Cardiovascular disease remains the leading global cause of mortality,projected to increase by 73.4%from 2025 to 2050 despite declining age-standardized rates.Contemporary interventions,such as percutaneous coronary in...Cardiovascular disease remains the leading global cause of mortality,projected to increase by 73.4%from 2025 to 2050 despite declining age-standardized rates.Contemporary interventions,such as percutaneous coronary intervention and statins,reduce major adverse cardiovascular events(MACE)by 25%-30%,yet a 20%five-year MACE risk persists in high-risk cohorts.These approaches,histor-ically focused on luminal stenosis,fail to address systemic atherogenesis drivers like endothelial dysfunction and inflammation.Specifically,dietary linoleic acid restriction(<5 g/day)reduces oxidized low-density lipoprotein by approximately 15%by limiting peroxidation-prone bisallylic bonds,mitigating arterial inflam-mation,a key atherogenic trigger.Enhanced external counterpulsation,through pulsatile shear stress,enhances nitric oxide-mediated coronary perfusion,alle-viating angina in approximately 70%of refractory cases unresponsive to revascu-larization.Nanoparticle-facilitated chelation targets atherosclerotic plaques with precision,reducing calcium content by up to 30%in preclinical models,offering a novel avenue for lesion reversal.These innovations collectively address residual risk by tackling root causes,oxidative stress,endothelial dysfunction,and plaque instability,potentially halving MACE rates with widespread adoption.Despite promising preliminary data,gaps remain in long-term safety and scalability.Robust clinical trials are needed to validate these approaches,which collectively aim to transform cardiovascular disease management by prioritizing prevention and vascular restoration,potentially reducing coronary events to a public health rarity.展开更多
Current Situation and Problems of the Treatment in Advanced Prostate Cancer In recent years,the incidence of prostate cancer shows a rising trend in China with an increase of 70%and has been the first place in the gro...Current Situation and Problems of the Treatment in Advanced Prostate Cancer In recent years,the incidence of prostate cancer shows a rising trend in China with an increase of 70%and has been the first place in the growth rate of malignant tumor in the male reproductive system. Prostate cancer has become a serious threat to male senior’s health.Because of the application of展开更多
Introduction Acetaminophen （APP） is one of the most common antipyretic analgesics and is generally considered as a safe drug. However, acute or accumulative overdose of it can cause liver damage, even liver failure...Introduction Acetaminophen （APP） is one of the most common antipyretic analgesics and is generally considered as a safe drug. However, acute or accumulative overdose of it can cause liver damage, even liver failure. Here we reported a case of an 11-year-old patient with acute liver failure （ALF） induced by taking 0.25 g APP orally, who was successfully treated by integrative Chinese and Western medicine.展开更多
Cancer remains a significant threat to public health globally.Within the Traditional Chinese Medicine(TCM)framework,cancer is perceived not merely as an isolated disease but as a manifestation of a broader imbalance w...Cancer remains a significant threat to public health globally.Within the Traditional Chinese Medicine(TCM)framework,cancer is perceived not merely as an isolated disease but as a manifestation of a broader imbalance within the human body.Recent advancements in modern medicine have garnered increased attention toward the integrative approach to cancer therapy,combining conventional treatments with TCM practices focusing on achieving a holistic balance.This article aims to delineate the comprehensive perspective of TCM in integrative cancer therapy,emphasizing its foundational principles of personalized treatment grounded in syndrome differentiation and treatment.展开更多
The integration of Chinese and Western medicine in the treatment of malignant tumors is becoming increasingly widespread.By combining modern medical technology with traditional Chinese medicine,this approach enhances ...The integration of Chinese and Western medicine in the treatment of malignant tumors is becoming increasingly widespread.By combining modern medical technology with traditional Chinese medicine,this approach enhances therapeutic efficacy while reducing side effects.This paper reviews the principles and mechanisms of integrated therapy and analyzes its clinical applications and advantages.Studies indicate that this approach is effective in treating common malignancies such as lung,stomach,and liver cancer,especially in slowing tumor progression,relieving symptoms,and improving patients’quality of life.Chemotherapy combined with Chinese medicine has shown positive effects on survival rates and immune function.However,limitations remain,including insufficient clinical trial data and differences in efficacy across different cancer types,necessitating further high-quality studies.Overall,integrated Chinese and Western medicine offers advantages such as reduced side effects,improved survival rates,and enhanced immune function,providing a comprehensive treatment strategy and a theoretical foundation for its clinical application.展开更多
In recent 20 years, there has been an increasing trend in the incidence of pancreatic cancer both at home and abroad. An estimated 31 860 new cases and 31 270 deaths are expected to occur in the United States in 2004 ...In recent 20 years, there has been an increasing trend in the incidence of pancreatic cancer both at home and abroad. An estimated 31 860 new cases and 31 270 deaths are expected to occur in the United States in 2004 due to this disease, the 4th and 5th leading cause of cancer death for men and women respectively. In China, new cases of pancreatic cancer continue to increase and are 6展开更多
