The presence of residual stresses in materials or engineering structures can significantly influence their mechanical per-formance.Accurate measurement of residual stresses is of great importance to ensure their in-se...The presence of residual stresses in materials or engineering structures can significantly influence their mechanical per-formance.Accurate measurement of residual stresses is of great importance to ensure their in-service reliability.Although numerous instrumented indentation methods have been proposed to evaluate residual stresses,the majority of them require a stress-free reference sample as a comparison benchmark,thereby limiting their applicability in scenarios where obtaining stress-free reference samples is challenging.In this work,through a number of finite element simulations,it was found that the loading exponent of the loading load-depth curve and the recovered depth during unloading are insensitive to residual stresses.The loading curve of the stress-free specimen was virtually reconstructed using such stress-insensitive parameters extracted from the load-depth curves of the stressed state,thus eliminating the requirement for stress-free reference samples.The residual stress was then correlated with the fractional change in loading work between stressed and stress-free loading curves through dimensional analysis and finite element simulations.Based on this correlation,an instrumented sharp indentation method for measuring equibiaxial residual stress without requiring a stress-free specimen was established.Both numerical and experimental verifications were carried out to demonstrate the accuracy and reliability of the newly proposed method.The maximum relative error and absolute error in measured residual stresses are typically within±20%and±20 MPa,respectively.展开更多
By using an instrumented impact pendulum, the force versus time curves of 7075-T651 aluminum welds were obtained from standard Charpy-V samples. Considering the force-time curves and constant impact velocity, the frac...By using an instrumented impact pendulum, the force versus time curves of 7075-T651 aluminum welds were obtained from standard Charpy-V samples. Considering the force-time curves and constant impact velocity, the fracture energies for different zones were quantified. A fracture energy improvement for the HAZ(33.6 J) was observed in comparison with the weld metal(7.88 J), and base metal(5.37 J and 7.37 J for longitudinal and transverse directions, respectively). This toughness increment was attributed to the microstructural transformation caused by the thermodynamic instability of η′ precipitates during the welding. Fracture energy for weld metal was higher than that for base metal, probably due to pores created during solidification. Regarding the dynamic yielding force obtained from the force-time curves, an approximation to the dynamic yield strength for weld, HAZ and base metal was determined. Fracture surfaces revealed an intergranular failure for base metal in longitudinal direction, whereas a predominately brittle failure(cleavage) with some insights of ductile characteristics was observed for the transverse direction. In contrast, a ductile failure was observed for weld metal and HAZ.展开更多
A nondestructive continuous instrumented wheelset design is proposed based on strain gauges placing inside of the wheel web and wireless telemetry system. The signal feature analysis including frequency contents and h...A nondestructive continuous instrumented wheelset design is proposed based on strain gauges placing inside of the wheel web and wireless telemetry system. The signal feature analysis including frequency contents and high order harmonic ripples is also carried out. The strain gradient decoupling method for vertical and lateral force identification is proposed based on the strain distributions under respective loads. The method implements minimum crosstalk effects and insensitive to the varying contact points. The KMT telemetry system is adopted for wireless inductive powering and signal transferring. The drilling holes on the wheel and axles are avoidable to ensure the integrity and long-term using of the wheelset. Bridging and demodulating schemes for lateral and vertical force are designed respectively as they have dramatic differences at the dynamic signal features. High order harmonic ripple analysis and error estimation are gotten by independent waveforms. Based on the data form calibration test rig, it is indicated that the high order ripple amplitudes are below 10% of the demodulation amplitudes and fulfill designed requirements.展开更多
BACKGROUND Acute spinal subdural haematoma(ASSH)is a rare and potentially devastating condition with a variable prognosis.Previously described subdural haematomas were thought to have occurred spontaneously or be rela...BACKGROUND Acute spinal subdural haematoma(ASSH)is a rare and potentially devastating condition with a variable prognosis.Previously described subdural haematomas were thought to have occurred spontaneously or be related to major or minor iatrogenic or traumatic injuries caused by surgery,spinal puncture or epidural anaesthesia.Other contributing pathologies have been described,such as intradural tumours or spinal arteriovenous malformations.ASSH has also been associated with anticoagulation therapy,haemostatic abnormalities and risk factors such as pregnancy.To the best of our knowledge,this case study described the first reported occurrence of an ASSH during spinal surgery in a paediatric patient.The patient was not known to have any coagulopathies,and no obvious vascular lesions were documented.The surgical procedure did not directly involve the dura mater,and no evident intraoperative dural tears were found.CASE SUMMARY We reported and discussed a case of ASSH complicating a posterior spinal instrumented fusion during surgery for paediatric congenital scoliosis.This condition has not been previously described.We made recommendations for facing such an occurrence,explored its aetiology in the context of malformation and discussed the benefits of neuromonitoring during scoliosis correction and the management protocol.We conducted a PubMed literature review for cases of paediatric ASSH and other closely related disorders.We reviewed recommendations regarding neuromonitoring and treatment management in such cases.CONCLUSION ASSH is a rare complication of posterior spinal instrumented fusion.Published cases are more often associated with anticoagulation therapy or coagulopathy.Neuromonitoring is strongly recommended to detect and assess neurological status,thus enabling rapid diagnosis and treatment and facilitating early spinal decompression and a return to a normal neurological status.展开更多
