE446)。
文摘With the rapid development of intelligent electronic and military equipment,multifunctional flexible materials that integrat electromagnetic interference(EMI)shielding,temperature sensing,and information encryption are urgently required.This study presents a bio-inspired hierarchical composite foam fabricated using supercritical nitrogen foaming technology.This material exhibits a honeycomb structure,with pore cell sizes controllable within a range of 30–92μm by regulating the filler.The carbon fiber felt(CFf)provides efficient reflection of electromagnetic waves,while the chloroprene rubber/carbon fiber/carbon black foam facilitates both wave absorption and temperature monitoring through its optimized conductive network.This synergistic mechanism results in an EMI shielding effectiveness(SE)of 60.06 d B with excellent temperature sensing performance(The temperature coefficient of resistance(TCR)is-2.642%/℃)in the 24–70℃ range.Notably,the material has a thermal conductivity of up to 0.159 W/(m·K),and the bio-inspired layered design enables information encryption,demonstrating the material's potential for secure communication applications.The foam also has tensile properties of up to 5.13 MPa and a tear strength of 33.02 N/mm.This biomimetic design overcomes the traditional limitations of flexible materials and provides a transformative solution for next-generation applications such as flexible electronics,aerospace systems and military equipment,which urgently need integrated electromagnetic protection,thermal management and information security.
基金supported by the National Natural Science Foundation of China(Grant No.12304379)the Natural Science Foundation of Liaoning Province(Grant No.2024BS-269)the Guangdong Basic and Applied Basic Research Foundation(Grant No.025A1515011117)。
文摘High-precision optical frequency measurement serves as a cornerstone of modern science and technology,enabling advancements in fields ranging from fundamental physics to quantum information technologies.Obtaining precise photon frequencies,especially in the ultraviolet or even extreme ultraviolet regimes,is a key goal in both light–matter interaction experiments and engineering applications.High-order harmonic generation(HHG)is an ideal light source for producing such photons.In this work,we propose an optical temporal interference model(OTIM)that establishes an analogy with multi-slit Fraunhofer diffraction(MSFD)to manipulate fine-frequency photon generation by exploiting the temporal coherence of HHG processes.Our model provides a unified physical framework for three distinct non-integer HHG generation schemes:single-pulse,shaped-pulse,and laser pulse train approaches,which correspond to single-MSFD-like,double-MSFD-like,and multi-MSFD-like processes,respectively.Arbitrary non-integer HHG photons can be obtained using our scheme.Our approach provides a new perspective for accurately measuring and controlling photon frequencies in fields such as frequency comb technology,interferometry,and atomic clocks.
基金supported by the Defitech Foundation(Morges,CH)to FCHthe Bertarelli Foundation-Catalyst program(Gstaad,CH)to FCH+2 种基金the Wyss Center for Bio and Neuroengineering the Lighthouse Partnership for AI-guided Neuromodulation to FCHthe Fonds de recherche du Quebec-Sante(FRQS#342969)to CEPthe Neuro X Postdoctoral Fellowship Program to CEP。
文摘Brain lesions,such as those caused by stroke or traumatic brain injury(TBI),frequently result in persistent motor and cognitive impairments that significantly affect the individual patient's quality of life.Despite differences in the mechanisms of injury,both conditions share a high prevalence of motor and cognitive impairments.These deficits show only limited natural recovery.
基金funded by the National Natural Science Foundation of China,grant number U24A20135Inner Mongolia Natural Science Foundation major project,grant number 2023ZD12+7 种基金Inner Mongolia Autonomous Region key research and development and achievement transformation plan project,grant number 2023YFHH0090Natural Science Foundation of Inner Mongolia,grant number 2022MS05006Inner Mongolia Autonomous Region Talent Development FundUniversity basic research business expenses,grant number 2023RCTD012University basic research business expenses,grant number 2023QNJS075Postgraduate Research Innovation Program and of Inner Mongolia Autonomous Region,grant number KC2024053BUniversity basic research business expenses,grant number 2024YXXS012National Key Laboratory of Special Vehicle Design and Manufacturing Integration Technology,grant number GZ2023KF012.
