With the modernization and internationalization of traditional Chinese medicine(TCM),the requirement for quality control has increased.The quality marker(Q-marker)is an important standard in this field and has been im...With the modernization and internationalization of traditional Chinese medicine(TCM),the requirement for quality control has increased.The quality marker(Q-marker)is an important standard in this field and has been implemented with remarkable success in recent years.However,the establishment of Qmarkers remains fragmented and the process lacks systematicity,resulting in inconsistent quality control and insufficient correlation with clinical efficacy and safety of TCM.This review introduces four multimodal integrated approaches that contribute to the discovery of more comprehensive and accurate Qmarkers,thus aiding in the establishment of new quality control patterns based on the characteristics and principles of TCM.These include the whole-process quality control strategy,chemical-activity-based screening method,efficacy,safety,and consistent combination strategy,and TCM theory-guided approach.Furthermore,methodologies and representative examples of these strategies are described,and important future directions and questions in this field are also proposed.展开更多
Improving the reversibility of anionic redox and inhibiting irreversible oxygen evolution are the main challenges in the application of high reversible capacity Li-rich Mn-based cathode materials.A facile synchronous ...Improving the reversibility of anionic redox and inhibiting irreversible oxygen evolution are the main challenges in the application of high reversible capacity Li-rich Mn-based cathode materials.A facile synchronous lithiation strategy combining the advantages of yttrium doping and LiYO_(2) surface coating is proposed.Yttrium doping effectively suppresses the oxygen evolution during the delithiation process by increasing the energy barrier of oxygen evolution reaction through strong Y–O bond energy.LiYO_(2) nanocoating has the function of structural constraint and protection,that protecting the lattice oxygen exposed to the surface,thus avoiding irreversible oxidation.As an Li^(+) conductor,LiYO_(2) nano-coating can provide a fast Li^(+) transfer channel,which enables the sample to have excellent rate performance.The synergistic effect of Y doping and nano-LiYO_(2) coating integration suppresses the oxygen release from the surface,accelerates the diffusion of Li^(+)from electrolyte to electrode and decreases the interfacial side reactions,enabling the lithium ion batteries to obtain good electrochemical performance.The lithium-ion full cell employing the Y-1 sample(cathode)and commercial graphite(anode)exhibit an excellent specific energy density of 442.9 Wh kg^(-1) at a current density of 0.1C,with very stable safety performance,which can be used in a wide temperature range(60 to-15℃)stable operation.This result illustrates a new integration strategy for advanced cathode materials to achieve high specific energy density.展开更多
Background:Schistosomiasis remains a major public health concern in China.Since 2004,an integrated strategy was developed to control the transmission of Schistosoma japonicum in China.However,the long-term effectivene...Background:Schistosomiasis remains a major public health concern in China.Since 2004,an integrated strategy was developed to control the transmission of Schistosoma japonicum in China.However,the long-term effectiveness of this integrated strategy for the interruption of schistosomiasis transmission remains unknown in the mountainous and hilly regions of China until now.This longitudinal study aims to evaluate the effectiveness of the integrated strategy on transmission interruption of schistosomiasis in Sichuan Province from 2005 through 2014.Methods:The data regarding replacement of bovines with machines,improved sanitation,access to clean water,construction of public toilets and household latrines,snail control,chemotherapy,and health education were captured from the annual report of the schistosomiasis control programmes in Sichuan Province from 2005 to 2014,and S.japonicum infection in humans,bovines and snails were estimated to evaluate the effectiveness of the integrated strategy.Results:During the 10-year period from 2005 through 2014,a total of 536568 machines were used to replace bovines,and 3284333 household lavatories and 15523 public latrines were built.Tap water was supplied to 19116344 residents living in the endemic villages.A total of 230098 hm2 snail habitats were given molluscicide treatment,and 357233 hm2 snail habitats received environmental improvements.There were 7268138 humans and 840845 bovines given praziquantel chemotherapy.During the 10-year study period,information,education and communication(IEC)materials were provided to village officers,teachers and schoolchildren.The 10-year implementation of the integrated strategy resulted in a great reduction in S.japonicum infection in humans,bovines and snails.Since 2007,no acute infection was detected,and no schistosomiasis cases or infected bovines were identified since 2012.In addition,the snail habitats reduced by 62.39%in 2014 as compared to that in 2005,and no S.japonicum infection was identified in snails since 2007.By 2014,88.9%of the endemic counties achieved the transmission interruption of schistosomiasis and transmission control of schistosmiasis was achieved in the whole province in 2008.Conclusion:The government-directed and multi-department integrated strategy is effective for interrupting the transmission of schistosomiasis in the mountainous and hilly regions of China.展开更多
Understanding of how combinations of agronomic options can be used to improve the grain yield and nitrogen use efficiency（NUE） of winter wheat is limited. A three-year experiment involving four integrated management...Understanding of how combinations of agronomic options can be used to improve the grain yield and nitrogen use efficiency（NUE） of winter wheat is limited. A three-year experiment involving four integrated management strategies was conducted from 2013 to 2015 in Tai＇an, Shandong Province, China, to evaluate changes in grain yield and NUE. The integrated management treatments were as follows： current practice（T1）; improvement of current practice（T2）; high-yield management（T3）, which aimed to maximize grain yield regardless of the cost of resource inputs; and integrated soil and crop system management（T4） with a higher seeding rate, delayed sowing date, and optimized nutrient management. Seeding rates increased by 75 seeds m^-2 with each treatment from T1（225 seeds m^-2） to T4（450 seeds m^-2）. The sowing dates were delayed from T1（5 th Oct.） to T2 and T3（8 th Oct.）, and to T4 treatment（12 th Oct.）