A more accurate determination for the Probability of Failure on Demand(PFD)of the Safety Instrumented System(SIS)contributes to more SIS realiability,thereby ensuring more safety and lower cost.IEC 61508 and ISA TR.84...A more accurate determination for the Probability of Failure on Demand(PFD)of the Safety Instrumented System(SIS)contributes to more SIS realiability,thereby ensuring more safety and lower cost.IEC 61508 and ISA TR.84.02 provide the PFD detemination formulas.However,these formulas suffer from an uncertaity issue due to the inclusion of uncertainty sources,which,including high redundant systems architectures,cannot be assessed,have perfect proof test assumption,and are neglegted in partial stroke testing(PST)of impact on the system PFD.On the other hand,determining the values of PFD variables to achieve the target risk reduction involves daunting efforts and consumes time.This paper proposes a new approach for system PFD determination and PFD variables optimization that contributes to reduce the uncertainty problem.A higher redundant system can be assessed by generalizing the PFD formula into KooN architecture without neglecting the diagnostic coverage factor(DC)and common cause failures(CCF).In order to simulate the proof test effectiveness,the Proof Test Coverage(PTC)factor has been incorporated into the formula.Additionally,the system PFD value has been improved by incorporating PST for the final control element into the formula.The new developed formula is modelled using the Genetic Algorithm(GA)artificial technique.The GA model saves time and effort to examine system PFD and estimate near optimal values for PFD variables.The proposed model has been applicated on SIS design for crude oil test separator using MATLAB.The comparison between the proposed model and PFD formulas provided by IEC 61508 and ISA TR.84.02 showed that the proposed GA model can assess any system structure and simulate industrial reality.Furthermore,the cost and associated implementation testing activities are reduced.展开更多
Our paper presents a project that involves two research questions: does the choice of a related problem by the tutorial system allow the problem solving process which is blocked for the student to be restarted? What i...Our paper presents a project that involves two research questions: does the choice of a related problem by the tutorial system allow the problem solving process which is blocked for the student to be restarted? What information about learning do related problems returned by the system provide us? We answer the first question according to the didactic engineering, whose mode of validation is internal and based on the confrontation between an a priori analysis and an a posteriori analysis that relies on data from experiments in schools. We consider the student as a subject whose adaptation processes are conditioned by the problem and the possible interactions with the computer environment, and also by his knowledge, usually implicit, of the institutional norms that condition his relationship with geometry. Choosing a set of good problems within the system is therefore an essential element of the learning model. Since the source of a problem depends on the student’s actions with the computer tool, it is necessary to wait and see what are the related to problems that are returned to him before being able to identify patterns and assess the learning. With the simultaneity of collecting and analysing interactions in each class, we answer the second question according to a grounded theory analysis. By approaching the problems posed by the system and the designs in play at learning blockages, our analysis links the characteristics of problems to the design components in order to theorize on the decisional, epistemological, representational, didactic and instrumental aspects of the subject-milieu system in interaction.展开更多
The precise calibration of indenter geometries is a critical factor in ensuring reliable instrumented indentation experiments,particularly at the microscale and nanoscale.This study presents the comprehensive and high...The precise calibration of indenter geometries is a critical factor in ensuring reliable instrumented indentation experiments,particularly at the microscale and nanoscale.This study presents the comprehensive and highly accurate calibration of a modified Berkovich indenter using a metrological large-range atomic force microscope,reaching a relative standard uncertainty of less than 1% for the projected area function(PAF)for indentation depths of 200 nm and more.In contrast to previous works,this study specifically focuses on the influence of data evaluation methods on the determination of indenter geometry and the estimation of the measurement uncertainty.A refined uncertainty estimation approach is implemented,overcoming the limitations of both the classical"Guide to the Expression of Uncertainty in Measurement"and the Monte Carlo method,which either require restrictive idealization assumptions on the indenter geometry or entail high computational costs.By leveraging a systematic simulationbased uncertainty assessment,this work provides a robust evaluation of the PAF uncertainty and its dominant contributing factors.展开更多
Background The purpose of this retrospective study was to compare the surgical outcomes of simple discectomy and instrumented posterior lumbar interbody fusion （iPLIF） in patients with lumbar disc herniation and Mod...Background The purpose of this retrospective study was to compare the surgical outcomes of simple discectomy and instrumented posterior lumbar interbody fusion （iPLIF） in patients with lumbar disc herniation and Modic endplate changes.Our hypothesis was that iPLIF could provide better outcome for patients with refractory lumbar disc herniation and Modic changes （LDH-MC）.Methods Ninety-one patients with single-segment LDH-MC were recruited.All patients experienced low back pain as well as radicular leg pain,and low back pain was more severe than leg pain.Forty-seven patients were treated with discectomy and 44 were treated with iPLIE The outcomes of both low back pain and radicular leg pain using visual analogue scale （VAS） as well as the clinical outcome related to low back pain using Japanese Orthopaedic Association （JOA） score were assessed before and 18 months after surgery,respectively.Results Both low back and leg pain were significantly improved 18 months after simple discectomy and iPLIE Compared to patients undergoing simple discectomy,low back pain was significantly reduced in patients undergoing iPLIE but there was no significant difference in leg pain between two groups.Solid fusion was achieved in all patients who underwent iPLIF.Conclusions In patients with LDH-MC,iPLIF can yield significantly superior outcome on the relief of low back pain compared to simple discectomy.Simple discectomy can relieve radicular leg pain as efficient as iPLIE Accordingly,iPLIF seems to be a reliable treatment for patients with LDH-MC and predominant low back pain.展开更多
Astronomical Techniques and Instruments would like to sincerely thank the following individuals who contribute to this issue.The success of our publication hinges on the contributions of time and energy put forth by t...Astronomical Techniques and Instruments would like to sincerely thank the following individuals who contribute to this issue.The success of our publication hinges on the contributions of time and energy put forth by these professionals.展开更多
