Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomed...Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.展开更多
In the context of energy structure transformation,digital and intelligent technologies have been introduced into the field of hydropower,which has accelerated the technological and equipment innovation of hydropower p...In the context of energy structure transformation,digital and intelligent technologies have been introduced into the field of hydropower,which has accelerated the technological and equipment innovation of hydropower plants.However,it has also brought severe challenges to the operation and maintenance of hydropower plants.Traditional hydropower plant operation and maintenance suffer from problems such as low efficiency,equipment aging,and high labor costs,which seriously hinder the innovation and upgrading of hydropower plant operation and maintenance.Therefore,this article focuses on the operation and maintenance of hydropower plants,summarizes a series of innovative strategies,and applies them in practice to effectively improve the operation and maintenance level of hydropower plants.展开更多
Shandong Port Group(SPG),which was established in August 2019,regards standardization as the cornerstone of modern enterprise management,and vigorously implements the standardization innovation strategy.Its standardiz...Shandong Port Group(SPG),which was established in August 2019,regards standardization as the cornerstone of modern enterprise management,and vigorously implements the standardization innovation strategy.Its standardization work mainly focuses on the following four aspects.展开更多
Colorectal cancer(CRC)is the third most common malignancy worldwide and the second leading cause of cancer-related deaths,accounting for approximately 10%of all cancer cases.By 2050,CRC incidence is expected to rise s...Colorectal cancer(CRC)is the third most common malignancy worldwide and the second leading cause of cancer-related deaths,accounting for approximately 10%of all cancer cases.By 2050,CRC incidence is expected to rise substantially,driven by population aging and greater exposure to risk factors in developing countries.Despite advances in medicine and pharmacy,the effectiveness of available treatments remains limited,underscoring the urgent need for innovative therapeutic strategies.This review summarizes and critically evaluates currently available CRC therapies and explores new emerging directions.Particular attention is given to the role of immunotherapy,targeted therapies,nanotechnology-based approaches,metal-based compounds,PROTAC technology,and personalized medicine,with emphasis on their efficacy,safety,accessibility,and mechanisms of drug resistance.In conclusion,surgery and chemotherapy remain the backbone of CRC treatment,but novel therapeutic approaches are reshaping the treatment landscape.Emerging strategies may offer improved patient tolerability and survival outcomes by reducing the occurrence of burdensome adverse effects.Persistent challenges such as drug toxicity,the emergence of resistance mechanisms,and inequalities in access to innovative therapies underscore the need for further translational research.Integrating personalized therapeutic approaches will also be crucial to achieving more effective,safer,and accessible treatment strategies for CRC.展开更多
With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The tr...With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The traditional financial investment management strategy can no longer meet the needs of enterprises in the new era and needs to be innovated with the times.For enterprises,the effectiveness and scientificity of financial investment management strategy will directly affect the competitiveness and long-term development of enterprises.Therefore,this study chooses the innovation based on the financial investment management strategy of enterprises in the new era as the research theme,aiming at exploring the innovative strategy to adapt to the needs of enterprises in the new era.展开更多
Display devices have significantly changed our daily life for decades,from the watches,television,to the laptop and smartphone.As the desire of advanced display device with high-resolution,long operation life and ligh...Display devices have significantly changed our daily life for decades,from the watches,television,to the laptop and smartphone.As the desire of advanced display device with high-resolution,long operation life and lightweight properties,several display techniques have been demonstrated.There are mainly four types of electronic display device:cathode ray tube(CRT),liquid-crystal display(LCD),organic light-emitting diode(OLED),and micro-LED.Due to the different working principles and device structures,each type of display device has its special characteristic properties.The performance of devices could be adjusted through the material selection or device design.With careful device structure regulation,not only the efficiency but also the stability would be improved.Herein,a brief review of innovative strategies towards the structure design is presented.展开更多
Based on the endogenous technology progress framework for late-moving large countries,this paper simulates the effects of market size on technology progress path and technology catch-up,and finds that under the strate...Based on the endogenous technology progress framework for late-moving large countries,this paper simulates the effects of market size on technology progress path and technology catch-up,and finds that under the strategy of combining innovation with imitation,the increase of market size will restrain the convergence of economies towards technology frontier and deepen their reliance on imitation.Under the strategy of replacing imitation with innovation,there is a non-uniform U-shaped threshold effect for market size to influence technology progress path and catch-up,and the threshold for the shift of technology progress path lags behind that for technology catch-up.Hence,we should follow technology catch-up as the benchmark and timely adjust our innovation strategy to unleash the advantages of economies of scale for innovation.The innovation-driven development strategy is a choice compatible with China’s changing market size.However,since China remains in a transition from a super-large economy to a super-strong one,the contribution of innovation will decrease at first before increasing afterwards.展开更多