Cases of widespread bone hydatid infection are relatively rare in clinical practice.In this study,we reported for the first time a validated integrated repair therapy for multiple bone tissues,including the hip,femur,...Cases of widespread bone hydatid infection are relatively rare in clinical practice.In this study,we reported for the first time a validated integrated repair therapy for multiple bone tissues,including the hip,femur,and knee,caused by echinococ cosis.Artificial intelligence(AI)was used to develop a targeted surgical plan and to design a personalized prosthesis.Finite element analysis(FEA)was used to optimize the mechanical effectiveness of a customized integrated replacement prosthesis and to model stress distribution in the surrounding bone.Three-dimensional(3 D)printing was used to fabricate a customized prosthesis.With the assistance of AI,FEA,and 3 D printing technology,a personalized surgical plan and customized prosthesis were successfully constructed based on the patient’s disease.This approach achieved a successful therapeutic effect,demonstrating that AI-assisted personalized medicine holds great promise for the future.展开更多
Play is a pleasurable physical or mental activity that enhances the child’s skills involving negotiation abilities,problem-solving,manual dexterity,sharing,decision-making,and working in a group.Play affects all the ...Play is a pleasurable physical or mental activity that enhances the child’s skills involving negotiation abilities,problem-solving,manual dexterity,sharing,decision-making,and working in a group.Play affects all the brain's areas,structures,and functions.Children with autism have adaptive behavior,adaptive response,and social interaction limitations.This review explores the different applications of play therapy in helping children with autism disorder.Play is usually significantly impaired in children with autism.Play therapy is mainly intended to help children to honor their unique mental abilities and developmental levels.The main aim of play therapy is to prevent or solve psychosocial difficulties and achieve optimal child-healthy growth and development.Play therapy helps children with autism to engage in play activities of their interest and choice to express themselves in the most comfortable ways.It changes their way of self-expression from unwanted behaviors to more non-injurious expressive behavior using toys or activities of their choice as their words.Play therapy also helps those children to experience feeling out various interaction styles.Every child with autism is unique and responds differently.Therefore,different types of intervention,like play therapy,could fit the differences in children with autism.Proper evaluation of the child is mandatory to evaluate which type fits the child more than the others.This narrative review revised the different types of play therapy that could fit children with autism in an evidence-based way.Despite weak evidence,play therapy still has potential benefits for patients and their families.展开更多
Dry eye is now one of the most common superficial disorders in ophthalmology at home and abroad, and more and more people attach importance to the study. The ideal approach for treatment of dry eye is to normalize the...Dry eye is now one of the most common superficial disorders in ophthalmology at home and abroad, and more and more people attach importance to the study. The ideal approach for treatment of dry eye is to normalize the condition by rebuilding the superficial circumstance of the eye, and to make tear film work as well as possible so as to relieve the irritating symptoms in the eye. The authors are making a comprehensive discussion on the methods and curative effects of treating dry eye by traditional Chinese medicine and by integrative Chinese and Western medicine in recent years, so as to introduce the distinctive features of the traditional Chinese medicine and integrative Chinese and Western medicine in this field.展开更多
The Geser legend related to the plot of treating diseases is an important part of Mongolian legend cul⁃ture,which embodies the wisdom and spiritual beliefs of the Mongolian people.These legends not only contain profou...The Geser legend related to the plot of treating diseases is an important part of Mongolian legend cul⁃ture,which embodies the wisdom and spiritual beliefs of the Mongolian people.These legends not only contain profound cultural roots such as the pursuit of eternal life,the ecological concept of harmonious co⁃existence between humans and nature,and hero worship,but also demonstrate the inheritance and devel⁃opment of medical knowledge through the integration of traditional therapies such as“drilling holes,medicinal baths,grass sniffing,and dietary therapy”with modern medicine.At the same time,these legends also have a multicultural function of strengthening the relationship between humans and nature,enriching the sacred function of hero Geser,and endowing natural landscapes with divine qualities.展开更多
BACKGROUND Gastric cancer is a major global health issue,especially in East Asia.Radical gastrectomy,the primary treatment,often leads to complications like malnutrition and infection,impairing recovery.Traditional Ch...BACKGROUND Gastric cancer is a major global health issue,especially in East Asia.Radical gastrectomy,the primary treatment,often leads to complications like malnutrition and infection,impairing recovery.Traditional Chinese medicine may offer benefits in regulating gastrointestinal function and immunity.This study investigated the effects of a modified Pingwei Baohe decoction(MPBD)on postoperative immune function and nutritional status in gastric cancer patients.AIM To explore the influence of MPBD on the postoperative immune function and nutritional status of patients with gastric cancer.METHODS A total of 55 gastric cancer patients who underwent radical proximal gastrectomy in Hebei Provincial People's Hospital and The Fourth Hospital of Hebei Medical University from June 2023 to June 2025 were selected as the research objects and divided into the observation group(28 cases,receiving chemotherapy plus MPBD)and the control group(27 cases,receiving chemotherapy alone)at a ratio of 1:1 according to the random number table method.Inflammatory indicators,immune function,nutritional status,and gastrointestinal function recovery time were compared before and 28 days after intervention.RESULTS After 28 days,the observation group showed significantly lower levels of inflammatory