Low-visibility phenomena strongly impact the environment,as well as transportation,aviation and other fields that are closely related to people's livelihoods;thus,they represent important ecological issues of soci...Low-visibility phenomena strongly impact the environment,as well as transportation,aviation and other fields that are closely related to people's livelihoods;thus,they represent important ecological issues of social concern.Based on observation data concerning low-visibility phenomena derived from 105 national meteorological stations in Xinjiang,China over the past 20 years,we systematically analyzed the differences between manual and instrument observations for six types of low-visibility phenomena,with a focus on exploring their spatiotemporal distribution characteristics using instrument data.The results revealed that low-visibility phenomena were dominated by fog-and haze-related events(mist,fog,and haze)in northern Xinjiang and dust-related events(dust storms,blowing sand,and floating dust)in southern Xinjiang,with transitional characteristics observed in eastern Xinjiang.Compared with manual observations,the instrument measurements significantly improved the fine-scale low-visibility phenomenon identification process.On the basis of the instrument observation data,spatial-dimension analysis results indicated that low-visibility phenomena in Xinjiang were significantly influenced by terrain factors.Constrained by the Tianshan Mountains,haze-like phenomena formed a core agglomeration area in northern Xinjiang,whereas dust-and sand-related phenomena radiated outward,with the Taklimakan Desert at the center.Moreover,the gripping effect of the terrain promoted dust transmission along low-altitude channels.Temporally,fog-and haze-related phenomena occurred mainly during autumn and winter,and the proportion of these events decreased from 76.7%to 55.1%.The fog-and haze-related phenomena demonstrated a U-shaped rebound trend,while the proportion of mist phenomena decreased by 34.2%.Dust storms occurred during spring,accounting for 23.3%to 44.9%of all storms.Instrument measurement technology has the advantages of high spatial and temporal resolutions and multiparameter coordination but provides a limited dust-haze mixed-pollution identification capacity.This study provides crucial reference data for enhancing the understanding of low-visibility events in Xinjiang and the potential responses while improving the accuracy of pollution source tracking and meteorological process diagnosis tasks.展开更多
Growing evidence suggests that abnormal lipid metabolism occurs in amyotrophic lateral sclerosis,even in the presymptomatic stage,implying an etiologic link.However,the genetic mechanism underlying altered lipid level...Growing evidence suggests that abnormal lipid metabolism occurs in amyotrophic lateral sclerosis,even in the presymptomatic stage,implying an etiologic link.However,the genetic mechanism underlying altered lipid levels in amyotrophic lateral sclerosis remains elusive.Therefore,in this study,we performed genetic correlation analysis,a cross-trait meta-analysis,tissue-specific enrichment analysis,and bidirectional two-sample Mendelian randomization analysis of European population to explore whether there is a genetic and causal relationship between lipids and amyotrophic lateral sclerosis.The effect of lipid-lowering drugs on amyotrophic lateral sclerosis was also evaluated using a drug target Mendelian randomization approach.The results showed a positive genetic correlation between amyotrophic lateral sclerosis and both high-density lipoprotein cholesterol and apolipoprotein A1 and identified 71 independent shared loci between amyotrophic lateral sclerosis and high-density lipoprotein cholesterol,as well as 55 independent shared loci between amyotrophic lateral sclerosis and apolipoprotein A1.These shared loci were enriched in the lipid metabolic pathway and the alcohol metabolic pathway.Further Mendelian randomization analysis targeting lipid-lowering drugs showed that single nucleotide polymorphisms within the ACLY and PCSK9 genes had a protective effect against amyotrophic lateral sclerosis risk by decreasing low-density lipoprotein cholesterol.The combination of ACLY and PCSK9 inhibitors has a greater protective effect on amyotrophic lateral sclerosis risk than that of PCSK9 inhibitors alone.In summary,there is a common genetic structure between lipids and amyotrophic lateral sclerosis.Mendelian randomization analysis supports an association between elevated blood lipids and the risk of developing amyotrophic lateral sclerosis,and the use of ACLY or PCSK9 inhibitors may improve disease prognosis.展开更多
Scientific instruments serve as foundational pillars for both scientific progress and industrial innovation,enabling deep exploration and driving technological breakthroughs.Their independent controllability and conti...Scientific instruments serve as foundational pillars for both scientific progress and industrial innovation,enabling deep exploration and driving technological breakthroughs.Their independent controllability and continuous innovation are indispensable for sustaining a competitive advantage in technological development,thereby securing national scientific capacity and long-term strategic growth.At present,however,China faces substantial risks of technological"stranglehold"in the high-end scientific instrument domain.The underlying causes are multifaceted,arising not only from insufficient accumulation of core technologies but also from entrenched systemic and ecosystem-level barriers that impede the application,scaling,and promotion of domestic instruments.This paper provides a systematic analysis of the challenges hindering the widespread adoption of domestically developed scientific instruments and proposes practical pathways to build a new,integrated"R&D-application-promotion"ecosystem.This ecosystem is anchored in trust,driven by user demand,and shaped through collaborative innovation.Key initiatives include organizing user visits to instrument manufacturers,convening seminars on domestic alternatives to imported equipment,establishing demonstration centers for application and promotion,and involving end-users directly in the R&D and iterative upgrading of domestic instruments.Together,these efforts aim to close the final critical gap,advancing domestic instruments from merely"functional"to genuinely"user-friendly",and ultimately to"widely implemented".By doing so,this framework offers both theoretical grounding and practical guidance for achieving high-level scientific and technological self-reliance and sustained innovation capacity.展开更多
Chinese video game Black Myth:Wukong has been a h it among gaming enthusiasts worldwide since its release in 2024, its breakout success demonstrating the potential global appeal of traditional Chinese culture. Based o...Chinese video game Black Myth:Wukong has been a h it among gaming enthusiasts worldwide since its release in 2024, its breakout success demonstrating the potential global appeal of traditional Chinese culture. Based on the 16th-century classic novel Journey to the West, the game not only introduces international audiences to Chinese literature but has also become a far-reaching platform for traditional Chinese music.展开更多
