This study focuses on the evolution of growth model and cultivation of competitive advantages under the ambidextrous innovation strategy.After a brief introduction of the connotation of ambidextrous innovation strateg...This study focuses on the evolution of growth model and cultivation of competitive advantages under the ambidextrous innovation strategy.After a brief introduction of the connotation of ambidextrous innovation strategy,the evolution of growth model of high-tech enterprises under the conventional strategy and the ambidextrous innovation strategy is analyzed.Furthermore,a discussion is made on how to cultivate enterprises’competitive advantages under the ambidextrous innovation strategy,thereby enabling enterprises to stand out from competitors under this new strategic model and truly achieve the goal of sustainable development.展开更多
This paper analyzed the relationship between organizational slack and technological innovation strategy in Chinese enterprises through building mathematic model and real options approach. The results show the organiza...This paper analyzed the relationship between organizational slack and technological innovation strategy in Chinese enterprises through building mathematic model and real options approach. The results show the organizational slack that explored and employed reached to a critical point and can promote enterprises to choose the independent innovation strategy based on R & D (Research and Development); And it is important to identify,explore and employ organizational slack correctly for strengthening the organizational independent innovation capability and raising its performance when the technological innovation strategy based on technological introduction is more and more difficult.展开更多
With the continuous improvement of Chinas social and economic system, internal audit has become one of the main work contents for enterprises to improve their own development ability and market competitive advantages....With the continuous improvement of Chinas social and economic system, internal audit has become one of the main work contents for enterprises to improve their own development ability and market competitive advantages. Under the influence of the big data environment, the impact of various information technologies for the data transmission work has also brought great challenges to the internal audit work of enterprises. In this context, the traditional internal audit mode of an enterprise has already met its actual development needs. At the present stage, one of the main tasks of the enterprises internal management work is to strengthen the innovative exploration of its own internal audit work by combining with the characteristics of the big data environment. Based on this, this paper takes the shortcomings of the enterprise internal audit work in the big data environment and the innovation needs of the enterprise internal audit work as the starting point, and analyzes several effective innovative ways of the enterprise internal audit work.展开更多
The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to ...The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to promote the modernization of education.Starting from the connotation of the deep integration of information technology and education and teaching,this paper analyzes the existing problems in the current integration process,and puts forward innovative strategies from the aspects of concept,resources,model,and evaluation.Through measures such as building a smart teaching environment,enriching high-quality teaching resources,innovating teaching organization models,and establishing multiple evaluation systems,we will realize the deep integration of information technology and teaching,promote the reform of teaching and learning methods,improve the quality of personnel training,and provide strong support for the modernization of education.展开更多
With the continuous growth of China's social economy, people's material and cultural living standards have been significantly improved. Under the background of gradually speeding up the process of urbanization...With the continuous growth of China's social economy, people's material and cultural living standards have been significantly improved. Under the background of gradually speeding up the process of urbanization, people's requirements for the comfort of living environment are also higher and higher. Urban construction, city appearance environment, urban management level has become important factors affecting the construction of landscape architecture. At present, the scale of urban greening construction is expanding. In the face of this situation, we must consider how to maximize the ecological benefits of urban landscape design, and how to promote the construction of urban landscape and the sustainable development of urban environment. Next, the article discusses the innovation strategy of modern urban landscape design.展开更多
The quality of construction determines the success or failure of the construction. Excellent construction engineering construction can make the building more stable. If the construction engineering construction is not...The quality of construction determines the success or failure of the construction. Excellent construction engineering construction can make the building more stable. If the construction engineering construction is not qualified, it will lead to the failure to carry out the construction work smoothly, which will affect the construction progress. It will also bring many hidden dangers to the subsequent construction work, affecting the safety, life and functionality of the building. This paper will conduct a detailed analysis of the construction management and construction work, and put forward the corresponding innovation strategies, in order to be able to provide reference for relevant units.展开更多
