The proliferation of wearable biodevices has boosted the development of soft,innovative,and multifunctional materials for human health monitoring.The integration of wearable sensors with intelligent systems is an over...The proliferation of wearable biodevices has boosted the development of soft,innovative,and multifunctional materials for human health monitoring.The integration of wearable sensors with intelligent systems is an overwhelming tendency,providing powerful tools for remote health monitoring and personal health management.Among many candidates,two-dimensional(2D)materials stand out due to several exotic mechanical,electrical,optical,and chemical properties that can be efficiently integrated into atomic-thin films.While previous reviews on 2D materials for biodevices primarily focus on conventional configurations and materials like graphene,the rapid development of new 2D materials with exotic properties has opened up novel applications,particularly in smart interaction and integrated functionalities.This review aims to consolidate recent progress,highlight the unique advantages of 2D materials,and guide future research by discussing existing challenges and opportunities in applying 2D materials for smart wearable biodevices.We begin with an in-depth analysis of the advantages,sensing mechanisms,and potential applications of 2D materials in wearable biodevice fabrication.Following this,we systematically discuss state-of-the-art biodevices based on 2D materials for monitoring various physiological signals within the human body.Special attention is given to showcasing the integration of multi-functionality in 2D smart devices,mainly including self-power supply,integrated diagnosis/treatment,and human–machine interaction.Finally,the review concludes with a concise summary of existing challenges and prospective solutions concerning the utilization of2D materials for advanced biodevices.展开更多
[Objective]Under the combined impact of climate change and urbanization,urban rainstorm flood disasters occur frequently,seriously restricting urban safety and sustainable development.Relying on traditional grey infra...[Objective]Under the combined impact of climate change and urbanization,urban rainstorm flood disasters occur frequently,seriously restricting urban safety and sustainable development.Relying on traditional grey infrastructure such as pipe networks for urban stormwater management is not enough to deal with urban rainstorm flood disasters under extreme rainfall events.The integration of green,grey and blue systems(GGB-integrated system)is gradually gaining recognition in the field of global flood prevention.It is necessary to further clarify the connotation,technical and engineering implementation strategies of the GGB-integrated system,to provide support for the resilient city construction.[Methods]Through literature retrieval and analysis,the relevant research and progress related to the layout optimization and joint scheduling optimization of the GGBintegrated system were systematically reviewed.In response to existing limitations and future engineering application requirements,key supporting technologies including the utilization of overground emergency storage spaces,safety protection of underground important infrastructure and multi-departmental collaboration,were proposed.A layout optimization framework and a joint scheduling framework for the GGB-integrated system were also developed.[Results]Current research on layout optimization predominantly focuses on the integration of green system and grey system,with relatively fewer studies incorporating blue system infrastructure into the optimization process.Moreover,these studies tend to be on a smaller scale with simpler scenarios,which do not fully capture the complexity of real-world systems.Additionally,optimization objective tend to prioritize environmental and economic goals,while social and ecological factors are less frequently considered.Current research on joint scheduling optimization is often limited to small-scale plots,with insufficient attention paid to the entire system.There is a deficiency in method for real-time,automated determination of optimal control strategies for combinations of multiple system facilities based on actual rainfall-runoff processes.Additionally,the application of emergency facilities during extreme conditions is not sufficiently addressed.Furthermore,both layout optimization and joint scheduling optimization lack consideration of the mute feed effect of flood and waterlogging in urban,watershed and regional scales.[Conclusion]Future research needs to improve the theoretical framework for layout optimization and joint scheduling optimization of GGB-integrated system.Through the comprehensive application of the Internet of things,artificial intelligence,coupling model development,multi-scale analysis,multi-scenario simulation,and the establishment of multi-departmental collaboration mechanisms,it can enhance the flood resilience of urban areas in response to rainfall events of varying intensities,particularly extreme rainfall events.展开更多
Background:Diabetic cardiomyopathy(DCM)is a type of cardiomyopathy caused by long-term diabetes,characterized by abnormal myocardial structure and function,which can lead to heart failure.Berberine(BBR),a quaternary a...Background:Diabetic cardiomyopathy(DCM)is a type of cardiomyopathy caused by long-term diabetes,characterized by abnormal myocardial structure and function,which can lead to heart failure.Berberine(BBR),a quaternary ammonium alkaloid isolated from Coptidis Rhizoma,a traditional Chinese medicine,has superior anti-diabetic and heart-protective properties.The purpose of this study is to assess the impact of BBR on DCM.Methods:This study used a systems pharmacology approach to evaluate the related proteins and signalling pathways between BBR and DCM targets,combined with experimental validation using diabetic mouse heart sections.Microstructural and pathological changes were observed using Hematoxylin-eosin,Masson’s trichrome stain and wheat germ agglutinin staining.Immunofluorescence and western blot were used to determine protein expression.Results:The results indicate that BBR and DCM share 21 core relevant targets,with cross-targets predominantly located in mitochondrial,endoplasmic reticulum,and plasma membrane components.BBR exerts its main effects in improving DCM by maintaining mitochondrial integrity,particularly involving the PI3K-AKT-GSK3βand apoptosis signalling pathways.In addition,post-treatment changes in the key targets of BBR,including cysteine aspartate specific protease(Caspase)-3,phosphoinositide 3-kinase(PI3K)and mitochondria-related proteins,are suggestive of its efficacy.Conclusion:BBR crucially improves DCM by maintaining mitochondrial integrity,inhibiting apoptosis,and modulating PI3K-AKT-GSK3βsignaling.Further studies must address animal model limitations and validate clinical efficacy to understand BBR’s mechanisms fully and its potential clinical use.展开更多