A strategic narrative is not merely a discursive account through which a state explains its behavior;it also serves as an instrument of discursive power and a key mechanism of interaction and rivalry among states.Upon...A strategic narrative is not merely a discursive account through which a state explains its behavior;it also serves as an instrument of discursive power and a key mechanism of interaction and rivalry among states.Upon his return to the White House,Donald Trump declared that“the golden age of America begins right now,”signaling a new round of adjustments to the U.S.strategic narrative.While the“golden age”narrative functions to promote the new administration’s policies externally and provide interpretive framing,it also incorporates deterrence into its broader narrative structure and employs deterrent rhetoric to project highly intense and wide-ranging aggressive discourse.展开更多
Background Wound infection following spinal instrumented surgery is a frequent complication. The optimal treatment of acute deep wound infection following spinal instrumentation fusion remains controversial because of...Background Wound infection following spinal instrumented surgery is a frequent complication. The optimal treatment of acute deep wound infection following spinal instrumentation fusion remains controversial because of variability in cohort identification, definition of an infection, and the instrument used to measure outcomes. This retrospective study evaluated the clinical curative effect for postoperative spinal infection after instrumented spine fusion with extensive debridement, or implant removal.展开更多
Instrument separation is a critical complication during root canal therapy,impacting treatment success and long-term tooth preservation.The etiology of instrument separation is multifactorial,involving the intricate a...Instrument separation is a critical complication during root canal therapy,impacting treatment success and long-term tooth preservation.The etiology of instrument separation is multifactorial,involving the intricate anatomy of the root canal system,instrument-related factors,and instrumentation techniques.Instrument separation can hinder thorough cleaning,shaping,and obturation of the root canal,posing challenges to successful treatment outcomes.Although retrieval of separated instrument is often feasible,it carries risks including perforation,excessive removal of tooth structure and root fractures.Effective management of separated instruments requires a comprehensive understanding of the contributing factors,meticulous preoperative assessment,and precise evaluation of the retrieval difficulty.The application of appropriate retrieval techniques is essential to minimize complications and optimize clinical outcomes.The current manuscript provides a framework for understanding the causes,risk factors,and clinical management principles of instrument separation.By integrating effective strategies,endodontists can enhance decision-making,improve endodontic treatment success and ensure the preservation of natural dentition.展开更多
The Si Tian project,designed to utilize 60 telescopes distributed across multiple sites in China,is a next-generation timedomain survey initiative.As a pathfinder for the Si Tian project,the Mini-Si Tian(MST)has been ...The Si Tian project,designed to utilize 60 telescopes distributed across multiple sites in China,is a next-generation timedomain survey initiative.As a pathfinder for the Si Tian project,the Mini-Si Tian(MST)has been proposed and implemented to test the Si Tian’s brain and data pipeline,and to evaluate the feasibility of its technology and science cases.Mounted at the Xinglong Observatory,the MST project comprises three 30 cm telescopes and has been operated since 2022 November.Each telescope of the MST possesses a large field of view,covering 2°.29×1°.53 FOV,and is equipped withg',r'andi'filters,respectively.Acting as the pioneer of the forthcoming Si Tian project,the MST is dedicated to the discovery of variable stars,transients,and outburst events,and has already obtained some interesting scientific results.In this paper,we will summarize the first-two-year operation of the MST project.展开更多
The proposed design of a microwave superconducting kinetic inductance detector(MKID)array readout system characterizes the performance of MKIDs through a digital homodyne frequency mixing architecture.Meanwhile,the re...The proposed design of a microwave superconducting kinetic inductance detector(MKID)array readout system characterizes the performance of MKIDs through a digital homodyne frequency mixing architecture.Meanwhile,the readout system is implemented using a frequency division multiplexing circuit system,coupled with an FFT design to enable the readout of MKID arrays.The system is characterized by its compact size,low cost,portability,and ease of further development.Together,these features have significant implications for the design and readout of terahertz MKID arrays,while simultaneously advancing both the theoretical and practical aspects of MKID technology.展开更多
Accurate measurement of helicopter rotor motion parameters(flap,lead-lag,torsion,and azimuth angles)is essential for rotor blade design,helicopter dynamics modeling,and flight safety and health monitoring.However,the ...Accurate measurement of helicopter rotor motion parameters(flap,lead-lag,torsion,and azimuth angles)is essential for rotor blade design,helicopter dynamics modeling,and flight safety and health monitoring.However,the existing methods face challenges in testing equipment installation,calibration,and data transmission,resulting in limited reports on real-time in-flight measurements of blade motion parameters.This paper proposes a non-contact optoelectronic method based on two-dimensional position-sensitive detectors for in-flight measurement and a ground calibration system to obtain real-time rotor motion parameters during helicopter flight.The proposed method establishes the time evolution relationship of rotor motion parameters and verifies the performance of the in-flight measurement system regarding measurement resolution and accuracy through the construction of a blade motion posture experimental platform.The proposed method has been applied to the flight measurement of a medium-sized single-rotor helicopter,and the obtained results have been compared with theoretical analysis outcomes.Furthermore,this paper examines the characteristics of blade motion parameters during flight and discusses the challenges and potential solutions for measuring rotor motion parameters during helicopter flight using the proposed method.展开更多
基金support from the National Natural Science Foundation of China(Grant Nos.12172332,11727803 and 12072009)the Zhejiang Provincial Natural Science Foundation of China(Grant No.LZ23A020007)the Fundamental Research Funds for the Provincial Universities of Zhejiang(Grant No.RF-C2022003).