markers(IL-6,IL-4,IL-2,IL-17A,IFN-γ,TNF-α,IL-10),neutrophil-to-lymphocyte ratio(NLR),and proportion of CONUT score>2,alongside significantly higher levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)ratio,absolute lymphocyte count(ALC),lymphocyte percentage(LYM%),and TNF-α/IL-4 ratio compared to the control group(P<0.05).In both groups,post-intervention levels of the aforementioned inflammatory markers,NLR,and proportion of CONUT score>2 were significantly lower than baseline,while the immune parameters(CD3^(+),CD4^(+),CD4^(+)/CD8^(+)ratio,ALC,LYM%,TNF-α/IL-4 ratio)were significantly higher(P<0.05).Additionally,gastrointestinal function recovery times(first flatus,bowel sounds recovery,abdominal distension relief)in the observation group were significantly shorter than in the control group(P<0.05).CONCLUSION MPBD significantly enhances postoperative immune function,mitigates inflammatory responses,improves nutritional status,and accelerates gastrointestinal function recovery in gastric cancer patients.展开更多
There is currently no drug or therapy that can cure the coronavirus disease 2019(COVID-19), which is highly contagious and can be life-threatening in severe cases. Therefore, seeking potential effective therapies is a...There is currently no drug or therapy that can cure the coronavirus disease 2019(COVID-19), which is highly contagious and can be life-threatening in severe cases. Therefore, seeking potential effective therapies is an urgent task. An older female at the Leishenshan Hospital in Wuhan, China, with a severe case of COVID-19 with significant shortness of breath and decrease in peripheral oxygen saturation(SpO_(2)),was treated using manual acupuncture and Chinese herbal medicine granule formula Fuzheng Rescue Lung with Xuebijing Injection in addition to standard care. The patient’s breath rate, SpO_(2), heart rate,ratio of neutrophil/lymphocyte(NLR), ratio of monocyte/lymphocyte(MLR), C-reactive protein(CRP),and chest computed tomography were monitored. Acupuncture significantly improved the patient’s breathing function, increased SpO_(2), and decreased her heart rate. Chinese herbal medicine might make the effect of acupuncture more stable;the use of herbal medicine also seemed to accelerate the absorption of lung infection lesions when its dosage was increased. The combination of acupuncture and herbs decreased NLR from 14.14 to 5.83, MLR from 1.15 to 0.33 and CRP from 15.25 to 6.01 mg/L. These results indicate that acupuncture and Chinese herbal medicine, as adjuvants to standard care, might achieve better results in treating severe cases of COVID-19.展开更多
Objective： The present study aimed to evaluate the analgesic and anti-inflammatory effects of far infrared-emitting ceramics （cFIRs） in a model of persistent inflammatory hyperalgesia and to elucidate the possible ...Objective： The present study aimed to evaluate the analgesic and anti-inflammatory effects of far infrared-emitting ceramics （cFIRs） in a model of persistent inflammatory hyperalgesia and to elucidate the possible mechanisms of these effects. Methods： Mice were injected with complete Freund＇s adjuvant （CFA） and treated with cFIRs via place- ment on a pad impregnated with cFIRs on the bottom of the housing unit for different periods of time. Mice underwent mechanical hyperalgesia and edema assessments, and tumor necrosis factor-α （TNF-α）, interleukin-1β （IL-1β） and IL-10 levels were measured. Twenty-four hours after CFA injection and 30 min before cFIR treatment, mice were pretreated with a nonselective adenosinergic antagonist, caffeine, the selective adenosine receptor A antagonist, 1,3-dipropyl-8-cyclopentylxanthine （DPCPX）, the selective cannabinoid receptor type 1 antagonist, AM281, the selective cannabinoid receptor type 2 antagonist, AM630, or the nonselective opioid receptor antagonist, naloxone, and mechanical hyperalge- sia was assessed. Results： cFIRs statistically （P 〈 0.05） decreased CFA-induced mechanical hyperalgesia （82.86 ±5.21）% in control group vs （56.67±9.54）% in cFIR group） and edema （（1699.0 ± 77.8） gm in control group vs （988.7±107.6） gm in cFIR group）, cFIRs statistically （P 〈 0.05） reduced TNF-α （0.478± 0.072） pg/mg of protein in control group vs （0.273 ±0.055） pg/mg of protein in cFIR group） and IL-113 （（95.81 ± 3.95） pg/mg of protein in control group vs （80.61 ±4.71）pg/mg of protein in cFIR group） levels and statistically （P〈 0.05） increased IL-10 （（18.32 ±0.78） pg/mg of protein in control group vs （25.89 ±1.23） pg/mg of protein in cFIR group） levels in post-CFA-injected paws. Peripheral pre-administration of inhibitory neuroreceptor antagonists （caffeine, DPCPX, AM281, AM630 and naloxone） prevented the analgesic effects of cF1Rs （P 〈 0.05）.Conclusion： These data provide additional support for the use of cFIRs in the treatment of painful inflam- matory conditions and contribute to our understanding of the neurobiological mechanisms of the ther- apeutic effects of cFIRs.展开更多
BACKGROUND Attention-deficit/hyperactivity disorder(ADHD)is one of the most common disorders in child and adolescent psychiatry,with a prevalence of more than 5%.Despite extensive research on ADHD in the last 10 to 20...BACKGROUND Attention-deficit/hyperactivity disorder(ADHD)is one of the most common disorders in child and adolescent psychiatry,with a prevalence of more than 5%.Despite extensive research on ADHD in the last 10 to 20 years,effective treatments are still lacking.Instead,the concept of ADHD seems to have become broader and more heterogeneous.Therefore,the diagnosis and treatment of ADHD remains challenging for clinicians.AIM To investigate the effects of a multimodal integrated intervention for children with ADHD.METHODS Between March 2019 and September 2020,a total of 100 children with ADHD who were diagnosed and treated at our hospital were assessed for eligibility,two of whom revoked their consent.A case-control study was conducted in which the children were equally assigned,using a randomized number table,to either a medication group(methylphenidate hydrochloride extended-release tablets and atomoxetine hydrochloride tablets)or a multimodal integrated intervention group(medication+parent training+behavior modification+sensory integration therapy+sand tray therapy),with 49 patients in each group.The