The design of Human Occupied Vehicle （HOV） is a typical multidisciplinary problem, but heavily dependent on the experience of naval architects at present engineering design. In order to relieve the experience depend...The design of Human Occupied Vehicle （HOV） is a typical multidisciplinary problem, but heavily dependent on the experience of naval architects at present engineering design. In order to relieve the experience dependence and improve the design, a new Multidisciplinary Design Optimization （MDO） method ＂Bi-Level Integrated System Collaborative Optimization （BLISCO）＂ is applied to the conceptual design of an HOV, which consists of hull module, resistance module, energy module, structure module, weight module, and the stability module. This design problem is defined by 21 design variables and 23 constraints, and its objective is to maximize the ratio of payload to weight. The results show that the general performance of the HOV can be greatly improved by BLISCO.展开更多
To solve the coupling relationship between the strip automatic gauge control and the looper control in traditional control strategy of tandem hot rolling,a distributed model predictive control(DMPC)strategy for the ta...To solve the coupling relationship between the strip automatic gauge control and the looper control in traditional control strategy of tandem hot rolling,a distributed model predictive control(DMPC)strategy for the tandem hot rolling was explored,and a series of simulation experiments were carried out.Firstly,based on the state space analysis method,the multivariable dynamic transition process of hot strip rolling was studied,and the state space model of a gauge-looper integrated system in tandem hot rolling was established.Secondly,DMPC strategy based on neighborhood optimization was proposed,which fully considered the coupling relationship in this integrated system.Finally,a series of experiments simulating disturbances and emergency situations were completed with actual rolling data.The experimental results showed that the proposed DMPC control strategy had better performance compared with the traditional proportional-integral control and centralized model predictive control,which is applicable for the gauge-looper integrated system.展开更多
In inertial navigation system(INS) and global positioning system(GPS) integrated system, GPS antennas are usually not located at the same location as the inertial measurement unit(IMU) of the INS, so the lever arm eff...In inertial navigation system(INS) and global positioning system(GPS) integrated system, GPS antennas are usually not located at the same location as the inertial measurement unit(IMU) of the INS, so the lever arm effect exists, which makes the observation equation highly nonlinear. The INS/GPS integration with constant lever arm effect is studied. The position relation of IMU and GPS's antenna is represented in the earth centered earth fixed frame, while the velocity relation of these two systems is represented in local horizontal frame. Due to the small integration time interval of INS, i.e. 0.1 s in this work, the nonlinearity in the INS error equation is trivial, so the linear INS error model is constructed and addressed by Kalman filter's prediction step. On the other hand, the high nonlinearity in the observation equation due to lever arm effect is addressed by unscented Kalman filter's update step to attain higher accuracy and better applicability. Simulation is designed and the performance of the hybrid filter is validated.展开更多
A novel distributed numerical control (DNC) integrated system based on plug-in software technology is proposed. It connects new or old numerical control (NC) machine tools which have inhomogeneous numerical control sy...A novel distributed numerical control (DNC) integrated system based on plug-in software technology is proposed. It connects new or old numerical control (NC) machine tools which have inhomogeneous numerical control systems with CAD/CAM system by CANbus network. A DNC computer is able to control 15 sets of NC machine tools reliably at the same time. The novel DNC system increases the efficiency of machine tools and improve the production management level by realizing non-paper production, agile manufacturing, networked manufacturing and so on in the near future. Key technologies to construct the novel DNC integrated system include the integration of inhomogeneous numerical control systems, NC program restart, and algorithm for communication competition. Such system has demonstrated successful applications in some corporations that have acquired good economic benefits and social effects.展开更多
Terahertz time-domain spectroscopy(THz-TDS)system,as a new means of spectral analysis and detection,plays an increasingly pivotal role in basic scientific research.However,owing to the long scanning time of the tradit...Terahertz time-domain spectroscopy(THz-TDS)system,as a new means of spectral analysis and detection,plays an increasingly pivotal role in basic scientific research.However,owing to the long scanning time of the traditional THz-TDS system and the complex control of the asynchronous optical scanning(ASOPS)system,which requires frequent calibration,we combine traditional THz-TDS and ASOPS systems to form a composite system and propose an all-fiber trigger signal generation method based on the time overlapping interference signal generated by the collinear motion of two laser pulses.Finally,the time-domain and frequency-domain spectra are obtained by using two independent systems in the integrated systems.It is found that the full width at half maximum(FWHM)of the time-domain spectra and the spectral width of the frequency-domain spectra are almost the same,but the sampling speed of the ASOPS system is significantly faster than that of the traditional THz-TDS system,which conduces to the study of the transient characteristics of substances.展开更多