文摘The presence of residual stresses in materials or engineering structures can significantly influence their mechanical per-formance.Accurate measurement of residual stresses is of great importance to ensure their in-service reliability.Although numerous instrumented indentation methods have been proposed to evaluate residual stresses,the majority of them require a stress-free reference sample as a comparison benchmark,thereby limiting their applicability in scenarios where obtaining stress-free reference samples is challenging.In this work,through a number of finite element simulations,it was found that the loading exponent of the loading load-depth curve and the recovered depth during unloading are insensitive to residual stresses.The loading curve of the stress-free specimen was virtually reconstructed using such stress-insensitive parameters extracted from the load-depth curves of the stressed state,thus eliminating the requirement for stress-free reference samples.The residual stress was then correlated with the fractional change in loading work between stressed and stress-free loading curves through dimensional analysis and finite element simulations.Based on this correlation,an instrumented sharp indentation method for measuring equibiaxial residual stress without requiring a stress-free specimen was established.Both numerical and experimental verifications were carried out to demonstrate the accuracy and reliability of the newly proposed method.The maximum relative error and absolute error in measured residual stresses are typically within±20%and±20 MPa,respectively.
基金CONACy T (project CB 177834)SIP-IPN for the funds given to conduct this research
文摘By using an instrumented impact pendulum, the force versus time curves of 7075-T651 aluminum welds were obtained from standard Charpy-V samples. Considering the force-time curves and constant impact velocity, the fracture energies for different zones were quantified. A fracture energy improvement for the HAZ(33.6 J) was observed in comparison with the weld metal(7.88 J), and base metal(5.37 J and 7.37 J for longitudinal and transverse directions, respectively). This toughness increment was attributed to the microstructural transformation caused by the thermodynamic instability of η′ precipitates during the welding. Fracture energy for weld metal was higher than that for base metal, probably due to pores created during solidification. Regarding the dynamic yielding force obtained from the force-time curves, an approximation to the dynamic yield strength for weld, HAZ and base metal was determined. Fracture surfaces revealed an intergranular failure for base metal in longitudinal direction, whereas a predominately brittle failure(cleavage) with some insights of ductile characteristics was observed for the transverse direction. In contrast, a ductile failure was observed for weld metal and HAZ.
文摘A nondestructive continuous instrumented wheelset design is proposed based on strain gauges placing inside of the wheel web and wireless telemetry system. The signal feature analysis including frequency contents and high order harmonic ripples is also carried out. The strain gradient decoupling method for vertical and lateral force identification is proposed based on the strain distributions under respective loads. The method implements minimum crosstalk effects and insensitive to the varying contact points. The KMT telemetry system is adopted for wireless inductive powering and signal transferring. The drilling holes on the wheel and axles are avoidable to ensure the integrity and long-term using of the wheelset. Bridging and demodulating schemes for lateral and vertical force are designed respectively as they have dramatic differences at the dynamic signal features. High order harmonic ripple analysis and error estimation are gotten by independent waveforms. Based on the data form calibration test rig, it is indicated that the high order ripple amplitudes are below 10% of the demodulation amplitudes and fulfill designed requirements.
文摘BACKGROUND Acute spinal subdural haematoma(ASSH)is a rare and potentially devastating condition with a variable prognosis.Previously described subdural haematomas were thought to have occurred spontaneously or be related to major or minor iatrogenic or traumatic injuries caused by surgery,spinal puncture or epidural anaesthesia.Other contributing pathologies have been described,such as intradural tumours or spinal arteriovenous malformations.ASSH has also been associated with anticoagulation therapy,haemostatic abnormalities and risk factors such as pregnancy.To the best of our knowledge,this case study described the first reported occurrence of an ASSH during spinal surgery in a paediatric patient.The patient was not known to have any coagulopathies,and no obvious vascular lesions were documented.The surgical procedure did not directly involve the dura mater,and no evident intraoperative dural tears were found.CASE SUMMARY We reported and discussed a case of ASSH complicating a posterior spinal instrumented fusion during surgery for paediatric congenital scoliosis.This condition has not been previously described.We made recommendations for facing such an occurrence,explored its aetiology in the context of malformation and discussed the benefits of neuromonitoring during scoliosis correction and the management protocol.We conducted a PubMed literature review for cases of paediatric ASSH and other closely related disorders.We reviewed recommendations regarding neuromonitoring and treatment management in such cases.CONCLUSION ASSH is a rare complication of posterior spinal instrumented fusion.Published cases are more often associated with anticoagulation therapy or coagulopathy.Neuromonitoring is strongly recommended to detect and assess neurological status,thus enabling rapid diagnosis and treatment and facilitating early spinal decompression and a return to a normal neurological status.