With the rapid development and widespread application of Big Data technology, the supply chain management of agricultural products enterprises is facing unprecedented reform and challenges. This study takes the perspe...With the rapid development and widespread application of Big Data technology, the supply chain management of agricultural products enterprises is facing unprecedented reform and challenges. This study takes the perspective of Big Data technology and collects relevant information on the application of supply chain management in 100 agricultural product enterprises through a survey questionnaire. The study found that the use of Big Data can effectively improve the accuracy of demand forecasting, inventory management efficiency, optimize logistics costs, improve supplier management efficiency, enhance the overall level of supply chain management of enterprises, and propose innovative strategies for supply chain management of agricultural products enterprises based on this. Big Data technology brings a new solution for agricultural products enterprises to enhance their supply chain management level, making the supply chain smarter and more efficient.展开更多
Technical innovation is the core for enterprise competence and sustaining. Technical innovation strategy is the policy which the enterprise carries out for technology innovation in a long term. The paper took the prac...Technical innovation is the core for enterprise competence and sustaining. Technical innovation strategy is the policy which the enterprise carries out for technology innovation in a long term. The paper took the practice of the technology innovation strategy in Petro China Changqing Oilfield Company as a case study, and illustrated the significance, function and features of the self-developed technology innovation, cooperation development technology innovation and introduction-innovation based on the strategy structure of the energy enterprises. The suggestions for technology innovation strategy structure for large energy enterprise were proposed in the paper.展开更多
Based on investigations of 112 Chinese firms and studies on foreign leading corporations, a theoretical framework of dynamic capabilities based strategy innovation (SI) is put forward. Several large firms in China wi...Based on investigations of 112 Chinese firms and studies on foreign leading corporations, a theoretical framework of dynamic capabilities based strategy innovation (SI) is put forward. Several large firms in China winning through SI were studied empirically. This paper complements previous publications on the theories of innovation and strategy. This work's findings will be useful for managers interested in our approach, which highlights the importance of SI and focuses on and points out the major pitfalls in the innovation processes. Implementing the dynamic capabilities based strategy innovation can effectively cultivate and develop core competences of corporations. It is concluded that implementing SI is the only path for Chinese enterprise growth in the intensified competition in the knowledge economy.展开更多
innovation driven development strategy,as a national strategy of our country,has attracted wide attention in the academic field,and it is very rich in theory and practice of innovation driven development.But innovatio...innovation driven development strategy,as a national strategy of our country,has attracted wide attention in the academic field,and it is very rich in theory and practice of innovation driven development.But innovation driven development,as a national strategy,is a long-term,not only from institutional and policy perspective,but also need to build a theoretical framework of relatively rich,can practice on the guiding role of theory.展开更多
English translation teaching must also evolve against the backdrop of rapid advancement in AI.There are many problems and limitations in the traditional English translation teaching model,such as students’over-relian...English translation teaching must also evolve against the backdrop of rapid advancement in AI.There are many problems and limitations in the traditional English translation teaching model,such as students’over-reliance on translation software,teachers’insufficient understanding of intelligent technology and insufficient integration of teaching and intelligent technology,which cannot meet the diversified learning needs of students.This paper tries to explore Innovative strategies for Artificial Intelligence(AI)based English translation teaching,including enhancing students’understanding and application of translation software,optimizing teachers’thinking on the application of AI technology,expanding ways to integrate translation courses with AI technology and increasing attention to AI in the course evaluation process.It aims at promoting AI-based English translation teaching and cultivating qualified English translators who meet the needs of the times.展开更多
This article first comprehensively analyzes the current development status of creative agriculture in Qinhuangdao City,pointing out that it has unique advantages in terms of resource endowments and cultural heritage.A...This article first comprehensively analyzes the current development status of creative agriculture in Qinhuangdao City,pointing out that it has unique advantages in terms of resource endowments and cultural heritage.Although it has achieved certain results in recent years,it still faces challenges such as low brand awareness,single marketing channels,and insufficient innovation in retail models.In terms of marketing strategy innovation,this article proposes innovative ideas such as digital marketing,cultural IP marketing,and experiential marketing.Regarding retail model innovation,this article explores models such as online and offline integration,community group buying,and live streaming sales.This article presents an outlook for the future development of creative agriculture in Qinhuangdao City based on the research findings.It is believed that with technological advancements and consumption upgrades,creative agriculture has broad prospects.展开更多