The research on water masses is always one important facet of Oceanography. I adopt the method of Fuzzy Density Clustering to analyse water masses. Meanwhile, I use Visual Basic 6.0 as developing platform and utilize ...The research on water masses is always one important facet of Oceanography. I adopt the method of Fuzzy Density Clustering to analyse water masses. Meanwhile, I use Visual Basic 6.0 as developing platform and utilize the MapX components to develop the platform of GIS. By integrating the Water Masses Model compiled by FORTRAN language, and GIS using Tight Coupling, I develop an Integrated System. That makes all phases are finished in one condition, including the gain of computing grid, the pick-up and analysis of data, the choice of parameters and resetting, the computing of model, and the result＇s visualization. It improves the efficiency of the data analysis and decision-making Finally, this system is applied in the Zhoushan fishing ground and adjacent region. The results are satisfying.展开更多
This paper describes the functions and the features of the integrated system of aerial survey and tower locations optimization for transmission lines, which includes all stages from data acquisition, data transmission...This paper describes the functions and the features of the integrated system of aerial survey and tower locations optimization for transmission lines, which includes all stages from data acquisition, data transmission and data processing to automatic optimization of the tower locations and drawing. The paper also briefly describes the economic benefit gained from this system, and finally proposes the directions of the future development for this system.展开更多
An integrated system has been provided with a-Si/H solar cells as energy conversion device,NiCo_(2)O_(4)battery-supercapacitor hybrid(BSH)as energy storage device,and light emitting diodes(LEDs)as energy utilization d...An integrated system has been provided with a-Si/H solar cells as energy conversion device,NiCo_(2)O_(4)battery-supercapacitor hybrid(BSH)as energy storage device,and light emitting diodes(LEDs)as energy utilization device.By designing three-dimensional hierarchical NiCo_(2)O_(4)arrays as faradic electrode,with capacitive electrode of active carbon(AC),BSHs were assembled with energy density of 16.6 Wh kg^(-1),power density of 7285 W kg^(-1),long-term stability with 100%retention after 15,000 cycles,and rather low self-discharge.The NiCo_(2)O_(4)//AC BSH was charged to 1.6 V in 1 s by solar cells and acted as reliable sources for powering LEDs.The integrated system is rational for operation,having an overall efficiency of 8.1%with storage efficiency of 74.24%.The integrated system demonstrates a stable solar power conversion,outstanding energy storage behavior,and reliable light emitting.Our study offers a precious strategy to design a self-driven integrated system for highly efficient energy utilization.展开更多
This article reports an innovative integrated system utilizing solar energy as power for decentralized wastewater treatment, which consists of an oxidation ditch with double channels and a photovoltaic （PV） system w...This article reports an innovative integrated system utilizing solar energy as power for decentralized wastewater treatment, which consists of an oxidation ditch with double channels and a photovoltaic （PV） system without a storage battery. Because the system operates without a storage battery, which can reduce the cost of the PV system, the solar radiation intensity affects the amount of power output from the PV system. To ensure that the power output is sufficient in all different weather conditions, the solar radiation intensity of 78 W/m 2 with 95% confidence interval was defined as a threshold of power output for the PV system according to the monitoring results in this study, and a step power output mode was used to utilize the solar energy as well as possible. The oxidation ditch driven by the PV system without storage battery ran during the day and stopped at night. Therefore, anaerobic, anoxic and aerobic conditions could periodically appear in the oxidation ditch, which was favorable to nitrogen and phosphate removal from the wastewater. The experimental results showed that the system was efficient, achieving average removal efficiencies of 88% COD, 98% NH 4 ＋ -N, 70% TN and 83% TP, under the loading rates of 140 mg COD/（g MLSS·day）, 32 mg NH 4 ＋ -N/（g MLSS·day）, 44 mg TN/（g MLSS·day） and 5 mg TP/（g MLSS·day）.展开更多
This paper discusses the progress of computer integrated processing （CIPS） of coal-preparation and then preserits an intelligence controlled production-process, device-maintenance and production-management system of...This paper discusses the progress of computer integrated processing （CIPS） of coal-preparation and then preserits an intelligence controlled production-process, device-maintenance and production-management system of coal- preparation based on multi-agents （IICMMS-CP）. The construction of the IICMMS-CP, the distributed network control system based on live intelligence control stations and the strategy of implementing distributed intelligence control system are studied in order to overcome the disadvantages brought about by the wide use of the PLC system by coaipreparation plants. The software frame, based on a Multi-Agent Intelligence Control and Maintenance Management integrated system, is studied and the implemention methods of IICMMS-CP are discussed. The characteristics of distributed architecture, cooperation and parallel computing meet the needs of integrated control of coal-preparation plants with large-scale spatial production distribution, densely-related processes and complex systems. Its application further improves the reliability and precision of process control, accuracy of fault identification and intelligence of production adjustment, establishes a technical basis for system integration and flexible production. The main function of the system has been tested in a coal-preparation plant to good effect in stabilizing product quality, improving efficiency and reducing consumption.展开更多
