Driven by the global energy transition and the urgent“dual carbon”goals,regional integrated energy system(RIES)planning is undergoing a paradigm shift from carbon reduction to negative carbon emissions.This paper pr...Driven by the global energy transition and the urgent“dual carbon”goals,regional integrated energy system(RIES)planning is undergoing a paradigm shift from carbon reduction to negative carbon emissions.This paper provides a comprehensive review of the theoretical frameworks and technical pathways for RIES planning from a carbon-centric perspective.A key contribution is the proposed Carbon-Energy-Economy(CEE)triple-dimensional governance framework,which endogenizes carbon factors into planning decisions through emission constraints,trading mechanisms,and capture technologies.We first analyze the fundamental characteristics of RIES and their critical role in achieving carbon neutrality,detailing advancements in multi-energy coupling models,energy router concepts,and standardized energy hub modeling.The paper further explores multi-energy flow analysis methods,and systematically compares the applicability and limitations of various planning algorithms,with emphasis on addressing uncertainties from renewable integration.Finally,we highlight the integration of artificial intelligence with traditional optimization methods,offering new pathways for intelligent,adaptive,and low-carbon RIES planning.This review underscores the transition towards data-physical fusion models,cooperative uncertainty optimization,multi-market planning,and innovative zero/negative-carbon technological routes.展开更多
This paper investigates the traffic offloading optimization challenge in Space-Air-Ground Integrated Networks(SAGIN)through a novel Recursive Multi-Agent Proximal Policy Optimization(RMAPPO)algorithm.The exponential g...This paper investigates the traffic offloading optimization challenge in Space-Air-Ground Integrated Networks(SAGIN)through a novel Recursive Multi-Agent Proximal Policy Optimization(RMAPPO)algorithm.The exponential growth of mobile devices and data traffic has substantially increased network congestion,particularly in urban areas and regions with limited terrestrial infrastructure.Our approach jointly optimizes unmanned aerial vehicle(UAV)trajectories and satellite-assisted offloading strategies to simultaneously maximize data throughput,minimize energy consumption,and maintain equitable resource distribution.The proposed RMAPPO framework incorporates recurrent neural networks(RNNs)to model temporal dependencies in UAV mobility patterns and utilizes a decentralized multi-agent reinforcement learning architecture to reduce communication overhead while improving system robustness.The proposed RMAPPO algorithm was evaluated through simulation experiments,with the results indicating that it significantly enhances the cumulative traffic offloading rate of nodes and reduces the energy consumption of UAVs.展开更多
Carbon-based air cathodes offer low cost,high electrical conductivity,and structural tunability.However,they suffer from limited catalytic activity and inefficient gas transport,and they typically rely on noble metal ...Carbon-based air cathodes offer low cost,high electrical conductivity,and structural tunability.However,they suffer from limited catalytic activity and inefficient gas transport,and they typically rely on noble metal additives or complex multilayer configurations.To tackle these issues,this study devised a self-activated integrated carbon-based air cathode.By integrating in situ catalytic site construction with structural optimization,the strategy not only induces the formation of oxygen functional groups(─C─OH,─C═O,─COOH),hierarchical pores,and uniformly distributed active sites,but also establishes a favorable electronic and mass-transport environment.Furthermore,the roll-pressing-based integrated design streamlines electrode construction,reinforces interfacial bonding,and significantly enhances mechanical stability.Density functional theory(DFT)calculations show that oxygen functional groups initiate hydrogen bonding interaction and promote charge enrichment,which improves the activity of the cathode and facilitates intermediate adsorption/desorption in oxygen reduction and evolution reactions processes.As a result,the integrated air cathode-based rechargeable zinc-air batteries(RZABs)achieve a high specific capacity of 811 mAh g^(-1).It also performs well in quasi-solid-state RZABs and silicon-air batteries systems across a wide temperature range,demonstrating strong adaptability and application potential.This study provides a scalable and cost-effective design strategy for high-performance carbon-based air cathodes,offering new insights into advancing durable and practical metal-air energy systems.展开更多
In recent years,with the accelerating aging process of the population,China has entered an aging society,and the number of elderly patients with chronic diseases has been increasing.The traditional medical and elderly...In recent years,with the accelerating aging process of the population,China has entered an aging society,and the number of elderly patients with chronic diseases has been increasing.The traditional medical and elderly care service models can no longer fully meet their needs.The integrated medical and elderly care model has emerged as the times require.It organically combines medical resources with elderly care resources to provide comprehensive and continuous health management services for the elderly,becoming an important approach to solving the problems of chronic disease management among the elderly.In this regard,this paper first elaborates on the role of integrated medical and elderly care in the management of chronic diseases among the elderly,and then puts forward application strategies of integrated medical and elderly care in the management of chronic diseases among the elderly,in order to provide certain reference for relevant researchers.展开更多
Solar-driven interfacial evaporation presents a promising approach to address global freshwater scarcity.Current challenges in photothermal membrane design lie in achieving concurrent optimization of high solar absorp...Solar-driven interfacial evaporation presents a promising approach to address global freshwater scarcity.Current challenges in photothermal membrane design lie in achieving concurrent optimization of high solar absorption,low thermal conductivity,and water transport,where existing materials fail to establish effective“water-heat-salt”synergistic regulation at the evaporation interface.This study develops a seamlessly integrated Janus membrane through growing hydrophilic Cu_(2−x)S nanostructure on a hydrophobic carbon cloth substrate with carbon black coating(CB/CC).By precisely engineering the submicron pore architecture within the Cu_(2−x)S layer,we established a synergistic optimization mechanism for interfacial water transport,heat management,and salt rejection.The resulting Janus membrane demonstrates a high evaporation rate of 2.22 kg m^(−2)h^(−1)under 1 sun with an energy efficiency of about 88.4%.Notably,the system maintains stable operation in hypersaline environments(20 wt%NaCl)and achieves continuous 5-h salt-resistant evaporation.Moreover,the Janus membranes can effectively purify various industrial wastewater,including acidic,alkaline,and organic pollutants.This study provides a new strategy for developing high-efficiency portable desalination systems through interfacial engineering of pore architecture.展开更多
