Combining practical engineering projects, this article analyzes the design strategies for the reconstruction and expansion of insufficient clearance sections in highway interchanges. This includes an overview of the p...Combining practical engineering projects, this article analyzes the design strategies for the reconstruction and expansion of insufficient clearance sections in highway interchanges. This includes an overview of the project, a comparison of design options for insufficient clearance in interchanges, and the main design strategies for reconstruction and expansion. It is hoped that this analysis can provide a reference for the design of such road reconstruction and expansion projects.展开更多
The hypoxic microenvironment and inflammatory state of residual tumors caused by insufficient radiofrequency ablation(iRFA)are major reasons for rapid tumor progression and pose challenges for immunotherapy.We retrosp...The hypoxic microenvironment and inflammatory state of residual tumors caused by insufficient radiofrequency ablation(iRFA)are major reasons for rapid tumor progression and pose challenges for immunotherapy.We retrospectively analyzed the clinical data of patients with hepatocellular carcinoma(HCC)treated with RFA and observed that iRFAwas associated with poor survival outcomes and progression-free survival.Using an orthotopic HCC mouse model and a colorectal liver metastasis model,we observed that treatment with melatonin after iRFA reduced tumor growth and metastasis and achieved the best outcomes when combined with anti-programmed death-ligand 1(anti-PD-L1)therapy.In mechanism,melatonin inhibited the expression of epithelial-mesenchymal transitions,hypoxia-inducible factor(HIF)-1a,and PD-L1 in tumor cells after iRFA.Flow cytometry revealed that melatonin reduced the proportion of myeloid-derived suppressor cells and increased the proportion of CD8t T cells.Transcriptomic analysis revealed an upregulation of immune-activated function-related genes in residual tumors.These findings demonstrated that melatonin can reverse hypoxia and iRFA-induced inflammation,thereby overcoming the immunosuppressive tumor microenvironment(TME)and enhancing the efficacy of immunotherapy.展开更多
AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(<250μm)after implantable collamer lens(ICL V4c;STAAR Surgical)implantation.METHODS:The participants ...AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(<250μm)after implantable collamer lens(ICL V4c;STAAR Surgical)implantation.METHODS:The participants underwent ICL surgery and were divided into the low(<250μm)and normal(250-1000μm)vault groups based on the postoperative vault at 3mo.The preoperative biometric parameters and clinical outcomes were compared between the two groups.The relationship between the 3-month vault values and preoperative ocular parameters were evaluated by Generalized estimating equations.RESULTS:Sixteen(23 eyes)and 36 patients(63 eyes)were in the low and normal vault groups,respectively.All implantation procedures were uneventful with no cataract formation in the early postoperative period.The sulcusto-sulcus lens rise(STSL)and iris ciliary angle(ICA)were correlated with vault at 3mo after surgery.Every 0.1 mm increase in STSL was associated with 38.9μm decrease in the postoperative 3-month vault.A rise of 1 degree in ICA is associated with a reduction of 4μm in vault.CONCLUSION:Eyes with a narrow ciliary sulcus are associated with a higher rate of low vault after ICL implantation,suggesting a need for adjustments to the ICL size in these patients.Evaluating the characteristics of the ciliary sulcus contributes valuable information to predict low vault after surgery.展开更多
In the research, available sulphur in 4 700 soil samples was tested and analyzed in 2006-2007 in Dengzhou, and the results showed that available sulphur was insufficient in farmlands in Dengzhou for cereal crop and ab...In the research, available sulphur in 4 700 soil samples was tested and analyzed in 2006-2007 in Dengzhou, and the results showed that available sulphur was insufficient in farmlands in Dengzhou for cereal crop and about 60% farmlands with available sulphur belong to the farmlands with potential shortage of available sulphur for Cruciferae, Liliaceae and Leguminosae. Meanwhile, the producing causes were analyzed from the perspectives of fertilization structure and planting structure and the countermeasures were proposed in terms of sulphur movements in plants and characters.展开更多
Traditional methods for judging the degree of insufficient fluid supply in oil wells have low efficiency and limited accuracy. To address this problem, a method for intelligently identifying the degree of insufficient...Traditional methods for judging the degree of insufficient fluid supply in oil wells have low efficiency and limited accuracy. To address this problem, a method for intelligently identifying the degree of insufficient fluid supply in oil wells based on convolutional neural networks is proposed in this paper. Firstly, 5000 indicator diagrams with insufficient liquid supply were collected from the oilfield site, and a sample set was established after preprocessing;then based on the AlexNet model, combined with the characteristics of the indicator diagram, a convolutional neural network model including 4 layers of convolutional layers, 3 layers of down-pooling layers and 2 layers of fully connected layers is established. The backpropagation, ReLu activation function and dropout regularization method are used to complete the training of the convolutional neural network;finally, the performance of the convolutional neural network under different iteration times and network structure is compared, and the super parameter optimization of the model is completed. It has laid a good foundation for realizing the self-adaptive and intelligent matching of oil well production parameters and formation fluid supply conditions. It has certain application prospects. The results show that the accuracy of training and verification of the method exceeds 98%, which can meet the actual application requirements on site.展开更多
Background Dental implants have been widely used in the last few decades.However,patients with insufficient bone height need reconstructive surgeries before implant insertion.Distraction implant(Dl)has been invented t...Background Dental implants have been widely used in the last few decades.However,patients with insufficient bone height need reconstructive surgeries before implant insertion.Distraction implant(Dl)has been invented to simplify the treatment procedure,but the shortcomings of Dl have limited its clinical use.We introduced biodegradable polyester to a novel Dl,called biodegradable interference distraction implant(BIDI).The purpose of this study was to assess the radiological,histological,and biomechanical properties of BIDI in animal models.Methods BIDIs were manufactured and inserted into the atrophied mandibles of 6 dogs.展开更多