文摘A more accurate determination for the Probability of Failure on Demand(PFD)of the Safety Instrumented System(SIS)contributes to more SIS realiability,thereby ensuring more safety and lower cost.IEC 61508 and ISA TR.84.02 provide the PFD detemination formulas.However,these formulas suffer from an uncertaity issue due to the inclusion of uncertainty sources,which,including high redundant systems architectures,cannot be assessed,have perfect proof test assumption,and are neglegted in partial stroke testing(PST)of impact on the system PFD.On the other hand,determining the values of PFD variables to achieve the target risk reduction involves daunting efforts and consumes time.This paper proposes a new approach for system PFD determination and PFD variables optimization that contributes to reduce the uncertainty problem.A higher redundant system can be assessed by generalizing the PFD formula into KooN architecture without neglecting the diagnostic coverage factor(DC)and common cause failures(CCF).In order to simulate the proof test effectiveness,the Proof Test Coverage(PTC)factor has been incorporated into the formula.Additionally,the system PFD value has been improved by incorporating PST for the final control element into the formula.The new developed formula is modelled using the Genetic Algorithm(GA)artificial technique.The GA model saves time and effort to examine system PFD and estimate near optimal values for PFD variables.The proposed model has been applicated on SIS design for crude oil test separator using MATLAB.The comparison between the proposed model and PFD formulas provided by IEC 61508 and ISA TR.84.02 showed that the proposed GA model can assess any system structure and simulate industrial reality.Furthermore,the cost and associated implementation testing activities are reduced.
文摘Our paper presents a project that involves two research questions: does the choice of a related problem by the tutorial system allow the problem solving process which is blocked for the student to be restarted? What information about learning do related problems returned by the system provide us? We answer the first question according to the didactic engineering, whose mode of validation is internal and based on the confrontation between an a priori analysis and an a posteriori analysis that relies on data from experiments in schools. We consider the student as a subject whose adaptation processes are conditioned by the problem and the possible interactions with the computer environment, and also by his knowledge, usually implicit, of the institutional norms that condition his relationship with geometry. Choosing a set of good problems within the system is therefore an essential element of the learning model. Since the source of a problem depends on the student’s actions with the computer tool, it is necessary to wait and see what are the related to problems that are returned to him before being able to identify patterns and assess the learning. With the simultaneity of collecting and analysing interactions in each class, we answer the second question according to a grounded theory analysis. By approaching the problems posed by the system and the designs in play at learning blockages, our analysis links the characteristics of problems to the design components in order to theorize on the decisional, epistemological, representational, didactic and instrumental aspects of the subject-milieu system in interaction.
基金the support of the Braunschweig International Graduate School of Metrology B-IGSM.
文摘The precise calibration of indenter geometries is a critical factor in ensuring reliable instrumented indentation experiments,particularly at the microscale and nanoscale.This study presents the comprehensive and highly accurate calibration of a modified Berkovich indenter using a metrological large-range atomic force microscope,reaching a relative standard uncertainty of less than 1% for the projected area function(PAF)for indentation depths of 200 nm and more.In contrast to previous works,this study specifically focuses on the influence of data evaluation methods on the determination of indenter geometry and the estimation of the measurement uncertainty.A refined uncertainty estimation approach is implemented,overcoming the limitations of both the classical"Guide to the Expression of Uncertainty in Measurement"and the Monte Carlo method,which either require restrictive idealization assumptions on the indenter geometry or entail high computational costs.By leveraging a systematic simulationbased uncertainty assessment,this work provides a robust evaluation of the PAF uncertainty and its dominant contributing factors.
文摘Background The purpose of this retrospective study was to compare the surgical outcomes of simple discectomy and instrumented posterior lumbar interbody fusion （iPLIF） in patients with lumbar disc herniation and Modic endplate changes.Our hypothesis was that iPLIF could provide better outcome for patients with refractory lumbar disc herniation and Modic changes （LDH-MC）.Methods Ninety-one patients with single-segment LDH-MC were recruited.All patients experienced low back pain as well as radicular leg pain,and low back pain was more severe than leg pain.Forty-seven patients were treated with discectomy and 44 were treated with iPLIE The outcomes of both low back pain and radicular leg pain using visual analogue scale （VAS） as well as the clinical outcome related to low back pain using Japanese Orthopaedic Association （JOA） score were assessed before and 18 months after surgery,respectively.Results Both low back and leg pain were significantly improved 18 months after simple discectomy and iPLIE Compared to patients undergoing simple discectomy,low back pain was significantly reduced in patients undergoing iPLIE but there was no significant difference in leg pain between two groups.Solid fusion was achieved in all patients who underwent iPLIF.Conclusions In patients with LDH-MC,iPLIF can yield significantly superior outcome on the relief of low back pain compared to simple discectomy.Simple discectomy can relieve radicular leg pain as efficient as iPLIE Accordingly,iPLIF seems to be a reliable treatment for patients with LDH-MC and predominant low back pain.
文摘Astronomical Techniques and Instruments would like to sincerely thank the following individuals who contribute to this issue.The success of our publication hinges on the contributions of time and energy put forth by these professionals.