. T1, T2, T3, and T4 received 315, 210, 315, and 240 kg N ha^-1, 120, 90, 210 and 120 kg P2O5 ha^-1, 30, 75, 90, and 45 kg K2O ha^-1, respectively. The ratio of basal application to topdressing for T1, T2, T3, and T4 was 6：4, 5：5, 4：6, and 4：6, respectively, with the N topdressing applied at regreening for T1 and at jointing stage for T2, T3, and T4. The P fertilizers in all treatments were applied as basal fertilizer. The K fertilizer for T1 and T2 was applied as basal fertilizer while the ratio of basal application to topdressing（at jointing stage） of K fertilizer for both T3 and T4 was 6：4. T1, T2, T3, and T4 were irrigated five, four, four and three times, respectively. Treatment T3 produced the highest grain yield among all treatments over three years and the average yield was 9 277.96 kg ha^-1. Grain yield averaged across three years with the T4 treatment（8 892.93 kg ha^-1） was 95.85% of that with T3 and was 21.72 and 6.10% higher than that with T1（7 305.95 kg ha^-1） and T2（8 381.41 kg ha^-1）, respectively. Treatment T2 produced the highest NUE of all the integrated treatments. The NUE with T4 was 95.36% of that with T2 and was 51.91 and 25.62% higher than that with T1 and T3, respectively. The N uptake efficiency（UPE） averaged across three years with T4 was 50.75 and 16.62% higher than that with T1and T3, respectively. The N utilization efficiency（UTE） averaged across three years with T4 was 7.74% higher than that with T3. The increased UPE with T4 compared with T3 could be attributed mostly to the lower available N in T4, while the increased UTE with T4 was mainly due to the highest N harvest index and low grain N concentration, which consequently led to improved NUE. The net profit for T4 was the highest among four treatments and was 174.94, 22.27, and 28.10% higher than that for T1, T2, and T3, respectively. Therefore, the T4 treatment should be a recommendable management strategy to obtain high grain yield, high NUE, and high economic benefits in the target region, although further improvements of NUE are required.展开更多
Phosphorus （P） reserve, largely derived from phosphate rock, is essential for crop growth to support the growing world population. However, a significant proportion of phosphorus used as a fertilizer runs into natur...Phosphorus （P） reserve, largely derived from phosphate rock, is essential for crop growth to support the growing world population. However, a significant proportion of phosphorus used as a fertilizer runs into natural waters, causing eutro- phication and ecological damage. Moreover, most P in the food is eventually discharged as waste after being digested by human and animals. Thus, industrial activities have created a one-way flow of non-renewable P from rocks to farms to lakes, rivers and oceans.展开更多
The Yangtze finless porpoise(YFP)is an endemic freshwater cetacean species that exclusively inhabits the middle and lower reaches of the Yangtze River basin.Since the late 1970s,the YFP has experienced a drastic popul...The Yangtze finless porpoise(YFP)is an endemic freshwater cetacean species that exclusively inhabits the middle and lower reaches of the Yangtze River basin.Since the late 1970s,the YFP has experienced a drastic population decline and was classified as critically endangered by the IUCN in 2013.To save this unique species,a range of integrated conservation measures have been implemented,including strengthening natural habitat protection(in-situ),enhancing insurance populations(ex-situ),and advancing captive breeding and research initiatives.These efforts have yielded significant progress in the conservation of the YFP.The natural population has been starting to increase after a sharp decline,and the establishment of three insurance populations has provided a solid foundation for recovery.Additionally,advancement in captive breeding and research has delivered crucial technical support for population conservation.As a flagship species of Yangtze River biodiversity and an indicator of the river’s ecosystem health,the YFP’s integrated conservation strategy not only benefits its own population but also offers valuable insights for the protection of other endangered aquatic species in the Yangtze River and other threatened small cetaceans worldwide.展开更多
Depression is a common comorbidity in gastric cancer(GC)patients,with prevalence rates reaching up to 57%,particularly in advanced stages and during active treatment.While prior studies have explored the bidirectional...Depression is a common comorbidity in gastric cancer(GC)patients,with prevalence rates reaching up to 57%,particularly in advanced stages and during active treatment.While prior studies have explored the bidirectional relationship between GC and depression,this editorial provides a structured synthesis of therapeutic strategies including pharmacological,psychotherapeutic,integrative,and biomarker-driven interventions,within a multidisciplinary care framework.Depression may exacerbate tumor progression through chronic stress and neurotransmitter dysregulation,such asβ2-adrenergic receptor activation,while the cancer burden deepens psychological distress.Antidepressants,especially selective serotonin reuptake inhibitors,have demonstrated efficacy in alleviating depressive symptoms in up to 70%of cases,particularly when used alongside chemotherapy.Psychotherapeutic modalities,including cognitive-behavioral therapy and family-based interventions,help reduce depressive symptoms,improve coping mechanisms,and prevent relapse.Integrative strategies like music therapy,mindfulness,and physical activity further support emotional wellbeing,particularly in mild-to-moderate depression.Multidisciplinary care that combines nutritional support,pain control,and psychosocial interventions is essential.Notably,the integration of interventional therapies with traditional Chinese medicine has shown potential in stabilizing tumor growth and improving mental health,enabling functional“tumor-bearing survival”.Emerging immunotherapies such as cadonilimab may also contribute indirectly to depression alleviation by enhancing treatment efficacy and extending survival.Future research should focus on biomarker-guided approaches,such as targetingβ2-adrenergic signaling,and developing personalized psychosocial care models.A holistic approach that integrates both physical and psychological care is vital to improving outcomes and quality of life in GC patients.展开更多