clinical endpoint was the efficacy of the different intervention modalities.RESULTS The two groups of children with ADHD had comparable patient characteristics(P>0.05).Multimodal integrated intervention resulted in a significantly higher treatment efficacy(91.84%)than medication alone(75.51%)(P<0.05).Children who received the multimodal integrated intervention showed lower scores in the Conners Parent Symptom Questionnaire and the Weiss Functional Impairment Rating Scale than those treated with medication alone(P<0.05).The Sensory Integration Scale scores of children in the multimodal integrated intervention group were higher than those of children in the medication group(P<0.05).Children who received the multimodal integrated intervention had higher compliance and family satisfaction and a lower incidence of adverse events than those treated with medication alone(P<0.05).CONCLUSION Multimodal integrated intervention effectively alleviated symptoms associated with ADHD in children.It enhanced their memory and attention with high safety and parental satisfaction,demonstrating good potential for clinical promotion.展开更多
Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treat...Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treatment of S ARS and its influence on the chief indexes in the process of the disease. Methods: The clinical study involving observation of 135 patients of SARS was conducted in the randomized, synchronously controlled and open way. The patients were divided into two groups, 68 in the ICWM group and 67 in the c ontrol group, all of whom were treated with the same basic treatment of western medicine, but to the ICWM group, Chinese drugs for clearing Heat, detoxifying an d removing Dampness were given additionally. The comprehensive effect on relievi ng fever, cell mediated immunity, pulmonary inflammation and secondary infect ion was compared between the two groups. Results: The therapeutic effect in the ICWM group was better than that in the control group in such aspects as steadily lowering body temperature, alleviating general symptoms, accelerating the absorption of pulmonary infiltra tion and easing cellular immunity suppression. Conclusion: The therapeutic effect of ICWM is better in treating SARS than that of western medicine alone.展开更多
Integrated diagnosis,treatment and whole-course management model of major depressive disorder(MDD)is an integrated drug-psychological-physical comprehensive treatment model based on rapid biological-psychological-soci...Integrated diagnosis,treatment and whole-course management model of major depressive disorder(MDD)is an integrated drug-psychological-physical comprehensive treatment model based on rapid biological-psychological-social evaluation for treating patients with major depressive disorder.This paper comprehensively evaluates the clinical efficacy and biochemical indexes of patients,and carries out symptom evaluation,problem classification,disease diagnosis and etiological analysis of visitors from the three dimensions about physiology,psychology and society.Then,according to the symptoms and causes of different dimensions,this paper formulates personalized drug,psychological and physical therapy programs,and constantly optimizes and adjusts the treatment plan in the treatment process,so as to cure both the symptoms and the root causes,providing a reliable strategy for the treatment of clinical MDD,and establishing a standardized characteristic model for further promotion and application of this technology.At present,the project has been used in the member units of Taihe Medical Group and Shiyan City and its surrounding areas,the market response is good,and will be gradually promoted to the whole country in the later stage.展开更多
Acute myocardial infarction （AMI） is the severest pathological basis of ventricular remodeling （VR） in coronary heart disease （CHD）. VR is a process of ventricular changes in size, shape, and tissue structure ca...Acute myocardial infarction （AMI） is the severest pathological basis of ventricular remodeling （VR） in coronary heart disease （CHD）. VR is a process of ventricular changes in size, shape, and tissue structure caused by increasing of myocardial load or myocardial damage,including myocardial infarction, poisoning, inflammation, and metabolist abnormality.展开更多
In the 1960s, a number of integrative Chinese and Western medicine （ICWM） surgeons （such as Prof. WU Xian-zhong） first started the application of traditional Chinese medicine （TCM） in acute abdominal surgery, an...In the 1960s, a number of integrative Chinese and Western medicine （ICWM） surgeons （such as Prof. WU Xian-zhong） first started the application of traditional Chinese medicine （TCM） in acute abdominal surgery, and thus they became the pioneers of perioperative therapy with ICWM. Since then, they haveaccumulated abundant experience in this field. At the 1st National Conference of Perioperative Therapy with ICWM in November 1994, the academician WU Xian-zhong, et al believed that perioperative therapy with ICWM hold promise for the future.展开更多
Objective:To explore the cardiac protective effect of integrative therapy in acute myocardial infarction(AMI) with elevated ST segment after reperfusion.Methods:Sixty-four AMI patients who having received decimalizati...Objective:To explore the cardiac protective effect of integrative therapy in acute myocardial infarction(AMI) with elevated ST segment after reperfusion.Methods:Sixty-four AMI patients who having received decimalization by thrombolysis were assigned to two groups by retrospective analysis,36 patients in the treated group and 28 in the control group.Both were treated by intravenous administering of urokinase for thrombolysis,and to the treated group,intravenous dripping of Xueshuantong Injection(血栓通注射液,XST) ...展开更多