文摘In dry-coupled ultrasonic thickness measurement,thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy.Existing methods struggle to resolve overlap-ping echoes under variable coupling conditions and non-stationary noise.This study proposes a novel dual-criterion framework integrating energy contribution and statistical impulsivity metrics to isolate specimen re-flections from coupling-layer interference.By decomposing A-scan signals into Intrinsic Mode Functions(IMFs),the framework employs energy contribution thresholds(>85%)and kurtosis indices(>3)to autonomously select IMFs containing valid specimen echoes.Hybrid time-frequency thresholding further suppresses interference through amplitude filtering and spectral focusing.Experimental results demonstrate the framework’s robustness,achieving 92.3%thickness accuracy for 5 mm steel specimens with 5 mm rubber coupling,outperforming conventional methods by up to 18.7%.The dual-criterion approach reduces operator dependency by 37%and maintainsΔT<0.03 mm under surface roughness up to 6.3μm,offering a practical solution for industrial nondestructive testing with thick dry-coupled interfaces.
基金supported by the National Nature Science Foundation Project(Nos.41604101 and U1562215)the National Grand Project for Science and Technology(No.2016ZX05024-004)+2 种基金the Natural Science Foundation of Shandong(No.BS2014NJ005)Science Foundation from SINOPEC Key Laboratory of Geophysics(No.33550006-15-FW2099-0027)the Fundamental Research Funds for the Central Universities
文摘Amplitude variations with offset or incident angle （AVO/AVA） inversion are typically combined with statistical methods, such as Bayesian inference or deterministic inversion. We propose a joint elastic inversion method in the time and frequency domain based on Bayesian inversion theory to improve the resolution of the estimated P- and S-wave velocities and density. We initially construct the objective function using Bayesian inference by combining seismic data in the time and frequency domain. We use Cauchy and Gaussian probability distribution density functions to obtain the prior information for the model parameters and the likelihood function, respectively. We estimate the elastic parameters by solving the initial objective function with added model constraints to improve the inversion robustness. The results of the synthetic data suggest that the frequency spectra of the estimated parameters are wider than those obtained with conventional elastic inversion in the time domain. In addition, the proposed inversion approach offers stronger antinoising compared to the inversion approach in the frequency domain. Furthermore, results from synthetic examples with added Gaussian noise demonstrate the robustness of the proposed approach. From the real data, we infer that more model parameter details can be reproduced with the proposed joint elastic inversion.
基金Project(2018YFC0807802)supported by the National Key R&D Program of ChinaProject(41874081)supported by the National Natural Science Foundation of China
文摘Due to the strong electromagnetic interferences and human interference,traditional electromagnetic methods cannot obtain high quality resistivity data of mineral deposits in Chinese mines.The wide field electromagnetic method(WFEM),in which the pseudo-random signal is taken as the transmitter source,can extract high quality resistivity data in areas with sever interference by only measuring the electric field component.We use the WFEM to extract the resistivity information of the Dongguashan mine in southeast China.Compared with the audio magnetotelluric(AMT)method,and the controlled source audio-frequency magnetotelluric(CSAMT) method,the WFEM can obtain data with higher quality and simpler operations.The inversion results indicate that the WFEM can accurately identify the location of the main ore-body,which can be used for deep mine exploration in areas with strong interference.
文摘A novel communication receiver which uses lapped transform(LT) incorporating modified median filter(MMF) algorithm was designed for narrow band interference(NBI) excision.Comparing to traditional Fourier Transform,LT has longer basis vectors,less spectral leakage,thus better frequency resolution.The LT domain MMF algorithm takes full advantages of the direct sequence spread spectrum signal,as well as the characteristics of LT,performs the transform domain filtering twice.The first filtering locates the position of interference and mitigates most of them.The second filtering is performed in a small neighborhood of the located interference.So LT domain MMF algorithm can completely mitigate the interference without distorting the desired signal.The simulation results demonstrate the improved BER(Bit Error Rate)performance and increased robustness of our receiver.
基金supported by the Fundamental Research Funds for the Central Universities and Heilongjiang Provincial Natural Science Foundation of China(Grant No.YQ2020E009).
文摘Robust, ultra-flexible, and multifunctional MXene-basedelectromagnetic interference (EMI) shielding nanocomposite filmsexhibit enormous potential for applications in artificial intelligence,wireless telecommunication, and portable/wearable electronic equipment.In this work, a nacre-inspired multifunctional heterocyclic aramid(HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper withlarge-scale, high strength, super toughness, and excellent tolerance tocomplex conditions is fabricated through the strategy of HA/MXenehydrogel template-assisted in-situ assembly of PPy. Benefiting from the"brick-and-mortar" layered structure and the strong hydrogen-bondinginteractions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa),outstanding toughness (57.6 MJ m−3), exceptional foldability, and structural stability against ultrasonication. By using the template effect ofHA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly,the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dBat an ultra-thin thickness (25.4 μm) and a high specific EMI SE of 17,204.7 dB cm2g−1. In addition, the papers also have excellent applicationsin electromagnetic protection, electro-/photothermal de-icing, thermal therapy, and fire safety. These findings broaden the ideas for developinghigh-performance and multifunctional MXene-based films with enormous application potential in EMI shielding and thermal management.