With the development of global economic integration,building a world-class facilitating business environment has become an urgent need for Hainan Free Trade Port.To solve the existing problems in financial policies,le...With the development of global economic integration,building a world-class facilitating business environment has become an urgent need for Hainan Free Trade Port.To solve the existing problems in financial policies,legal supervision,and other aspects,this paper takes Hainan Free Trade Port as an example to analyze and study its institutional integration strategy for creating a world-class facilitating business environment.The specific integration strategies are summarized to promote the internationalization and facilitation of the business environment of Hainan Free Trade Port and promote the high development of the local economy.展开更多
This minireview focuses on psychological distress and treatment adherence-issues in patients with chronic hepatitis B(CHB).It begins by discussing the epidemiology and disease burden of CHB,and addresses the relations...This minireview focuses on psychological distress and treatment adherence-issues in patients with chronic hepatitis B(CHB).It begins by discussing the epidemiology and disease burden of CHB,and addresses the relationship between psychological distress and treatment adherence.Next,it delves into the current status and risk factors for psychological distress among patients with CHB,and explores the challenges and risk factors related to treatment adherence.Subsequently,it explores the development and implementation of integrated nursing strategies,including psychological interventions and support,self-efficacy enhancement strategies,social support-system optimization,personalized medical care,and technological innovation.Finally,it highlights the limitations of current interventions and clarifies future research priorities.This minireview aims to provide a comprehensive theoretical basis and practical guidance for improving treatment outcomes and quality of life of patients with CHB.In summary,we reveal that psychological distress significantly impacts treatment adherence in patients with CHB and that it is essential to adopt integrated nursing strategies to address these challenges.These findings highlight the need to consider the psychological states of individuals and develop targeted interventions to improve treatment outcomes.展开更多
The article focuses on the design and application of an active reconfigurable controller that mitigates the effects of gust load and actuator faults on a flexible aircraft.A novel integrated adaptive output feedback s...The article focuses on the design and application of an active reconfigurable controller that mitigates the effects of gust load and actuator faults on a flexible aircraft.A novel integrated adaptive output feedback scheme is investigated to address the actuator faults.The real-time fault values provided by the fault estimation module are considered in the reconfigurable control law to improve the fault-tolerant capability.The estimate values of faults and control gains are calculated by analyzing the stability of the overall system.The proposed controller is simulated using a flexible aircraft model with a discrete‘1-cosine’gust,and the results show that it can effectively mitigate the wing root moments and recover the flight maneuver stability after the aircraft suffered from gusts.展开更多
Production planning models generated by common modeling systems do not involve constraints for process operations, and a solution optimized by these models is called a quasi-optimal plan. The quasi-optimal plan cannot...Production planning models generated by common modeling systems do not involve constraints for process operations, and a solution optimized by these models is called a quasi-optimal plan. The quasi-optimal plan cannot be executed in practice some time for no corresponding operating conditions. In order to determine a practi- cally feasible optimal plan and corresponding operating conditions of fluidized catalytic cracking unit （FCCU）, a novel close-loop integrated strategy, including determination of a quasi-optimal plan, search of operating conditions of FCCU and revision of the production planning model, was proposed in this article. In the strategy, a generalized genetic algorithm （GA） coupled with a sequential process simulator of FCCU was applied to search operating conditions implementing the quasi-optimal plan of FCCU and output the optimal individual in the GA search as a final genetic individual. When no corresponding operating conditions were found, the final genetic individual based correction （FGIC） method was presented to revise the production planning model, and then a new quasi-optimal production plan was determined. The above steps were repeated until a practically feasible optimal plan and corresponding operating conditions of FCCU were obtained. The close-loop integrated strategy was validated by two cases, and it was indicated that the strategy was efficient in determining a practically executed optimal plan and corresponding operating conditions of FCCU.展开更多
Traditional Chinese Medicine(TCM)has been extensively used as a mainstay for treating various pathologies.Combing the pharmacology and systems biology approaches,the network pharmacology(NP)approach was developed to p...Traditional Chinese Medicine(TCM)has been extensively used as a mainstay for treating various pathologies.Combing the pharmacology and systems biology approaches,the network pharmacology(NP)approach was developed to predict the probable mechanism underlying the therapeutic effect of TCM.However,approaches solely based on NP cannot effectively elucidate the curative mechanism in a holistic and reliable manner due to limitations in NP-based methods and complexity of TCM components.Thus,integration strategies combining NP with other approaches are increasingly being used.Since the interdisciplinary research in TCM has received much attention in the advent of the big data era of which the NPbased integration strategy is broadly used,the strategy is clearly elaborated in the present review.We summarized several NP-based integration strategies and their applications in TCM studies,including multi-omics approach,gut microbiota study,chemical information analysis,data-mining,and network toxicology study.展开更多