A new adaptive federal Kalman filter for a strapdown integrated navigation system/global positioning system (SINS/GPS) is given. The developed federal Kalman filter is based on the trace operation of parameters estima...A new adaptive federal Kalman filter for a strapdown integrated navigation system/global positioning system (SINS/GPS) is given. The developed federal Kalman filter is based on the trace operation of parameters estimation's error covariance matrix and the spectral radius of update measurement noise variance-covariance matrix for the proper choice of the filter weight and hence the filter gain factors. Theoretical analysis and results from simulation in which the SINS/GPS was compared to conventional Kalman filter are presented. Results show that the algorithm of this adaptive federal Kalman filter is simpler than that of the conventional one. Furthermore, it outperforms the conventional Kalman filter when the system is undertaken measurement malfunctions because of its possession of adaptive ability. This filter can be used in the vehicle integrated navigation system.展开更多
An integrated CAD/CAPP/CAM system of tube manufacturing based on integration frame is presented. In this system, two kinds of data conventions describing tube shape are presented in tube CAD subsystem, the object-orie...An integrated CAD/CAPP/CAM system of tube manufacturing based on integration frame is presented. In this system, two kinds of data conventions describing tube shape are presented in tube CAD subsystem, the object-oriented concept and the goal-driven inference mechanism have been applied in the development of the knowledge-based CAPP subsystem and simulation of tube processing under tube bending simulation subsystem is performed based on the tube model＇s piecewise representation. A tube product case is considered to give the application of the integrated system, and the advantages of the system in the use of tube bending are revealed.展开更多
BACKGROUND Since December 2019,there have been many new cases of coronavirus pneumonia in Wuhan,Hubei Province,which has gradually spread throughout the country.AIM To explore our hospital’s innovative management sys...BACKGROUND Since December 2019,there have been many new cases of coronavirus pneumonia in Wuhan,Hubei Province,which has gradually spread throughout the country.AIM To explore our hospital’s innovative management system to ensure the efficient operation of fever clinics during the epidemic,since controlling the spread of disease is an important way to prevent and control the epidemic.METHODS In total,200 outpatients with fever at our hospital between November 2019 and July 2020 were selected and allocated into two groups.RESULTS The fever clinic in our hospital operated smoothly,and infection with the novel coronavirus disease(COVID-19)has not been reported in our hospital.Additionally,we did not have any cases of missed diagnosis.The awareness regarding COVID-19 infection sources,transmission routes,early symptoms,and preventive measures was significantly higher in our fever clinic than in those of the pre-management group.CONCLUSION"An integrated system,three separate responsibilities"ensured the efficient functioning of our fever outpatient clinic and early screening of COVID-19 cases,which effectively curbed the transmission of COVID-19 and hence prevented COVID-19 pneumonia epidemic in our hospital,ultimately achieving the maximum effect of epidemic prevention and control.展开更多
Heterogeneity is inevitable in enterprises due to their various input requirements. The usage of proprietary integration products results in the increased cost of enterprises. During the integration, the focus area ha...Heterogeneity is inevitable in enterprises due to their various input requirements. The usage of proprietary integration products results in the increased cost of enterprises. During the integration, the focus area has been found to often address only the functional requirements, while the non-functional requirements are side-stepped during the initial stages of a project. Moreover, the use of proprietary integration products and non-standards-based integration platform has given rise to an inflexible integration infrastructure resulting in adaptability concerns. Web services-based integration, based on open standards, is deemed to be the only feasible solution in such cases. This paper explains the performance analysis of enterprise integration in heterogeneous environments for the distributed and the transactional applications. The analysis presented in this paper is seen as a step towards making intelligent decisions well in advance when choosing the integration mechanism/products to address the functional as well as the non-functional requirements considering the future integration needs.展开更多
This paper addresses some key issues in supporting product family design in a 3 D CAD/ PDM integrated system and introduces the techniques developed or adopted in building the integrated system. The general architectu...This paper addresses some key issues in supporting product family design in a 3 D CAD/ PDM integrated system and introduces the techniques developed or adopted in building the integrated system. The general architecture of a 3D CAD/PDM integrated system is organized as five tiers. Multi-agent technology is applied with a collaborative design environment. The rule-based product family architecture （ PFA ） and tabular layouts of article characteristics （TLAC） technique are applied to represent the knowledge for product families. They make the knowledge understandable, simplified and can be exchanged among heterogeneous information systems. A transparently concentric integrated mode is put forward to enable the heterogeneous processes to interact and communicate regardless of the language used to construct each process. With the mode, function calling and information exchanging among different processes are carried out via message translation/parse approach. Currently, the integrated system is implemented in the platform of Windows NT and 2000.展开更多