This study focuses on the evolution of growth model and cultivation of competitive advantages under the ambidextrous innovation strategy.After a brief introduction of the connotation of ambidextrous innovation strateg...This study focuses on the evolution of growth model and cultivation of competitive advantages under the ambidextrous innovation strategy.After a brief introduction of the connotation of ambidextrous innovation strategy,the evolution of growth model of high-tech enterprises under the conventional strategy and the ambidextrous innovation strategy is analyzed.Furthermore,a discussion is made on how to cultivate enterprises’competitive advantages under the ambidextrous innovation strategy,thereby enabling enterprises to stand out from competitors under this new strategic model and truly achieve the goal of sustainable development.展开更多
Based on investigations of 112 Chinese firms and studies on foreign leading corporations, a theoretical framework of dynamic capabilities based strategy innovation (SI) is put forward. Several large firms in China wi...Based on investigations of 112 Chinese firms and studies on foreign leading corporations, a theoretical framework of dynamic capabilities based strategy innovation (SI) is put forward. Several large firms in China winning through SI were studied empirically. This paper complements previous publications on the theories of innovation and strategy. This work's findings will be useful for managers interested in our approach, which highlights the importance of SI and focuses on and points out the major pitfalls in the innovation processes. Implementing the dynamic capabilities based strategy innovation can effectively cultivate and develop core competences of corporations. It is concluded that implementing SI is the only path for Chinese enterprise growth in the intensified competition in the knowledge economy.展开更多
This paper analyzed the relationship between organizational slack and technological innovation strategy in Chinese enterprises through building mathematic model and real options approach. The results show the organiza...This paper analyzed the relationship between organizational slack and technological innovation strategy in Chinese enterprises through building mathematic model and real options approach. The results show the organizational slack that explored and employed reached to a critical point and can promote enterprises to choose the independent innovation strategy based on R & D (Research and Development); And it is important to identify,explore and employ organizational slack correctly for strengthening the organizational independent innovation capability and raising its performance when the technological innovation strategy based on technological introduction is more and more difficult.展开更多
Background: Globally, UNAIDS report 2022 shows, there are 84.2 million people affected by HIV/AIDS and 40.1 million deaths from AIDS since the start of epidemic. In sub-Saharan Africa, women and girls accounted for 63...Background: Globally, UNAIDS report 2022 shows, there are 84.2 million people affected by HIV/AIDS and 40.1 million deaths from AIDS since the start of epidemic. In sub-Saharan Africa, women and girls accounted for 63% of all new HIV infections in 2021 with, six in seven new HIV infections among adolescents aged 15 - 19 years being girls. Key populations accounted for 70% of HIV infections globally in 2021, with 51% of these new HIV infections in sub-Saharan Africa. Reflecting on the 4 decades’ journey of HIV epidemic amidst local, national and international efforts, the UN target of ending AIDS as a public health threat by 2030 remains questionable unless new innovative ways are used. This study aimed at analyzing existing HIV/AIDS interventions, discuss UN interventions in line with ending HIV/AIDS by 2030 then, suggest and discuss new innovative ways of ending HIV scourge by 2030. Methods: Systematic literature review methodology was used to extract existing published information on HIV prevention strategies from 1981 to 2023. The articles were previewed by 2 experts for quality and grouped by intervention. Of the 637 articles accessed, on HIV prevention/control only 45 met the inclusion criteria. Data were synthesized using a narrative synthesis approach following standard guidelines on synthesis without meta-analysis. Descriptive analysis was done, strength and limitations were identified. UNAIDS recommendations for ending HIV/AIDS by 2030 identified and analyzed. New Innovations in HIV/AIDS were presented and discussed. The scope of the reviewed literature was limited to HIV preventive strategies practiced between 1981 and 2023. Results: Findings show that, Uganda’s HIV prevalence was at a peak in 1991 of 15% (30% among pregnant women in urban areas). ABC strategy is claimed to have turned sharply downward the prevalence through the mid-1990s and reached 5% (14% for pregnant urban women) by 2001. Analysis of the strategy showed that the achievements of the strategy could not be sustained, subsequently HIV prevalence rose again. This is because none of the ABC components can independently reduce HIV problem. In the real world, 100% abstinence has failed, condom use only reduces infection by 90% (WHO), and lifelong monogamy is impractical. Such limitations weaken ABC strategy. The study established that Post-exposure prophylaxis (PEP) i.e. taking HIV medicines within 72 hours (3 days) after a possible exposure to HIV infection is a safe, effective and a globally practiced HIV preventive intervention in emergency situations of HIV exposure. However, PEP is limited to care sought within 72 hours after exposure and yet timely access especially in rural areas and for key populations remains a big challenge. Oral PrEP was also identified as effective HIV preventive measure that can reduce HIV risk from sex by about 99% and from injection drug users by 74%. However, like PEP, timely access especially in rural areas and for key populations remains a big challenge. The UNAIDS 95-95-95 strategy (i.e. 95% of people know their HIV status, 95% with +HIV status be on sustained ART and 95% on ART get viral load suppression) formed the basis for setting the target of ending HIV/AIDS epidemic by 2030. However, our analysis shows that this target is unrealistic given the above highlighted limitations/ barriers in preventive measures and the unlikely perfect adherence (100%) to ART by all enrolled HIV positive persons. Conclusion: Ending HIV/AIDS by 2030 cannot be achieved by implementing the current preventing strategies and control measures. This study established that most of the existing HIV preventive strategies and control measures have a number of limitations. However, with sustained UN 95-95-95 strategy supplemented with additional innovative ways, there is hope that the UN dream of ending HIV/AIDS though not necessarily by 2030, can in the long run be achieved.展开更多