Cases of widespread bone hydatid infection are relatively rare in clinical practice.In this study,we reported for the first time a validated integrated repair therapy for multiple bone tissues,including the hip,femur,...Cases of widespread bone hydatid infection are relatively rare in clinical practice.In this study,we reported for the first time a validated integrated repair therapy for multiple bone tissues,including the hip,femur,and knee,caused by echinococ cosis.Artificial intelligence(AI)was used to develop a targeted surgical plan and to design a personalized prosthesis.Finite element analysis(FEA)was used to optimize the mechanical effectiveness of a customized integrated replacement prosthesis and to model stress distribution in the surrounding bone.Three-dimensional(3 D)printing was used to fabricate a customized prosthesis.With the assistance of AI,FEA,and 3 D printing technology,a personalized surgical plan and customized prosthesis were successfully constructed based on the patient’s disease.This approach achieved a successful therapeutic effect,demonstrating that AI-assisted personalized medicine holds great promise for the future.展开更多
As one of the major volatile components in extraterrestrial materials,nitrogen(N_(2))isotopes serve not only as tracers for the formation and evolution of the solar system,but also play a critical role in assessing pl...As one of the major volatile components in extraterrestrial materials,nitrogen(N_(2))isotopes serve not only as tracers for the formation and evolution of the solar system,but also play a critical role in assessing planetary habitability and the search for extraterrestrial life.The integrated measurement of N_(2)and argon(Ar)isotopes by using noble gas mass spectrometry represents a state-of-the-art technique for such investigations.To support the growing demands of planetary science research in China,we have developed a high-efficiency,high-precision method for the integrated analysis of N_(2)and Ar isotopes.This was achieved by enhancing gas extraction and purification systems and integrating them with a static noble gas mass spectrometer.This method enables integrated N_(2)-Ar isotope measurements on submilligram samples,significantly improving sample utilization and reducing the impact of sample heterogeneity on volatile analysis.The system integrates CO_(2)laser heating,a modular two-stage Zr-Al getter pump,and a CuO furnace-based purification process,effectively reducing background levels(N_(2)blank as low as 0.35×10^(−6)cubic centimeters at standard temperature and pressure[ccSTP]).Analytical precision is ensured through calibration with atmospheric air and CO corrections.To validate the reliability of the method,we performed N_(2)-Ar isotope analyses on the Allende carbonaceous chondrite,one of the most extensively studied meteorites internationally.The measured N_(2)concentrations range from 19.2 to 29.8 ppm,withδ15N values between−44.8‰and−33.0‰.Concentrations of 40Ar,36Ar,and 38Ar are(12.5-21.1)×10^(−6)ccSTP/g,(90.9-150.3)×10^(−9)ccSTP/g,and(19.2-30.7)×10^(−9)ccSTP/g,respectively.These values correspond to cosmic-ray exposure ages of 4.5-5.7 Ma,consistent with previous reports.Step-heating experiments further reveal distinct release patterns of N and Ar isotopes,as well as their associations with specific mineral phases in the meteorite.In summary,the combined N_(2)-Ar isotopic system offers significant advantages for tracing volatile sources in extraterrestrial materials and will provide essential analytical support for upcoming Chinese planetary missions,such as Tianwen-2.展开更多
Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs:the integrated stress response(ISR)and the senescence-associated secretory phenotype(SASP)...Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs:the integrated stress response(ISR)and the senescence-associated secretory phenotype(SASP).These pathways act as a Yin-Yang system,balancing beneficial and detrimental outcomes across development,tissue homeostasis,and disease.On the yin(protective)side,transient ISR activation and acute SASP signaling foster adaptation,embryonic patterning,wound healing,and regeneration.On the yang(maladaptive)side,chronic ISR signaling and unresolved SASP output drive stem cell exhaustion,fibrosis,inflammation,and tumorigenesis.This duality highlights their roles as both guardians and disruptors of stem cell integrity.Mechanistically,ISR regulates translational control via eukaryotic initiation factor 2 alpha(eIF2α)phosphorylation and activating transcription factor 4(ATF4)-dependent transcription,while SASP reprograms the extracellular milieu through cytokines,growth factors,and proteases.Their crosstalk creates feedback loops that shape tissue niches and long-termstemcell potential.Framing ISR-SASP interactions through a Yin-Yang lens underscores the balance between resilience and decline,to offer new insights into regenerative medicine,anti-aging interventions,and cancer therapeutics.展开更多
This Special Topic of the Journal of Semiconductors(JOS)features expanded versions of key articles presented at the 2024 IEEE International Conference on Integrated Circuits Technologies and Applications(ICTA),which w...This Special Topic of the Journal of Semiconductors(JOS)features expanded versions of key articles presented at the 2024 IEEE International Conference on Integrated Circuits Technologies and Applications(ICTA),which was held in Hangzhou,Zhejiang,China,from October 25 to 27,2024.展开更多
Objective:To analyze the application effectiveness of the integrated medical-nursing comprehensive care model in cases of cerebral infarction and clarify its clinical practical value for the patient rehabilitation pro...Objective:To analyze the application effectiveness of the integrated medical-nursing comprehensive care model in cases of cerebral infarction and clarify its clinical practical value for the patient rehabilitation process.Methods:A total of 60 patients with cerebral infarction admitted from June 2024 to December 2024 were selected as the research subjects and randomly divided into a control group and a research group,with 30 cases in each group.Patients in the control group received routine clinical nursing measures,while those in the study group underwent collaborative healthcare intervention in addition to routine nursing.The intervention included joint disease assessment,personalized rehabilitation training guidance,psychological counseling,and continuous nursing services after discharge.A comparative study was conducted by evaluating indicators such as the scores on adverse emotion scales,the extent of neurological recovery,the effectiveness rate of clinical rehabilitation treatment,and the level of satisfaction with nursing services between the two groups.Results:After the intervention,the scores on the Self-Rating Anxiety Scale(SAS)and the Self-Rating Depression Scale(SDS)in the study group decreased to(40.12±5.01)and(41.36±5.20),respectively,both significantly lower than those in the control group,which were(47.36±5.82)and(48.95±5.63),respectively.The differences between the two groups were statistically significant(p<0.05).The improvement in the neurological deficit scores of patients in the study group reached(9.18±2.04),higher than that in the control group,which was(5.17±1.82)(p<0.05).The overall clinical rehabilitation effectiveness rate in the study group was 93.3%,significantly higher than that in the control group,which was 73.3%.The satisfaction rate with nursing services in the study group reached 96.7%,also higher than that in the control group,which was 83.3%.The differences between the two groups were statistically significant(p<0.05).Conclusion:The integrated healthcare nursing model can effectively alleviate adverse emotional states in patients with cerebral infarction,facilitate the repair and reconstruction of neurological function,improve the effectiveness of clinical rehabilitation treatment and satisfaction with nursing services,and thus holds high value for clinical promotion and application.展开更多