Objective： To analyze the clinical evaluation of Parkinson＇s disease （PD） patients receiving integrated Chinese and Western medicine therapy. Methods： One hundred and twenty patients were enrolled and randomly al...Objective： To analyze the clinical evaluation of Parkinson＇s disease （PD） patients receiving integrated Chinese and Western medicine therapy. Methods： One hundred and twenty patients were enrolled and randomly allocated to a control group or treatment group. Patients in the two groups received placebo and Bushen Huoxue Granule （补肾活血颗粒, BHG）, respectively. Both groups received baseline levodopa and benserazide （Madopar）. The effects of treatment were assessed monthly during the 9-month treatment. Means of evaluation included Unified PD Rating Scale （UPDRS） scores （Ⅱ and Ⅲ）, sleep scale score, 10 m turn back test （getting up time, 10 m × 2 times, and turning time）, timing motor test （TMT）-Ieft and TMT-right, which were treated as the dependent variables; and age, sex, duration of PD, Hoehn and Yahr （H-Y） stage and Madopar dosage of admitted PD patients were as the independent variables. Multiple linear regression was used to analyze these factors. Results： H-Y stage significantly affected UPDRSⅡ score, UPDRS Ⅲ score, and getting up time （P〈0.01）. Madopar dosage and H-Y stage significantly affected the 10 m × 2 times （P〈0.05 or P〈0.01）. Madopar dosage significantly affected the sleep scale score （P〈0.05）. There were also significant correlations between age and TMT-left or TMT-right （P〈0.01）, and duration of PD and TMT-right （P〈0.05）. Conclusions： The six assessed means of clinical evaluation （including UPDRS Ⅱ and UPDRS Ⅲ scores, sleep scale score, getting up time, 10 m × 2 times, and turning time） are sensitive indexes in all PD patients. H-Y stage and Madopar dosage are the major factors influencing means of clinical assessment of PD treatment.展开更多
文摘Cardiovascular disease remains the leading global cause of mortality,projected to increase by 73.4%from 2025 to 2050 despite declining age-standardized rates.Contemporary interventions,such as percutaneous coronary intervention and statins,reduce major adverse cardiovascular events(MACE)by 25%-30%,yet a 20%five-year MACE risk persists in high-risk cohorts.These approaches,histor-ically focused on luminal stenosis,fail to address systemic atherogenesis drivers like endothelial dysfunction and inflammation.Specifically,dietary linoleic acid restriction(<5 g/day)reduces oxidized low-density lipoprotein by approximately 15%by limiting peroxidation-prone bisallylic bonds,mitigating arterial inflam-mation,a key atherogenic trigger.Enhanced external counterpulsation,through pulsatile shear stress,enhances nitric oxide-mediated coronary perfusion,alle-viating angina in approximately 70%of refractory cases unresponsive to revascu-larization.Nanoparticle-facilitated chelation targets atherosclerotic plaques with precision,reducing calcium content by up to 30%in preclinical models,offering a novel avenue for lesion reversal.These innovations collectively address residual risk by tackling root causes,oxidative stress,endothelial dysfunction,and plaque instability,potentially halving MACE rates with widespread adoption.Despite promising preliminary data,gaps remain in long-term safety and scalability.Robust clinical trials are needed to validate these approaches,which collectively aim to transform cardiovascular disease management by prioritizing prevention and vascular restoration,potentially reducing coronary events to a public health rarity.
基金Supported by the National Natural Science Foundation of China(No.30873268)
文摘Current Situation and Problems of the Treatment in Advanced Prostate Cancer In recent years,the incidence of prostate cancer shows a rising trend in China with an increase of 70%and has been the first place in the growth rate of malignant tumor in the male reproductive system. Prostate cancer has become a serious threat to male senior’s health.Because of the application of
基金Supported by National Science and Technology Major Project (No.2012ZX10005010-004)
文摘Introduction Acetaminophen （APP） is one of the most common antipyretic analgesics and is generally considered as a safe drug. However, acute or accumulative overdose of it can cause liver damage, even liver failure. Here we reported a case of an 11-year-old patient with acute liver failure （ALF） induced by taking 0.25 g APP orally, who was successfully treated by integrative Chinese and Western medicine.
基金Fundamental Research Ability Improvement Project for Young and Middle-aged Teachers in Guangxi Universities(Natural Science),Agreement No.2022KY0300Innovation Project of Guangxi Graduate Education of GXUCM,Agreement No.YCBXJ2023040Administration of Traditional Chinese Medicine of Guangxi Zhuang Autonomous Region Selffunded Scientific Research Project(Natural Science),Agreement No.GXZYZ20210346.
文摘Cancer remains a significant threat to public health globally.Within the Traditional Chinese Medicine(TCM)framework,cancer is perceived not merely as an isolated disease but as a manifestation of a broader imbalance within the human body.Recent advancements in modern medicine have garnered increased attention toward the integrative approach to cancer therapy,combining conventional treatments with TCM practices focusing on achieving a holistic balance.This article aims to delineate the comprehensive perspective of TCM in integrative cancer therapy,emphasizing its foundational principles of personalized treatment grounded in syndrome differentiation and treatment.
文摘The integration of Chinese and Western medicine in the treatment of malignant tumors is becoming increasingly widespread.By combining modern medical technology with traditional Chinese medicine,this approach enhances therapeutic efficacy while reducing side effects.This paper reviews the principles and mechanisms of integrated therapy and analyzes its clinical applications and advantages.Studies indicate that this approach is effective in treating common malignancies such as lung,stomach,and liver cancer,especially in slowing tumor progression,relieving symptoms,and improving patients’quality of life.Chemotherapy combined with Chinese medicine has shown positive effects on survival rates and immune function.However,limitations remain,including insufficient clinical trial data and differences in efficacy across different cancer types,necessitating further high-quality studies.Overall,integrated Chinese and Western medicine offers advantages such as reduced side effects,improved survival rates,and enhanced immune function,providing a comprehensive treatment strategy and a theoretical foundation for its clinical application.
