Water is the key medium to transport numerous constituents and to provide a platform for physiological processes to take place in the living organisms in general;it also participates actively in many of these processe...Water is the key medium to transport numerous constituents and to provide a platform for physiological processes to take place in the living organisms in general;it also participates actively in many of these processes. In humans, there are different vehicles to contain water and its constituents. Our objective is to find out whether there is an overall water-base circulation system in the human body by analyzing the updated findings of different research groups on the physiological functions of various seemingly isolated fluid systems. By 1963, there were five separate fluid systems discovered in mammalians: (i) The Primo Vasculature Fluid (PVF) with protein precursors and micro cells held in the Primo Vasculature System (PVS). (ii) Blood with its constituents held in the cardio vasculature. (iii) Extracranial interstitial fluid (ISF) whose vehicle had a very irregular structure—the interstitium all over the body. (iv) The cerebrospinal fluid had been considered to be within the brain ventricles and spinal canal. (v) The extra-cranial lymphatic system which drained ISF, and had been known to join the subclavian vein. Fluid (i) was first reported in 1963 and fluids (ii) to (v) have been known for many decades, but the failure to detect a lymphatic system inside the skull has also been a mystery for many decades. The intra-cranial ISF (which we name as BISF) has drawn little attention, apart from discussing the mechanism of the blood-brain-barrier. During the past decade, there has been direct evidence indicating that CSF and BISF are actually mixed. After that, the intracranial lymphatic system was discovered and confirmed in animal models only slightly over one year back, and we called such fluid as glymphatic-fluid. After reviewing the stated “classical” five fluid systems together with the new findings in Sections 2 - 7, we propose, for the first time, that the PVF, the blood, ISF, a mixture of CSF-BISF, and a mixture of glymphatic-fluid and lymph form an integrative circulation system in water base in the human and other mammalian bodies, as schematically represented in the last section. In this paper, we point out the positive correlation of chronic neuro degenerative diseases such as Alzheimer’s disease, Parkinson’s diseases and the insufficient brain wastes clearance by the glymphatic system. We also discuss the role played by the venous vessels as part of such clearance in upright posture. Moreover, simple non-invasive maneuver techniques are introduced here, as one example of enhancement of glymphatic fluid flow out of the skull to join the lymphatic system. A series of questions are raised in Section 8, the answers to which would help us to understand the transition from physio- to pathological states in the development of many diseases. Detailed analysis of this paper leads us to consider that research in understanding this integrative circulation system is only at the infancy stage, and fluid dynamics investigation seems to be the plausible modality of approach in the near future.展开更多
Due to complex geological structures and a narrow safe mud density window,offshore fractured formations frequently encounter severe lost circulation(LC)during drilling,significantly hindering oil and gas exploration a...Due to complex geological structures and a narrow safe mud density window,offshore fractured formations frequently encounter severe lost circulation(LC)during drilling,significantly hindering oil and gas exploration and development.Predicting LC risks enables the targeted implementation of mitigation strategies,thereby reducing the frequency of such incidents.To address the limitations of existing 3D geomechanical modeling in predicting LC,such as arbitrary factor selection,subjective weight assignment,and the inability to achieve pre-drilling prediction along the entire well section,an improved prediction method is proposed.This method integrates multi-source data and incorporates three LC-related sensitivity factors:fracture characteristics,rock brittleness,and in-situ stress conditions.A quantitative risk assessment model for LC is developed by combining the subjective analytic hierarchy process with the objective entropy weight method(EWM)to assign weights.Subsequently,3D geomechanical modeling is applied to identify regional risk zones,enabling digital visualization for pre-drilling risk prediction.The developed 3D LC risk prediction model was validated using actual LC incidents from drilled wells.Results were generally consistent with field-identified LC zones,with an average relative error of 19.08%,confirming its reliability.This method provides practical guidance for mitigating potential LC risks and optimizing drilling program designs in fractured formations.展开更多