innovation driven development strategy,as a national strategy of our country,has attracted wide attention in the academic field,and it is very rich in theory and practice of innovation driven development.But innovatio...innovation driven development strategy,as a national strategy of our country,has attracted wide attention in the academic field,and it is very rich in theory and practice of innovation driven development.But innovation driven development,as a national strategy,is a long-term,not only from institutional and policy perspective,but also need to build a theoretical framework of relatively rich,can practice on the guiding role of theory.展开更多
This study conducted an in-depth analysis of the current tax preferential policies for small-scale individual businesses and compared them with similar policies both domestically and internationally,aiming to reveal t...This study conducted an in-depth analysis of the current tax preferential policies for small-scale individual businesses and compared them with similar policies both domestically and internationally,aiming to reveal the advantages and disadvantages of the current system.After examining the impact of these tax preferential policies on the economic status of individual business owners and the broader social economy,this article proposes a set of innovative tax preferential strategies based on theoretical foundations.By developing these innovative strategies and clarifying their implementation paths,the aim is to promote the sustainable and healthy development of small-scale individual businesses,thereby fostering comprehensive socio-economic progress.The conclusion of this study not only summarizes policy recommendations with practical significance but also provides theoretical support for the optimization and innovation of future related systems.展开更多
With the continuous improvement of Chinas social and economic system, internal audit has become one of the main work contents for enterprises to improve their own development ability and market competitive advantages....With the continuous improvement of Chinas social and economic system, internal audit has become one of the main work contents for enterprises to improve their own development ability and market competitive advantages. Under the influence of the big data environment, the impact of various information technologies for the data transmission work has also brought great challenges to the internal audit work of enterprises. In this context, the traditional internal audit mode of an enterprise has already met its actual development needs. At the present stage, one of the main tasks of the enterprises internal management work is to strengthen the innovative exploration of its own internal audit work by combining with the characteristics of the big data environment. Based on this, this paper takes the shortcomings of the enterprise internal audit work in the big data environment and the innovation needs of the enterprise internal audit work as the starting point, and analyzes several effective innovative ways of the enterprise internal audit work.展开更多
The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to ...The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to promote the modernization of education.Starting from the connotation of the deep integration of information technology and education and teaching,this paper analyzes the existing problems in the current integration process,and puts forward innovative strategies from the aspects of concept,resources,model,and evaluation.Through measures such as building a smart teaching environment,enriching high-quality teaching resources,innovating teaching organization models,and establishing multiple evaluation systems,we will realize the deep integration of information technology and teaching,promote the reform of teaching and learning methods,improve the quality of personnel training,and provide strong support for the modernization of education.展开更多
With the rapid development and widespread application of Big Data technology, the supply chain management of agricultural products enterprises is facing unprecedented reform and challenges. This study takes the perspe...With the rapid development and widespread application of Big Data technology, the supply chain management of agricultural products enterprises is facing unprecedented reform and challenges. This study takes the perspective of Big Data technology and collects relevant information on the application of supply chain management in 100 agricultural product enterprises through a survey questionnaire. The study found that the use of Big Data can effectively improve the accuracy of demand forecasting, inventory management efficiency, optimize logistics costs, improve supplier management efficiency, enhance the overall level of supply chain management of enterprises, and propose innovative strategies for supply chain management of agricultural products enterprises based on this. Big Data technology brings a new solution for agricultural products enterprises to enhance their supply chain management level, making the supply chain smarter and more efficient.展开更多
基金supported by the National Natural Science Foundation of China[82003956]the National Key Research and Development Program of China[No.2022YFA1205802]+2 种基金financially supported by Henan Province Health Science and Technology Innovation Youth Talent Project(YQRC2023013 and YQRC2024013)the Key Project of Medical Science and Technology of Henan Province(SBGJ202302072)the Science and Technology Research Project of Henan Province(252102311236).