At 0.12 mmol/L γ-glutamyl p-nitroaniline(GGPNA),an improved integrated method was developed for kinetic analysis of γ-glutamyltransferase(GGT) reaction process and the integration with the classical initial rate met...At 0.12 mmol/L γ-glutamyl p-nitroaniline(GGPNA),an improved integrated method was developed for kinetic analysis of γ-glutamyltransferase(GGT) reaction process and the integration with the classical initial rate method to measure serum GGT.For the improved integrated method,an integrated rate equation,which used the predictor variable of reaction time and considered inhibitions by both GGPNA and products,was nonlinearly fit to GGT reaction processes.For the integration strategy,classical initial rates were estimated when GGPNA consumption percentages were below 50%;otherwise,maximal reaction rates of GGT were estimated by the improved integrated method and converted into initial rates according to the differential rate equation at 0.11 mmol/L GGPNA.The inte-gration strategy was validated using optimized GGT kinetic parameters and 10-s intervals to record reaction curves within 8.0 min.By the integration strategy,there was a linear response from 0.9 to 32.0 U/L GGT,coefficients of variation were below 3.5%for GGT from 8.0 to 32.0 U/L(n=5) ,and GGT activities in clinical sera responded linearly to their classical initial rates at 2.00 mmol/L GGPNA with an expected slope.Therefore,the integration strategy was successful in measuring GGT at 0.12 mmol/L GGPNA.展开更多
As an important sustainable development goal,the creation of low-carbon cities(LCCs)has become crucial to creating livable cities and environmental sustainability.Thus,we aimed to understand the factors that support t...As an important sustainable development goal,the creation of low-carbon cities(LCCs)has become crucial to creating livable cities and environmental sustainability.Thus,we aimed to understand the factors that support the transition of traditional cities to LCCs,by analyzing and synthesizing how to promote practical LCC across 15 pilot municipalities in four regions of Thailand,covering four strategies:City of Trees,City of Waste Minimization,City of Energy Efficiency,and City of Sustainable Consumption.Literature research,in-depth interviews,and observations were employed for data collection,while the 5W(who,says what,in which channel,to whom,and with what effect)and SMCR(sender,message,channel,and receiver)models were used to create a communication analysis framework.Results revealed that the effective activities of municipalities should increase tree planting and implement more serious regulations for the conservation of existing trees.Making compost and establishing waste recycling banks are recommended for rural municipalities,while optimization of garbage and wastewater management systems and facilities should be highlighted in urban municipalities.Moreover,recycling,low-carbon agriculture,second-hand shops/markets,green markets,and homegrown vegetables should be encouraged for sustainable consumption.Working with local municipalities,credible leaders and representatives were the key senders.Additionally,message design should compare the pros and cons of behaviors,connect with local health and tourism,and promote dialogue in easy-to-understand and thought-provoking language.Receivers that drive LCC should have an excellent understanding of LCC practice and its benefits,be public-minded,and have a desire to live in a good environment.展开更多
The establishment and rapid rise of the European Union (EU) have increasingly made Europe an independent force. Objectively, the enlargement of both the EU and NATO has speeded up the process of European integration, ...The establishment and rapid rise of the European Union (EU) have increasingly made Europe an independent force. Objectively, the enlargement of both the EU and NATO has speeded up the process of European integration, and "One important link of Russia’s diplomacy展开更多
Merger is a kind of strategic behavior of seeking long-term development. A new enterprise coming from merger is different from the one that come into existence. The strategy of new enterprise formed from merger is con...Merger is a kind of strategic behavior of seeking long-term development. A new enterprise coming from merger is different from the one that come into existence. The strategy of new enterprise formed from merger is constituted through the integration of the strategy for each side. Strategy integration is the guide for the integration of other elements after merger, the way for enterprises to adapt the change of environment and the warranty for the enterprises to achieve strategy synergistic effect. Strategy integration of the merging-enterprises can be realized through several steps： preparation for strategy integration, readjustment to strategy, reorientation of the enterprise and effective communication with target enterprise in the course of carrying out the strategy.展开更多
Effective learning is not merely a matter of an individual having a high IQ. What appears to be important is the learners＇ ability to respond to the particular learning situation and to manage their learning in an ap...Effective learning is not merely a matter of an individual having a high IQ. What appears to be important is the learners＇ ability to respond to the particular learning situation and to manage their learning in an appropriate way. Studies of successful and unsuccessful learners show that people who succeed in learning have developed a range of strategies from which they are able to select those that are most appropriate for a particular problem, to adapt them flexibly for the needs of the specific situation, and to monitor their level of success. Based on the assumption that integrating strategies into foreign language teaching is both valuable and achievable and that their accomplishment can enhance independent foreign language learning, this paper offered a model of strategy-based instruction, which includes both explicit and implicit integration of strategies into classroom instruction.展开更多
The professional and moral education of high school mathematics teachers will make classroom management work better,but their work pressure will also lead to classroom management problems.To do a good job in high scho...The professional and moral education of high school mathematics teachers will make classroom management work better,but their work pressure will also lead to classroom management problems.To do a good job in high school class teacher management and organically integrate it with mathematics teaching,we need to start from two aspects:mathematics teaching class teachers and class teacher work teaching,and penetrate mathematical thinking into daily classroom management,moral education,and classroom culture construction.Based on the attributes of the subject,we guide high school students to reflect after class to stimulate their self-management initiative through the cultivation of qualified class representatives.In addition,it is necessary to skillfully resolve classroom generative problems,change the roles of teachers and students,and integrate classroom management with mathematics teaching.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.:81973701)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.:ZYYCXTD-D-202002)Westlake Laboratory(Westlake Laboratory of Life Sciences and Biomedicine).