Vertebrobasilar dolichoectasia(VBD),a rare posterior circulation vascular variant disease,is an important risk factor for many acute cerebrovascular diseases.An insufficient understanding of VBD often leads to misdiag...Vertebrobasilar dolichoectasia(VBD),a rare posterior circulation vascular variant disease,is an important risk factor for many acute cerebrovascular diseases.An insufficient understanding of VBD often leads to misdiagnose.Two cases of VBD that were initially diagnosed as posterior circulation watershed infarction are reported here.Absence of common causes of stroke including hypoperfusion,blood system diseases,carotid and aortic dissection,and eosinophil elevation,the symptoms of the 2 patients met the diagnostic criteria of VBD.Both patients displayed symptoms that were in line with the Traditional Chinese Medicine(TCM)syndrome pattern of"Qi deficiency and blood stasis".Accordingly,they were comprehensively treated with Supplementing Qi and activating blood circulation method.The clinical manifestations of the 2 patients were remarkably improved and no recurrence of watershed infarction was found in a 1-year follow-up.A detailed medical history and laboratory examination are capable of improving diagnostic accuracy of VBD.TCM treatment based on syndrome identification might be a promising candidate for VBD management.展开更多
A graph is called an integral graph if it has an integral spectrum i.e.,all eigenvalues are integers.A graph is called circulant graph if it is Cayley graph on the circulant group,i.e.,its adjacency matrix is circulan...A graph is called an integral graph if it has an integral spectrum i.e.,all eigenvalues are integers.A graph is called circulant graph if it is Cayley graph on the circulant group,i.e.,its adjacency matrix is circulant.The rank of a graph is defined to be the rank of its adjacency matrix.This importance of the rank,due to applications in physics,chemistry and combinatorics.In this paper,using Ramanujan sums,we study the rank of integral circulant graphs and gave some simple computational formulas for the rank and provide an example which shows the formula is sharp.展开更多
The Regional Integrated Environmental Model System （RIEMS 2.0） coupled with a chemistry-aerosol model and the Princeton Ocean Model （POM） is employed to simulate regional oceanic impact on atmospheric circulation ...The Regional Integrated Environmental Model System （RIEMS 2.0） coupled with a chemistry-aerosol model and the Princeton Ocean Model （POM） is employed to simulate regional oceanic impact on atmospheric circulation and the direct radiative effect （DRE） of aerosol over East Asia. The aerosols considered in this study include both major anthropogenic aerosols （e.g., sulfate, black carbon, and organic carbon） and natural aerosols （e.g., soil dust and sea salt）. The RIEMS 2.0 is driven by NCEP/NCAR reanalysis II, and the simulated period is from 1 January to 31 December 2006. The results show the following： （1） The simulated annual mean sea-level pressure by RIEMS 2.0 with POM is lower than without POM over the mainland and higher without POM over the ocean. （2） In summer, the subtropical high simulated by RIEMS 2.0 with POM is stronger and extends further westward, and the continental low is stronger than without POM in summer. （3） The aerosol optical depth （AOD） simulated by RIEMS 2.0 with POM is larger in the middle and lower reaches of the Yangtze River than without POM. （4） The direct radiative effect with POM is stronger than that without POM in the middle and lower reaches of the Yangtze River and parts of southern China. Therefore, the authors should take account of the impact of the regional ocean model on studying the direct climate effect ＆aerosols in long term simulation.展开更多
<u>Background:</u><span style="font-family:Verdana;"> Extracorporeal</span><span style="font-family:;" "=""> </span><span style="font-fami...<u>Background:</u><span style="font-family:Verdana;"> Extracorporeal</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">membrane oxygenation is a rescue life support technique used in life threatening</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">conditions of refractory respiratory and/or cardiac distress. Indication for extracorporeal life support in children</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">depends on age and varies from pulmonary to cardiac pathologies. In some cases</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> it may be used as a bridge to a</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">therapeutic procedure.</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">We described here the management of respiratory failure due to hemoptysis in a child with a Fontan circulation</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">and veno-venous extracorporeal membrane oxygenation which served as a bridge to angio-embolization. Hemoptysis can be a life threatening condition which can lead to hypovolemic shock and impaired alveolar gas</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">exchange. The latter can result in respiratory failure and consequent asphyxia.