Reliability analysis and reliability-based optimization design require accurate measurement of failure probability under input uncertainties.A unified probabilistic reliability measure approach is proposed to calculat...Reliability analysis and reliability-based optimization design require accurate measurement of failure probability under input uncertainties.A unified probabilistic reliability measure approach is proposed to calculate the probability of failure and sensitivity indices considering a mixture of uncertainties under insufficient input data.The input uncertainty variables are classified into statistical variables,sparse variables,and interval variables.The conservativeness level of the failure probability is calculated through uncertainty propagation analysis of distribution parameters of sparse variables and auxiliary parameters of interval variables.The design sensitivity of the conservativeness level of the failure probability at design points is derived using a semi-analysis and sampling-based method.The proposed unified reliability measure method is extended to consider p-box variables,multi-domain variables,and evidence theory variables.Numerical and engineering examples demonstrate the effectiveness of the proposed method,which can obtain an accurate confidence level of reliability index and sensitivity indices with lower function evaluation number.展开更多
The rotating parts looseness is one of the common failures in rotating machinery.The current researches of looseness fault mainly focus on non-rotating components.However,the looseness fault of disc-shaft system,which...The rotating parts looseness is one of the common failures in rotating machinery.The current researches of looseness fault mainly focus on non-rotating components.However,the looseness fault of disc-shaft system,which is the main work part in the rotor system,is almost ignored.Here,a dynamic model of the rotor system with loose disc caused by the insufficient interference force is proposed based on the contact model of disc-shaft system with the microscopic surface topography,the vibration characteristics of the system are analyzed and discussed by the number simulation,and verified by the experiment.The results show that the speed of the shaft,the contact stiffness,the clearance between the disc and shaft,the damping of the disc and the rotational damping have an influence on the rotation state of the disc.When the rotation speed of the disc and the shaft are same,the collision frequency is mainly composed of one frequency multiplication component and very weak high frequency multiplication components.When the rotation speed of the disc and the shaft is close,the vibration of the disc occurs a beat vibration phenomenon in the horizontal direction.Simultaneously,a periodical similar beat vibration phenomenon also occurs in the waveform of the disc-shaft displacement difference.The collision frequency is mainly composed of a low frequency and a weak high frequency component.When the rotation speed of the disc and the shaft has great difference,the collision frequency is mainly composed of one frequency multiplication,a few weak high frequency multiplication components and a few low frequency multiplication component.With the reduction of the relative speed of the disc,the trajectory of the disc changes from circle-shape to inner eight-shape,and then to circle-shape.In the inner eight-shape,the inner ring first gradually becomes smaller and then gradually becomes larger,and the outer ring is still getting smaller.The obtained research results in this paper has important theoretical value for the diagnosis of the rotor system with the loose disc.展开更多
Hepatocellular carcinoma （HCC）, a major subtype of liver cancers, is a prevalent human malignancy worldwide. In men, HCC is the fifth frequently diagnosed cancer but the second most common cause of cancer death. In ...Hepatocellular carcinoma （HCC）, a major subtype of liver cancers, is a prevalent human malignancy worldwide. In men, HCC is the fifth frequently diagnosed cancer but the second most common cause of cancer death. In women, it ranks seventh in cancer diagnosis and sixth in cancer-related death （Jemal et al., 2011）. Unlike some other cancers, such as breast cancer and colon cancer, the molecular etiology of HCC re- mains largely unknown. Infection of hepatitis virus is considered as a major risk factor in the development of liver cancers （Parkin, 2006）. Currently, there are limited options to treat HCC except for chemotherapy. Elucidating molecular mechanism of hepatocyte transformation will help develop new treatments for cancer. The widely accepted multi-step progression of carcinogenesis consists of genetic alterations which regulate cell proliferation, apoptosis and so on （Vogelstein and Kinzler, 1993）. Moreover, abnormal activation of signaling pathways has been proposed as an oncogenic driver for cancer development. For example, Kras activation occurs in 7% of human liver cancer patients. Activated Kras is sufficient to induce robust liver tumorigenesis in transgenic animal models （Nguyen et al., 2011）.展开更多
This study attempted to determine the effectiveness of the number of extra negative items in identifying insufficient effort responses in Attitudes toward Statistics (SATS-36). The (SATS-36), which consists of 36 5-po...This study attempted to determine the effectiveness of the number of extra negative items in identifying insufficient effort responses in Attitudes toward Statistics (SATS-36). The (SATS-36), which consists of 36 5-point Likert Scale items, was used to actually achieve the goal of this study. Furthermore, the researchers developed three forms, each with a different set of extra negative items (2, 4, and 6). The three forms were distributed to a sample of (750) students at Yarmouk University. The results revealed that form 1, which enclosed 6 extra negative items, had the lowest detected rate of insufficient effort responses (IERs) (7.20%), while form 3, which contained 2 extra negative items, had the highest detection rate (15.6%). The detection rate was discovered respectively among the Lie Detection Scale, Mahalanobois, l<sup>p</sup>z</sub> and the method of extra negative items. The highest detection rate was found in form 3 with two extra negative items, and data reliability decreased after the insufficient effort responses were removed (IERs). Furthermore, the results showed that the maximum changes in model-data fit indices after data filtering were in form 3, which contained two extra negative items. Moreover, the results indicate that the reliability of data after filtering those with insufficient effort responses (IERs) is reduced.展开更多