An optimal structure design of the lattice mismatched GaInP/GaInAs/Ge solar cell with high photoelectric conversion efficiency was proposed. Two-dimensional Bi2Te3/Sb2Te3 nanosheets were prepared by solvothermal synth...An optimal structure design of the lattice mismatched GaInP/GaInAs/Ge solar cell with high photoelectric conversion efficiency was proposed. Two-dimensional Bi2Te3/Sb2Te3 nanosheets were prepared by solvothermal synthesis method used as thermoelectric(TE) functional materials, which is further hybrid with high conductive reduced graphene oxide(rGO) and carbon nanotubes(CNTs). TE film was then fabricated based on above materials. The power factor of the n-type TE film is 19.31 μW/mK2, and the power factor of the p-type TE film is 97.40 μW/mK2. The flexible TE device was integrated with flexible solar cell. Compared with the single photovoltaic(PV) cell, the efficiency of the as-prepared flexible integrated device measured under the AM1.5 illumination is significantly improved. The efficiency of the two parallel tests is increased from 27.26% and 26.59%, to 29.11% and 28.92%, respectively. The increasing ratio reaches 6.7%-8.8%.展开更多
基金the support from the National Natural Science Foundation of China(22272004,62272041)the Fundamental Research Funds for the Central Universities(YWF-22-L-1256)+1 种基金the National Key R&D Program of China(2023YFC3402600)the Beijing Institute of Technology Research Fund Program for Young Scholars(No.1870011182126)。
文摘The proliferation of wearable biodevices has boosted the development of soft,innovative,and multifunctional materials for human health monitoring.The integration of wearable sensors with intelligent systems is an overwhelming tendency,providing powerful tools for remote health monitoring and personal health management.Among many candidates,two-dimensional(2D)materials stand out due to several exotic mechanical,electrical,optical,and chemical properties that can be efficiently integrated into atomic-thin films.While previous reviews on 2D materials for biodevices primarily focus on conventional configurations and materials like graphene,the rapid development of new 2D materials with exotic properties has opened up novel applications,particularly in smart interaction and integrated functionalities.This review aims to consolidate recent progress,highlight the unique advantages of 2D materials,and guide future research by discussing existing challenges and opportunities in applying 2D materials for smart wearable biodevices.We begin with an in-depth analysis of the advantages,sensing mechanisms,and potential applications of 2D materials in wearable biodevice fabrication.Following this,we systematically discuss state-of-the-art biodevices based on 2D materials for monitoring various physiological signals within the human body.Special attention is given to showcasing the integration of multi-functionality in 2D smart devices,mainly including self-power supply,integrated diagnosis/treatment,and human–machine interaction.Finally,the review concludes with a concise summary of existing challenges and prospective solutions concerning the utilization of2D materials for advanced biodevices.
文摘[Objective]Under the combined impact of climate change and urbanization,urban rainstorm flood disasters occur frequently,seriously restricting urban safety and sustainable development.Relying on traditional grey infrastructure such as pipe networks for urban stormwater management is not enough to deal with urban rainstorm flood disasters under extreme rainfall events.The integration of green,grey and blue systems(GGB-integrated system)is gradually gaining recognition in the field of global flood prevention.It is necessary to further clarify the connotation,technical and engineering implementation strategies of the GGB-integrated system,to provide support for the resilient city construction.[Methods]Through literature retrieval and analysis,the relevant research and progress related to the layout optimization and joint scheduling optimization of the GGBintegrated system were systematically reviewed.In response to existing limitations and future engineering application requirements,key supporting technologies including the utilization of overground emergency storage spaces,safety protection of underground important infrastructure and multi-departmental collaboration,were proposed.A layout optimization framework and a joint scheduling framework for the GGB-integrated system were also developed.[Results]Current research on layout optimization predominantly focuses on the integration of green system and grey system,with relatively fewer studies incorporating blue system infrastructure into the optimization process.Moreover,these studies tend to be on a smaller scale with simpler scenarios,which do not fully capture the complexity of real-world systems.Additionally,optimization objective tend to prioritize environmental and economic goals,while social and ecological factors are less frequently considered.Current research on joint scheduling optimization is often limited to small-scale plots,with insufficient attention paid to the entire system.There is a deficiency in method for real-time,automated determination of optimal control strategies for combinations of multiple system facilities based on actual rainfall-runoff processes.Additionally,the application of emergency facilities during extreme conditions is not sufficiently addressed.Furthermore,both layout optimization and joint scheduling optimization lack consideration of the mute feed effect of flood and waterlogging in urban,watershed and regional scales.[Conclusion]Future research needs to improve the theoretical framework for layout optimization and joint scheduling optimization of GGB-integrated system.Through the comprehensive application of the Internet of things,artificial intelligence,coupling model development,multi-scale analysis,multi-scenario simulation,and the establishment of multi-departmental collaboration mechanisms,it can enhance the flood resilience of urban areas in response to rainfall events of varying intensities,particularly extreme rainfall events.
基金supported by the National Natural Science Foundation of China(Grant No.82270892)Natural Science Foundation of Hubei Province(Grant No.2022CFB287)+2 种基金Xianning City Science and Technology Plan Project(Grant No.2022ZRKX052)School projects of Hubei University of Science and Technology(Grant No.2022T01,2021WG05,2021TNB01)Hubei University of Science and Technology School-level Fund(Grant No.BK202122).