</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">When hemoptysis occurs in a patient with a univentricular</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">heart and a Fontan circulation, management of this</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">clinical situation can be challenging due to the particular physiology of the latter. Total cavopulmonary connection is a palliative surgical repair which constitutes Fontan circulation as a definitive treatment in patients with a univentricular heart. </span><u><span style="font-family:Verdana;">Methods:</span></u><span style="font-family:Verdana;"> Case report description of a 16 year-old boy with a univentricular heart and a Fontan circulation</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">who presented hemoptysis managed with a veno-venous extracorporeal membrane oxygenation (ECMO) as a</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">bridge to angio-embolization. </span><u><span style="font-family:Verdana;">Results:</span></u><span style="font-family:Verdana;"> Hemoptysis due to diffuse intra-alveolar hemorrhage from collateral circulation was successfully treated</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">in this young patient with pulmonary vascular embolization. This allowed to wean the patient from</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">extra-corporeal membrane oxygenation. </span><u><span style="font-family:Verdana;">Conclusion:</span></u><span style="font-family:Verdana;"> Veno-venous ECMO can be life-saving as a bridge to angio-embolization for severe hemoptysis in</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">patients with Fontan circulation. The reported case allows to underline that </span><span style="font-family:Verdana;">our multidisciplinary approach in</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">this complex pediatric patient surely</span><span style="font-family:Verdana;"> participated to improve outcome.</span>展开更多
In recent years, the need to identify molecular markers characterized by high sensitivity and specificity in detecting and monitoring early and colorectal cancer lesions has increased. Up to now, none of the markers o...In recent years, the need to identify molecular markers characterized by high sensitivity and specificity in detecting and monitoring early and colorectal cancer lesions has increased. Up to now, none of the markers or panels of markers analyzed have met the rigorous standards required of a screening program. The important discovery of circulating nucleic acids in biological fluids has aroused intense scientific interest because of their usefulness in malignant and non malignant diseases. Over time, their yield and stability have been identified and compared with other “standard” biomarkers. The analysis of circulating DNA from blood and stool is a relatively simple and non-invasive procedure, representing a very attractive marker to detect genetic and epigenetic mutations and to monitor disease progression. A correlation between blood and stool biomarkers could also help to enhance currently available diagnostic approaches. However, various processing and analytic problems need to be resolved before such an approach can be applied in clinical practice.展开更多
The main idea of this paper is to find an analytical formula for the input conductance of an elevated ferrite film circu-lator to match it systematically to the desired matching network. For solving the ferrite loaded...The main idea of this paper is to find an analytical formula for the input conductance of an elevated ferrite film circu-lator to match it systematically to the desired matching network. For solving the ferrite loaded dielectric resonator included in stripline elevated ferrite film circulator, the off diagonal components of the permeability tensor are taken as the perturbation. The electromagnetic fields computations are done for unperturbed structure. The dipolar resonant frequencies corresponding to harmonics of the resonant modes are then calculated using the perturbation integrals. The quality factor of the circulator is derived in terms of these dipolar resonant frequencies. Energy integrals are calculated to find the energy stored in the ferrite and dielectic layers. An analytical expression for the input conductance of the elevated ferrite film circulators is derived by using the quality factor and energy integrals. In this expression the ferrite and dielectric layers can have different permittivities. Some discussions about the effect of ferrite film thickness and permittivity mismatch on the bandwidth of the circulator are investigated by HFSS commercial software.展开更多
The design of an integral pressurized water reactor (IPWR) focuses on enhancing the safety and reliability of the reactor by incorporating a number of inherent safety features and engineered safety features. However, ...The design of an integral pressurized water reactor (IPWR) focuses on enhancing the safety and reliability of the reactor by incorporating a number of inherent safety features and engineered safety features. However, the characteristics of passive safety systems for the marine reactors are quiet different from those for the land nuclear power plant because of the more formidable and dangerous operation environments of them. This paper presents results of marine black out accident analyses. In the case of a transient, the passive residual heat removal system (PRHRS) is designed to cool the reactor coolant system (RCS) from a normal operation condition to a hot shutdown condition by a natural circulation, and the shutdown cooling system (SCS) is designed to cool the primary system from a hot shutdown condition to a refueling condition by a forced circulation. A realistic calculation has been carried out by using the RELAP5/MOD3.4 code and a sensitivity analysis has been performed to evaluate a passive cooldown capability. The results of the accident analyses show that the reactor coolant system and the passive residual heat removal system adequately remove the core decay heat by a natural circulation.展开更多