This paper, using multiple-Hubbert model, forecasts oil production trend of Iran with special focus on Iran＇s insufficient investment for developing recently discovered oilfields and overproduction from mature oilfie...This paper, using multiple-Hubbert model, forecasts oil production trend of Iran with special focus on Iran＇s insufficient investment for developing recently discovered oilfields and overproduction from mature oilfields. This is mostly due to Iran＇s political and technical limitations to carry out oil and gas projects. The trend of Iran＇s oil production has been forecasted based on a multi-cycle modified Hubbert. Three different scenarios have been assumed. In the first scenario, it is assumed that Iran does not have any limitations to carry out oil and gas projects and develop its oilfields. International sanctions and lack of foreign investment have been taken into account in the second scenario. Overproduction from currently producing mature oilfields and its effect on production trend is investigated in the third scenario. The most important parameter to forecast oil production trend is URR （ultimate recoverable resource）. URR of Iran has been estimated by parabolic fractal curve. Here, based on the plotted parabolic fractal curve for the oil fields, amount of URR of Iran has been calculated that is around 200 Gb. First scenario has two peaks while the second and third scenarios have three peaks. All of the scenarios have forecasted Iran＇s first peak in 1975 at annual production rate of 2 Gb/Year. Based on first scenario, Iran＇s second peak will occur in 2029 at 2.334 Gb/Year. Second scenario has forecasted Iran＇s second and third peaks in 2011 at 1.575 Gb/Year and in 2064 at 2.205 Gb/Year respectively, and third scenario＇s peaks have been estimated to occur in 2011 at 1.573 Gb/Year and in 2061 at 2.030 Gb/Year.展开更多
BACKGROUND: This study aimed to investigate the prevalence rate of critical illness-related corticosteroid insuffi ciency(CIRCI) and the effect of low-dose glucocorticoid on prognosis of CIRCI in patients with acute e...BACKGROUND: This study aimed to investigate the prevalence rate of critical illness-related corticosteroid insuffi ciency(CIRCI) and the effect of low-dose glucocorticoid on prognosis of CIRCI in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).METHODS: Since January 2010 to December 2012, 385 patients, who met the criteria of AECOPD, were enrolled in the Intensive Care Unit(ICU) of the First People's Hospital and Municipal Central Hospital of Xiangtan City. The AECOPD patients complicated with CIRCI screened by an adrenalcorticotrophic hormone test within 12 hours after admission to ICU were divided into a treatment group(n=32) and a control group(n=31) for a prospective, randomized and controlled clinical trial. Hydrocortisone(150 mg/d) or normal saline was injected intravenously for 7 days. The patients were followed up for 28 days after injection. The endpoint included 28-day survival time, non-shock time, ICU stay and the period of non-mechanical ventilation. The markers ofinfl ammation C-reactive protein, tumor necrosis factor-α, interleukin 6 and procalcitonin were measured at baseline and 7 days after treatment. The variables were analyzed by Student's t test, the non-parametric statistical test, the Chi-square test or the Kaplan-Meier method with SPSS18.0 statistic software. A P value <0.05 was considered statistically signifi cant.RESULTS: Totally 63 patients were diagnosed with CIRCI by an adrenalcorticotrophic hormone test and the prevalence rate was 16.4%. The shock rate of the AECOPD patients complicated with CIRCI was higher than that of the AECOPD patients without CIRCI(23.8% vs. 8.7%, P<0.01). KaplanMeier analysis revealed that the 28-day survival time of the treatment group was obviously longer than that of the control group(P<0.05). Compared with the control group, shock-free days within 28 days was longer in the treatment group(18.2±9.5 vs. 25.8±4.1, P<0.05). Treatment with low-dose glucocorticoid obviously decreased the markers ofinfection and inflammation(P<0.01), such as C-reactive protein(13.2±5.5 mg/L vs. 8.3±3.1 mg/L for the control group; 13.5±5.9 mg/L vs. 5.1±2.3 mg/L for the treatment group), tumor necrosis factor-α(26.1±16.2 g/L vs. 17.5±11.7 g/L for the control group; 25.0±14.8 g/L vs. 10.4±7.8 g/L for the treatment group) and procalcitonin(3.88 g/L vs. 2.03 g/L for the control group; 3.77 g/L vs. 1.26 g/L for the treatment group). Furthermore, the markers in the treatment group decreased more obviously than those in the control group(P<0.01).CONCLUSION: The prevalence rate of CIRCI was higher in the patients with AECOPD in the department of critical medicine, and low-dose glucocorticoid treatment for one week reduced the 28-day mortality, shock time and markers ofinfection and infl ammation.展开更多
Living organisms derive energy for cellular activities through three primary mechanisms. The first is photosynthesis, which is restricted to plants and certain bacteria. It uses energy in sunlight to combine carbon di...Living organisms derive energy for cellular activities through three primary mechanisms. The first is photosynthesis, which is restricted to plants and certain bacteria. It uses energy in sunlight to combine carbon dioxide with water to form carbohydrates plus oxygen. The second is chemical energy, which is ob-tainable by all organisms from the cellular metabolism of carbohydrates and other organic molecules. The third mechanism of obtaining cellular energy is the alternative cellular energy (ACE) pathway. The ACE pathway is expressed as an added dynamic (kinetic) quality of the body’s fluids. It results from the absorption of an environmental force termed KELEA (kinetic energy limiting electrostatic attraction). The fundamental role of KELEA is presumably to pre-vent the fusion and annihilation of electrostatically attracted opposing electrical charges. KELEA can loosen the hydrogen bonding between fluid molecules. KELEA benefits living organisms in part by enabling more efficient biochemical reactions. Cells require a minimal amount of energy to remain viable. Additional energy is required to undertake specialized cellular functions. Illnesses result if cells have insufficient cellular energy (ICE) for their specialized functions. Since KELEA is attracted to separated electrical charges, it is presumably attracted to the electrical charges comprising the membrane potential of cells. It is proposed that the depolarization of neuronal cells leads to the partial release of KELEA for use by the depolarized cell and as a contribution to the overall activation of the body’s fluids. Many brain illnesses currently attributed to cellular neurodegeneration are explainable as neuronal cells’ adaptations to ICE. The adaptations likely comprise initial hyper-excitability to obtain additional KELEA, followed by functional quiescence prior to actual neuronal cell death. Clinical recovery during both the hyper-excitable and hypoactive phases is potentially achievable by enhancing the ACE pathway. Furthermore, among the restored specialized functions of quiescent neuronal cells may be the capacity to again attract KELEA, leading to sustainable recovery. The opportunity exists for extended clinical trials involving the ACE pathway in neurological and psychiatric illnesses.展开更多