文摘Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.
文摘In the context of energy structure transformation,digital and intelligent technologies have been introduced into the field of hydropower,which has accelerated the technological and equipment innovation of hydropower plants.However,it has also brought severe challenges to the operation and maintenance of hydropower plants.Traditional hydropower plant operation and maintenance suffer from problems such as low efficiency,equipment aging,and high labor costs,which seriously hinder the innovation and upgrading of hydropower plant operation and maintenance.Therefore,this article focuses on the operation and maintenance of hydropower plants,summarizes a series of innovative strategies,and applies them in practice to effectively improve the operation and maintenance level of hydropower plants.
文摘Shandong Port Group(SPG),which was established in August 2019,regards standardization as the cornerstone of modern enterprise management,and vigorously implements the standardization innovation strategy.Its standardization work mainly focuses on the following four aspects.
文摘Colorectal cancer(CRC)is the third most common malignancy worldwide and the second leading cause of cancer-related deaths,accounting for approximately 10%of all cancer cases.By 2050,CRC incidence is expected to rise substantially,driven by population aging and greater exposure to risk factors in developing countries.Despite advances in medicine and pharmacy,the effectiveness of available treatments remains limited,underscoring the urgent need for innovative therapeutic strategies.This review summarizes and critically evaluates currently available CRC therapies and explores new emerging directions.Particular attention is given to the role of immunotherapy,targeted therapies,nanotechnology-based approaches,metal-based compounds,PROTAC technology,and personalized medicine,with emphasis on their efficacy,safety,accessibility,and mechanisms of drug resistance.In conclusion,surgery and chemotherapy remain the backbone of CRC treatment,but novel therapeutic approaches are reshaping the treatment landscape.Emerging strategies may offer improved patient tolerability and survival outcomes by reducing the occurrence of burdensome adverse effects.Persistent challenges such as drug toxicity,the emergence of resistance mechanisms,and inequalities in access to innovative therapies underscore the need for further translational research.Integrating personalized therapeutic approaches will also be crucial to achieving more effective,safer,and accessible treatment strategies for CRC.
文摘With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The traditional financial investment management strategy can no longer meet the needs of enterprises in the new era and needs to be innovated with the times.For enterprises,the effectiveness and scientificity of financial investment management strategy will directly affect the competitiveness and long-term development of enterprises.Therefore,this study chooses the innovation based on the financial investment management strategy of enterprises in the new era as the research theme,aiming at exploring the innovative strategy to adapt to the needs of enterprises in the new era.
基金Projects(71572028,71872027)supported by the National Natural Science Foundation of China。
文摘Display devices have significantly changed our daily life for decades,from the watches,television,to the laptop and smartphone.As the desire of advanced display device with high-resolution,long operation life and lightweight properties,several display techniques have been demonstrated.There are mainly four types of electronic display device:cathode ray tube(CRT),liquid-crystal display(LCD),organic light-emitting diode(OLED),and micro-LED.Due to the different working principles and device structures,each type of display device has its special characteristic properties.The performance of devices could be adjusted through the material selection or device design.With careful device structure regulation,not only the efficiency but also the stability would be improved.Herein,a brief review of innovative strategies towards the structure design is presented.