文摘Water is the key medium to transport numerous constituents and to provide a platform for physiological processes to take place in the living organisms in general;it also participates actively in many of these processes. In humans, there are different vehicles to contain water and its constituents. Our objective is to find out whether there is an overall water-base circulation system in the human body by analyzing the updated findings of different research groups on the physiological functions of various seemingly isolated fluid systems. By 1963, there were five separate fluid systems discovered in mammalians: (i) The Primo Vasculature Fluid (PVF) with protein precursors and micro cells held in the Primo Vasculature System (PVS). (ii) Blood with its constituents held in the cardio vasculature. (iii) Extracranial interstitial fluid (ISF) whose vehicle had a very irregular structure—the interstitium all over the body. (iv) The cerebrospinal fluid had been considered to be within the brain ventricles and spinal canal. (v) The extra-cranial lymphatic system which drained ISF, and had been known to join the subclavian vein. Fluid (i) was first reported in 1963 and fluids (ii) to (v) have been known for many decades, but the failure to detect a lymphatic system inside the skull has also been a mystery for many decades. The intra-cranial ISF (which we name as BISF) has drawn little attention, apart from discussing the mechanism of the blood-brain-barrier. During the past decade, there has been direct evidence indicating that CSF and BISF are actually mixed. After that, the intracranial lymphatic system was discovered and confirmed in animal models only slightly over one year back, and we called such fluid as glymphatic-fluid. After reviewing the stated “classical” five fluid systems together with the new findings in Sections 2 - 7, we propose, for the first time, that the PVF, the blood, ISF, a mixture of CSF-BISF, and a mixture of glymphatic-fluid and lymph form an integrative circulation system in water base in the human and other mammalian bodies, as schematically represented in the last section. In this paper, we point out the positive correlation of chronic neuro degenerative diseases such as Alzheimer’s disease, Parkinson’s diseases and the insufficient brain wastes clearance by the glymphatic system. We also discuss the role played by the venous vessels as part of such clearance in upright posture. Moreover, simple non-invasive maneuver techniques are introduced here, as one example of enhancement of glymphatic fluid flow out of the skull to join the lymphatic system. A series of questions are raised in Section 8, the answers to which would help us to understand the transition from physio- to pathological states in the development of many diseases. Detailed analysis of this paper leads us to consider that research in understanding this integrative circulation system is only at the infancy stage, and fluid dynamics investigation seems to be the plausible modality of approach in the near future.
基金supported by the National Natural Science Foundation of China(No.52074312)the CNPC Science and Technology Innovation Foundation(No.2021DQ02-0505)+1 种基金the Open Fund Project of the National Key Laboratory for the Enrichment Mechanism and Efficient Development of Shale Oil and Gas(No.36650000-24-ZC0609-0006)the Major Science and Technology Project of Karamay City(No.20232023zdzx0003).
文摘Due to complex geological structures and a narrow safe mud density window,offshore fractured formations frequently encounter severe lost circulation(LC)during drilling,significantly hindering oil and gas exploration and development.Predicting LC risks enables the targeted implementation of mitigation strategies,thereby reducing the frequency of such incidents.To address the limitations of existing 3D geomechanical modeling in predicting LC,such as arbitrary factor selection,subjective weight assignment,and the inability to achieve pre-drilling prediction along the entire well section,an improved prediction method is proposed.This method integrates multi-source data and incorporates three LC-related sensitivity factors:fracture characteristics,rock brittleness,and in-situ stress conditions.A quantitative risk assessment model for LC is developed by combining the subjective analytic hierarchy process with the objective entropy weight method(EWM)to assign weights.Subsequently,3D geomechanical modeling is applied to identify regional risk zones,enabling digital visualization for pre-drilling risk prediction.The developed 3D LC risk prediction model was validated using actual LC incidents from drilled wells.Results were generally consistent with field-identified LC zones,with an average relative error of 19.08%,confirming its reliability.This method provides practical guidance for mitigating potential LC risks and optimizing drilling program designs in fractured formations.