Background:Giant cell arteritis(GCA),the most common systemic vasculitis affecting elderly individuals,currently lacks specific therapies.This study aimed to systematically identify therapeutic targets for GCA through...Background:Giant cell arteritis(GCA),the most common systemic vasculitis affecting elderly individuals,currently lacks specific therapies.This study aimed to systematically identify therapeutic targets for GCA through integration of large-scale multi-omics datasets.Methods:We constructed a multi-stage analytical framework encompassing 32 proteomic datasets(covering 2914 unique plasma proteins)and 6 transcriptomic datasets.Multi-omics integration strategies,including two-sample Mendelian randomization,colocalization analysis,and functional enrichment analysis,were employed to identify and validate causal relationships between candidate targets and GCA risk across 4 independent European-ancestry GCA cohorts.Single-cell RNA sequencing analysis of peripheral blood mononuclear cells from untreated GCA patients was performed to characterize hub gene-immune cell relationships.Results:We identified 43 plasma proteins causally associated with GCA[false discovery rate(FDR)<0.05],with 17 representing novel therapeutic targets.Through dual validation using proteome-wide association studies and transcriptome-wide association studies,we identified 13 high-confidence candidate targets with distinct tissue-specific expression patterns.Unc-51 like kinase 3(ULK3)emerged as the strongest protective factor(odds ratio=0.47,95%confidence interval:0.37–0.71)through autophagy regulation,while SLAMF7 represents an immediate drug repositioning opportunity as the target of food and drug administration-approved elotuzumab.Five targets have existing approved drugs(SLAMF7,ICAM1,IL18,IL6ST,CTSS).Single-cell analysis revealed profound disruption of hub gene-immune cell relationships in untreated GCA patients,with cell-type-specific alterations in inflammatory gene expression,and TYMP as the most critical hub gene.Conclusions:This study provides a clinically-actionable atlas of 43 potential therapeutic targets in GCA,identifying novel mechanisms including autophagy modulation and metabolic reprogramming,with immediate drug repositioning opportunities and precision medicine strategies based on tissue-specific and cell-type-specific expression patterns.These findings require experimental validation before clinical translation.展开更多
Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sen...Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sensing mechanism of the human skin,we have developed a flexible monolithic 3D-integrated tactile sensing system based on a holey MXene paste,where each vertical one-body unit simultaneously functions as a microsupercapacitor and pressure sensor.The in-plane mesopores of MXene significantly improve ion accessibility,mitigate the self-stacking of nanosheets,and allow the holey MXene to multifunctionally act as a sensing material,an active electrode,and a conductive interconnect,thus drastically reducing the interface mismatch and enhancing the mechanical robustness.Furthermore,we fabricate a large-scale device using a blade-coating and stamping method,which demonstrates excellent mechanical flexibility,low-power consumption,rapid response,and stable long-term operation.As a proof-of-concept application,we integrate our sensing array into a smart access control system,leveraging deep learning to accurately identify users based on their unique pressing behaviors.This study provides a promising approach for designing highly integrated,intelligent,and flexible electronic systems for advanced human-computer interactions and personalized electronics.展开更多
A case of imported severe falciparum malaria with spontaneous splenic rupture was reported in this paper.The patient,an African migrant worker,developed hemolytic anemia,sepsis,thrombocytopenia,coagulation dysfunction...A case of imported severe falciparum malaria with spontaneous splenic rupture was reported in this paper.The patient,an African migrant worker,developed hemolytic anemia,sepsis,thrombocytopenia,coagulation dysfunction,liver failure,renal insufficiency,electrolyte disturbance and other clinical manifestations after returning to the local area.Plasmodium falciparum was found by peripheral blood smearscopy and was diagnosed as severe falciparum malaria.After standardized anti-malaria treatment,plasma exchange+cytokine adsorption therapy,the establishment of“forewarning-forewarning-prevention-emergency”predictive nursing management model,the establishment of an integrated nursing team,the division of medical care is clear,professional knowledge is complementary,after three months of regular follow-up,the patient has no malaria recurrence,no refire,the function of all organs returned to normal.展开更多
From April 8 to 9,2025,the Central Conference on Work Related to Neighboring Countries was held in Beijing.General Secretary of the Communist Party of China(CPC)Central Committee Xi Jinping systematically summarized t...From April 8 to 9,2025,the Central Conference on Work Related to Neighboring Countries was held in Beijing.General Secretary of the Communist Party of China(CPC)Central Committee Xi Jinping systematically summarized the achievements and experience of China’s neighborhood work in the new era,scientifically analyzed the situation,clarified the goals,tasks,ideas and measures for neighborhood work in the coming period,and emphasized the need to focus on building a community with a shared future with neighboring countries,striving to break new ground in neighborhood work.Facing the ever-changing international landscape,especially the surrounding environment,China needs to carry out integrated diplomacy,reshape the neighborhood environment,translate the concepts and policies of the CPC neighborhood diplomacy into diplomatic practices and achieve greater results.展开更多
As key technologies in 6G,Space-Air-Ground Integrated Networks(SAGIN)promises to provide seamless global coverage through a comprehensive,ubiquitous communication system,while Integrated Sensing and Communications(ISA...As key technologies in 6G,Space-Air-Ground Integrated Networks(SAGIN)promises to provide seamless global coverage through a comprehensive,ubiquitous communication system,while Integrated Sensing and Communications(ISAC)effectively addresses spectrum congestion by sharing spectrum resources and transceivers for simultaneous communication and sensing operations.However,existing ISAC research has primarily focused on terrestrial networks,with limited exploration of its applications in SAGIN environments.This paper proposes a novel SAGIN-ISAC scheme leveraging High-Altitude Platform Stations(HAPS).In this scheme,HAPS serves as a relay node that not only amplifies and forwards communication signals but also receives and processes target echo signals for parameter estimation.The satellite employs Resilient Massive Access(RMA)to provide communication services to different User Terminals(UTs).To address scenarios with an unknown number of targets,we develop a Two-threshold Detection and Parameter Multiple Signal Classification(MUSIC)algorithm(TDPM),which employs dual-threshold correlation detection to determine the number of targets and utilizes the MUSIC algorithm to estimate targets’Angle of Arrival(AoA),range,and relative velocity.Furthermore,we establish a joint optimization framework that considers both communication and sensing performance,optimizing energy efficiency,detection probability,and the Cramér-Rao bound.The power allocation coefficients are derived through Nash equilibrium,while the precoding matrix is optimized using Sequential Convex Approximation(SCA)to address the non-convex nature of the optimization problem.Experimental results demonstrate that our proposed scheme significantly enhances the overall performance of the SAGIN-ISAC system.展开更多