Shandong Port Group(SPG),which was established in August 2019,regards standardization as the cornerstone of modern enterprise management,and vigorously implements the standardization innovation strategy.Its standardiz...Shandong Port Group(SPG),which was established in August 2019,regards standardization as the cornerstone of modern enterprise management,and vigorously implements the standardization innovation strategy.Its standardization work mainly focuses on the following four aspects.展开更多
This paper attempts to broaden the theory of dynamic competences, defining them as the abilities of firms to integrate and reconstruct in a chaotic and complex environment of technical paradigm transformation （TP tra...This paper attempts to broaden the theory of dynamic competences, defining them as the abilities of firms to integrate and reconstruct in a chaotic and complex environment of technical paradigm transformation （TP transformation）. We have created a semi-interactive theoretical framework based on dynamic competences, technical paradigms and innovation strategies to investigate how corporate dynamic competences support innovation during TP transformation. Under this theoretical framework, this paper attempts to open the popular question of mobile Internet industry - the black box of ＂micro innovation＂ - to conduct an in-depth case study of WeChat＇s micro-innovation featuring ＂integration＂ and ＂iteration ＂. The authors have discovered that the success of WeChat can be attributed to the following factors： seizure of strategic opportunities during TP transformation, effective organizational learning and knowledge management, and powerful virtual integration competences across regions, sectors and firms. These factors have led to the rapid, repetitive and precise iteration of innovation based on technical knowledge and user information. Open and coordinated innovation was carried out ahead of competitors, partners and lead customers, and effective quality control of micro-innovation was conducted to mitigate the uncertainties and risks of innovation failures. These factors have enabled WeChat to become a third-party service platform of disruptive innovation and value creation in the mobile lnternet era. The theoretical contributions of this paper are as follows：it has enriche＇d the theory of dynamic competences, conducted a groundbreaking analysis on the intrinsic mechanism of micro-innovation strategy for Internet firms from the height of technical paradigms, and elaborated how dynamic competences support innovation strategies during TP transformation. This paper offers theoretical support and practical guidance for Internet firms to innovate in the context of TP transformation.展开更多
Based on the endogenous technology progress framework for late-moving large countries,this paper simulates the effects of market size on technology progress path and technology catch-up,and finds that under the strate...Based on the endogenous technology progress framework for late-moving large countries,this paper simulates the effects of market size on technology progress path and technology catch-up,and finds that under the strategy of combining innovation with imitation,the increase of market size will restrain the convergence of economies towards technology frontier and deepen their reliance on imitation.Under the strategy of replacing imitation with innovation,there is a non-uniform U-shaped threshold effect for market size to influence technology progress path and catch-up,and the threshold for the shift of technology progress path lags behind that for technology catch-up.Hence,we should follow technology catch-up as the benchmark and timely adjust our innovation strategy to unleash the advantages of economies of scale for innovation.The innovation-driven development strategy is a choice compatible with China’s changing market size.However,since China remains in a transition from a super-large economy to a super-strong one,the contribution of innovation will decrease at first before increasing afterwards.展开更多
Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomed...Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.展开更多
Technological innovations significantly influence individual firms and other innova-tions,such as financial innovations.The future of a firm depends on its innovation investment strategy.According to the literature,in...Technological innovations significantly influence individual firms and other innova-tions,such as financial innovations.The future of a firm depends on its innovation investment strategy.According to the literature,innovation investments are affected by ambiguity.This study examines how ambiguity affects the innovation strategies of managers.We show that the innovation strategies of ambiguity-averse managers differ from those of ambiguity-neutral managers.Unlike ambiguity-neutral managers,ambiguity-averse managers consider a broader variety of innovation strategies for a wider range of future innovation arrival times.Regarding the profitability of a future innovation,ambiguity-averse managers delay the investment decision until the profit-ability of the innovation is less ambiguous.Moreover,we examine innovation strategies under various conditions,including the risk of innovation outdatedness,management disputes,and the varying volatility of innovations.展开更多
Colorectal cancer(CRC)is the third most common malignancy worldwide and the second leading cause of cancer-related deaths,accounting for approximately 10%of all cancer cases.By 2050,CRC incidence is expected to rise s...Colorectal cancer(CRC)is the third most common malignancy worldwide and the second leading cause of cancer-related deaths,accounting for approximately 10%of all cancer cases.By 2050,CRC incidence is expected to rise substantially,driven by population aging and greater exposure to risk factors in developing countries.Despite advances in medicine and pharmacy,the effectiveness of available treatments remains limited,underscoring the urgent need for innovative therapeutic strategies.This review summarizes and critically evaluates currently available CRC therapies and explores new emerging directions.Particular attention is given to the role of immunotherapy,targeted therapies,nanotechnology-based approaches,metal-based compounds,PROTAC technology,and personalized medicine,with emphasis on their efficacy,safety,accessibility,and mechanisms of drug resistance.In conclusion,surgery and chemotherapy remain the backbone of CRC treatment,but novel therapeutic approaches are reshaping the treatment landscape.Emerging strategies may offer improved patient tolerability and survival outcomes by reducing the occurrence of burdensome adverse effects.Persistent challenges such as drug toxicity,the emergence of resistance mechanisms,and inequalities in access to innovative therapies underscore the need for further translational research.Integrating personalized therapeutic approaches will also be crucial to achieving more effective,safer,and accessible treatment strategies for CRC.展开更多