文摘Background:Diabetic cardiomyopathy(DCM)is a type of cardiomyopathy caused by long-term diabetes,characterized by abnormal myocardial structure and function,which can lead to heart failure.Berberine(BBR),a quaternary ammonium alkaloid isolated from Coptidis Rhizoma,a traditional Chinese medicine,has superior anti-diabetic and heart-protective properties.The purpose of this study is to assess the impact of BBR on DCM.Methods:This study used a systems pharmacology approach to evaluate the related proteins and signalling pathways between BBR and DCM targets,combined with experimental validation using diabetic mouse heart sections.Microstructural and pathological changes were observed using Hematoxylin-eosin,Masson’s trichrome stain and wheat germ agglutinin staining.Immunofluorescence and western blot were used to determine protein expression.Results:The results indicate that BBR and DCM share 21 core relevant targets,with cross-targets predominantly located in mitochondrial,endoplasmic reticulum,and plasma membrane components.BBR exerts its main effects in improving DCM by maintaining mitochondrial integrity,particularly involving the PI3K-AKT-GSK3βand apoptosis signalling pathways.In addition,post-treatment changes in the key targets of BBR,including cysteine aspartate specific protease(Caspase)-3,phosphoinositide 3-kinase(PI3K)and mitochondria-related proteins,are suggestive of its efficacy.Conclusion:BBR crucially improves DCM by maintaining mitochondrial integrity,inhibiting apoptosis,and modulating PI3K-AKT-GSK3βsignaling.Further studies must address animal model limitations and validate clinical efficacy to understand BBR’s mechanisms fully and its potential clinical use.
基金financially supported by the National Natural Science Foundation of China(Grant No.51109132)the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20110073120015)
文摘The design of Human Occupied Vehicle （HOV） is a typical multidisciplinary problem, but heavily dependent on the experience of naval architects at present engineering design. In order to relieve the experience dependence and improve the design, a new Multidisciplinary Design Optimization （MDO） method ＂Bi-Level Integrated System Collaborative Optimization （BLISCO）＂ is applied to the conceptual design of an HOV, which consists of hull module, resistance module, energy module, structure module, weight module, and the stability module. This design problem is defined by 21 design variables and 23 constraints, and its objective is to maximize the ratio of payload to weight. The results show that the general performance of the HOV can be greatly improved by BLISCO.
基金This work was supported by the National Key R&D Program of China(Grant Nos.2018YFB1308700)the National Natural Science Foundation of China(Grant Nos.U21A20117 and 52074085+1 种基金the Fundamental Research Funds for the Central Univer-sities(Grant No.N2004010)the Liaoning Revitalization Talents651 Program(XLYC1907065).
文摘To solve the coupling relationship between the strip automatic gauge control and the looper control in traditional control strategy of tandem hot rolling,a distributed model predictive control(DMPC)strategy for the tandem hot rolling was explored,and a series of simulation experiments were carried out.Firstly,based on the state space analysis method,the multivariable dynamic transition process of hot strip rolling was studied,and the state space model of a gauge-looper integrated system in tandem hot rolling was established.Secondly,DMPC strategy based on neighborhood optimization was proposed,which fully considered the coupling relationship in this integrated system.Finally,a series of experiments simulating disturbances and emergency situations were completed with actual rolling data.The experimental results showed that the proposed DMPC control strategy had better performance compared with the traditional proportional-integral control and centralized model predictive control,which is applicable for the gauge-looper integrated system.
基金Project(41374018)supported by the National Natural Science Foundation of ChinaProject(J13LN74)supported by the Shandong Province Higher Educational Science and Technology Program,China
文摘In inertial navigation system(INS) and global positioning system(GPS) integrated system, GPS antennas are usually not located at the same location as the inertial measurement unit(IMU) of the INS, so the lever arm effect exists, which makes the observation equation highly nonlinear. The INS/GPS integration with constant lever arm effect is studied. The position relation of IMU and GPS's antenna is represented in the earth centered earth fixed frame, while the velocity relation of these two systems is represented in local horizontal frame. Due to the small integration time interval of INS, i.e. 0.1 s in this work, the nonlinearity in the INS error equation is trivial, so the linear INS error model is constructed and addressed by Kalman filter's prediction step. On the other hand, the high nonlinearity in the observation equation due to lever arm effect is addressed by unscented Kalman filter's update step to attain higher accuracy and better applicability. Simulation is designed and the performance of the hybrid filter is validated.
文摘A novel distributed numerical control (DNC) integrated system based on plug-in software technology is proposed. It connects new or old numerical control (NC) machine tools which have inhomogeneous numerical control systems with CAD/CAM system by CANbus network. A DNC computer is able to control 15 sets of NC machine tools reliably at the same time. The novel DNC system increases the efficiency of machine tools and improve the production management level by realizing non-paper production, agile manufacturing, networked manufacturing and so on in the near future. Key technologies to construct the novel DNC integrated system include the integration of inhomogeneous numerical control systems, NC program restart, and algorithm for communication competition. Such system has demonstrated successful applications in some corporations that have acquired good economic benefits and social effects.
基金Project supported by the National Key Research and Development Program of China(Grant No.2021YFB3200100)the National Natural Science Foundation of China(Grant No.61575131)。
文摘Terahertz time-domain spectroscopy(THz-TDS)system,as a new means of spectral analysis and detection,plays an increasingly pivotal role in basic scientific research.However,owing to the long scanning time of the traditional THz-TDS system and the complex control of the asynchronous optical scanning(ASOPS)system,which requires frequent calibration,we combine traditional THz-TDS and ASOPS systems to form a composite system and propose an all-fiber trigger signal generation method based on the time overlapping interference signal generated by the collinear motion of two laser pulses.Finally,the time-domain and frequency-domain spectra are obtained by using two independent systems in the integrated systems.It is found that the full width at half maximum(FWHM)of the time-domain spectra and the spectral width of the frequency-domain spectra are almost the same,but the sampling speed of the ASOPS system is significantly faster than that of the traditional THz-TDS system,which conduces to the study of the transient characteristics of substances.