文摘With the modernization and internationalization of traditional Chinese medicine(TCM),the requirement for quality control has increased.The quality marker(Q-marker)is an important standard in this field and has been implemented with remarkable success in recent years.However,the establishment of Qmarkers remains fragmented and the process lacks systematicity,resulting in inconsistent quality control and insufficient correlation with clinical efficacy and safety of TCM.This review introduces four multimodal integrated approaches that contribute to the discovery of more comprehensive and accurate Qmarkers,thus aiding in the establishment of new quality control patterns based on the characteristics and principles of TCM.These include the whole-process quality control strategy,chemical-activity-based screening method,efficacy,safety,and consistent combination strategy,and TCM theory-guided approach.Furthermore,methodologies and representative examples of these strategies are described,and important future directions and questions in this field are also proposed.
基金This work was supported by the Fundamental Research Funds for the Central Universities(DUT20LAB123 and DUT20LAB307)the Natural Science Foundation of Jiangsu Province(BK20191167).
文摘Improving the reversibility of anionic redox and inhibiting irreversible oxygen evolution are the main challenges in the application of high reversible capacity Li-rich Mn-based cathode materials.A facile synchronous lithiation strategy combining the advantages of yttrium doping and LiYO_(2) surface coating is proposed.Yttrium doping effectively suppresses the oxygen evolution during the delithiation process by increasing the energy barrier of oxygen evolution reaction through strong Y–O bond energy.LiYO_(2) nanocoating has the function of structural constraint and protection,that protecting the lattice oxygen exposed to the surface,thus avoiding irreversible oxidation.As an Li^(+) conductor,LiYO_(2) nano-coating can provide a fast Li^(+) transfer channel,which enables the sample to have excellent rate performance.The synergistic effect of Y doping and nano-LiYO_(2) coating integration suppresses the oxygen release from the surface,accelerates the diffusion of Li^(+)from electrolyte to electrode and decreases the interfacial side reactions,enabling the lithium ion batteries to obtain good electrochemical performance.The lithium-ion full cell employing the Y-1 sample(cathode)and commercial graphite(anode)exhibit an excellent specific energy density of 442.9 Wh kg^(-1) at a current density of 0.1C,with very stable safety performance,which can be used in a wide temperature range(60 to-15℃)stable operation.This result illustrates a new integration strategy for advanced cathode materials to achieve high specific energy density.
基金This study was supported by the grant from the China UK Global Health Support Programme(grant no.GHSPOP101).
文摘Background:Schistosomiasis remains a major public health concern in China.Since 2004,an integrated strategy was developed to control the transmission of Schistosoma japonicum in China.However,the long-term effectiveness of this integrated strategy for the interruption of schistosomiasis transmission remains unknown in the mountainous and hilly regions of China until now.This longitudinal study aims to evaluate the effectiveness of the integrated strategy on transmission interruption of schistosomiasis in Sichuan Province from 2005 through 2014.Methods:The data regarding replacement of bovines with machines,improved sanitation,access to clean water,construction of public toilets and household latrines,snail control,chemotherapy,and health education were captured from the annual report of the schistosomiasis control programmes in Sichuan Province from 2005 to 2014,and S.japonicum infection in humans,bovines and snails were estimated to evaluate the effectiveness of the integrated strategy.Results:During the 10-year period from 2005 through 2014,a total of 536568 machines were used to replace bovines,and 3284333 household lavatories and 15523 public latrines were built.Tap water was supplied to 19116344 residents living in the endemic villages.A total of 230098 hm2 snail habitats were given molluscicide treatment,and 357233 hm2 snail habitats received environmental improvements.There were 7268138 humans and 840845 bovines given praziquantel chemotherapy.During the 10-year study period,information,education and communication(IEC)materials were provided to village officers,teachers and schoolchildren.The 10-year implementation of the integrated strategy resulted in a great reduction in S.japonicum infection in humans,bovines and snails.Since 2007,no acute infection was detected,and no schistosomiasis cases or infected bovines were identified since 2012.In addition,the snail habitats reduced by 62.39%in 2014 as compared to that in 2005,and no S.japonicum infection was identified in snails since 2007.By 2014,88.9%of the endemic counties achieved the transmission interruption of schistosomiasis and transmission control of schistosmiasis was achieved in the whole province in 2008.Conclusion:The government-directed and multi-department integrated strategy is effective for interrupting the transmission of schistosomiasis in the mountainous and hilly regions of China.