基金Project name:Evolution of Growth Model and Cultivation of Competitive Advantage under Ambidextrous Innovation Strategy-A case study of China’s high-tech enterprises Project no.:JKY106320,Project category:National key project of the“14th Five-Year Plan”of Education and Scientific Research of the Ministry of Education The organization of the project chair:University of Malaya。
文摘This study focuses on the evolution of growth model and cultivation of competitive advantages under the ambidextrous innovation strategy.After a brief introduction of the connotation of ambidextrous innovation strategy,the evolution of growth model of high-tech enterprises under the conventional strategy and the ambidextrous innovation strategy is analyzed.Furthermore,a discussion is made on how to cultivate enterprises’competitive advantages under the ambidextrous innovation strategy,thereby enabling enterprises to stand out from competitors under this new strategic model and truly achieve the goal of sustainable development.
基金This paper was supported by Hunan Soft Scientific Researching Project (No.2007ZK3084)
文摘This paper analyzed the relationship between organizational slack and technological innovation strategy in Chinese enterprises through building mathematic model and real options approach. The results show the organizational slack that explored and employed reached to a critical point and can promote enterprises to choose the independent innovation strategy based on R & D (Research and Development); And it is important to identify,explore and employ organizational slack correctly for strengthening the organizational independent innovation capability and raising its performance when the technological innovation strategy based on technological introduction is more and more difficult.
文摘With the continuous improvement of Chinas social and economic system, internal audit has become one of the main work contents for enterprises to improve their own development ability and market competitive advantages. Under the influence of the big data environment, the impact of various information technologies for the data transmission work has also brought great challenges to the internal audit work of enterprises. In this context, the traditional internal audit mode of an enterprise has already met its actual development needs. At the present stage, one of the main tasks of the enterprises internal management work is to strengthen the innovative exploration of its own internal audit work by combining with the characteristics of the big data environment. Based on this, this paper takes the shortcomings of the enterprise internal audit work in the big data environment and the innovation needs of the enterprise internal audit work as the starting point, and analyzes several effective innovative ways of the enterprise internal audit work.
文摘The rapid development of information technology provides a new opportunity and impetus for the reform of education and teaching.Deep integration of information technology and education and teaching is the only way to promote the modernization of education.Starting from the connotation of the deep integration of information technology and education and teaching,this paper analyzes the existing problems in the current integration process,and puts forward innovative strategies from the aspects of concept,resources,model,and evaluation.Through measures such as building a smart teaching environment,enriching high-quality teaching resources,innovating teaching organization models,and establishing multiple evaluation systems,we will realize the deep integration of information technology and teaching,promote the reform of teaching and learning methods,improve the quality of personnel training,and provide strong support for the modernization of education.
文摘With the continuous growth of China's social economy, people's material and cultural living standards have been significantly improved. Under the background of gradually speeding up the process of urbanization, people's requirements for the comfort of living environment are also higher and higher. Urban construction, city appearance environment, urban management level has become important factors affecting the construction of landscape architecture. At present, the scale of urban greening construction is expanding. In the face of this situation, we must consider how to maximize the ecological benefits of urban landscape design, and how to promote the construction of urban landscape and the sustainable development of urban environment. Next, the article discusses the innovation strategy of modern urban landscape design.
文摘The quality of construction determines the success or failure of the construction. Excellent construction engineering construction can make the building more stable. If the construction engineering construction is not qualified, it will lead to the failure to carry out the construction work smoothly, which will affect the construction progress. It will also bring many hidden dangers to the subsequent construction work, affecting the safety, life and functionality of the building. This paper will conduct a detailed analysis of the construction management and construction work, and put forward the corresponding innovation strategies, in order to be able to provide reference for relevant units.