基金the National Natural Science Foundation of China(Grant No.42174047 and No.42174036)the National Science Foundation Project for Outstanding Youth(No.42104034).
文摘This paper realizes the full-domain collaborative deployment of multiple interference sources of the global satellite navigation system(GNSS)and evaluates the deployment effect to enhance the ability to disturb the attacker and the capability to defend the GNSS during navigation countermeasures.Key evaluation indicators for the jamming effect of GNSS suppressive and deceptive jamming sources are first created,their evaluation models are built,and their detection procedures are sorted out,as the basis for determining the deployment principles.The principles for collaboratively deploying multi-jamming sources are developed to obtain the deployment structures(including the required number,structures in demand,and corresponding positions)of three single interference sources required by collaboratively deploying.Accordingly,simulation and hardware-in-loop testing results are presented to determine a rational configuration of the collaborative deployment of multi-jamming sources in the set situation and further realize the full-domain deployment of an interference network from ground,air to space.Varied evaluation indices for the deployment effect are finally developed to evaluate the deployment effect of the proposed configuration and further verify its reliability and rationality.
基金supported by the Natural Science Foundation of Anhui Province(No.2308085QE146 and 2208085ME116)the National Natural Science Foundation of China(No.52173039)+1 种基金the Natural Science Foundation of Jiangsu Province(No.BK20210894)the Anhui Provincial Universities Outstanding Youth Research Project(No.2023AH020018).
文摘Electromagnetic interference(EMI)shielding materials with superior shielding efficiency and low-reflection properties hold promising potential for utilization across electronic components,precision instruments,and fifth-generation communication equipment.In this study,multistage microcellular waterborne polyurethane(WPU)composites were constructed via gradient induction,layer-by-layer casting,and supercritical carbon dioxide foaming.The gradient-structured WPU/ironcobalt loaded reduced graphene oxide(FeCo@rGO)foam serves as an impedance-matched absorption layer,while the highly conductive WPU/silver loaded glass microspheres(Ag@GM)layer is employed as a reflection layer.Thanks to the incorporation of an asymmetric structure,as well as the introduction of gradient and porous configurations,the composite foam demonstrates excellent conductivity,outstanding EMI SE(74.9 dB),and minimal reflection characteristics(35.28%)in 8.2-12.4 GHz,implying that more than 99.99999%of electromagnetic(EM)waves were blocked and only 35.28%were reflected to the external environment.Interestingly,the reflectivity of the composite foam is reduced to 0.41%at 10.88 GHz due to the resonance for incident and reflected EM waves.Beyond that,the composite foam is characterized by low density(0.47 g/cm^(3))and great stability of EMI shielding properties.This work offers a viable approach for craft-ing lightweight,highly shielding,and minimally reflective EMI shielding composites.
基金supported by the Natural Science Fund of China(31771724)the Key Research and Development Project of Shaanxi Province(2024NC-ZDCYL-01-10).
文摘The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use efficiency and enhancing crop stress resistance.Nevertheless,the precise interaction between soil warming(SW)and SN remains unclear.In order to ascertain the impact of SW on maize growth and whether SN can improve the tolerance of maize to SW,a two-year field experiment was conducted(2022-2023).The aim was to examine the influence of two SW ranges(MT,warming 1.40℃;HT,warming 2.75℃)and two nitrogen application methods(N1,one-time basal application of nitrogen fertilizer;N2,one third of base nitrogen fertilizer+two thirds of jointing stage supplemental nitrogen fertilizer)on maize root growth,photosynthetic characteristics,nitrogen use efficiency,and yield.The results demonstrated that SW impeded root growth and precipitated the premature aging of maize leaves following anthesis,particularly in the HT,which led to a notable reduction in maize yield.In comparison to N1,SN has been shown to increase root length density by 8.54%,root bleeding rate by 8.57%,and enhance root distribution ratio in the middle soil layers(20-60 cm).The interaction between SW and SN had a notable impact on maize growth and yield.The SN improved the absorption and utilization efficiency of nitrogen by promoting root development and downward canopy growth,thus improving the tolerance of maize to SW at the later stage of growth.In particular,the N2HT resulted in a 14.51%increase in the photosynthetic rate,a 18.58%increase in nitrogen absorption efficiency,and a 18.32%increase in maize yield compared with N1HT.It can be posited that the SN represents a viable nitrogen management measure with the potential to enhance maize tolerance to soil high-temperature stress.