基金supported by the National Basic Research Program of China (2015CB150404)the Special Fund for Agro-scientific Research in the Public Interest, China (201203096)the Project of Shandong Province Higher Educational Science and Technology Program, China (J15LF07)
文摘Understanding of how combinations of agronomic options can be used to improve the grain yield and nitrogen use efficiency（NUE） of winter wheat is limited. A three-year experiment involving four integrated management strategies was conducted from 2013 to 2015 in Tai＇an, Shandong Province, China, to evaluate changes in grain yield and NUE. The integrated management treatments were as follows： current practice（T1）; improvement of current practice（T2）; high-yield management（T3）, which aimed to maximize grain yield regardless of the cost of resource inputs; and integrated soil and crop system management（T4） with a higher seeding rate, delayed sowing date, and optimized nutrient management. Seeding rates increased by 75 seeds m^-2 with each treatment from T1（225 seeds m^-2） to T4（450 seeds m^-2）. The sowing dates were delayed from T1（5 th Oct.） to T2 and T3（8 th Oct.）, and to T4 treatment（12 th Oct.）. T1, T2, T3, and T4 received 315, 210, 315, and 240 kg N ha^-1, 120, 90, 210 and 120 kg P2O5 ha^-1, 30, 75, 90, and 45 kg K2O ha^-1, respectively. The ratio of basal application to topdressing for T1, T2, T3, and T4 was 6：4, 5：5, 4：6, and 4：6, respectively, with the N topdressing applied at regreening for T1 and at jointing stage for T2, T3, and T4. The P fertilizers in all treatments were applied as basal fertilizer. The K fertilizer for T1 and T2 was applied as basal fertilizer while the ratio of basal application to topdressing（at jointing stage） of K fertilizer for both T3 and T4 was 6：4. T1, T2, T3, and T4 were irrigated five, four, four and three times, respectively. Treatment T3 produced the highest grain yield among all treatments over three years and the average yield was 9 277.96 kg ha^-1. Grain yield averaged across three years with the T4 treatment（8 892.93 kg ha^-1） was 95.85% of that with T3 and was 21.72 and 6.10% higher than that with T1（7 305.95 kg ha^-1） and T2（8 381.41 kg ha^-1）, respectively. Treatment T2 produced the highest NUE of all the integrated treatments. The NUE with T4 was 95.36% of that with T2 and was 51.91 and 25.62% higher than that with T1 and T3, respectively. The N uptake efficiency（UPE） averaged across three years with T4 was 50.75 and 16.62% higher than that with T1and T3, respectively. The N utilization efficiency（UTE） averaged across three years with T4 was 7.74% higher than that with T3. The increased UPE with T4 compared with T3 could be attributed mostly to the lower available N in T4, while the increased UTE with T4 was mainly due to the highest N harvest index and low grain N concentration, which consequently led to improved NUE. The net profit for T4 was the highest among four treatments and was 174.94, 22.27, and 28.10% higher than that for T1, T2, and T3, respectively. Therefore, the T4 treatment should be a recommendable management strategy to obtain high grain yield, high NUE, and high economic benefits in the target region, although further improvements of NUE are required.
基金supported by the National Key Research and Development Program of China (No. 2017YFA0207204)
文摘Phosphorus （P） reserve, largely derived from phosphate rock, is essential for crop growth to support the growing world population. However, a significant proportion of phosphorus used as a fertilizer runs into natural waters, causing eutro- phication and ecological damage. Moreover, most P in the food is eventually discharged as waste after being digested by human and animals. Thus, industrial activities have created a one-way flow of non-renewable P from rocks to farms to lakes, rivers and oceans.
文摘The Yangtze finless porpoise(YFP)is an endemic freshwater cetacean species that exclusively inhabits the middle and lower reaches of the Yangtze River basin.Since the late 1970s,the YFP has experienced a drastic population decline and was classified as critically endangered by the IUCN in 2013.To save this unique species,a range of integrated conservation measures have been implemented,including strengthening natural habitat protection(in-situ),enhancing insurance populations(ex-situ),and advancing captive breeding and research initiatives.These efforts have yielded significant progress in the conservation of the YFP.The natural population has been starting to increase after a sharp decline,and the establishment of three insurance populations has provided a solid foundation for recovery.Additionally,advancement in captive breeding and research has delivered crucial technical support for population conservation.As a flagship species of Yangtze River biodiversity and an indicator of the river’s ecosystem health,the YFP’s integrated conservation strategy not only benefits its own population but also offers valuable insights for the protection of other endangered aquatic species in the Yangtze River and other threatened small cetaceans worldwide.