文摘In recent 20 years, there has been an increasing trend in the incidence of pancreatic cancer both at home and abroad. An estimated 31 860 new cases and 31 270 deaths are expected to occur in the United States in 2004 due to this disease, the 4th and 5th leading cause of cancer death for men and women respectively. In China, new cases of pancreatic cancer continue to increase and are 6
基金partially supported by the National Natural Science Foundation of China(Nos.32471474 and 82102574)the Precision Medicine Project of People’s Hospital of Xinjiang Uygur Autonomous Region(No.20220305)+4 种基金Chengdu Advanced Metal Materials Industry Technology Research Institute Co.,Ltd.Support Project(No.24H0802)Sichuan Science and Technology Program(Nos.2025YFHZ0086,2023YFS0053,2024YFHZ0125,and 2025ZNSFSC0381)Project of Tianfu Jincheng Laboratory(No.2025ZH009)Guangdong Basic and Applied Basic Research Foundation(No.2023A1515220102)Xinjiang Autonomous Region Science and Technology Support Project Plan(Directive)Project(No.2024E02049)。
文摘Cases of widespread bone hydatid infection are relatively rare in clinical practice.In this study,we reported for the first time a validated integrated repair therapy for multiple bone tissues,including the hip,femur,and knee,caused by echinococ cosis.Artificial intelligence(AI)was used to develop a targeted surgical plan and to design a personalized prosthesis.Finite element analysis(FEA)was used to optimize the mechanical effectiveness of a customized integrated replacement prosthesis and to model stress distribution in the surrounding bone.Three-dimensional(3 D)printing was used to fabricate a customized prosthesis.With the assistance of AI,FEA,and 3 D printing technology,a personalized surgical plan and customized prosthesis were successfully constructed based on the patient’s disease.This approach achieved a successful therapeutic effect,demonstrating that AI-assisted personalized medicine holds great promise for the future.
文摘Play is a pleasurable physical or mental activity that enhances the child’s skills involving negotiation abilities,problem-solving,manual dexterity,sharing,decision-making,and working in a group.Play affects all the brain's areas,structures,and functions.Children with autism have adaptive behavior,adaptive response,and social interaction limitations.This review explores the different applications of play therapy in helping children with autism disorder.Play is usually significantly impaired in children with autism.Play therapy is mainly intended to help children to honor their unique mental abilities and developmental levels.The main aim of play therapy is to prevent or solve psychosocial difficulties and achieve optimal child-healthy growth and development.Play therapy helps children with autism to engage in play activities of their interest and choice to express themselves in the most comfortable ways.It changes their way of self-expression from unwanted behaviors to more non-injurious expressive behavior using toys or activities of their choice as their words.Play therapy also helps those children to experience feeling out various interaction styles.Every child with autism is unique and responds differently.Therefore,different types of intervention,like play therapy,could fit the differences in children with autism.Proper evaluation of the child is mandatory to evaluate which type fits the child more than the others.This narrative review revised the different types of play therapy that could fit children with autism in an evidence-based way.Despite weak evidence,play therapy still has potential benefits for patients and their families.
文摘Dry eye is now one of the most common superficial disorders in ophthalmology at home and abroad, and more and more people attach importance to the study. The ideal approach for treatment of dry eye is to normalize the condition by rebuilding the superficial circumstance of the eye, and to make tear film work as well as possible so as to relieve the irritating symptoms in the eye. The authors are making a comprehensive discussion on the methods and curative effects of treating dry eye by traditional Chinese medicine and by integrative Chinese and Western medicine in recent years, so as to introduce the distinctive features of the traditional Chinese medicine and integrative Chinese and Western medicine in this field.
文摘The Geser legend related to the plot of treating diseases is an important part of Mongolian legend cul⁃ture,which embodies the wisdom and spiritual beliefs of the Mongolian people.These legends not only contain profound cultural roots such as the pursuit of eternal life,the ecological concept of harmonious co⁃existence between humans and nature,and hero worship,but also demonstrate the inheritance and devel⁃opment of medical knowledge through the integration of traditional therapies such as“drilling holes,medicinal baths,grass sniffing,and dietary therapy”with modern medicine.At the same time,these legends also have a multicultural function of strengthening the relationship between humans and nature,enriching the sacred function of hero Geser,and endowing natural landscapes with divine qualities.
文摘BACKGROUND Gastric cancer is a major global health issue,especially in East Asia.Radical gastrectomy,the primary treatment,often leads to complications like malnutrition and infection,impairing recovery.Traditional Chinese medicine may offer benefits in regulating gastrointestinal function and immunity.This study investigated the effects of a modified Pingwei Baohe decoction(MPBD)on postoperative immune function and nutritional status in gastric cancer patients.AIM To explore the influence of MPBD on the postoperative immune function and nutritional status of patients with gastric cancer.METHODS A total of 55 gastric cancer patients who underwent radical proximal gastrectomy in Hebei Provincial People's Hospital and The Fourth Hospital of Hebei Medical University from June 2023 to June 2025 were selected as the research objects and divided into the observation group(28 cases,receiving chemotherapy plus MPBD)and the control group(27 cases,receiving chemotherapy alone)at a ratio of 1:1 according to the random number table method.Inflammatory indicators,immune function,nutritional status,and gastrointestinal function recovery time were compared before and 28 days after intervention.RESULTS After 28 days,the observation group showed significantly lower levels of inflammatory markers(IL-6,IL-4,IL-2,IL-17A,IFN-γ,TNF-α,IL-10),neutrophil-to-lymphocyte ratio(NLR),and proportion of CONUT score>2,alongside significantly higher levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)ratio,absolute lymphocyte count(ALC),lymphocyte percentage(LYM%),and TNF-α/IL-4 ratio compared to the control group(P<0.05).In both groups,post-intervention levels of the aforementioned inflammatory markers,NLR,and proportion of CONUT score>2 were significantly lower than baseline,while the immune parameters(CD3^(+),CD4^(+),CD4^(+)/CD8^(+)ratio,ALC,LYM%,TNF-α/IL-4 ratio)were significantly higher(P<0.05).Additionally,gastrointestinal function recovery times(first flatus,bowel sounds recovery,abdominal distension relief)in the observation group were significantly shorter than in the control group(P<0.05).CONCLUSION MPBD significantly enhances postoperative immune function,mitigates inflammatory responses,improves nutritional status,and accelerates gastrointestinal function recovery in gastric cancer patients.