文摘With the rapid development and widespread application of Big Data technology, the supply chain management of agricultural products enterprises is facing unprecedented reform and challenges. This study takes the perspective of Big Data technology and collects relevant information on the application of supply chain management in 100 agricultural product enterprises through a survey questionnaire. The study found that the use of Big Data can effectively improve the accuracy of demand forecasting, inventory management efficiency, optimize logistics costs, improve supplier management efficiency, enhance the overall level of supply chain management of enterprises, and propose innovative strategies for supply chain management of agricultural products enterprises based on this. Big Data technology brings a new solution for agricultural products enterprises to enhance their supply chain management level, making the supply chain smarter and more efficient.
文摘Technical innovation is the core for enterprise competence and sustaining. Technical innovation strategy is the policy which the enterprise carries out for technology innovation in a long term. The paper took the practice of the technology innovation strategy in Petro China Changqing Oilfield Company as a case study, and illustrated the significance, function and features of the self-developed technology innovation, cooperation development technology innovation and introduction-innovation based on the strategy structure of the energy enterprises. The suggestions for technology innovation strategy structure for large energy enterprise were proposed in the paper.
文摘Based on investigations of 112 Chinese firms and studies on foreign leading corporations, a theoretical framework of dynamic capabilities based strategy innovation (SI) is put forward. Several large firms in China winning through SI were studied empirically. This paper complements previous publications on the theories of innovation and strategy. This work's findings will be useful for managers interested in our approach, which highlights the importance of SI and focuses on and points out the major pitfalls in the innovation processes. Implementing the dynamic capabilities based strategy innovation can effectively cultivate and develop core competences of corporations. It is concluded that implementing SI is the only path for Chinese enterprise growth in the intensified competition in the knowledge economy.
文摘innovation driven development strategy,as a national strategy of our country,has attracted wide attention in the academic field,and it is very rich in theory and practice of innovation driven development.But innovation driven development,as a national strategy,is a long-term,not only from institutional and policy perspective,but also need to build a theoretical framework of relatively rich,can practice on the guiding role of theory.
文摘English translation teaching must also evolve against the backdrop of rapid advancement in AI.There are many problems and limitations in the traditional English translation teaching model,such as students’over-reliance on translation software,teachers’insufficient understanding of intelligent technology and insufficient integration of teaching and intelligent technology,which cannot meet the diversified learning needs of students.This paper tries to explore Innovative strategies for Artificial Intelligence(AI)based English translation teaching,including enhancing students’understanding and application of translation software,optimizing teachers’thinking on the application of AI technology,expanding ways to integrate translation courses with AI technology and increasing attention to AI in the course evaluation process.It aims at promoting AI-based English translation teaching and cultivating qualified English translators who meet the needs of the times.
基金Research on the Development of Creative Agriculture in Qinhuangdao City(202401A213)。
文摘This article first comprehensively analyzes the current development status of creative agriculture in Qinhuangdao City,pointing out that it has unique advantages in terms of resource endowments and cultural heritage.Although it has achieved certain results in recent years,it still faces challenges such as low brand awareness,single marketing channels,and insufficient innovation in retail models.In terms of marketing strategy innovation,this article proposes innovative ideas such as digital marketing,cultural IP marketing,and experiential marketing.Regarding retail model innovation,this article explores models such as online and offline integration,community group buying,and live streaming sales.This article presents an outlook for the future development of creative agriculture in Qinhuangdao City based on the research findings.It is believed that with technological advancements and consumption upgrades,creative agriculture has broad prospects.
文摘Shandong Port Group(SPG),which was established in August 2019,regards standardization as the cornerstone of modern enterprise management,and vigorously implements the standardization innovation strategy.Its standardization work mainly focuses on the following four aspects.