In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy sys...In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy system(IIES).The upper level represents the integrated energy operator,and the lower level is the electricity-heatgas load aggregator.Owing to the benefit conflict between the upper and lower levels of the IIES,a dynamic pricing mechanism for coordinating the interests of the upper and lower levels is proposed,combined with factors such as the carbon emissions of the IIES,as well as the lower load interruption power.The price of selling energy can be dynamically adjusted to the lower LA in the mechanism,according to the information on carbon emissions and load interruption power.Mutual benefits and win-win situations are achieved between the upper and lower multistakeholders.Finally,CPLEX is used to iteratively solve the bilevel optimization model.The optimal solution is selected according to the joint optimal discrimination mechanism.Thesimulation results indicate that the sourceload coordinate operation can reduce the upper and lower operation costs.Using the proposed pricingmechanism,the carbon emissions and load interruption power of IEO-LA are reduced by 9.78%and 70.19%,respectively,and the capture power of the carbon capture equipment is improved by 36.24%.The validity of the proposed model and method is verified.展开更多
The multi-terminal direct current(DC)grid has extinctive superiorities over the traditional alternating current system in integrating large-scale renewable energy.Both the DC circuit breaker(DCCB)and the current flow ...The multi-terminal direct current(DC)grid has extinctive superiorities over the traditional alternating current system in integrating large-scale renewable energy.Both the DC circuit breaker(DCCB)and the current flow controller(CFC)are demanded to ensure the multiterminal DC grid to operates reliably and flexibly.However,since the CFC and the DCCB are all based on fully controlled semiconductor switches(e.g.,insulated gate bipolar transistor,integrated gate commutated thyristor,etc.),their separation configuration in the multiterminal DC grid will lead to unaffordable implementation costs and conduction power losses.To solve these problems,integrated equipment with both current flow control and fault isolation abilities is proposed,which shares the expensive and duplicated components of CFCs and DCCBs among adjacent lines.In addition,the complicated coordination control of CFCs and DCCBs can be avoided by adopting the integrated equipment in themultiterminal DC grid.In order to examine the current flow control and fault isolation abilities of the integrated equipment,the simulation model of a specific meshed four-terminal DC grid is constructed in the PSCAD/EMTDC software.Finally,the comparison between the integrated equipment and the separate solution is presented a specific result or conclusion needs to be added to the abstract.展开更多
Accurate estimation of mineralogy from geophysical well logs is crucial for characterizing geological formations,particularly in hydrocarbon exploration,CO_(2) sequestration,and geothermal energy development.Current t...Accurate estimation of mineralogy from geophysical well logs is crucial for characterizing geological formations,particularly in hydrocarbon exploration,CO_(2) sequestration,and geothermal energy development.Current techniques,such as multimineral petrophysical analysis,offer details into mineralogical distribution.However,it is inherently time-intensive and demands substantial geological expertise for accurate model evaluation.Furthermore,traditional machine learning techniques often struggle to predict mineralogy accurately and sometimes produce estimations that violate fundamental physical principles.To address this,we present a new approach using Physics-Integrated Neural Networks(PINNs),that combines data-driven learning with domain-specific physical constraints,embedding petrophysical relationships directly into the neural network architecture.This approach enforces that predictions adhere to physical laws.The methodology is applied to the Broom Creek Deep Saline aquifer,a CO_(2) sequestration site in the Williston Basin,to predict the volumes of key mineral constituents—quartz,dolomite,feldspar,anhydrite,illite—along with porosity.Compared to traditional artificial neural networks (ANN),the PINN approach demonstrates higher accuracy and better generalizability,significantly enhancing predictive performance on unseen well datasets.The average mean error across the three blind wells is 0.123 for ANN and 0.042 for PINN,highlighting the superior accuracy of the PINN approach.This method reduces uncertainties in reservoir characterization by improving the reliability of mineralogy and porosity predictions,providing a more robust tool for decision-making in various subsurface geoscience applications.展开更多
Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orien...Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies.展开更多
The proliferation of wearable biodevices has boosted the development of soft,innovative,and multifunctional materials for human health monitoring.The integration of wearable sensors with intelligent systems is an over...The proliferation of wearable biodevices has boosted the development of soft,innovative,and multifunctional materials for human health monitoring.The integration of wearable sensors with intelligent systems is an overwhelming tendency,providing powerful tools for remote health monitoring and personal health management.Among many candidates,two-dimensional(2D)materials stand out due to several exotic mechanical,electrical,optical,and chemical properties that can be efficiently integrated into atomic-thin films.While previous reviews on 2D materials for biodevices primarily focus on conventional configurations and materials like graphene,the rapid development of new 2D materials with exotic properties has opened up novel applications,particularly in smart interaction and integrated functionalities.This review aims to consolidate recent progress,highlight the unique advantages of 2D materials,and guide future research by discussing existing challenges and opportunities in applying 2D materials for smart wearable biodevices.We begin with an in-depth analysis of the advantages,sensing mechanisms,and potential applications of 2D materials in wearable biodevice fabrication.Following this,we systematically discuss state-of-the-art biodevices based on 2D materials for monitoring various physiological signals within the human body.Special attention is given to showcasing the integration of multi-functionality in 2D smart devices,mainly including self-power supply,integrated diagnosis/treatment,and human–machine interaction.Finally,the review concludes with a concise summary of existing challenges and prospective solutions concerning the utilization of2D materials for advanced biodevices.展开更多
基金supported by the Natural Science Foundation of China(Grants U2166211)Zhejiang Provincial Natural Science Foundation of China(Grants LY24E070006 and LMS25E070002).
文摘Driven by the global energy transition and the urgent“dual carbon”goals,regional integrated energy system(RIES)planning is undergoing a paradigm shift from carbon reduction to negative carbon emissions.This paper provides a comprehensive review of the theoretical frameworks and technical pathways for RIES planning from a carbon-centric perspective.A key contribution is the proposed Carbon-Energy-Economy(CEE)triple-dimensional governance framework,which endogenizes carbon factors into planning decisions through emission constraints,trading mechanisms,and capture technologies.We first analyze the fundamental characteristics of RIES and their critical role in achieving carbon neutrality,detailing advancements in multi-energy coupling models,energy router concepts,and standardized energy hub modeling.The paper further explores multi-energy flow analysis methods,and systematically compares the applicability and limitations of various planning algorithms,with emphasis on addressing uncertainties from renewable integration.Finally,we highlight the integration of artificial intelligence with traditional optimization methods,offering new pathways for intelligent,adaptive,and low-carbon RIES planning.This review underscores the transition towards data-physical fusion models,cooperative uncertainty optimization,multi-market planning,and innovative zero/negative-carbon technological routes.