基金the National Social Science Fund of China (NSSFC) Youth Project “Study on the Evaluation, Comparison and Improvement Path of China’s Regional TFP under the Perspective of Suitable Technology Options”(Grant No. 17CJY002)
文摘Based on the endogenous technology progress framework for late-moving large countries,this paper simulates the effects of market size on technology progress path and technology catch-up,and finds that under the strategy of combining innovation with imitation,the increase of market size will restrain the convergence of economies towards technology frontier and deepen their reliance on imitation.Under the strategy of replacing imitation with innovation,there is a non-uniform U-shaped threshold effect for market size to influence technology progress path and catch-up,and the threshold for the shift of technology progress path lags behind that for technology catch-up.Hence,we should follow technology catch-up as the benchmark and timely adjust our innovation strategy to unleash the advantages of economies of scale for innovation.The innovation-driven development strategy is a choice compatible with China’s changing market size.However,since China remains in a transition from a super-large economy to a super-strong one,the contribution of innovation will decrease at first before increasing afterwards.
基金Project name:Evolution of Growth Model and Cultivation of Competitive Advantage under Ambidextrous Innovation Strategy-A case study of China’s high-tech enterprises Project no.:JKY106320,Project category:National key project of the“14th Five-Year Plan”of Education and Scientific Research of the Ministry of Education The organization of the project chair:University of Malaya。
文摘This study focuses on the evolution of growth model and cultivation of competitive advantages under the ambidextrous innovation strategy.After a brief introduction of the connotation of ambidextrous innovation strategy,the evolution of growth model of high-tech enterprises under the conventional strategy and the ambidextrous innovation strategy is analyzed.Furthermore,a discussion is made on how to cultivate enterprises’competitive advantages under the ambidextrous innovation strategy,thereby enabling enterprises to stand out from competitors under this new strategic model and truly achieve the goal of sustainable development.
文摘Based on investigations of 112 Chinese firms and studies on foreign leading corporations, a theoretical framework of dynamic capabilities based strategy innovation (SI) is put forward. Several large firms in China winning through SI were studied empirically. This paper complements previous publications on the theories of innovation and strategy. This work's findings will be useful for managers interested in our approach, which highlights the importance of SI and focuses on and points out the major pitfalls in the innovation processes. Implementing the dynamic capabilities based strategy innovation can effectively cultivate and develop core competences of corporations. It is concluded that implementing SI is the only path for Chinese enterprise growth in the intensified competition in the knowledge economy.
基金This paper was supported by Hunan Soft Scientific Researching Project (No.2007ZK3084)
文摘This paper analyzed the relationship between organizational slack and technological innovation strategy in Chinese enterprises through building mathematic model and real options approach. The results show the organizational slack that explored and employed reached to a critical point and can promote enterprises to choose the independent innovation strategy based on R & D (Research and Development); And it is important to identify,explore and employ organizational slack correctly for strengthening the organizational independent innovation capability and raising its performance when the technological innovation strategy based on technological introduction is more and more difficult.
文摘Background: Globally, UNAIDS report 2022 shows, there are 84.2 million people affected by HIV/AIDS and 40.1 million deaths from AIDS since the start of epidemic. In sub-Saharan Africa, women and girls accounted for 63% of all new HIV infections in 2021 with, six in seven new HIV infections among adolescents aged 15 - 19 years being girls. Key populations accounted for 70% of HIV infections globally in 2021, with 51% of these new HIV infections in sub-Saharan Africa. Reflecting on the 4 decades’ journey of HIV epidemic amidst local, national and international efforts, the UN target of ending AIDS as a public health threat by 2030 remains questionable unless new innovative ways are used. This study aimed at analyzing existing HIV/AIDS interventions, discuss UN interventions in line with ending HIV/AIDS by 2030 then, suggest and discuss new innovative ways of ending HIV scourge by 2030. Methods: Systematic literature review methodology was used to extract existing published information on HIV prevention strategies from 1981 to 2023. The articles were previewed by 2 experts for quality and grouped by intervention. Of the 637 articles accessed, on HIV prevention/control only 45 met the inclusion criteria. Data were synthesized using a narrative synthesis approach following standard guidelines on synthesis without meta-analysis. Descriptive analysis was done, strength and limitations were identified. UNAIDS recommendations for ending HIV/AIDS by 2030 identified and analyzed. New Innovations in HIV/AIDS were presented and discussed. The scope of the reviewed literature was limited to HIV preventive strategies practiced between 1981 and 2023. Results: Findings show that, Uganda’s HIV prevalence was at a peak in 1991 of 15% (30% among pregnant women in urban areas). ABC strategy is claimed to have turned sharply downward the prevalence through the mid-1990s and reached 5% (14% for pregnant urban women) by 2001. Analysis of the strategy showed that the achievements of the strategy could not be sustained, subsequently HIV prevalence rose again. This is because none of the