文摘Depression is a common comorbidity in gastric cancer(GC)patients,with prevalence rates reaching up to 57%,particularly in advanced stages and during active treatment.While prior studies have explored the bidirectional relationship between GC and depression,this editorial provides a structured synthesis of therapeutic strategies including pharmacological,psychotherapeutic,integrative,and biomarker-driven interventions,within a multidisciplinary care framework.Depression may exacerbate tumor progression through chronic stress and neurotransmitter dysregulation,such asβ2-adrenergic receptor activation,while the cancer burden deepens psychological distress.Antidepressants,especially selective serotonin reuptake inhibitors,have demonstrated efficacy in alleviating depressive symptoms in up to 70%of cases,particularly when used alongside chemotherapy.Psychotherapeutic modalities,including cognitive-behavioral therapy and family-based interventions,help reduce depressive symptoms,improve coping mechanisms,and prevent relapse.Integrative strategies like music therapy,mindfulness,and physical activity further support emotional wellbeing,particularly in mild-to-moderate depression.Multidisciplinary care that combines nutritional support,pain control,and psychosocial interventions is essential.Notably,the integration of interventional therapies with traditional Chinese medicine has shown potential in stabilizing tumor growth and improving mental health,enabling functional“tumor-bearing survival”.Emerging immunotherapies such as cadonilimab may also contribute indirectly to depression alleviation by enhancing treatment efficacy and extending survival.Future research should focus on biomarker-guided approaches,such as targetingβ2-adrenergic signaling,and developing personalized psychosocial care models.A holistic approach that integrates both physical and psychological care is vital to improving outcomes and quality of life in GC patients.
基金General Scientific Research Project of Hainan Vocational University of Science and Technology-—Exploration of the Impact of Financial Reform on Enterprises in Hainan Free Trade Port(HKKY2024-13)。
文摘With the development of global economic integration,building a world-class facilitating business environment has become an urgent need for Hainan Free Trade Port.To solve the existing problems in financial policies,legal supervision,and other aspects,this paper takes Hainan Free Trade Port as an example to analyze and study its institutional integration strategy for creating a world-class facilitating business environment.The specific integration strategies are summarized to promote the internationalization and facilitation of the business environment of Hainan Free Trade Port and promote the high development of the local economy.
文摘This minireview focuses on psychological distress and treatment adherence-issues in patients with chronic hepatitis B(CHB).It begins by discussing the epidemiology and disease burden of CHB,and addresses the relationship between psychological distress and treatment adherence.Next,it delves into the current status and risk factors for psychological distress among patients with CHB,and explores the challenges and risk factors related to treatment adherence.Subsequently,it explores the development and implementation of integrated nursing strategies,including psychological interventions and support,self-efficacy enhancement strategies,social support-system optimization,personalized medical care,and technological innovation.Finally,it highlights the limitations of current interventions and clarifies future research priorities.This minireview aims to provide a comprehensive theoretical basis and practical guidance for improving treatment outcomes and quality of life of patients with CHB.In summary,we reveal that psychological distress significantly impacts treatment adherence in patients with CHB and that it is essential to adopt integrated nursing strategies to address these challenges.These findings highlight the need to consider the psychological states of individuals and develop targeted interventions to improve treatment outcomes.
基金supported by the National Key Research and Development Plan of China(No.2019YFB1706001)the National Natural Science Foundation of China(No.61773001)。
文摘The article focuses on the design and application of an active reconfigurable controller that mitigates the effects of gust load and actuator faults on a flexible aircraft.A novel integrated adaptive output feedback scheme is investigated to address the actuator faults.The real-time fault values provided by the fault estimation module are considered in the reconfigurable control law to improve the fault-tolerant capability.The estimate values of faults and control gains are calculated by analyzing the stability of the overall system.The proposed controller is simulated using a flexible aircraft model with a discrete‘1-cosine’gust,and the results show that it can effectively mitigate the wing root moments and recover the flight maneuver stability after the aircraft suffered from gusts.
文摘Production planning models generated by common modeling systems do not involve constraints for process operations, and a solution optimized by these models is called a quasi-optimal plan. The quasi-optimal plan cannot be executed in practice some time for no corresponding operating conditions. In order to determine a practi- cally feasible optimal plan and corresponding operating conditions of fluidized catalytic cracking unit （FCCU）, a novel close-loop integrated strategy, including determination of a quasi-optimal plan, search of operating conditions of FCCU and revision of the production planning model, was proposed in this article. In the strategy, a generalized genetic algorithm （GA） coupled with a sequential process simulator of FCCU was applied to search operating conditions implementing the quasi-optimal plan of FCCU and output the optimal individual in the GA search as a final genetic individual. When no corresponding operating conditions were found, the final genetic individual based correction （FGIC） method was presented to revise the production planning model, and then a new quasi-optimal production plan was determined. The above steps were repeated until a practically feasible optimal plan and corresponding operating conditions of FCCU were obtained. The close-loop integrated strategy was validated by two cases, and it was indicated that the strategy was efficient in determining a practically executed optimal plan and corresponding operating conditions of FCCU.
文摘Traditional Chinese Medicine(TCM)has been extensively used as a mainstay for treating various pathologies.Combing the pharmacology and systems biology approaches,the network pharmacology(NP)approach was developed to predict the probable mechanism underlying the therapeutic effect of TCM.However,approaches solely based on NP cannot effectively elucidate the curative mechanism in a holistic and reliable manner due to limitations in NP-based methods and complexity of TCM components.Thus,integration strategies combining NP with other approaches are increasingly being used.Since the interdisciplinary research in TCM has received much attention in the advent of the big data era of which the NPbased integration strategy is broadly used,the strategy is clearly elaborated in the present review.We summarized several NP-based integration strategies and their applications in TCM studies,including multi-omics approach,gut microbiota study,chemical information analysis,data-mining,and network toxicology study.