文摘This paper investigates the traffic offloading optimization challenge in Space-Air-Ground Integrated Networks(SAGIN)through a novel Recursive Multi-Agent Proximal Policy Optimization(RMAPPO)algorithm.The exponential growth of mobile devices and data traffic has substantially increased network congestion,particularly in urban areas and regions with limited terrestrial infrastructure.Our approach jointly optimizes unmanned aerial vehicle(UAV)trajectories and satellite-assisted offloading strategies to simultaneously maximize data throughput,minimize energy consumption,and maintain equitable resource distribution.The proposed RMAPPO framework incorporates recurrent neural networks(RNNs)to model temporal dependencies in UAV mobility patterns and utilizes a decentralized multi-agent reinforcement learning architecture to reduce communication overhead while improving system robustness.The proposed RMAPPO algorithm was evaluated through simulation experiments,with the results indicating that it significantly enhances the cumulative traffic offloading rate of nodes and reduces the energy consumption of UAVs.
基金funded by the National Nature Science Foundation of China(62264006,62574102)“Thousand Talents Program”of Yunnan Province for Young Talents,Innovative Research Teams(in Science and Technology)in the University of Yunnan Province(IRTSTYN),XingDian Talent Support Program for Young Talents,and Frontier Research Team of Kunming University 2023,The Basic Research Project of Yunnan Province(Nos.202201AU070022)+2 种基金Kunming University Talent Introduction Fund(Nos.YJL20024)Yunnan Province Education Department Scientific Research Fund Project(Nos.2024Y759)Undergraduate Innovation and Entrepreneurship Training Program Project of Yunnan Provincial(202411393005)。
文摘Carbon-based air cathodes offer low cost,high electrical conductivity,and structural tunability.However,they suffer from limited catalytic activity and inefficient gas transport,and they typically rely on noble metal additives or complex multilayer configurations.To tackle these issues,this study devised a self-activated integrated carbon-based air cathode.By integrating in situ catalytic site construction with structural optimization,the strategy not only induces the formation of oxygen functional groups(─C─OH,─C═O,─COOH),hierarchical pores,and uniformly distributed active sites,but also establishes a favorable electronic and mass-transport environment.Furthermore,the roll-pressing-based integrated design streamlines electrode construction,reinforces interfacial bonding,and significantly enhances mechanical stability.Density functional theory(DFT)calculations show that oxygen functional groups initiate hydrogen bonding interaction and promote charge enrichment,which improves the activity of the cathode and facilitates intermediate adsorption/desorption in oxygen reduction and evolution reactions processes.As a result,the integrated air cathode-based rechargeable zinc-air batteries(RZABs)achieve a high specific capacity of 811 mAh g^(-1).It also performs well in quasi-solid-state RZABs and silicon-air batteries systems across a wide temperature range,demonstrating strong adaptability and application potential.This study provides a scalable and cost-effective design strategy for high-performance carbon-based air cathodes,offering new insights into advancing durable and practical metal-air energy systems.
文摘In recent years,with the accelerating aging process of the population,China has entered an aging society,and the number of elderly patients with chronic diseases has been increasing.The traditional medical and elderly care service models can no longer fully meet their needs.The integrated medical and elderly care model has emerged as the times require.It organically combines medical resources with elderly care resources to provide comprehensive and continuous health management services for the elderly,becoming an important approach to solving the problems of chronic disease management among the elderly.In this regard,this paper first elaborates on the role of integrated medical and elderly care in the management of chronic diseases among the elderly,and then puts forward application strategies of integrated medical and elderly care in the management of chronic diseases among the elderly,in order to provide certain reference for relevant researchers.
基金the financial support of the National Natural Science Foundation of China(No.52075309)the Youth Innovation Team of Shaanxi Universities(21JP021).
文摘Solar-driven interfacial evaporation presents a promising approach to address global freshwater scarcity.Current challenges in photothermal membrane design lie in achieving concurrent optimization of high solar absorption,low thermal conductivity,and water transport,where existing materials fail to establish effective“water-heat-salt”synergistic regulation at the evaporation interface.This study develops a seamlessly integrated Janus membrane through growing hydrophilic Cu_(2−x)S nanostructure on a hydrophobic carbon cloth substrate with carbon black coating(CB/CC).By precisely engineering the submicron pore architecture within the Cu_(2−x)S layer,we established a synergistic optimization mechanism for interfacial water transport,heat management,and salt rejection.The resulting Janus membrane demonstrates a high evaporation rate of 2.22 kg m^(−2)h^(−1)under 1 sun with an energy efficiency of about 88.4%.Notably,the system maintains stable operation in hypersaline environments(20 wt%NaCl)and achieves continuous 5-h salt-resistant evaporation.Moreover,the Janus membranes can effectively purify various industrial wastewater,including acidic,alkaline,and organic pollutants.This study provides a new strategy for developing high-efficiency portable desalination systems through interfacial engineering of pore architecture.
基金partially supported by the National Natural Science Foundation of China(Nos.32471474 and 82102574)the Precision Medicine Project of People’s Hospital of Xinjiang Uygur Autonomous Region(No.20220305)+4 种基金Chengdu Advanced Metal Materials Industry Technology Research Institute Co.,Ltd.Support Project(No.24H0802)Sichuan Science and Technology Program(Nos.2025YFHZ0086,2023YFS0053,2024YFHZ0125,and 2025ZNSFSC0381)Project of Tianfu Jincheng Laboratory(No.2025ZH009)Guangdong Basic and Applied Basic Research Foundation(No.2023A1515220102)Xinjiang Autonomous Region Science and Technology Support Project Plan(Directive)Project(No.2024E02049)。
文摘Cases of widespread bone hydatid infection are relatively rare in clinical practice.In this study,we reported for the first time a validated integrated repair therapy for multiple bone tissues,including the hip,femur,and knee,caused by echinococ cosis.Artificial intelligence(AI)was used to develop a targeted surgical plan and to design a personalized prosthesis.Finite element analysis(FEA)was used to optimize the mechanical effectiveness of a customized integrated replacement prosthesis and to model stress distribution in the surrounding bone.Three-dimensional(3 D)printing was used to fabricate a customized prosthesis.With the assistance of AI,FEA,and 3 D printing technology,a personalized surgical plan and customized prosthesis were successfully constructed based on the patient’s disease.This approach achieved a successful therapeutic effect,demonstrating that AI-assisted personalized medicine holds great promise for the future.