基金the 2019 Major Difficult Diseases Clinical Collaboration Capacity Building Project of Traditional Chinese and Western Medicine-cerebral Infarction(No.YW082)。
文摘Vertebrobasilar dolichoectasia(VBD),a rare posterior circulation vascular variant disease,is an important risk factor for many acute cerebrovascular diseases.An insufficient understanding of VBD often leads to misdiagnose.Two cases of VBD that were initially diagnosed as posterior circulation watershed infarction are reported here.Absence of common causes of stroke including hypoperfusion,blood system diseases,carotid and aortic dissection,and eosinophil elevation,the symptoms of the 2 patients met the diagnostic criteria of VBD.Both patients displayed symptoms that were in line with the Traditional Chinese Medicine(TCM)syndrome pattern of"Qi deficiency and blood stasis".Accordingly,they were comprehensively treated with Supplementing Qi and activating blood circulation method.The clinical manifestations of the 2 patients were remarkably improved and no recurrence of watershed infarction was found in a 1-year follow-up.A detailed medical history and laboratory examination are capable of improving diagnostic accuracy of VBD.TCM treatment based on syndrome identification might be a promising candidate for VBD management.
基金Foundation item： Supported by Hunan Provincial Natural Science Foundation（13JJ3118）
文摘A graph is called an integral graph if it has an integral spectrum i.e.,all eigenvalues are integers.A graph is called circulant graph if it is Cayley graph on the circulant group,i.e.,its adjacency matrix is circulant.The rank of a graph is defined to be the rank of its adjacency matrix.This importance of the rank,due to applications in physics,chemistry and combinatorics.In this paper,using Ramanujan sums,we study the rank of integral circulant graphs and gave some simple computational formulas for the rank and provide an example which shows the formula is sharp.
基金supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No.KZCX2-YW-Q11-03)the National Basic Research Program of China(Grant Nos.2010CB950900 and 2009CB421100)+1 种基金the National Natural Science Foundation of China(Grant No. 91025003)the R&D Special Fund for Public Welfare Industry (Meteorology)(Grant No.GYHY200906020)
文摘The Regional Integrated Environmental Model System （RIEMS 2.0） coupled with a chemistry-aerosol model and the Princeton Ocean Model （POM） is employed to simulate regional oceanic impact on atmospheric circulation and the direct radiative effect （DRE） of aerosol over East Asia. The aerosols considered in this study include both major anthropogenic aerosols （e.g., sulfate, black carbon, and organic carbon） and natural aerosols （e.g., soil dust and sea salt）. The RIEMS 2.0 is driven by NCEP/NCAR reanalysis II, and the simulated period is from 1 January to 31 December 2006. The results show the following： （1） The simulated annual mean sea-level pressure by RIEMS 2.0 with POM is lower than without POM over the mainland and higher without POM over the ocean. （2） In summer, the subtropical high simulated by RIEMS 2.0 with POM is stronger and extends further westward, and the continental low is stronger than without POM in summer. （3） The aerosol optical depth （AOD） simulated by RIEMS 2.0 with POM is larger in the middle and lower reaches of the Yangtze River than without POM. （4） The direct radiative effect with POM is stronger than that without POM in the middle and lower reaches of the Yangtze River and parts of southern China. Therefore, the authors should take account of the impact of the regional ocean model on studying the direct climate effect ＆aerosols in long term simulation.