基金Project supported by the National Natural Science Foundation of China (No.30200266)the Program for New Century Excellent Talents in University of Ministry of Education of China(No.NCET-09-928)
文摘At 0.12 mmol/L γ-glutamyl p-nitroaniline(GGPNA),an improved integrated method was developed for kinetic analysis of γ-glutamyltransferase(GGT) reaction process and the integration with the classical initial rate method to measure serum GGT.For the improved integrated method,an integrated rate equation,which used the predictor variable of reaction time and considered inhibitions by both GGPNA and products,was nonlinearly fit to GGT reaction processes.For the integration strategy,classical initial rates were estimated when GGPNA consumption percentages were below 50%;otherwise,maximal reaction rates of GGT were estimated by the improved integrated method and converted into initial rates according to the differential rate equation at 0.11 mmol/L GGPNA.The inte-gration strategy was validated using optimized GGT kinetic parameters and 10-s intervals to record reaction curves within 8.0 min.By the integration strategy,there was a linear response from 0.9 to 32.0 U/L GGT,coefficients of variation were below 3.5%for GGT from 8.0 to 32.0 U/L(n=5) ,and GGT activities in clinical sera responded linearly to their classical initial rates at 2.00 mmol/L GGPNA with an expected slope.Therefore,the integration strategy was successful in measuring GGT at 0.12 mmol/L GGPNA.
基金supported by the National Research Council of Thailand(NRCT)and Biodiversity-Based Economy Development Office(Public Organization)(BEDO),[Grant number.49/2559]。
文摘As an important sustainable development goal,the creation of low-carbon cities(LCCs)has become crucial to creating livable cities and environmental sustainability.Thus,we aimed to understand the factors that support the transition of traditional cities to LCCs,by analyzing and synthesizing how to promote practical LCC across 15 pilot municipalities in four regions of Thailand,covering four strategies:City of Trees,City of Waste Minimization,City of Energy Efficiency,and City of Sustainable Consumption.Literature research,in-depth interviews,and observations were employed for data collection,while the 5W(who,says what,in which channel,to whom,and with what effect)and SMCR(sender,message,channel,and receiver)models were used to create a communication analysis framework.Results revealed that the effective activities of municipalities should increase tree planting and implement more serious regulations for the conservation of existing trees.Making compost and establishing waste recycling banks are recommended for rural municipalities,while optimization of garbage and wastewater management systems and facilities should be highlighted in urban municipalities.Moreover,recycling,low-carbon agriculture,second-hand shops/markets,green markets,and homegrown vegetables should be encouraged for sustainable consumption.Working with local municipalities,credible leaders and representatives were the key senders.Additionally,message design should compare the pros and cons of behaviors,connect with local health and tourism,and promote dialogue in easy-to-understand and thought-provoking language.Receivers that drive LCC should have an excellent understanding of LCC practice and its benefits,be public-minded,and have a desire to live in a good environment.
文摘The establishment and rapid rise of the European Union (EU) have increasingly made Europe an independent force. Objectively, the enlargement of both the EU and NATO has speeded up the process of European integration, and "One important link of Russia’s diplomacy
文摘Merger is a kind of strategic behavior of seeking long-term development. A new enterprise coming from merger is different from the one that come into existence. The strategy of new enterprise formed from merger is constituted through the integration of the strategy for each side. Strategy integration is the guide for the integration of other elements after merger, the way for enterprises to adapt the change of environment and the warranty for the enterprises to achieve strategy synergistic effect. Strategy integration of the merging-enterprises can be realized through several steps： preparation for strategy integration, readjustment to strategy, reorientation of the enterprise and effective communication with target enterprise in the course of carrying out the strategy.
文摘Effective learning is not merely a matter of an individual having a high IQ. What appears to be important is the learners＇ ability to respond to the particular learning situation and to manage their learning in an appropriate way. Studies of successful and unsuccessful learners show that people who succeed in learning have developed a range of strategies from which they are able to select those that are most appropriate for a particular problem, to adapt them flexibly for the needs of the specific situation, and to monitor their level of success. Based on the assumption that integrating strategies into foreign language teaching is both valuable and achievable and that their accomplishment can enhance independent foreign language learning, this paper offered a model of strategy-based instruction, which includes both explicit and implicit integration of strategies into classroom instruction.
文摘The professional and moral education of high school mathematics teachers will make classroom management work better,but their work pressure will also lead to classroom management problems.To do a good job in high school class teacher management and organically integrate it with mathematics teaching,we need to start from two aspects:mathematics teaching class teachers and class teacher work teaching,and penetrate mathematical thinking into daily classroom management,moral education,and classroom culture construction.Based on the attributes of the subject,we guide high school students to reflect after class to stimulate their self-management initiative through the cultivation of qualified class representatives.In addition,it is necessary to skillfully resolve classroom generative problems,change the roles of teachers and students,and integrate classroom management with mathematics teaching.