基金Guangdong Provincial Famous TCM Veteran Experts Zou Xu Inheritance Studio。
文摘There is currently no drug or therapy that can cure the coronavirus disease 2019(COVID-19), which is highly contagious and can be life-threatening in severe cases. Therefore, seeking potential effective therapies is an urgent task. An older female at the Leishenshan Hospital in Wuhan, China, with a severe case of COVID-19 with significant shortness of breath and decrease in peripheral oxygen saturation(SpO_(2)),was treated using manual acupuncture and Chinese herbal medicine granule formula Fuzheng Rescue Lung with Xuebijing Injection in addition to standard care. The patient’s breath rate, SpO_(2), heart rate,ratio of neutrophil/lymphocyte(NLR), ratio of monocyte/lymphocyte(MLR), C-reactive protein(CRP),and chest computed tomography were monitored. Acupuncture significantly improved the patient’s breathing function, increased SpO_(2), and decreased her heart rate. Chinese herbal medicine might make the effect of acupuncture more stable;the use of herbal medicine also seemed to accelerate the absorption of lung infection lesions when its dosage was increased. The combination of acupuncture and herbs decreased NLR from 14.14 to 5.83, MLR from 1.15 to 0.33 and CRP from 15.25 to 6.01 mg/L. These results indicate that acupuncture and Chinese herbal medicine, as adjuvants to standard care, might achieve better results in treating severe cases of COVID-19.
基金supported by grants from the National Council of Scientific and Technological Development(CNPq)grant#14/2013the Santa Catarina State Foundation in Support of Research and Innovation(FAPESC)grant#04/2012+1 种基金the Coordination of Higher Education Personnel Improvement(CAPES)the UNISUL Scientific Initiation Program(PUIC),Brazil
文摘Objective： The present study aimed to evaluate the analgesic and anti-inflammatory effects of far infrared-emitting ceramics （cFIRs） in a model of persistent inflammatory hyperalgesia and to elucidate the possible mechanisms of these effects. Methods： Mice were injected with complete Freund＇s adjuvant （CFA） and treated with cFIRs via place- ment on a pad impregnated with cFIRs on the bottom of the housing unit for different periods of time. Mice underwent mechanical hyperalgesia and edema assessments, and tumor necrosis factor-α （TNF-α）, interleukin-1β （IL-1β） and IL-10 levels were measured. Twenty-four hours after CFA injection and 30 min before cFIR treatment, mice were pretreated with a nonselective adenosinergic antagonist, caffeine, the selective adenosine receptor A antagonist, 1,3-dipropyl-8-cyclopentylxanthine （DPCPX）, the selective cannabinoid receptor type 1 antagonist, AM281, the selective cannabinoid receptor type 2 antagonist, AM630, or the nonselective opioid receptor antagonist, naloxone, and mechanical hyperalge- sia was assessed. Results： cFIRs statistically （P 〈 0.05） decreased CFA-induced mechanical hyperalgesia （82.86 ±5.21）% in control group vs （56.67±9.54）% in cFIR group） and edema （（1699.0 ± 77.8） gm in control group vs （988.7±107.6） gm in cFIR group）, cFIRs statistically （P 〈 0.05） reduced TNF-α （0.478± 0.072） pg/mg of protein in control group vs （0.273 ±0.055） pg/mg of protein in cFIR group） and IL-113 （（95.81 ± 3.95） pg/mg of protein in control group vs （80.61 ±4.71）pg/mg of protein in cFIR group） levels and statistically （P〈 0.05） increased IL-10 （（18.32 ±0.78） pg/mg of protein in control group vs （25.89 ±1.23） pg/mg of protein in cFIR group） levels in post-CFA-injected paws. Peripheral pre-administration of inhibitory neuroreceptor antagonists （caffeine, DPCPX, AM281, AM630 and naloxone） prevented the analgesic effects of cF1Rs （P 〈 0.05）.Conclusion： These data provide additional support for the use of cFIRs in the treatment of painful inflam- matory conditions and contribute to our understanding of the neurobiological mechanisms of the ther- apeutic effects of cFIRs.
基金Supported by Ningbo Medical Key Fostering Discipline Child Health Science,No.2022-F26Ningbo Science and Technology Plan Project Public Welfare Plan,No.2019C50099.
文摘BACKGROUND Attention-deficit/hyperactivity disorder(ADHD)is one of the most common disorders in child and adolescent psychiatry,with a prevalence of more than 5%.Despite extensive research on ADHD in the last 10 to 20 years,effective treatments are still lacking.Instead,the concept of ADHD seems to have become broader and more heterogeneous.Therefore,the diagnosis and treatment of ADHD remains challenging for clinicians.AIM To investigate the effects of a multimodal integrated intervention for children with ADHD.METHODS Between March 2019 and September 2020,a total of 100 children with ADHD who were diagnosed and treated at our hospital were assessed for eligibility,two of whom revoked their consent.A case-control study was conducted in which the children were equally assigned,using a randomized number table,to either a medication group(methylphenidate hydrochloride extended-release tablets and atomoxetine hydrochloride tablets)or a multimodal integrated intervention group(medication+parent training+behavior modification+sensory integration therapy+sand tray therapy),with 49 patients in each group.The clinical endpoint was the efficacy of the different intervention modalities.RESULTS The two groups of children with ADHD had comparable patient characteristics(P>0.05).Multimodal integrated intervention resulted in a significantly higher treatment efficacy(91.84%)than medication alone(75.51%)(P<0.05).Children who received the multimodal integrated intervention showed lower scores in the Conners Parent Symptom Questionnaire and the Weiss Functional Impairment Rating Scale than those treated with medication alone(P<0.05).The Sensory Integration Scale scores of children in the multimodal integrated intervention group were higher than those of children in the medication group(P<0.05).Children who received the multimodal integrated intervention had higher compliance and family satisfaction and a lower incidence of adverse events than those treated with medication alone(P<0.05).CONCLUSION Multimodal integrated intervention effectively alleviated symptoms associated with ADHD in children.It enhanced their memory and attention with high safety and parental satisfaction,demonstrating good potential for clinical promotion.