基金supported by the Bureau of Frontier Sciences and Basic Research,Chinese Academy of Sciences(Grant No.QYJ-2025-0103)the National Natural Science Foundation of China(Grant Nos.42441834,42241105,42441825,and 42203048)the Key Research Program of the Institute of Geology and Geophysics,Chinese Academy of Sciences(Grant No.IGGCAS-202401).
文摘As one of the major volatile components in extraterrestrial materials,nitrogen(N_(2))isotopes serve not only as tracers for the formation and evolution of the solar system,but also play a critical role in assessing planetary habitability and the search for extraterrestrial life.The integrated measurement of N_(2)and argon(Ar)isotopes by using noble gas mass spectrometry represents a state-of-the-art technique for such investigations.To support the growing demands of planetary science research in China,we have developed a high-efficiency,high-precision method for the integrated analysis of N_(2)and Ar isotopes.This was achieved by enhancing gas extraction and purification systems and integrating them with a static noble gas mass spectrometer.This method enables integrated N_(2)-Ar isotope measurements on submilligram samples,significantly improving sample utilization and reducing the impact of sample heterogeneity on volatile analysis.The system integrates CO_(2)laser heating,a modular two-stage Zr-Al getter pump,and a CuO furnace-based purification process,effectively reducing background levels(N_(2)blank as low as 0.35×10^(−6)cubic centimeters at standard temperature and pressure[ccSTP]).Analytical precision is ensured through calibration with atmospheric air and CO corrections.To validate the reliability of the method,we performed N_(2)-Ar isotope analyses on the Allende carbonaceous chondrite,one of the most extensively studied meteorites internationally.The measured N_(2)concentrations range from 19.2 to 29.8 ppm,withδ15N values between−44.8‰and−33.0‰.Concentrations of 40Ar,36Ar,and 38Ar are(12.5-21.1)×10^(−6)ccSTP/g,(90.9-150.3)×10^(−9)ccSTP/g,and(19.2-30.7)×10^(−9)ccSTP/g,respectively.These values correspond to cosmic-ray exposure ages of 4.5-5.7 Ma,consistent with previous reports.Step-heating experiments further reveal distinct release patterns of N and Ar isotopes,as well as their associations with specific mineral phases in the meteorite.In summary,the combined N_(2)-Ar isotopic system offers significant advantages for tracing volatile sources in extraterrestrial materials and will provide essential analytical support for upcoming Chinese planetary missions,such as Tianwen-2.
基金funded by the National Institutes of Health,grant numbers UG3OD023285,P42ES030991,and P30ES036084.
文摘Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs:the integrated stress response(ISR)and the senescence-associated secretory phenotype(SASP).These pathways act as a Yin-Yang system,balancing beneficial and detrimental outcomes across development,tissue homeostasis,and disease.On the yin(protective)side,transient ISR activation and acute SASP signaling foster adaptation,embryonic patterning,wound healing,and regeneration.On the yang(maladaptive)side,chronic ISR signaling and unresolved SASP output drive stem cell exhaustion,fibrosis,inflammation,and tumorigenesis.This duality highlights their roles as both guardians and disruptors of stem cell integrity.Mechanistically,ISR regulates translational control via eukaryotic initiation factor 2 alpha(eIF2α)phosphorylation and activating transcription factor 4(ATF4)-dependent transcription,while SASP reprograms the extracellular milieu through cytokines,growth factors,and proteases.Their crosstalk creates feedback loops that shape tissue niches and long-termstemcell potential.Framing ISR-SASP interactions through a Yin-Yang lens underscores the balance between resilience and decline,to offer new insights into regenerative medicine,anti-aging interventions,and cancer therapeutics.
文摘This Special Topic of the Journal of Semiconductors(JOS)features expanded versions of key articles presented at the 2024 IEEE International Conference on Integrated Circuits Technologies and Applications(ICTA),which was held in Hangzhou,Zhejiang,China,from October 25 to 27,2024.
基金Science and Technology Support Program Project of Baoding City,Hebei Province(Project No.:2541ZF107)。
文摘Objective:To analyze the application effectiveness of the integrated medical-nursing comprehensive care model in cases of cerebral infarction and clarify its clinical practical value for the patient rehabilitation process.Methods:A total of 60 patients with cerebral infarction admitted from June 2024 to December 2024 were selected as the research subjects and randomly divided into a control group and a research group,with 30 cases in each group.Patients in the control group received routine clinical nursing measures,while those in the study group underwent collaborative healthcare intervention in addition to routine nursing.The intervention included joint disease assessment,personalized rehabilitation training guidance,psychological counseling,and continuous nursing services after discharge.A comparative study was conducted by evaluating indicators such as the scores on adverse emotion scales,the extent of neurological recovery,the effectiveness rate of clinical rehabilitation treatment,and the level of satisfaction with nursing services between the two groups.Results:After the intervention,the scores on the Self-Rating Anxiety Scale(SAS)and the Self-Rating Depression Scale(SDS)in the study group decreased to(40.12±5.01)and(41.36±5.20),respectively,both significantly lower than those in the control group,which were(47.36±5.82)and(48.95±5.63),respectively.The differences between the two groups were statistically significant(p<0.05).The improvement in the neurological deficit scores of patients in the study group reached(9.18±2.04),higher than that in the control group,which was(5.17±1.82)(p<0.05).The overall clinical rehabilitation effectiveness rate in the study group was 93.3%,significantly higher than that in the control group,which was 73.3%.The satisfaction rate with nursing services in the study group reached 96.7%,also higher than that in the control group,which was 83.3%.The differences between the two groups were statistically significant(p<0.05).Conclusion:The integrated healthcare nursing model can effectively alleviate adverse emotional states in patients with cerebral infarction,facilitate the repair and reconstruction of neurological function,improve the effectiveness of clinical rehabilitation treatment and satisfaction with nursing services,and thus holds high value for clinical promotion and application.
基金supported by grants from the Fundamental Research Funds for the Central Universities(No.2025ZFJH03)the Central Guidance Fund for Local Science and Technology Development(No.2024ZY01054)the CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-045).
