objective: To investigate the effects of Reduqing （RDQ, 热毒清） on plasma interleukin-8 （IL-8）complement 5a （C5a）and polymorphonuclear neutrophilic leukocyte （PMN） chemotaxis Index （CI） in rabbits with endot...objective: To investigate the effects of Reduqing （RDQ, 热毒清） on plasma interleukin-8 （IL-8）complement 5a （C5a）and polymorphonuclear neutrophilic leukocyte （PMN） chemotaxis Index （CI） in rabbits with endotoxin-induced disseminated intravascular coagulation （DIC）. Methods: Endotoxin-induced DIC model made by injection of LiPoPolysacchrides （LPS） was used in the experiment. Above-mentioned indexes were determined before and after RDQ treatment and compared with blank and dexamethasone treated group. Results: Plasma IL-8,C5a and CI level of PMN increased markedly in the model group, which were confirmed pathologically with obvious damage of tissues or organs. In the RDQ group, the abovementiond parameters and damage of tissues or organs were reduced significantly （P ＜ 0.01 ）. Conclusion: IL-8 and NO might be involved in pathogenesis of endotoxin-induced DIC, and RDQ could be used in preventing or treating DIC through the mechanism of regulation of cytokines network.展开更多
文摘objective: To investigate the effects of Reduqing （RDQ, 热毒清） on plasma interleukin-8 （IL-8）complement 5a （C5a）and polymorphonuclear neutrophilic leukocyte （PMN） chemotaxis Index （CI） in rabbits with endotoxin-induced disseminated intravascular coagulation （DIC）. Methods: Endotoxin-induced DIC model made by injection of LiPoPolysacchrides （LPS） was used in the experiment. Above-mentioned indexes were determined before and after RDQ treatment and compared with blank and dexamethasone treated group. Results: Plasma IL-8,C5a and CI level of PMN increased markedly in the model group, which were confirmed pathologically with obvious damage of tissues or organs. In the RDQ group, the abovementiond parameters and damage of tissues or organs were reduced significantly （P ＜ 0.01 ）. Conclusion: IL-8 and NO might be involved in pathogenesis of endotoxin-induced DIC, and RDQ could be used in preventing or treating DIC through the mechanism of regulation of cytokines network.