文摘Objective: To improve the effects of treatment of severe acute re spiratory syndrome (SARS) and to explore the clinical significance of integrate d traditional Chinese medicine and western medicine (ICWM) in the treatment of S ARS and its influence on the chief indexes in the process of the disease. Methods: The clinical study involving observation of 135 patients of SARS was conducted in the randomized, synchronously controlled and open way. The patients were divided into two groups, 68 in the ICWM group and 67 in the c ontrol group, all of whom were treated with the same basic treatment of western medicine, but to the ICWM group, Chinese drugs for clearing Heat, detoxifying an d removing Dampness were given additionally. The comprehensive effect on relievi ng fever, cell mediated immunity, pulmonary inflammation and secondary infect ion was compared between the two groups. Results: The therapeutic effect in the ICWM group was better than that in the control group in such aspects as steadily lowering body temperature, alleviating general symptoms, accelerating the absorption of pulmonary infiltra tion and easing cellular immunity suppression. Conclusion: The therapeutic effect of ICWM is better in treating SARS than that of western medicine alone.
基金Supported by Grants from the National Key R&D Program of China (2018YFC1314600)the 2021 Shiyan City Guidance Project (21Y33)
文摘Integrated diagnosis,treatment and whole-course management model of major depressive disorder(MDD)is an integrated drug-psychological-physical comprehensive treatment model based on rapid biological-psychological-social evaluation for treating patients with major depressive disorder.This paper comprehensively evaluates the clinical efficacy and biochemical indexes of patients,and carries out symptom evaluation,problem classification,disease diagnosis and etiological analysis of visitors from the three dimensions about physiology,psychology and society.Then,according to the symptoms and causes of different dimensions,this paper formulates personalized drug,psychological and physical therapy programs,and constantly optimizes and adjusts the treatment plan in the treatment process,so as to cure both the symptoms and the root causes,providing a reliable strategy for the treatment of clinical MDD,and establishing a standardized characteristic model for further promotion and application of this technology.At present,the project has been used in the member units of Taihe Medical Group and Shiyan City and its surrounding areas,the market response is good,and will be gradually promoted to the whole country in the later stage.
文摘Acute myocardial infarction （AMI） is the severest pathological basis of ventricular remodeling （VR） in coronary heart disease （CHD）. VR is a process of ventricular changes in size, shape, and tissue structure caused by increasing of myocardial load or myocardial damage,including myocardial infarction, poisoning, inflammation, and metabolist abnormality.
文摘In the 1960s, a number of integrative Chinese and Western medicine （ICWM） surgeons （such as Prof. WU Xian-zhong） first started the application of traditional Chinese medicine （TCM） in acute abdominal surgery, and thus they became the pioneers of perioperative therapy with ICWM. Since then, they haveaccumulated abundant experience in this field. At the 1st National Conference of Perioperative Therapy with ICWM in November 1994, the academician WU Xian-zhong, et al believed that perioperative therapy with ICWM hold promise for the future.
文摘Objective:To explore the cardiac protective effect of integrative therapy in acute myocardial infarction(AMI) with elevated ST segment after reperfusion.Methods:Sixty-four AMI patients who having received decimalization by thrombolysis were assigned to two groups by retrospective analysis,36 patients in the treated group and 28 in the control group.Both were treated by intravenous administering of urokinase for thrombolysis,and to the treated group,intravenous dripping of Xueshuantong Injection(血栓通注射液,XST) ...
基金Supported by the National Ministry of Science and Technology "Eleventh Five-Year" Project of China(No.2006BA104A11)
文摘Objective： To analyze the clinical evaluation of Parkinson＇s disease （PD） patients receiving integrated Chinese and Western medicine therapy. Methods： One hundred and twenty patients were enrolled and randomly allocated to a control group or treatment group. Patients in the two groups received placebo and Bushen Huoxue Granule （补肾活血颗粒, BHG）, respectively. Both groups received baseline levodopa and benserazide （Madopar）. The effects of treatment were assessed monthly during the 9-month treatment. Means of evaluation included Unified PD Rating Scale （UPDRS） scores （Ⅱ and Ⅲ）, sleep scale score, 10 m turn back test （getting up time, 10 m × 2 times, and turning time）, timing motor test （TMT）-Ieft and TMT-right, which were treated as the dependent variables; and age, sex, duration of PD, Hoehn and Yahr （H-Y） stage and Madopar dosage of admitted PD patients were as the independent variables. Multiple linear regression was used to analyze these factors. Results： H-Y stage significantly affected UPDRSⅡ score, UPDRS Ⅲ score, and getting up time （P〈0.01）. Madopar dosage and H-Y stage significantly affected the 10 m × 2 times （P〈0.05 or P〈0.01）. Madopar dosage significantly affected the sleep scale score （P〈0.05）. There were also significant correlations between age and TMT-left or TMT-right （P〈0.01）, and duration of PD and TMT-right （P〈0.05）. Conclusions： The six assessed means of clinical evaluation （including UPDRS Ⅱ and UPDRS Ⅲ scores, sleep scale score, getting up time, 10 m × 2 times, and turning time） are sensitive indexes in all PD patients. H-Y stage and Madopar dosage are the major factors influencing means of clinical assessment of PD treatment.