Insufficient blood supply to vertebrobasilarartery is one of the ischemic cerebrovascular diseasesencountered commonly and frequently in old people.Its clinical symptoms are capricious,and severeischemia may jeopardiz...Insufficient blood supply to vertebrobasilarartery is one of the ischemic cerebrovascular diseasesencountered commonly and frequently in old people.Its clinical symptoms are capricious,and severeischemia may jeopardize the life of the patient.Thekey point for saving the patient's life and raising thequality of life is to relieve the symptoms and improveblood supply to the brain.From May 1995 to展开更多
Acupuncture moxibustion has been recognized to be effective for treatment of cerebral ischemia, but there are still some problems such as undefined criteria for evaluating the effectiveness and unchecked selection of ...Acupuncture moxibustion has been recognized to be effective for treatment of cerebral ischemia, but there are still some problems such as undefined criteria for evaluating the effectiveness and unchecked selection of acupoints. In the late 1980s, cerebrovascular examination was revolutionized in China展开更多
Sleep health literacy encompasses the knowledge, motivation, and skills required to promote healthy sleep and recognize sleep disorders. In Japan, sleep-related issues are a significant contributor to prolonged studen...Sleep health literacy encompasses the knowledge, motivation, and skills required to promote healthy sleep and recognize sleep disorders. In Japan, sleep-related issues are a significant contributor to prolonged student absenteeism, underscoring the urgent need to address these challenges within school health programs. This review explores the historical evolution of Japan’s perspectives on sleep, shedding light on misconceptions rooted in Neo-Confucianism (Shushigaku), such as the notion of “sacrificing sleep for achievement”. While the 2018 Work Style Reform Act has introduced measures to ensure workplace rest, similar initiatives for students remain absent, perpetuating a culture of sleep deprivation. Misunderstandings surrounding adolescent sleep patterns, chronotypes, and sleep-related health factors are addressed. The review concludes by proposing seven core principles for advancing sleep health literacy: 1) Exposure to morning light;2) Engagement in daytime physical activity;3) Resting in darkness at night;4) Consuming breakfast and avoiding late-night meals;5) Maintaining regular elimination;6) Minimizing stimulants and excessive media use;7) Respecting pre-sleep rituals. Enhancing sleep health literacy, particularly within educational settings, is vital for tackling adolescent sleep challenges and fostering long-term well-being. School health professionals must take the lead in driving this transformative initiative.展开更多
With the unprecedented prevalence of Industrial Internet of Things(IIoT)and 5G technology,various applications supported by industrial communication systems have generated exponentially increased processing tasks,whic...With the unprecedented prevalence of Industrial Internet of Things(IIoT)and 5G technology,various applications supported by industrial communication systems have generated exponentially increased processing tasks,which makes task assignment inefficient due to insufficient workers.In this paper,an Intelligent and Trustworthy task assignment method based on Trust and Social relations(ITTS)is proposed for scenarios with many tasks and few workers.Specifically,ITTS first makes initial assignments based on trust and social influences,thereby transforming the complex large-scale industrial task assignment of the platform into the small-scale task assignment for each worker.Then,an intelligent Q-decision mechanism based on workers'social relation is proposed,which adopts the first-exploration-then-utilization principle to allocate tasks.Only when a worker cannot cope with the assigned tasks,it initiates dynamic worker recruitment,thus effectively solving the worker shortage problem as well as the cold start issue.More importantly,we consider trust and security issues,and evaluate the trust and social circles of workers by accumulating task feedback,to provide the platform a reference for worker recruitment,thereby creating a high-quality worker pool.Finally,extensive simulations demonstrate ITTS outperforms two benchmark methods by increasing task completion rates by 56.49%-61.53%and profit by 42.34%-47.19%.展开更多
Concerned that fewer than 20%of adolescents meet the World Health Organization(WHO)’s physical activity(PA)guidelines of engaging in≥60 min each day of the week of moderate-to-vigorous PA(MVPA),classifying them as i...Concerned that fewer than 20%of adolescents meet the World Health Organization(WHO)’s physical activity(PA)guidelines of engaging in≥60 min each day of the week of moderate-to-vigorous PA(MVPA),classifying them as insufficiently active,1 Araujo et al.2 sought to identify the global prevalence of adolescents reporting less frequent MVPA(≥60 min per day of MVPA≥1 days per week)and identify differences in this prevalence by age,gender.展开更多
Mild thyroid stimulating hormone （TSH） elevations are highly prevalent whereas large proportion of individuals with TSH elevations is without chronic autoimmune thyroid diseases.TSH secretion exhibits a daily circad...Mild thyroid stimulating hormone （TSH） elevations are highly prevalent whereas large proportion of individuals with TSH elevations is without chronic autoimmune thyroid diseases.TSH secretion exhibits a daily circadian rhythm,and we previously reported that individuals with sleep disorders have significantly higher TSH levels than controls.展开更多
文摘Combining practical engineering projects, this article analyzes the design strategies for the reconstruction and expansion of insufficient clearance sections in highway interchanges. This includes an overview of the project, a comparison of design options for insufficient clearance in interchanges, and the main design strategies for reconstruction and expansion. It is hoped that this analysis can provide a reference for the design of such road reconstruction and expansion projects.