基金financially funded by the National Natural Science Foundation of China(U2004205)the China Agricultural University-Syngenta Project.
文摘Fusarium ear rot(FER),caused by Fusarium verticillioides,is a destructive fungal disease of maize.FER resistance is a complex,quantitatively inherited trait controlled by multiple minor-effect genes.In this study,we employed two recombinant inbred line(RIL)populations with the common resistant parental line CML304 to identify FER-resistance loci.Initial QTL analysis identified 23 FER-resistance QTL,each explaining 5.21%-30.51%of the total phenotypic variation.Notably,one major QTL,qRfv2,on chromosome 2 was repeatedly detected,accounting for 11.92%-30.51%of the total phenotypic variation.qRfv2 was fine mapped to an interval of 1.01 Mb,flanked by the markers IDP8 and IDP10.qRfv2 is a semidominant resistance gene that could reduce the disease severity index(DSI)by 12.4%-20%,suggesting its potential for enhancing FER resistance in maize.Transcriptome analysis showed that 22 of the 28 annotated functional genes in the qRfv2 region displayed differential expression between parental lines in response to FER.One of the candidate genes,ZmLOX6,was validated to presumably provide a positive effect on FER resistance.Our study provides a basis for the potential cloning and application of FER resistance genes in maize breeding.
基金the financial support from the National Key Research and Development Program of China(No.2023YFB3907001)the National Natural Science Foundation of China(Nos.U2233217,62371029)the UK Engineering and Physical Sciences Research Council(EPSRC),China(Nos.EP/M026981/1,EP/T021063/1 and EP/T024917/)。
文摘Interference significantly impacts the performance of the Global Navigation Satellite Systems(GNSS),highlighting the need for advanced interference localization technology to bolster anti-interference and defense capabilities.The Uniform Circular Array(UCA)enables concurrent estimation of the Direction of Arrival(DOA)in both azimuth and elevation.Given the paramount importance of stability and real-time performance in interference localization,this work proposes an innovative approach to reduce the complexity and increase the robustness of the DOA estimation.The proposed method reduces computational complexity by selecting a reduced number of array elements to reconstruct a non-uniform sparse array from a UCA.To ensure DOA estimation accuracy,minimizing the Cramér-Rao Bound(CRB)is the objective,and the Spatial Correlation Coefficient(SCC)is incorporated as a constraint to mitigate side-lobe.The optimization model is a quadratic fractional model,which is solved by Semi-Definite Relaxation(SDR).When the array has perturbations,the mathematical expressions for CRB and SCC are re-derived to enhance the robustness of the reconstructed array.Simulation and hardware experiments validate the effectiveness of the proposed method in estimating interference DOA,showing high robustness and reductions in hardware and computational costs associated with DOA estimation.
文摘With the boom in maritime activities,the need for highly reliable maritime communication is becoming urgent,which is an important component of 5G/6G communication networks.However,the bandwidth reuse characteristic of 5G/6G networks will inevitably lead to severe interference,resulting in degradation in the communication performance of maritime users.In this paper,we propose a safe deep reinforcement learning based interference coordination scheme to jointly optimize the power control and bandwidth allocation in maritime communication systems,and exploit the quality-of-service requirements of users as the risk value references to evaluate the communication policies.In particular,this scheme designs a deep neural network to select the communication policies through the evaluation network and update the parameters using the target network,which improves the communication performance and speeds up the convergence rate.Moreover,the Nash equilibrium of the interference coordination game and the computational complexity of the proposed scheme are analyzed.Simulation and experimental results verify the performance gain of the proposed scheme compared with benchmarks.
基金supported by the Key Research and Development Program of Sichuan Province(Grant No.2023ZHCG0050)the Fundamental Research Funds for the Central Universities of China(Grant No.2682024QZ006 and 2682024ZTPY042)the Analytic and Testing Center of Southwest Jiaotong University.