文摘The research on water masses is always one important facet of Oceanography. I adopt the method of Fuzzy Density Clustering to analyse water masses. Meanwhile, I use Visual Basic 6.0 as developing platform and utilize the MapX components to develop the platform of GIS. By integrating the Water Masses Model compiled by FORTRAN language, and GIS using Tight Coupling, I develop an Integrated System. That makes all phases are finished in one condition, including the gain of computing grid, the pick-up and analysis of data, the choice of parameters and resetting, the computing of model, and the result＇s visualization. It improves the efficiency of the data analysis and decision-making Finally, this system is applied in the Zhoushan fishing ground and adjacent region. The results are satisfying.
文摘This paper describes the functions and the features of the integrated system of aerial survey and tower locations optimization for transmission lines, which includes all stages from data acquisition, data transmission and data processing to automatic optimization of the tower locations and drawing. The paper also briefly describes the economic benefit gained from this system, and finally proposes the directions of the future development for this system.
基金support of National Natural Science Foundation of China(Nos.51702284 and 21878270)Zhejiang Provincial Natural Science Foundation of China(LR19B060002)+5 种基金the Startup Foundation for Hundred-Talent Program of Zhejiang University(112100-193820101/001/022)the support of Shenzhen Science and Technology Project of China(JCYJ20170412105400428)the support of Zhejiang Provincial Natural Science Foundation of China(LR16F040001)Open Project of Laboratory for Biomedical Engineering of Ministry of Education,Zhejiang Universitythe support of Innovation Platform of Energy Storage Engineering and New Material in Zhejiang University(K19-534202-002)Provincial Innovation Team on Hydrogen Electric Hybrid Power Systems in Zhejiang Province
文摘An integrated system has been provided with a-Si/H solar cells as energy conversion device,NiCo_(2)O_(4)battery-supercapacitor hybrid(BSH)as energy storage device,and light emitting diodes(LEDs)as energy utilization device.By designing three-dimensional hierarchical NiCo_(2)O_(4)arrays as faradic electrode,with capacitive electrode of active carbon(AC),BSHs were assembled with energy density of 16.6 Wh kg^(-1),power density of 7285 W kg^(-1),long-term stability with 100%retention after 15,000 cycles,and rather low self-discharge.The NiCo_(2)O_(4)//AC BSH was charged to 1.6 V in 1 s by solar cells and acted as reliable sources for powering LEDs.The integrated system is rational for operation,having an overall efficiency of 8.1%with storage efficiency of 74.24%.The integrated system demonstrates a stable solar power conversion,outstanding energy storage behavior,and reliable light emitting.Our study offers a precious strategy to design a self-driven integrated system for highly efficient energy utilization.
基金supported by the National Natural Science Foundation of China (No.51138009, 50678170)
文摘This article reports an innovative integrated system utilizing solar energy as power for decentralized wastewater treatment, which consists of an oxidation ditch with double channels and a photovoltaic （PV） system without a storage battery. Because the system operates without a storage battery, which can reduce the cost of the PV system, the solar radiation intensity affects the amount of power output from the PV system. To ensure that the power output is sufficient in all different weather conditions, the solar radiation intensity of 78 W/m 2 with 95% confidence interval was defined as a threshold of power output for the PV system according to the monitoring results in this study, and a step power output mode was used to utilize the solar energy as well as possible. The oxidation ditch driven by the PV system without storage battery ran during the day and stopped at night. Therefore, anaerobic, anoxic and aerobic conditions could periodically appear in the oxidation ditch, which was favorable to nitrogen and phosphate removal from the wastewater. The experimental results showed that the system was efficient, achieving average removal efficiencies of 88% COD, 98% NH 4 ＋ -N, 70% TN and 83% TP, under the loading rates of 140 mg COD/（g MLSS·day）, 32 mg NH 4 ＋ -N/（g MLSS·day）, 44 mg TN/（g MLSS·day） and 5 mg TP/（g MLSS·day）.
文摘This paper discusses the progress of computer integrated processing （CIPS） of coal-preparation and then preserits an intelligence controlled production-process, device-maintenance and production-management system of coal- preparation based on multi-agents （IICMMS-CP）. The construction of the IICMMS-CP, the distributed network control system based on live intelligence control stations and the strategy of implementing distributed intelligence control system are studied in order to overcome the disadvantages brought about by the wide use of the PLC system by coaipreparation plants. The software frame, based on a Multi-Agent Intelligence Control and Maintenance Management integrated system, is studied and the implemention methods of IICMMS-CP are discussed. The characteristics of distributed architecture, cooperation and parallel computing meet the needs of integrated control of coal-preparation plants with large-scale spatial production distribution, densely-related processes and complex systems. Its application further improves the reliability and precision of process control, accuracy of fault identification and intelligence of production adjustment, establishes a technical basis for system integration and flexible production. The main function of the system has been tested in a coal-preparation plant to good effect in stabilizing product quality, improving efficiency and reducing consumption.