文摘This paper attempts to broaden the theory of dynamic competences, defining them as the abilities of firms to integrate and reconstruct in a chaotic and complex environment of technical paradigm transformation （TP transformation）. We have created a semi-interactive theoretical framework based on dynamic competences, technical paradigms and innovation strategies to investigate how corporate dynamic competences support innovation during TP transformation. Under this theoretical framework, this paper attempts to open the popular question of mobile Internet industry - the black box of ＂micro innovation＂ - to conduct an in-depth case study of WeChat＇s micro-innovation featuring ＂integration＂ and ＂iteration ＂. The authors have discovered that the success of WeChat can be attributed to the following factors： seizure of strategic opportunities during TP transformation, effective organizational learning and knowledge management, and powerful virtual integration competences across regions, sectors and firms. These factors have led to the rapid, repetitive and precise iteration of innovation based on technical knowledge and user information. Open and coordinated innovation was carried out ahead of competitors, partners and lead customers, and effective quality control of micro-innovation was conducted to mitigate the uncertainties and risks of innovation failures. These factors have enabled WeChat to become a third-party service platform of disruptive innovation and value creation in the mobile lnternet era. The theoretical contributions of this paper are as follows：it has enriche＇d the theory of dynamic competences, conducted a groundbreaking analysis on the intrinsic mechanism of micro-innovation strategy for Internet firms from the height of technical paradigms, and elaborated how dynamic competences support innovation strategies during TP transformation. This paper offers theoretical support and practical guidance for Internet firms to innovate in the context of TP transformation.
基金the National Social Science Fund of China (NSSFC) Youth Project “Study on the Evaluation, Comparison and Improvement Path of China’s Regional TFP under the Perspective of Suitable Technology Options”(Grant No. 17CJY002)
文摘Based on the endogenous technology progress framework for late-moving large countries,this paper simulates the effects of market size on technology progress path and technology catch-up,and finds that under the strategy of combining innovation with imitation,the increase of market size will restrain the convergence of economies towards technology frontier and deepen their reliance on imitation.Under the strategy of replacing imitation with innovation,there is a non-uniform U-shaped threshold effect for market size to influence technology progress path and catch-up,and the threshold for the shift of technology progress path lags behind that for technology catch-up.Hence,we should follow technology catch-up as the benchmark and timely adjust our innovation strategy to unleash the advantages of economies of scale for innovation.The innovation-driven development strategy is a choice compatible with China’s changing market size.However,since China remains in a transition from a super-large economy to a super-strong one,the contribution of innovation will decrease at first before increasing afterwards.
基金supported by the National Natural Science Foundation of China[82003956]the National Key Research and Development Program of China[No.2022YFA1205802]+2 种基金financially supported by Henan Province Health Science and Technology Innovation Youth Talent Project(YQRC2023013 and YQRC2024013)the Key Project of Medical Science and Technology of Henan Province(SBGJ202302072)the Science and Technology Research Project of Henan Province(252102311236).
文摘Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.
文摘Technological innovations significantly influence individual firms and other innova-tions,such as financial innovations.The future of a firm depends on its innovation investment strategy.According to the literature,innovation investments are affected by ambiguity.This study examines how ambiguity affects the innovation strategies of managers.We show that the innovation strategies of ambiguity-averse managers differ from those of ambiguity-neutral managers.Unlike ambiguity-neutral managers,ambiguity-averse managers consider a broader variety of innovation strategies for a wider range of future innovation arrival times.Regarding the profitability of a future innovation,ambiguity-averse managers delay the investment decision until the profit-ability of the innovation is less ambiguous.Moreover,we examine innovation strategies under various conditions,including the risk of innovation outdatedness,management disputes,and the varying volatility of innovations.
文摘Colorectal cancer(CRC)is the third most common malignancy worldwide and the second leading cause of cancer-related deaths,accounting for approximately 10%of all cancer cases.By 2050,CRC incidence is expected to rise substantially,driven by population aging and greater exposure to risk factors in developing countries.Despite advances in medicine and pharmacy,the effectiveness of available treatments remains limited,underscoring the urgent need for innovative therapeutic strategies.This review summarizes and critically evaluates currently available CRC therapies and explores new emerging directions.Particular attention is given to the role of immunotherapy,targeted therapies,nanotechnology-based approaches,metal-based compounds,PROTAC technology,and personalized medicine,with emphasis on their efficacy,safety,accessibility,and mechanisms of drug resistance.In conclusion,surgery and chemotherapy remain the backbone of CRC treatment,but novel therapeutic approaches are reshaping the treatment landscape.Emerging strategies may offer improved patient tolerability and survival outcomes by reducing the occurrence of burdensome adverse effects.Persistent challenges such as drug toxicity,the emergence of resistance mechanisms,and inequalities in access to innovative therapies underscore the need for further translational research.Integrating personalized therapeutic approaches will also be crucial to achieving more effective,safer,and accessible treatment strategies for CRC.