文摘<u>Background:</u><span style="font-family:Verdana;"> Extracorporeal</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">membrane oxygenation is a rescue life support technique used in life threatening</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">conditions of refractory respiratory and/or cardiac distress. Indication for extracorporeal life support in children</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">depends on age and varies from pulmonary to cardiac pathologies. In some cases</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> it may be used as a bridge to a</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">therapeutic procedure.</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">We described here the management of respiratory failure due to hemoptysis in a child with a Fontan circulation</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">and veno-venous extracorporeal membrane oxygenation which served as a bridge to angio-embolization. Hemoptysis can be a life threatening condition which can lead to hypovolemic shock and impaired alveolar gas</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">exchange. The latter can result in respiratory failure and consequent asphyxia.</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">When hemoptysis occurs in a patient with a univentricular</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">heart and a Fontan circulation, management of this</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">clinical situation can be challenging due to the particular physiology of the latter. Total cavopulmonary connection is a palliative surgical repair which constitutes Fontan circulation as a definitive treatment in patients with a univentricular heart. </span><u><span style="font-family:Verdana;">Methods:</span></u><span style="font-family:Verdana;"> Case report description of a 16 year-old boy with a univentricular heart and a Fontan circulation</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">who presented hemoptysis managed with a veno-venous extracorporeal membrane oxygenation (ECMO) as a</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">bridge to angio-embolization. </span><u><span style="font-family:Verdana;">Results:</span></u><span style="font-family:Verdana;"> Hemoptysis due to diffuse intra-alveolar hemorrhage from collateral circulation was successfully treated</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">in this young patient with pulmonary vascular embolization. This allowed to wean the patient from</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">extra-corporeal membrane oxygenation. </span><u><span style="font-family:Verdana;">Conclusion:</span></u><span style="font-family:Verdana;"> Veno-venous ECMO can be life-saving as a bridge to angio-embolization for severe hemoptysis in</span></span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">patients with Fontan circulation. The reported case allows to underline that </span><span style="font-family:Verdana;">our multidisciplinary approach in</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">this complex pediatric patient surely</span><span style="font-family:Verdana;"> participated to improve outcome.</span>
基金Supported by the National Natural Science Foundation of China(2 0 0 0 CG0 1 0 3) the Fund of"The Developing Program for Outstanding Person"in NPUS & T Innovation Foundation for Young Teachers of Northwestern Polytechnical University.
文摘In this paper, the spectrum and characteristic polynomial for a special kind of symmetric block circulant matrices are given.
文摘In recent years, the need to identify molecular markers characterized by high sensitivity and specificity in detecting and monitoring early and colorectal cancer lesions has increased. Up to now, none of the markers or panels of markers analyzed have met the rigorous standards required of a screening program. The important discovery of circulating nucleic acids in biological fluids has aroused intense scientific interest because of their usefulness in malignant and non malignant diseases. Over time, their yield and stability have been identified and compared with other “standard” biomarkers. The analysis of circulating DNA from blood and stool is a relatively simple and non-invasive procedure, representing a very attractive marker to detect genetic and epigenetic mutations and to monitor disease progression. A correlation between blood and stool biomarkers could also help to enhance currently available diagnostic approaches. However, various processing and analytic problems need to be resolved before such an approach can be applied in clinical practice.
文摘The main idea of this paper is to find an analytical formula for the input conductance of an elevated ferrite film circu-lator to match it systematically to the desired matching network. For solving the ferrite loaded dielectric resonator included in stripline elevated ferrite film circulator, the off diagonal components of the permeability tensor are taken as the perturbation. The electromagnetic fields computations are done for unperturbed structure. The dipolar resonant frequencies corresponding to harmonics of the resonant modes are then calculated using the perturbation integrals. The quality factor of the circulator is derived in terms of these dipolar resonant frequencies. Energy integrals are calculated to find the energy stored in the ferrite and dielectic layers. An analytical expression for the input conductance of the elevated ferrite film circulators is derived by using the quality factor and energy integrals. In this expression the ferrite and dielectric layers can have different permittivities. Some discussions about the effect of ferrite film thickness and permittivity mismatch on the bandwidth of the circulator are investigated by HFSS commercial software.
文摘The design of an integral pressurized water reactor (IPWR) focuses on enhancing the safety and reliability of the reactor by incorporating a number of inherent safety features and engineered safety features. However, the characteristics of passive safety systems for the marine reactors are quiet different from those for the land nuclear power plant because of the more formidable and dangerous operation environments of them. This paper presents results of marine black out accident analyses. In the case of a transient, the passive residual heat removal system (PRHRS) is designed to cool the reactor coolant system (RCS) from a normal operation condition to a hot shutdown condition by a natural circulation, and the shutdown cooling system (SCS) is designed to cool the primary system from a hot shutdown condition to a refueling condition by a forced circulation. A realistic calculation has been carried out by using the RELAP5/MOD3.4 code and a sensitivity analysis has been performed to evaluate a passive cooldown capability. The results of the accident analyses show that the reactor coolant system and the passive residual heat removal system adequately remove the core decay heat by a natural circulation.
