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Treatment of moderate to severe keratoconus with 6-mm Intacs SK
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作者 Sasan Niknam Mehrdad Shamshiri +3 位作者 Seyed Sahabaldin Shahrzad Abbas Alipour Mohammad Bagher Rajabi Mohammad Taher Rajabi 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2012年第4期513-516,共4页
·AIM:To evaluate the effect of Intacs SK corneal ring segment implant for treatment of patients with moderate to severe keratoconus, who have clear central cornea and cannot tolerate contact lens. ·METHODS:I... ·AIM:To evaluate the effect of Intacs SK corneal ring segment implant for treatment of patients with moderate to severe keratoconus, who have clear central cornea and cannot tolerate contact lens. ·METHODS:In this prospective, non-comparative, intervent- ional case series study performed in Dena Hospital, Shiraz, Iran, thirty-seven eyes of thirty-six patients with moderate to severe keratoconus, clear central cornea, and contact lens intolerance were enrolled and underwent Intacs SK corneal ring segment implantation. Preoperatively, uncorrected distance visual acuity (UCDVA), best-corrected distance visual acuity (BCDVA), central corneal thickness(CCT) and average keratometry (Av-K) were measured and compared with post-operative results at one week, one month, three months, and six months. ·RESULTS:Mean preoperative UCDVA and BCDVA were (1.32±0.31) logMAR and (1.07±0.27) logMAR, respectively. Av-K was (52.13±0.39)D, and the CCT was (432±39.5)μm. Post-operative examinations showed a clinically significant improvement in both UCDVA and BCDVA (P <0.001). There was also a significant effect based on the time of assessment on both UCDVA and BCDVA and both parameters had a continuous improvement during the follow-up period. Three months after operation there was a statistical significant reduction of Av-K (P =0.0001), but there were no significant changes in CCT (P =0.149). ·CONCLUSION:Intacs SK corneal ring segment implants seem to be a safe and effective treatment option for patients who have keratoconus, clear central cornea, and contact lens intolerance. 展开更多
关键词 KERATOCONUS intacs MYOPIA
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Intacs治疗圆锥角膜一年治疗结果的总结
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作者 Samuel Levinger +2 位作者 Russell Pokroy 陈慧瑾(译) 《美国医学会眼科杂志(中文版)》 2006年第4期245-245,共1页
目的:描述使用Intacs(Addition Technology Inc,Fremont,Calif)治疗圆锥角膜的视觉改善效果,并制定预测良好治疗效果的标准。
关键词 intacs 圆锥角膜 治疗结果 改善效果
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INTAC复合体的功能研究与机制探索新进展 被引量:1
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作者 路丹荑 宋爱霞 陈飞 《科学通报》 北大核心 2025年第15期2385-2396,共12页
基因表达的精确时空调控对生物体的生存和发育至关重要.Integrator作为一种后生动物特异性的多亚基复合物,能够与蛋白磷酸酶PP2A核心酶(PP2A-AC)形成稳定的复合体,被命名为INTAC(Integrator-PP2A-AC).INTAC复合体是RNA聚合酶Ⅱ启动子近... 基因表达的精确时空调控对生物体的生存和发育至关重要.Integrator作为一种后生动物特异性的多亚基复合物,能够与蛋白磷酸酶PP2A核心酶(PP2A-AC)形成稳定的复合体,被命名为INTAC(Integrator-PP2A-AC).INTAC复合体是RNA聚合酶Ⅱ启动子近端暂停和提前终止的关键调节因子,还对多种非编码RNA进行3?末端加工.INTAC复合体在转录调控中发挥重要作用,其功能缺失与多种生理过程异常及疾病发生密切相关.本文系统梳理了INTAC复合体的发现历程、结构特征及功能进展,重点解析了其在转录调控过程中的多重作用,并总结了INTAC复合体在生理和疾病中的关键功能. 展开更多
关键词 INTAC INTEGRATOR PP2A RNA聚合酶Ⅱ 转录终止
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