文摘As modern communication and detection technologies advance at a swift pace,multifunctional electromagnetic interference(EMI)shielding materials with active/positive infrared stealth,hydrophobicity,and electric-thermal conversion ability have received extensive attention.Meeting the aforesaid requirements simultaneously remains a huge challenge.In this research,the melamine foam(MF)/polypyrrole(PPy)nanowire arrays(MF@PPy)were fabricated via one-step electrochemical polymerization.The hierarchical MF@PPy foam was composed of three-dimensional PPy micro-skeleton and ordered PPy nanowire arrays.Due to the upwardly grown PPy nanowire arrays,the MF@PPy foam possessed good hydrophobicity ability with a water contact angle of 142.00°and outstanding stability under various harsh environments.Meanwhile,the MF@PPy foam showed excellent thermal insulation property on account of the low thermal conductivity and elongated ligament characteristic of PPy nanowire arrays.Furthermore,taking advantage of the high conductivity(128.2 S m^(-1)),the MF@PPy foam exhibited rapid Joule heating under 3 V,resulting in dynamic infrared stealth and thermal camouflage effects.More importantly,the MF@PPy foam exhibited remarkable EMI shielding effectiveness values of 55.77 dB and 19,928.57 dB cm^(2)g^(-1).Strong EMI shielding was put down to the hierarchically porous PPy structure,which offered outstanding impedance matching,conduction loss,and multiple attenuations.This innovative approach provides significant insights to the development of advanced multifunctional EMI shielding foams by constructing PPy nanowire arrays,showing great applications in both military and civilian fields.
基金financially supported by the National Natural Science Foundation of China(Nos.52303090,52403132,52403112,52473083)the Natural Science Basic Research Plan in Shaanxi Province of China(No.2023-JC-QN-0168,2024JC-TBZC-04)+6 种基金the Innovation Capability Support Plan of Shaanxi Province(No.2024ZC-KJXX-022)the Shaanxi Province Key Research and Development Plan Project(No.2023-YBGY-461)the Innovation Capability Support Program of Shaanxi(No.2024RS-CXTD-57)the Natural Science Foundation of Chongqing,China(No.2023NSCQ-MSX2547)the Youth Talent Promotion Project of Shaanxi Science and Technology Association(No.20240426)The Special Scientific Research Plan of Education Department of Shaanxi Province(No.23JK0376)the authors would also like to thank Shiyaniia lab for the sup-port of SEM and XPS tests.
文摘Flexible multifunctional polymer-based electromagnetic interference(EMI)shielding composite films play a pivotal role in 5 G communication technology,smart wearables,automotive electronics,and aerospace.In this work,(Ti_(3)C_(2)T_(x) MXene/cellulose nanofibers(CNF)-(hydroxy‑functionalized BNNS(BNNS-OH)/CNF)composite films(TBCF)with Janus structure are prepared via vacuum-assisted filtration of BNNS-OH/CNF and Ti_(3)C_(2)T_(x)/CNF suspension by one after another.Then ionic bonding-strengthened TBCF(ITBCF)is obtained by Ca^(2+)ion infiltration and cold-pressing technique.The Janus structure endows ITBCF with the unique“conductive on one side and insulating on the other”property.When the mass ratio of Ti_(3)C_(2)T_(x) and BNNS is 1:1 and the total mass fraction is 70 wt.%,the electrical conductivity(σ)of the Ti_(3)C_(2)T_(x)/CNF side of ITBCF reaches 166.7 S/cm,while the surface resistivity of the BNNS-OH/CNF side is as high as 304 MΩ.After Ca^(2+)ion infiltration,the mechanical properties of ITBCF are significantly enhanced.The tensile strength and modulus of ITBCF are 73.5 MPa and 15.6 GPa,which are increased by 75.9%and 46.2%compared with those of TBCF,respectively.Moreover,ITBCF exhibits outstanding EMI shielding effectiveness(SE)of 57 dB and thermal conductivity(λ)of 9.49 W/(m K).In addition,ITBCF also presents excellent photothermal and photoelectric energy conversion performance.Under simulated solar irradiation with a power density of 120 mW/cm^(2),the surface stabilization temperature reaches up to 65.3°C and the maximum steady state voltage reaches up to 58.2 mV.
基金supported by the National Key Research and Development Program Project(2021YFC2400203)the Shaanxi Province Key Research and Development Program Project(2023-YBSF-120)+1 种基金the Shandong Provincial Natural Science Foundation(ZR2024QF287)the National Natural Science Foundation of China(31972907).
文摘Temporal interference(TI)is a form of stimulation that epitomizes an innovative and non-invasive approach for profound neuromodulation of the brain,a technique that has been validated in mice.Yet,the thin cranial bone structure of mice has a marginal influence on the effect of the TI technique and may not effectively showcase its effectiveness in larger animals.Based on this,we carried out TI stimulation experiments on rats.Following the TI intervention,analysis of electrophysiological data and immunofluorescence staining indicated the generation of a stimulation focus within the nucleus accumbens(depth,8.5 mm)in rats.Our findings affirm the viability of the TI methodology in the presence of thick cranial bones,furnishing efficacious parameters for profound stimulation with TI administered under such conditions.This experiment not only sheds light on the intervention effects of TI deep in the brain but also furnishes robust evidence in support of its prospective clinical utility.