基金supported by grant from the National Nature Science Foundation of China(Grant Nos.:82102168 and 81873919).
文摘The hypoxic microenvironment and inflammatory state of residual tumors caused by insufficient radiofrequency ablation(iRFA)are major reasons for rapid tumor progression and pose challenges for immunotherapy.We retrospectively analyzed the clinical data of patients with hepatocellular carcinoma(HCC)treated with RFA and observed that iRFAwas associated with poor survival outcomes and progression-free survival.Using an orthotopic HCC mouse model and a colorectal liver metastasis model,we observed that treatment with melatonin after iRFA reduced tumor growth and metastasis and achieved the best outcomes when combined with anti-programmed death-ligand 1(anti-PD-L1)therapy.In mechanism,melatonin inhibited the expression of epithelial-mesenchymal transitions,hypoxia-inducible factor(HIF)-1a,and PD-L1 in tumor cells after iRFA.Flow cytometry revealed that melatonin reduced the proportion of myeloid-derived suppressor cells and increased the proportion of CD8t T cells.Transcriptomic analysis revealed an upregulation of immune-activated function-related genes in residual tumors.These findings demonstrated that melatonin can reverse hypoxia and iRFA-induced inflammation,thereby overcoming the immunosuppressive tumor microenvironment(TME)and enhancing the efficacy of immunotherapy.
基金Supported by National Natural Science Foundation of China(No.81900910)Natural Science Foundation of Zhejiang Province(No.LQ19H120003)Basic Scientific Research Project of Wenzhou(No.Y2023809).
文摘AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(<250μm)after implantable collamer lens(ICL V4c;STAAR Surgical)implantation.METHODS:The participants underwent ICL surgery and were divided into the low(<250μm)and normal(250-1000μm)vault groups based on the postoperative vault at 3mo.The preoperative biometric parameters and clinical outcomes were compared between the two groups.The relationship between the 3-month vault values and preoperative ocular parameters were evaluated by Generalized estimating equations.RESULTS:Sixteen(23 eyes)and 36 patients(63 eyes)were in the low and normal vault groups,respectively.All implantation procedures were uneventful with no cataract formation in the early postoperative period.The sulcusto-sulcus lens rise(STSL)and iris ciliary angle(ICA)were correlated with vault at 3mo after surgery.Every 0.1 mm increase in STSL was associated with 38.9μm decrease in the postoperative 3-month vault.A rise of 1 degree in ICA is associated with a reduction of 4μm in vault.CONCLUSION:Eyes with a narrow ciliary sulcus are associated with a higher rate of low vault after ICL implantation,suggesting a need for adjustments to the ICL size in these patients.Evaluating the characteristics of the ciliary sulcus contributes valuable information to predict low vault after surgery.
文摘In the research, available sulphur in 4 700 soil samples was tested and analyzed in 2006-2007 in Dengzhou, and the results showed that available sulphur was insufficient in farmlands in Dengzhou for cereal crop and about 60% farmlands with available sulphur belong to the farmlands with potential shortage of available sulphur for Cruciferae, Liliaceae and Leguminosae. Meanwhile, the producing causes were analyzed from the perspectives of fertilization structure and planting structure and the countermeasures were proposed in terms of sulphur movements in plants and characters.
文摘Traditional methods for judging the degree of insufficient fluid supply in oil wells have low efficiency and limited accuracy. To address this problem, a method for intelligently identifying the degree of insufficient fluid supply in oil wells based on convolutional neural networks is proposed in this paper. Firstly, 5000 indicator diagrams with insufficient liquid supply were collected from the oilfield site, and a sample set was established after preprocessing;then based on the AlexNet model, combined with the characteristics of the indicator diagram, a convolutional neural network model including 4 layers of convolutional layers, 3 layers of down-pooling layers and 2 layers of fully connected layers is established. The backpropagation, ReLu activation function and dropout regularization method are used to complete the training of the convolutional neural network;finally, the performance of the convolutional neural network under different iteration times and network structure is compared, and the super parameter optimization of the model is completed. It has laid a good foundation for realizing the self-adaptive and intelligent matching of oil well production parameters and formation fluid supply conditions. It has certain application prospects. The results show that the accuracy of training and verification of the method exceeds 98%, which can meet the actual application requirements on site.
