BACKGROUND Some non-insulin-based insulin resistance(IR)indices have been found to be associated with metabolic syndrome(MetS);however,few cohort studies have compared the capacities of these indices for predicting in...BACKGROUND Some non-insulin-based insulin resistance(IR)indices have been found to be associated with metabolic syndrome(MetS);however,few cohort studies have compared the capacities of these indices for predicting incident MetS in young adults.AIM To investigate the associations of various non-insulin-based IR(NI-IR)indices with new-onset MetS in young military personnel.METHODS A total of 2890 armed forces personnel in Taiwan who were aged 18-39 years and did not have MetS at baseline were followed to monitor the incidence of new-onset MetS from 2014 to the end of 2020.Six NI-IR indices,including the metabolic score for IR(METS-IR),triglyceride(TG)-to-high-density lipoprotein cholesterol(HDL-C)ratio,TG glucose(TyG)index,Zhejiang University(ZJU)index,total cholesterol(TC)-to-HDL-C ratio,and alanine transaminase(ALT)-to-aspartate transaminase(AST)ratio,were defined according to specific criteria.Incident MetS was identified on the basis of each annual health examination using the International Diabetes Federation criteria.Multiple Cox regression analyses were conducted,adjusting for age,sex,waist circumference,smoking status,alcohol consumption status,and physical activity,to assess the associations of the NI-IR indices with incident MetS.The area under the receiver operating characteristic curve(AUROC)was used to compare the capacities of these NI-IR indices for predicting new-onset MetS.RESULTS During a median follow-up of 5.8 years,there were 673 patients with new-onset MetS(23%).All six of the NI-IR indices were significantly and positively associated with incident MetS.In the entire cohort,the greatest AUROC was found for the METS-IR[0.782;95%confidence interval(CI):0.762-0.801;all P values compared to the other NIIR indices<0.05],followed by the TG/HDL-C ratio(0.752;95%CI:0.731-0.772),ZJU index(0.743;95%CI:0.722-0.764),TyG index(0.734;95%CI:0.713-0.756),TC/HDL-C ratio(0.731;95%CI:0.709-0.752),and then the ALT/AST ratio(0.734;95%CI:0.713-0.756).CONCLUSION This study suggests that almost all the NI-IR indices are associated with the development of MetS in military young adults.The METS-IR is the strongest predictor of new-onset MetS before midlife.展开更多
Objective To investigate the correlation between insulin resistance surrogate indicators and early-stage kidney injury in type 2 diabetes mellitus(T2DM).Methods A total of 918 T2DM patients hospitalized in the Endocri...Objective To investigate the correlation between insulin resistance surrogate indicators and early-stage kidney injury in type 2 diabetes mellitus(T2DM).Methods A total of 918 T2DM patients hospitalized in the Endocrinology Department of Xinhua Hospital from January 2018 to December 2020 were selected,including 313 patients with early-stage kidney injury and 605 without.Differences in insulin resistance surrogate indicators,including triglycerideetohigh-density lipoprotein cholesterol ratio(TG/HDL-C),triglyceride glucose(TyG)index,and triglyceride glucose-body mass index(TyG-BMI),were compared between the two groups.Factors associated with early-stage kidney injury in T2DM were analyzed,and the impact of TG/HDL-C,TyG index,and TyG-BMI on early-stage kidney injury in T2DM were explored.Results Compared with T2DM patients without early-stage kidney injury,those with early-stage kidney injury exhibited significantly elevated levels of TG/HDL-C,TyG index,and TyG-BMI(P<0.001).TG/HDL-C,TyG index,TyG-BMI,age,duration of diabetes,systolic blood pressure,fasting insulin,and HbAic were identified as independent risk factors for early-stage kidney injury in T2DM.Compared to the Q_(1) quartile,the risk in the Q_(4) quartile was 3.168 times(95%CI 1.993-5.036)for TG/HDL-C,2.714 times(95%CI 1.710-4.306)for TyG index,and 2.893 times(95%CI 1.820-5.598)for TyG-BMI.Conclusion Insulin resistance surrogate indicators TG/HDL-C,TyG index,and TyG-BMI are significantly elevated in T2DM patients with early-stage kidney injury,serving as independent risk factors for early-stage renal impairment in T2DM.展开更多
基金Supported by Medical Affairs Bureau Ministry of National Defense,No.MND-MAB-D-114222Hualien Armed Forces General Hospital,No.HAFGH-D-114008.