文摘Background:Giant cell arteritis(GCA),the most common systemic vasculitis affecting elderly individuals,currently lacks specific therapies.This study aimed to systematically identify therapeutic targets for GCA through integration of large-scale multi-omics datasets.Methods:We constructed a multi-stage analytical framework encompassing 32 proteomic datasets(covering 2914 unique plasma proteins)and 6 transcriptomic datasets.Multi-omics integration strategies,including two-sample Mendelian randomization,colocalization analysis,and functional enrichment analysis,were employed to identify and validate causal relationships between candidate targets and GCA risk across 4 independent European-ancestry GCA cohorts.Single-cell RNA sequencing analysis of peripheral blood mononuclear cells from untreated GCA patients was performed to characterize hub gene-immune cell relationships.Results:We identified 43 plasma proteins causally associated with GCA[false discovery rate(FDR)<0.05],with 17 representing novel therapeutic targets.Through dual validation using proteome-wide association studies and transcriptome-wide association studies,we identified 13 high-confidence candidate targets with distinct tissue-specific expression patterns.Unc-51 like kinase 3(ULK3)emerged as the strongest protective factor(odds ratio=0.47,95%confidence interval:0.37–0.71)through autophagy regulation,while SLAMF7 represents an immediate drug repositioning opportunity as the target of food and drug administration-approved elotuzumab.Five targets have existing approved drugs(SLAMF7,ICAM1,IL18,IL6ST,CTSS).Single-cell analysis revealed profound disruption of hub gene-immune cell relationships in untreated GCA patients,with cell-type-specific alterations in inflammatory gene expression,and TYMP as the most critical hub gene.Conclusions:This study provides a clinically-actionable atlas of 43 potential therapeutic targets in GCA,identifying novel mechanisms including autophagy modulation and metabolic reprogramming,with immediate drug repositioning opportunities and precision medicine strategies based on tissue-specific and cell-type-specific expression patterns.These findings require experimental validation before clinical translation.
基金supported by the National Natural Science Foundation of China(52272177,12204010)the Foundation for the Introduction of High-Level Talents of Anhui University(S020118002/097)+1 种基金the University Synergy Innovation Program of Anhui Province(GXXT-2023-066)the Scientific Research Project of Anhui Provincial Higher Education Institution(2023AH040008)。
文摘Flexible electronics face critical challenges in achieving monolithic three-dimensional(3D)integration,including material compatibility,structural stability,and scalable fabrication methods.Inspired by the tactile sensing mechanism of the human skin,we have developed a flexible monolithic 3D-integrated tactile sensing system based on a holey MXene paste,where each vertical one-body unit simultaneously functions as a microsupercapacitor and pressure sensor.The in-plane mesopores of MXene significantly improve ion accessibility,mitigate the self-stacking of nanosheets,and allow the holey MXene to multifunctionally act as a sensing material,an active electrode,and a conductive interconnect,thus drastically reducing the interface mismatch and enhancing the mechanical robustness.Furthermore,we fabricate a large-scale device using a blade-coating and stamping method,which demonstrates excellent mechanical flexibility,low-power consumption,rapid response,and stable long-term operation.As a proof-of-concept application,we integrate our sensing array into a smart access control system,leveraging deep learning to accurately identify users based on their unique pressing behaviors.This study provides a promising approach for designing highly integrated,intelligent,and flexible electronic systems for advanced human-computer interactions and personalized electronics.
基金“Artificial Liver Special Fund”of Beijing Gan Dan Xiang Zhao Public Welfare Foundation(Project No.:iGandanF-1082024-RGG055)。
文摘A case of imported severe falciparum malaria with spontaneous splenic rupture was reported in this paper.The patient,an African migrant worker,developed hemolytic anemia,sepsis,thrombocytopenia,coagulation dysfunction,liver failure,renal insufficiency,electrolyte disturbance and other clinical manifestations after returning to the local area.Plasmodium falciparum was found by peripheral blood smearscopy and was diagnosed as severe falciparum malaria.After standardized anti-malaria treatment,plasma exchange+cytokine adsorption therapy,the establishment of“forewarning-forewarning-prevention-emergency”predictive nursing management model,the establishment of an integrated nursing team,the division of medical care is clear,professional knowledge is complementary,after three months of regular follow-up,the patient has no malaria recurrence,no refire,the function of all organs returned to normal.
文摘From April 8 to 9,2025,the Central Conference on Work Related to Neighboring Countries was held in Beijing.General Secretary of the Communist Party of China(CPC)Central Committee Xi Jinping systematically summarized the achievements and experience of China’s neighborhood work in the new era,scientifically analyzed the situation,clarified the goals,tasks,ideas and measures for neighborhood work in the coming period,and emphasized the need to focus on building a community with a shared future with neighboring countries,striving to break new ground in neighborhood work.Facing the ever-changing international landscape,especially the surrounding environment,China needs to carry out integrated diplomacy,reshape the neighborhood environment,translate the concepts and policies of the CPC neighborhood diplomacy into diplomatic practices and achieve greater results.
基金supported in part by the Natural Science Foundation of Chongqing under Grant CSTB2023NSCQ-LZX0118in part by the National Natural Science Foundation of China under Grant 62471052in part by the Beijing University of Posts and Telecommunications(BUPT)Excellent Ph.D.Students Foundation under Grant CX2023139.
文摘As key technologies in 6G,Space-Air-Ground Integrated Networks(SAGIN)promises to provide seamless global coverage through a comprehensive,ubiquitous communication system,while Integrated Sensing and Communications(ISAC)effectively addresses spectrum congestion by sharing spectrum resources and transceivers for simultaneous communication and sensing operations.However,existing ISAC research has primarily focused on terrestrial networks,with limited exploration of its applications in SAGIN environments.This paper proposes a novel SAGIN-ISAC scheme leveraging High-Altitude Platform Stations(HAPS).In this scheme,HAPS serves as a relay node that not only amplifies and forwards communication signals but also receives and processes target echo signals for parameter estimation.The satellite employs Resilient Massive Access(RMA)to provide communication services to different User Terminals(UTs).To address scenarios with an unknown number of targets,we develop a Two-threshold Detection and Parameter Multiple Signal Classification(MUSIC)algorithm(TDPM),which employs dual-threshold correlation detection to determine the number of targets and utilizes the MUSIC algorithm to estimate targets’Angle of Arrival(AoA),range,and relative velocity.Furthermore,we establish a joint optimization framework that considers both communication and sensing performance,optimizing energy efficiency,detection probability,and the Cramér-Rao bound.The power allocation coefficients are derived through Nash equilibrium,while the precoding matrix is optimized using Sequential Convex Approximation(SCA)to address the non-convex nature of the optimization problem.Experimental results demonstrate that our proposed scheme significantly enhances the overall performance of the SAGIN-ISAC system.