ABC components can independently reduce HIV problem. In the real world, 100% abstinence has failed, condom use only reduces infection by 90% (WHO), and lifelong monogamy is impractical. Such limitations weaken ABC strategy. The study established that Post-exposure prophylaxis (PEP) i.e. taking HIV medicines within 72 hours (3 days) after a possible exposure to HIV infection is a safe, effective and a globally practiced HIV preventive intervention in emergency situations of HIV exposure. However, PEP is limited to care sought within 72 hours after exposure and yet timely access especially in rural areas and for key populations remains a big challenge. Oral PrEP was also identified as effective HIV preventive measure that can reduce HIV risk from sex by about 99% and from injection drug users by 74%. However, like PEP, timely access especially in rural areas and for key populations remains a big challenge. The UNAIDS 95-95-95 strategy (i.e. 95% of people know their HIV status, 95% with +HIV status be on sustained ART and 95% on ART get viral load suppression) formed the basis for setting the target of ending HIV/AIDS epidemic by 2030. However, our analysis shows that this target is unrealistic given the above highlighted limitations/ barriers in preventive measures and the unlikely perfect adherence (100%) to ART by all enrolled HIV positive persons. Conclusion: Ending HIV/AIDS by 2030 cannot be achieved by implementing the current preventing strategies and control measures. This study established that most of the existing HIV preventive strategies and control measures have a number of limitations. However, with sustained UN 95-95-95 strategy supplemented with additional innovative ways, there is hope that the UN dream of ending HIV/AIDS though not necessarily by 2030, can in the long run be achieved.
文摘innovation driven development strategy,as a national strategy of our country,has attracted wide attention in the academic field,and it is very rich in theory and practice of innovation driven development.But innovation driven development,as a national strategy,is a long-term,not only from institutional and policy perspective,but also need to build a theoretical framework of relatively rich,can practice on the guiding role of theory.
文摘This study conducted an in-depth analysis of the current tax preferential policies for small-scale individual businesses and compared them with similar policies both domestically and internationally,aiming to reveal the advantages and disadvantages of the current system.After examining the impact of these tax preferential policies on the economic status of individual business owners and the broader social economy,this article proposes a set of innovative tax preferential strategies based on theoretical foundations.By developing these innovative strategies and clarifying their implementation paths,the aim is to promote the sustainable and healthy development of small-scale individual businesses,thereby fostering comprehensive socio-economic progress.The conclusion of this study not only summarizes policy recommendations with practical significance but also provides theoretical support for the optimization and innovation of future related systems.
文摘With the continuous improvement of Chinas social and economic system, internal audit has become one of the main work contents for enterprises to improve their own development ability and market competitive advantages. Under the influence of the big data environment, the impact of various information technologies for the data transmission work has also brought great challenges to the internal audit work of enterprises. In this context, the traditional internal audit mode of an enterprise has already met its actual development needs. At the present stage, one of the main tasks of the enterprises internal management work is to strengthen the innovative exploration of its own internal audit work by combining with the characteristics of the big data environment. Based on this, this paper takes the shortcomings of the enterprise internal audit work in the big data environment and the innovation needs of the enterprise internal audit work as the starting point, and analyzes several effective innovative ways of the enterprise internal audit work.
文摘The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to promote the modernization of education.Starting from the connotation of the deep integration of information technology and education and teaching,this paper analyzes the existing problems in the current integration process,and puts forward innovative strategies from the aspects of concept,resources,model,and evaluation.Through measures such as building a smart teaching environment,enriching high-quality teaching resources,innovating teaching organization models,and establishing multiple evaluation systems,we will realize the deep integration of information technology and teaching,promote the reform of teaching and learning methods,improve the quality of personnel training,and provide strong support for the modernization of education.
文摘With the rapid development and widespread application of Big Data technology, the supply chain management of agricultural products enterprises is facing unprecedented reform and challenges. This study takes the perspective of Big Data technology and collects relevant information on the application of supply chain management in 100 agricultural product enterprises through a survey questionnaire. The study found that the use of Big Data can effectively improve the accuracy of demand forecasting, inventory management efficiency, optimize logistics costs, improve supplier management efficiency, enhance the overall level of supply chain management of enterprises, and propose innovative strategies for supply chain management of agricultural products enterprises based on this. Big Data technology brings a new solution for agricultural products enterprises to enhance their supply chain management level, making the supply chain smarter and more efficient.