基金supported by the National Natural Science Foundation of China(No. 30900284,No.31100668,and No.31070873)
文摘Background Dental implants have been widely used in the last few decades.However,patients with insufficient bone height need reconstructive surgeries before implant insertion.Distraction implant(Dl)has been invented to simplify the treatment procedure,but the shortcomings of Dl have limited its clinical use.We introduced biodegradable polyester to a novel Dl,called biodegradable interference distraction implant(BIDI).The purpose of this study was to assess the radiological,histological,and biomechanical properties of BIDI in animal models.Methods BIDIs were manufactured and inserted into the atrophied mandibles of 6 dogs.
基金supported by the Key Research and Development Program of Zhejiang Province(No.2021C01008)the National Natural Science Foundation of China(No.52105279)the Ningbo Natural Science Foundation of China(No.2021J163)。
文摘Reliability analysis and reliability-based optimization design require accurate measurement of failure probability under input uncertainties.A unified probabilistic reliability measure approach is proposed to calculate the probability of failure and sensitivity indices considering a mixture of uncertainties under insufficient input data.The input uncertainty variables are classified into statistical variables,sparse variables,and interval variables.The conservativeness level of the failure probability is calculated through uncertainty propagation analysis of distribution parameters of sparse variables and auxiliary parameters of interval variables.The design sensitivity of the conservativeness level of the failure probability at design points is derived using a semi-analysis and sampling-based method.The proposed unified reliability measure method is extended to consider p-box variables,multi-domain variables,and evidence theory variables.Numerical and engineering examples demonstrate the effectiveness of the proposed method,which can obtain an accurate confidence level of reliability index and sensitivity indices with lower function evaluation number.
基金National Natural Science Foundation of China(Grant Nos.51675258,51875301,51265039)State Key Laboratory of Mechanical System and Vibration of China(Grant No.MSV201914)Laboratory of Science and Technology on Integrated Logistics Support,National University of Defense Technology of China(Grant No.6142003190210).
文摘The rotating parts looseness is one of the common failures in rotating machinery.The current researches of looseness fault mainly focus on non-rotating components.However,the looseness fault of disc-shaft system,which is the main work part in the rotor system,is almost ignored.Here,a dynamic model of the rotor system with loose disc caused by the insufficient interference force is proposed based on the contact model of disc-shaft system with the microscopic surface topography,the vibration characteristics of the system are analyzed and discussed by the number simulation,and verified by the experiment.The results show that the speed of the shaft,the contact stiffness,the clearance between the disc and shaft,the damping of the disc and the rotational damping have an influence on the rotation state of the disc.When the rotation speed of the disc and the shaft are same,the collision frequency is mainly composed of one frequency multiplication component and very weak high frequency multiplication components.When the rotation speed of the disc and the shaft is close,the vibration of the disc occurs a beat vibration phenomenon in the horizontal direction.Simultaneously,a periodical similar beat vibration phenomenon also occurs in the waveform of the disc-shaft displacement difference.The collision frequency is mainly composed of a low frequency and a weak high frequency component.When the rotation speed of the disc and the shaft has great difference,the collision frequency is mainly composed of one frequency multiplication,a few weak high frequency multiplication components and a few low frequency multiplication component.With the reduction of the relative speed of the disc,the trajectory of the disc changes from circle-shape to inner eight-shape,and then to circle-shape.In the inner eight-shape,the inner ring first gradually becomes smaller and then gradually becomes larger,and the outer ring is still getting smaller.The obtained research results in this paper has important theoretical value for the diagnosis of the rotor system with the loose disc.
基金financially supported through grants from National Natural Science Foundation of China(Nos.3147135931271563 and 81572076)+1 种基金the Ministry of Science and Technology of China(Nos.2011CB944002 and2013CB945000)the Chinese Academy of Sciences(No.XDA01010108)
文摘Hepatocellular carcinoma （HCC）, a major subtype of liver cancers, is a prevalent human malignancy worldwide. In men, HCC is the fifth frequently diagnosed cancer but the second most common cause of cancer death. In women, it ranks seventh in cancer diagnosis and sixth in cancer-related death （Jemal et al., 2011）. Unlike some other cancers, such as breast cancer and colon cancer, the molecular etiology of HCC re- mains largely unknown. Infection of hepatitis virus is considered as a major risk factor in the development of liver cancers （Parkin, 2006）. Currently, there are limited options to treat HCC except for chemotherapy. Elucidating molecular mechanism of hepatocyte transformation will help develop new treatments for cancer. The widely accepted multi-step progression of carcinogenesis consists of genetic alterations which regulate cell proliferation, apoptosis and so on （Vogelstein and Kinzler, 1993）. Moreover, abnormal activation of signaling pathways has been proposed as an oncogenic driver for cancer development. For example, Kras activation occurs in 7% of human liver cancer patients. Activated Kras is sufficient to induce robust liver tumorigenesis in transgenic animal models （Nguyen et al., 2011）.