基金supported by the Central Government Guides Local Science and Technology Development Fund Project(2023ZY0020)Key R&D and Achievement Transformation Project in InnerMongolia Autonomous Region(2022YFHH0019)+3 种基金the Fundamental Research Funds for Inner Mongolia University of Science&Technology(2022053)Natural Science Foundation of Inner Mongolia(2022LHQN05002)National Natural Science Foundation of China(52067018)Metallurgical Engineering First-Class Discipline Construction Project in Inner Mongolia University of Science and Technology,Control Science and Engineering Quality Improvement and Cultivation Discipline Project in Inner Mongolia University of Science and Technology。
文摘In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy system(IIES).The upper level represents the integrated energy operator,and the lower level is the electricity-heatgas load aggregator.Owing to the benefit conflict between the upper and lower levels of the IIES,a dynamic pricing mechanism for coordinating the interests of the upper and lower levels is proposed,combined with factors such as the carbon emissions of the IIES,as well as the lower load interruption power.The price of selling energy can be dynamically adjusted to the lower LA in the mechanism,according to the information on carbon emissions and load interruption power.Mutual benefits and win-win situations are achieved between the upper and lower multistakeholders.Finally,CPLEX is used to iteratively solve the bilevel optimization model.The optimal solution is selected according to the joint optimal discrimination mechanism.Thesimulation results indicate that the sourceload coordinate operation can reduce the upper and lower operation costs.Using the proposed pricingmechanism,the carbon emissions and load interruption power of IEO-LA are reduced by 9.78%and 70.19%,respectively,and the capture power of the carbon capture equipment is improved by 36.24%.The validity of the proposed model and method is verified.
基金supported in part by Natural Science Foundation of Jiangsu Province under Grant BK20230255Natural Science Foundation of Shandong Province under Grant ZR2023QE281.
文摘The multi-terminal direct current(DC)grid has extinctive superiorities over the traditional alternating current system in integrating large-scale renewable energy.Both the DC circuit breaker(DCCB)and the current flow controller(CFC)are demanded to ensure the multiterminal DC grid to operates reliably and flexibly.However,since the CFC and the DCCB are all based on fully controlled semiconductor switches(e.g.,insulated gate bipolar transistor,integrated gate commutated thyristor,etc.),their separation configuration in the multiterminal DC grid will lead to unaffordable implementation costs and conduction power losses.To solve these problems,integrated equipment with both current flow control and fault isolation abilities is proposed,which shares the expensive and duplicated components of CFCs and DCCBs among adjacent lines.In addition,the complicated coordination control of CFCs and DCCBs can be avoided by adopting the integrated equipment in themultiterminal DC grid.In order to examine the current flow control and fault isolation abilities of the integrated equipment,the simulation model of a specific meshed four-terminal DC grid is constructed in the PSCAD/EMTDC software.Finally,the comparison between the integrated equipment and the separate solution is presented a specific result or conclusion needs to be added to the abstract.
基金the North Dakota Industrial Commission (NDIC) for their financial supportprovided by the University of North Dakota Computational Research Center。
文摘Accurate estimation of mineralogy from geophysical well logs is crucial for characterizing geological formations,particularly in hydrocarbon exploration,CO_(2) sequestration,and geothermal energy development.Current techniques,such as multimineral petrophysical analysis,offer details into mineralogical distribution.However,it is inherently time-intensive and demands substantial geological expertise for accurate model evaluation.Furthermore,traditional machine learning techniques often struggle to predict mineralogy accurately and sometimes produce estimations that violate fundamental physical principles.To address this,we present a new approach using Physics-Integrated Neural Networks(PINNs),that combines data-driven learning with domain-specific physical constraints,embedding petrophysical relationships directly into the neural network architecture.This approach enforces that predictions adhere to physical laws.The methodology is applied to the Broom Creek Deep Saline aquifer,a CO_(2) sequestration site in the Williston Basin,to predict the volumes of key mineral constituents—quartz,dolomite,feldspar,anhydrite,illite—along with porosity.Compared to traditional artificial neural networks (ANN),the PINN approach demonstrates higher accuracy and better generalizability,significantly enhancing predictive performance on unseen well datasets.The average mean error across the three blind wells is 0.123 for ANN and 0.042 for PINN,highlighting the superior accuracy of the PINN approach.This method reduces uncertainties in reservoir characterization by improving the reliability of mineralogy and porosity predictions,providing a more robust tool for decision-making in various subsurface geoscience applications.
基金Under the auspices of National Natural Science Foundation of China(No.42293270)。
文摘Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies.
基金the support from the National Natural Science Foundation of China(22272004,62272041)the Fundamental Research Funds for the Central Universities(YWF-22-L-1256)+1 种基金the National Key R&D Program of China(2023YFC3402600)the Beijing Institute of Technology Research Fund Program for Young Scholars(No.1870011182126)。
文摘The proliferation of wearable biodevices has boosted the development of soft,innovative,and multifunctional materials for human health monitoring.The integration of wearable sensors with intelligent systems is an overwhelming tendency,providing powerful tools for remote health monitoring and personal health management.Among many candidates,two-dimensional(2D)materials stand out due to several exotic mechanical,electrical,optical,and chemical properties that can be efficiently integrated into atomic-thin films.While previous reviews on 2D materials for biodevices primarily focus on conventional configurations and materials like graphene,the rapid development of new 2D materials with exotic properties has opened up novel applications,particularly in smart interaction and integrated functionalities.This review aims to consolidate recent progress,highlight the unique advantages of 2D materials,and guide future research by discussing existing challenges and opportunities in applying 2D materials for smart wearable biodevices.We begin with an in-depth analysis of the advantages,sensing mechanisms,and potential applications of 2D materials in wearable biodevice fabrication.Following this,we systematically discuss state-of-the-art biodevices based on 2D materials for monitoring various physiological signals within the human body.Special attention is given to showcasing the integration of multi-functionality in 2D smart devices,mainly including self-power supply,integrated diagnosis/treatment,and human–machine interaction.Finally,the review concludes with a concise summary of existing challenges and prospective solutions concerning the utilization of2D materials for advanced biodevices.