文摘A new adaptive federal Kalman filter for a strapdown integrated navigation system/global positioning system (SINS/GPS) is given. The developed federal Kalman filter is based on the trace operation of parameters estimation's error covariance matrix and the spectral radius of update measurement noise variance-covariance matrix for the proper choice of the filter weight and hence the filter gain factors. Theoretical analysis and results from simulation in which the SINS/GPS was compared to conventional Kalman filter are presented. Results show that the algorithm of this adaptive federal Kalman filter is simpler than that of the conventional one. Furthermore, it outperforms the conventional Kalman filter when the system is undertaken measurement malfunctions because of its possession of adaptive ability. This filter can be used in the vehicle integrated navigation system.
基金Sponsored bythe Ministerial Level Research Foundation(T29483939)
文摘An integrated CAD/CAPP/CAM system of tube manufacturing based on integration frame is presented. In this system, two kinds of data conventions describing tube shape are presented in tube CAD subsystem, the object-oriented concept and the goal-driven inference mechanism have been applied in the development of the knowledge-based CAPP subsystem and simulation of tube processing under tube bending simulation subsystem is performed based on the tube model＇s piecewise representation. A tube product case is considered to give the application of the integrated system, and the advantages of the system in the use of tube bending are revealed.
基金Supported by the Zhejiang Natural Science Foundation of China,No.LGF18H030009.
文摘BACKGROUND Since December 2019,there have been many new cases of coronavirus pneumonia in Wuhan,Hubei Province,which has gradually spread throughout the country.AIM To explore our hospital’s innovative management system to ensure the efficient operation of fever clinics during the epidemic,since controlling the spread of disease is an important way to prevent and control the epidemic.METHODS In total,200 outpatients with fever at our hospital between November 2019 and July 2020 were selected and allocated into two groups.RESULTS The fever clinic in our hospital operated smoothly,and infection with the novel coronavirus disease(COVID-19)has not been reported in our hospital.Additionally,we did not have any cases of missed diagnosis.The awareness regarding COVID-19 infection sources,transmission routes,early symptoms,and preventive measures was significantly higher in our fever clinic than in those of the pre-management group.CONCLUSION"An integrated system,three separate responsibilities"ensured the efficient functioning of our fever outpatient clinic and early screening of COVID-19 cases,which effectively curbed the transmission of COVID-19 and hence prevented COVID-19 pneumonia epidemic in our hospital,ultimately achieving the maximum effect of epidemic prevention and control.
文摘Heterogeneity is inevitable in enterprises due to their various input requirements. The usage of proprietary integration products results in the increased cost of enterprises. During the integration, the focus area has been found to often address only the functional requirements, while the non-functional requirements are side-stepped during the initial stages of a project. Moreover, the use of proprietary integration products and non-standards-based integration platform has given rise to an inflexible integration infrastructure resulting in adaptability concerns. Web services-based integration, based on open standards, is deemed to be the only feasible solution in such cases. This paper explains the performance analysis of enterprise integration in heterogeneous environments for the distributed and the transactional applications. The analysis presented in this paper is seen as a step towards making intelligent decisions well in advance when choosing the integration mechanism/products to address the functional as well as the non-functional requirements considering the future integration needs.
基金This paper is supported by National High-Tech Research and Development Plan Foundation in China(2005AA4Z3060) and Electronic Development Fund in 2003.
文摘This paper addresses some key issues in supporting product family design in a 3 D CAD/ PDM integrated system and introduces the techniques developed or adopted in building the integrated system. The general architecture of a 3D CAD/PDM integrated system is organized as five tiers. Multi-agent technology is applied with a collaborative design environment. The rule-based product family architecture （ PFA ） and tabular layouts of article characteristics （TLAC） technique are applied to represent the knowledge for product families. They make the knowledge understandable, simplified and can be exchanged among heterogeneous information systems. A transparently concentric integrated mode is put forward to enable the heterogeneous processes to interact and communicate regardless of the language used to construct each process. With the mode, function calling and information exchanging among different processes are carried out via message translation/parse approach. Currently, the integrated system is implemented in the platform of Windows NT and 2000.
文摘An optimal structure design of the lattice mismatched GaInP/GaInAs/Ge solar cell with high photoelectric conversion efficiency was proposed. Two-dimensional Bi2Te3/Sb2Te3 nanosheets were prepared by solvothermal synthesis method used as thermoelectric(TE) functional materials, which is further hybrid with high conductive reduced graphene oxide(rGO) and carbon nanotubes(CNTs). TE film was then fabricated based on above materials. The power factor of the n-type TE film is 19.31 μW/mK2, and the power factor of the p-type TE film is 97.40 μW/mK2. The flexible TE device was integrated with flexible solar cell. Compared with the single photovoltaic(PV) cell, the efficiency of the as-prepared flexible integrated device measured under the AM1.5 illumination is significantly improved. The efficiency of the two parallel tests is increased from 27.26% and 26.59%, to 29.11% and 28.92%, respectively. The increasing ratio reaches 6.7%-8.8%.