文摘This study attempted to determine the effectiveness of the number of extra negative items in identifying insufficient effort responses in Attitudes toward Statistics (SATS-36). The (SATS-36), which consists of 36 5-point Likert Scale items, was used to actually achieve the goal of this study. Furthermore, the researchers developed three forms, each with a different set of extra negative items (2, 4, and 6). The three forms were distributed to a sample of (750) students at Yarmouk University. The results revealed that form 1, which enclosed 6 extra negative items, had the lowest detected rate of insufficient effort responses (IERs) (7.20%), while form 3, which contained 2 extra negative items, had the highest detection rate (15.6%). The detection rate was discovered respectively among the Lie Detection Scale, Mahalanobois, l<sup>p</sup>z</sub> and the method of extra negative items. The highest detection rate was found in form 3 with two extra negative items, and data reliability decreased after the insufficient effort responses were removed (IERs). Furthermore, the results showed that the maximum changes in model-data fit indices after data filtering were in form 3, which contained two extra negative items. Moreover, the results indicate that the reliability of data after filtering those with insufficient effort responses (IERs) is reduced.
文摘This paper, using multiple-Hubbert model, forecasts oil production trend of Iran with special focus on Iran＇s insufficient investment for developing recently discovered oilfields and overproduction from mature oilfields. This is mostly due to Iran＇s political and technical limitations to carry out oil and gas projects. The trend of Iran＇s oil production has been forecasted based on a multi-cycle modified Hubbert. Three different scenarios have been assumed. In the first scenario, it is assumed that Iran does not have any limitations to carry out oil and gas projects and develop its oilfields. International sanctions and lack of foreign investment have been taken into account in the second scenario. Overproduction from currently producing mature oilfields and its effect on production trend is investigated in the third scenario. The most important parameter to forecast oil production trend is URR （ultimate recoverable resource）. URR of Iran has been estimated by parabolic fractal curve. Here, based on the plotted parabolic fractal curve for the oil fields, amount of URR of Iran has been calculated that is around 200 Gb. First scenario has two peaks while the second and third scenarios have three peaks. All of the scenarios have forecasted Iran＇s first peak in 1975 at annual production rate of 2 Gb/Year. Based on first scenario, Iran＇s second peak will occur in 2029 at 2.334 Gb/Year. Second scenario has forecasted Iran＇s second and third peaks in 2011 at 1.575 Gb/Year and in 2064 at 2.205 Gb/Year respectively, and third scenario＇s peaks have been estimated to occur in 2011 at 1.573 Gb/Year and in 2061 at 2.030 Gb/Year.
文摘BACKGROUND: This study aimed to investigate the prevalence rate of critical illness-related corticosteroid insuffi ciency(CIRCI) and the effect of low-dose glucocorticoid on prognosis of CIRCI in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).METHODS: Since January 2010 to December 2012, 385 patients, who met the criteria of AECOPD, were enrolled in the Intensive Care Unit(ICU) of the First People's Hospital and Municipal Central Hospital of Xiangtan City. The AECOPD patients complicated with CIRCI screened by an adrenalcorticotrophic hormone test within 12 hours after admission to ICU were divided into a treatment group(n=32) and a control group(n=31) for a prospective, randomized and controlled clinical trial. Hydrocortisone(150 mg/d) or normal saline was injected intravenously for 7 days. The patients were followed up for 28 days after injection. The endpoint included 28-day survival time, non-shock time, ICU stay and the period of non-mechanical ventilation. The markers ofinfl ammation C-reactive protein, tumor necrosis factor-α, interleukin 6 and procalcitonin were measured at baseline and 7 days after treatment. The variables were analyzed by Student's t test, the non-parametric statistical test, the Chi-square test or the Kaplan-Meier method with SPSS18.0 statistic software. A P value <0.05 was considered statistically signifi cant.RESULTS: Totally 63 patients were diagnosed with CIRCI by an adrenalcorticotrophic hormone test and the prevalence rate was 16.4%. The shock rate of the AECOPD patients complicated with CIRCI was higher than that of the AECOPD patients without CIRCI(23.8% vs. 8.7%, P<0.01). KaplanMeier analysis revealed that the 28-day survival time of the treatment group was obviously longer than that of the control group(P<0.05). Compared with the control group, shock-free days within 28 days was longer in the treatment group(18.2±9.5 vs. 25.8±4.1, P<0.05). Treatment with low-dose glucocorticoid obviously decreased the markers ofinfection and inflammation(P<0.01), such as C-reactive protein(13.2±5.5 mg/L vs. 8.3±3.1 mg/L for the control group; 13.5±5.9 mg/L vs. 5.1±2.3 mg/L for the treatment group), tumor necrosis factor-α(26.1±16.2 g/L vs. 17.5±11.7 g/L for the control group; 25.0±14.8 g/L vs. 10.4±7.8 g/L for the treatment group) and procalcitonin(3.88 g/L vs. 2.03 g/L for the control group; 3.77 g/L vs. 1.26 g/L for the treatment group). Furthermore, the markers in the treatment group decreased more obviously than those in the control group(P<0.01).CONCLUSION: The prevalence rate of CIRCI was higher in the patients with AECOPD in the department of critical medicine, and low-dose glucocorticoid treatment for one week reduced the 28-day mortality, shock time and markers ofinfection and infl ammation.