基金supported by the Central Government Guidance Funds for Local Science and Technology Development Program(grant no.ZYYD2025ZY21)the Science and Technology Plan Project of the Xinjiang Production and Construction Corps(2023AB036)+1 种基金the Xinjiang Meteorological Bureau High-Level Key Talent Programthe Natural Science Foundation of the Xinjiang Uygur Autonomous Region(2023D01A17 and 2025D01A109).
文摘Low-visibility phenomena strongly impact the environment,as well as transportation,aviation and other fields that are closely related to people's livelihoods;thus,they represent important ecological issues of social concern.Based on observation data concerning low-visibility phenomena derived from 105 national meteorological stations in Xinjiang,China over the past 20 years,we systematically analyzed the differences between manual and instrument observations for six types of low-visibility phenomena,with a focus on exploring their spatiotemporal distribution characteristics using instrument data.The results revealed that low-visibility phenomena were dominated by fog-and haze-related events(mist,fog,and haze)in northern Xinjiang and dust-related events(dust storms,blowing sand,and floating dust)in southern Xinjiang,with transitional characteristics observed in eastern Xinjiang.Compared with manual observations,the instrument measurements significantly improved the fine-scale low-visibility phenomenon identification process.On the basis of the instrument observation data,spatial-dimension analysis results indicated that low-visibility phenomena in Xinjiang were significantly influenced by terrain factors.Constrained by the Tianshan Mountains,haze-like phenomena formed a core agglomeration area in northern Xinjiang,whereas dust-and sand-related phenomena radiated outward,with the Taklimakan Desert at the center.Moreover,the gripping effect of the terrain promoted dust transmission along low-altitude channels.Temporally,fog-and haze-related phenomena occurred mainly during autumn and winter,and the proportion of these events decreased from 76.7%to 55.1%.The fog-and haze-related phenomena demonstrated a U-shaped rebound trend,while the proportion of mist phenomena decreased by 34.2%.Dust storms occurred during spring,accounting for 23.3%to 44.9%of all storms.Instrument measurement technology has the advantages of high spatial and temporal resolutions and multiparameter coordination but provides a limited dust-haze mixed-pollution identification capacity.This study provides crucial reference data for enhancing the understanding of low-visibility events in Xinjiang and the potential responses while improving the accuracy of pollution source tracking and meteorological process diagnosis tasks.
基金funded by the National Natural Science Foundation of China,Nos.82401670(to KX),81873784(to DF),and 82071426(to DF)the Clinical Cohort Construction Program of Peking University Third Hospital,No.BYSYDL2019002(to DF)the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation,No.GZC20230152(to KX).
文摘Growing evidence suggests that abnormal lipid metabolism occurs in amyotrophic lateral sclerosis,even in the presymptomatic stage,implying an etiologic link.However,the genetic mechanism underlying altered lipid levels in amyotrophic lateral sclerosis remains elusive.Therefore,in this study,we performed genetic correlation analysis,a cross-trait meta-analysis,tissue-specific enrichment analysis,and bidirectional two-sample Mendelian randomization analysis of European population to explore whether there is a genetic and causal relationship between lipids and amyotrophic lateral sclerosis.The effect of lipid-lowering drugs on amyotrophic lateral sclerosis was also evaluated using a drug target Mendelian randomization approach.The results showed a positive genetic correlation between amyotrophic lateral sclerosis and both high-density lipoprotein cholesterol and apolipoprotein A1 and identified 71 independent shared loci between amyotrophic lateral sclerosis and high-density lipoprotein cholesterol,as well as 55 independent shared loci between amyotrophic lateral sclerosis and apolipoprotein A1.These shared loci were enriched in the lipid metabolic pathway and the alcohol metabolic pathway.Further Mendelian randomization analysis targeting lipid-lowering drugs showed that single nucleotide polymorphisms within the ACLY and PCSK9 genes had a protective effect against amyotrophic lateral sclerosis risk by decreasing low-density lipoprotein cholesterol.The combination of ACLY and PCSK9 inhibitors has a greater protective effect on amyotrophic lateral sclerosis risk than that of PCSK9 inhibitors alone.In summary,there is a common genetic structure between lipids and amyotrophic lateral sclerosis.Mendelian randomization analysis supports an association between elevated blood lipids and the risk of developing amyotrophic lateral sclerosis,and the use of ACLY or PCSK9 inhibitors may improve disease prognosis.
基金Management Research Project on the Transformation of Scientific and Technological Achievements at Peking University Health Science Center(Grant No.KT202501)Peking University Health Science Center 2025 Party Building Research Project(General Category,No.2)。
文摘Scientific instruments serve as foundational pillars for both scientific progress and industrial innovation,enabling deep exploration and driving technological breakthroughs.Their independent controllability and continuous innovation are indispensable for sustaining a competitive advantage in technological development,thereby securing national scientific capacity and long-term strategic growth.At present,however,China faces substantial risks of technological"stranglehold"in the high-end scientific instrument domain.The underlying causes are multifaceted,arising not only from insufficient accumulation of core technologies but also from entrenched systemic and ecosystem-level barriers that impede the application,scaling,and promotion of domestic instruments.This paper provides a systematic analysis of the challenges hindering the widespread adoption of domestically developed scientific instruments and proposes practical pathways to build a new,integrated"R&D-application-promotion"ecosystem.This ecosystem is anchored in trust,driven by user demand,and shaped through collaborative innovation.Key initiatives include organizing user visits to instrument manufacturers,convening seminars on domestic alternatives to imported equipment,establishing demonstration centers for application and promotion,and involving end-users directly in the R&D and iterative upgrading of domestic instruments.Together,these efforts aim to close the final critical gap,advancing domestic instruments from merely"functional"to genuinely"user-friendly",and ultimately to"widely implemented".By doing so,this framework offers both theoretical grounding and practical guidance for achieving high-level scientific and technological self-reliance and sustained innovation capacity.