文摘BACKGROUND Some non-insulin-based insulin resistance(IR)indices have been found to be associated with metabolic syndrome(MetS);however,few cohort studies have compared the capacities of these indices for predicting incident MetS in young adults.AIM To investigate the associations of various non-insulin-based IR(NI-IR)indices with new-onset MetS in young military personnel.METHODS A total of 2890 armed forces personnel in Taiwan who were aged 18-39 years and did not have MetS at baseline were followed to monitor the incidence of new-onset MetS from 2014 to the end of 2020.Six NI-IR indices,including the metabolic score for IR(METS-IR),triglyceride(TG)-to-high-density lipoprotein cholesterol(HDL-C)ratio,TG glucose(TyG)index,Zhejiang University(ZJU)index,total cholesterol(TC)-to-HDL-C ratio,and alanine transaminase(ALT)-to-aspartate transaminase(AST)ratio,were defined according to specific criteria.Incident MetS was identified on the basis of each annual health examination using the International Diabetes Federation criteria.Multiple Cox regression analyses were conducted,adjusting for age,sex,waist circumference,smoking status,alcohol consumption status,and physical activity,to assess the associations of the NI-IR indices with incident MetS.The area under the receiver operating characteristic curve(AUROC)was used to compare the capacities of these NI-IR indices for predicting new-onset MetS.RESULTS During a median follow-up of 5.8 years,there were 673 patients with new-onset MetS(23%).All six of the NI-IR indices were significantly and positively associated with incident MetS.In the entire cohort,the greatest AUROC was found for the METS-IR[0.782;95%confidence interval(CI):0.762-0.801;all P values compared to the other NIIR indices<0.05],followed by the TG/HDL-C ratio(0.752;95%CI:0.731-0.772),ZJU index(0.743;95%CI:0.722-0.764),TyG index(0.734;95%CI:0.713-0.756),TC/HDL-C ratio(0.731;95%CI:0.709-0.752),and then the ALT/AST ratio(0.734;95%CI:0.713-0.756).CONCLUSION This study suggests that almost all the NI-IR indices are associated with the development of MetS in military young adults.The METS-IR is the strongest predictor of new-onset MetS before midlife.
文摘Objective To investigate the correlation between insulin resistance surrogate indicators and early-stage kidney injury in type 2 diabetes mellitus(T2DM).Methods A total of 918 T2DM patients hospitalized in the Endocrinology Department of Xinhua Hospital from January 2018 to December 2020 were selected,including 313 patients with early-stage kidney injury and 605 without.Differences in insulin resistance surrogate indicators,including triglycerideetohigh-density lipoprotein cholesterol ratio(TG/HDL-C),triglyceride glucose(TyG)index,and triglyceride glucose-body mass index(TyG-BMI),were compared between the two groups.Factors associated with early-stage kidney injury in T2DM were analyzed,and the impact of TG/HDL-C,TyG index,and TyG-BMI on early-stage kidney injury in T2DM were explored.Results Compared with T2DM patients without early-stage kidney injury,those with early-stage kidney injury exhibited significantly elevated levels of TG/HDL-C,TyG index,and TyG-BMI(P<0.001).TG/HDL-C,TyG index,TyG-BMI,age,duration of diabetes,systolic blood pressure,fasting insulin,and HbAic were identified as independent risk factors for early-stage kidney injury in T2DM.Compared to the Q_(1) quartile,the risk in the Q_(4) quartile was 3.168 times(95%CI 1.993-5.036)for TG/HDL-C,2.714 times(95%CI 1.710-4.306)for TyG index,and 2.893 times(95%CI 1.820-5.598)for TyG-BMI.Conclusion Insulin resistance surrogate indicators TG/HDL-C,TyG index,and TyG-BMI are significantly elevated in T2DM patients with early-stage kidney injury,serving as independent risk factors for early-stage renal impairment in T2DM.