文摘Living organisms derive energy for cellular activities through three primary mechanisms. The first is photosynthesis, which is restricted to plants and certain bacteria. It uses energy in sunlight to combine carbon dioxide with water to form carbohydrates plus oxygen. The second is chemical energy, which is ob-tainable by all organisms from the cellular metabolism of carbohydrates and other organic molecules. The third mechanism of obtaining cellular energy is the alternative cellular energy (ACE) pathway. The ACE pathway is expressed as an added dynamic (kinetic) quality of the body’s fluids. It results from the absorption of an environmental force termed KELEA (kinetic energy limiting electrostatic attraction). The fundamental role of KELEA is presumably to pre-vent the fusion and annihilation of electrostatically attracted opposing electrical charges. KELEA can loosen the hydrogen bonding between fluid molecules. KELEA benefits living organisms in part by enabling more efficient biochemical reactions. Cells require a minimal amount of energy to remain viable. Additional energy is required to undertake specialized cellular functions. Illnesses result if cells have insufficient cellular energy (ICE) for their specialized functions. Since KELEA is attracted to separated electrical charges, it is presumably attracted to the electrical charges comprising the membrane potential of cells. It is proposed that the depolarization of neuronal cells leads to the partial release of KELEA for use by the depolarized cell and as a contribution to the overall activation of the body’s fluids. Many brain illnesses currently attributed to cellular neurodegeneration are explainable as neuronal cells’ adaptations to ICE. The adaptations likely comprise initial hyper-excitability to obtain additional KELEA, followed by functional quiescence prior to actual neuronal cell death. Clinical recovery during both the hyper-excitable and hypoactive phases is potentially achievable by enhancing the ACE pathway. Furthermore, among the restored specialized functions of quiescent neuronal cells may be the capacity to again attract KELEA, leading to sustainable recovery. The opportunity exists for extended clinical trials involving the ACE pathway in neurological and psychiatric illnesses.
文摘Insufficient blood supply to vertebrobasilarartery is one of the ischemic cerebrovascular diseasesencountered commonly and frequently in old people.Its clinical symptoms are capricious,and severeischemia may jeopardize the life of the patient.Thekey point for saving the patient's life and raising thequality of life is to relieve the symptoms and improveblood supply to the brain.From May 1995 to
文摘Acupuncture moxibustion has been recognized to be effective for treatment of cerebral ischemia, but there are still some problems such as undefined criteria for evaluating the effectiveness and unchecked selection of acupoints. In the late 1980s, cerebrovascular examination was revolutionized in China
文摘Sleep health literacy encompasses the knowledge, motivation, and skills required to promote healthy sleep and recognize sleep disorders. In Japan, sleep-related issues are a significant contributor to prolonged student absenteeism, underscoring the urgent need to address these challenges within school health programs. This review explores the historical evolution of Japan’s perspectives on sleep, shedding light on misconceptions rooted in Neo-Confucianism (Shushigaku), such as the notion of “sacrificing sleep for achievement”. While the 2018 Work Style Reform Act has introduced measures to ensure workplace rest, similar initiatives for students remain absent, perpetuating a culture of sleep deprivation. Misunderstandings surrounding adolescent sleep patterns, chronotypes, and sleep-related health factors are addressed. The review concludes by proposing seven core principles for advancing sleep health literacy: 1) Exposure to morning light;2) Engagement in daytime physical activity;3) Resting in darkness at night;4) Consuming breakfast and avoiding late-night meals;5) Maintaining regular elimination;6) Minimizing stimulants and excessive media use;7) Respecting pre-sleep rituals. Enhancing sleep health literacy, particularly within educational settings, is vital for tackling adolescent sleep challenges and fostering long-term well-being. School health professionals must take the lead in driving this transformative initiative.
基金supported by the National Natural Science Foundation of China under Grant No.62072475 and No.62302062in part by the Hunan Provincial Natural Science Foundation of China under Grant Number 2023JJ40081。
文摘With the unprecedented prevalence of Industrial Internet of Things(IIoT)and 5G technology,various applications supported by industrial communication systems have generated exponentially increased processing tasks,which makes task assignment inefficient due to insufficient workers.In this paper,an Intelligent and Trustworthy task assignment method based on Trust and Social relations(ITTS)is proposed for scenarios with many tasks and few workers.Specifically,ITTS first makes initial assignments based on trust and social influences,thereby transforming the complex large-scale industrial task assignment of the platform into the small-scale task assignment for each worker.Then,an intelligent Q-decision mechanism based on workers'social relation is proposed,which adopts the first-exploration-then-utilization principle to allocate tasks.Only when a worker cannot cope with the assigned tasks,it initiates dynamic worker recruitment,thus effectively solving the worker shortage problem as well as the cold start issue.More importantly,we consider trust and security issues,and evaluate the trust and social circles of workers by accumulating task feedback,to provide the platform a reference for worker recruitment,thereby creating a high-quality worker pool.Finally,extensive simulations demonstrate ITTS outperforms two benchmark methods by increasing task completion rates by 56.49%-61.53%and profit by 42.34%-47.19%.
文摘Concerned that fewer than 20%of adolescents meet the World Health Organization(WHO)’s physical activity(PA)guidelines of engaging in≥60 min each day of the week of moderate-to-vigorous PA(MVPA),classifying them as insufficiently active,1 Araujo et al.2 sought to identify the global prevalence of adolescents reporting less frequent MVPA(≥60 min per day of MVPA≥1 days per week)and identify differences in this prevalence by age,gender.
基金This study was supported by a grant from the National Natural Science Foundation of China （No. 81600603）.
文摘Mild thyroid stimulating hormone （TSH） elevations are highly prevalent whereas large proportion of individuals with TSH elevations is without chronic autoimmune thyroid diseases.TSH secretion exhibits a daily circadian rhythm,and we previously reported that individuals with sleep disorders have significantly higher TSH levels than controls.