文摘Chinese video game Black Myth:Wukong has been a h it among gaming enthusiasts worldwide since its release in 2024, its breakout success demonstrating the potential global appeal of traditional Chinese culture. Based on the 16th-century classic novel Journey to the West, the game not only introduces international audiences to Chinese literature but has also become a far-reaching platform for traditional Chinese music.
文摘A strategic narrative is not merely a discursive account through which a state explains its behavior;it also serves as an instrument of discursive power and a key mechanism of interaction and rivalry among states.Upon his return to the White House,Donald Trump declared that“the golden age of America begins right now,”signaling a new round of adjustments to the U.S.strategic narrative.While the“golden age”narrative functions to promote the new administration’s policies externally and provide interpretive framing,it also incorporates deterrence into its broader narrative structure and employs deterrent rhetoric to project highly intense and wide-ranging aggressive discourse.
文摘Background Wound infection following spinal instrumented surgery is a frequent complication. The optimal treatment of acute deep wound infection following spinal instrumentation fusion remains controversial because of variability in cohort identification, definition of an infection, and the instrument used to measure outcomes. This retrospective study evaluated the clinical curative effect for postoperative spinal infection after instrumented spine fusion with extensive debridement, or implant removal.
文摘Instrument separation is a critical complication during root canal therapy,impacting treatment success and long-term tooth preservation.The etiology of instrument separation is multifactorial,involving the intricate anatomy of the root canal system,instrument-related factors,and instrumentation techniques.Instrument separation can hinder thorough cleaning,shaping,and obturation of the root canal,posing challenges to successful treatment outcomes.Although retrieval of separated instrument is often feasible,it carries risks including perforation,excessive removal of tooth structure and root fractures.Effective management of separated instruments requires a comprehensive understanding of the contributing factors,meticulous preoperative assessment,and precise evaluation of the retrieval difficulty.The application of appropriate retrieval techniques is essential to minimize complications and optimize clinical outcomes.The current manuscript provides a framework for understanding the causes,risk factors,and clinical management principles of instrument separation.By integrating effective strategies,endodontists can enhance decision-making,improve endodontic treatment success and ensure the preservation of natural dentition.
基金supported by the National Key R&D Program of China(grant No.2023YFA1608304 and No.2023YFA1608300)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0550100 and XDB0550000)the National Natural Science Foundation of China(NSFC,grant Nos.12090041,12090040,11903054,12422303,and 12261141690)。
文摘The Si Tian project,designed to utilize 60 telescopes distributed across multiple sites in China,is a next-generation timedomain survey initiative.As a pathfinder for the Si Tian project,the Mini-Si Tian(MST)has been proposed and implemented to test the Si Tian’s brain and data pipeline,and to evaluate the feasibility of its technology and science cases.Mounted at the Xinglong Observatory,the MST project comprises three 30 cm telescopes and has been operated since 2022 November.Each telescope of the MST possesses a large field of view,covering 2°.29×1°.53 FOV,and is equipped withg',r'andi'filters,respectively.Acting as the pioneer of the forthcoming Si Tian project,the MST is dedicated to the discovery of variable stars,transients,and outburst events,and has already obtained some interesting scientific results.In this paper,we will summarize the first-two-year operation of the MST project.
基金funded by the National Key Research and Development Program of China under Nos.2023YFA1608200&2020YFC2201703the National Natural Science Foundation of China(NSFC,Grant No.12020101002)the Natural Science Foundation of China for the youth under No.12103093。
文摘The proposed design of a microwave superconducting kinetic inductance detector(MKID)array readout system characterizes the performance of MKIDs through a digital homodyne frequency mixing architecture.Meanwhile,the readout system is implemented using a frequency division multiplexing circuit system,coupled with an FFT design to enable the readout of MKID arrays.The system is characterized by its compact size,low cost,portability,and ease of further development.Together,these features have significant implications for the design and readout of terahertz MKID arrays,while simultaneously advancing both the theoretical and practical aspects of MKID technology.
基金the funding provided by the National Helicopter Development Project of China。
文摘Accurate measurement of helicopter rotor motion parameters(flap,lead-lag,torsion,and azimuth angles)is essential for rotor blade design,helicopter dynamics modeling,and flight safety and health monitoring.However,the existing methods face challenges in testing equipment installation,calibration,and data transmission,resulting in limited reports on real-time in-flight measurements of blade motion parameters.This paper proposes a non-contact optoelectronic method based on two-dimensional position-sensitive detectors for in-flight measurement and a ground calibration system to obtain real-time rotor motion parameters during helicopter flight.The proposed method establishes the time evolution relationship of rotor motion parameters and verifies the performance of the in-flight measurement system regarding measurement resolution and accuracy through the construction of a blade motion posture experimental platform.The proposed method has been applied to the flight measurement of a medium-sized single-rotor helicopter,and the obtained results have been compared with theoretical analysis outcomes.Furthermore,this paper examines the characteristics of blade motion parameters during flight and discusses the challenges and potential solutions for measuring rotor motion parameters during helicopter flight using the proposed method.
