Infrared(IR) optics have garnered significant attention due to growing demands in advanced optical imaging,communication, detection, and sensing. Among various IR devices, microlenses and microlens arrays offer distin...Infrared(IR) optics have garnered significant attention due to growing demands in advanced optical imaging,communication, detection, and sensing. Among various IR devices, microlenses and microlens arrays offer distinct advantages in integration capability, imaging precision, multifunctionality, and cost-effective manufacturing. We present a novel design of high-resolution achromatic microlens in the mid-IR region. Different from traditional high-refractive-index convex microlenses embedded within a low-index background medium, the current design is a low-index air concave microlens embedded within a high-index silicon medium. The designed air microlens exhibits capabilities in high-resolution imaging(~λ/6) and achromatic performance across the 3–5 μm mid-IR spectrum. The air microlens could be assembled in large-area microlens arrays or as part of multi-lens system.When combined with the HgCdTe detector system placed on the focal plane, the air microlens can find promising applications in high-resolution optical imaging and high-sensitivity photoelectric detection.展开更多
This experiment studies on the used infrared spectroscopy to establish technology methods for liquor identification methods, as well as offers the science data for establishment of the fingerprint in white spirit. The...This experiment studies on the used infrared spectroscopy to establish technology methods for liquor identification methods, as well as offers the science data for establishment of the fingerprint in white spirit. The results have shown that using near-infrared spectroscopy analysis of liquor has the obvious features such as strong specificity, good reproducibility, simple operation, and finally confirmed that it is an authentic and ideal method for identification in white spirit.展开更多
Optical frequency combbased Fourier transform spectroscopy has the features of broad spectral bandwidth,high sensitivity,andmultiplexed trace gas detection,which has valuable application potential in the fields of pre...Optical frequency combbased Fourier transform spectroscopy has the features of broad spectral bandwidth,high sensitivity,andmultiplexed trace gas detection,which has valuable application potential in the fields of precision spectroscopy and trace gas detection.Here,we report the development of a mid-infrared Fourier transform spectrometer based on an optical frequency comb combined with a Herriott-type multipass cell.Using this instrument,the broadband absorption spectra of several important molecules,including methane,acetylene,water molecules and nitrous oxide,are measured by near real-time data acquisition in the 2800-3500 cm^(-1)spectral region.The achieved minimum detectable absorption of the instrument is 4.4×10^(-8)cm^(-1)·Hz^(-1/2)per spectral element.Broadband spectra of H_(2)0 are fited using the Voigt profile multispectral fitting technique and the consistency of the concentration inversion is 1%.Our system also enables precise spectroscopic measurements,and it allows the determination of the spectral line positions and upper state constants of N_(2)O in the(0002)-(1000)band,with results in good agreement with those reported by Toth[Appl.Opt.30,5289(1991)].展开更多
The cyanine dyes represented by IR780 can achieve synergistic photodynamic therapy(PDT)and photothermal therapy(PTT)under the stimulation of near-infrared(NIR)light(commonly 808 nm).Unfortunately,the stability of NIR-...The cyanine dyes represented by IR780 can achieve synergistic photodynamic therapy(PDT)and photothermal therapy(PTT)under the stimulation of near-infrared(NIR)light(commonly 808 nm).Unfortunately,the stability of NIR-excited cyanine dyes is not satisfactory.These cyanine dyes can be attacked by self-generated reactive oxygen species(ROS)during PDT processes,resulting in structural damage and rapid degradation,which is fatal for phototherapy.To address this issue,a novel non-cyanine dye(IR890)was elaborately designed and synthesized by our team.The maximum absorption wavelength of IR890 was located in the deep NIR region(ca.890 nm),which was beneficial for further improving tissue penetration depth.Importantly,IR890 exhibited good stability when continuously illuminated by deep NIR light.To improve the hydrophilicity and biocompatibility,the hydrophobic IR890 dye was grafted onto the side chain of hydrophilic polymer(POEGMA-b-PGMA-g-C≡CH)via click chemistry.Then,the synthesized POEGMA-b-PGMA-g-IR890 amphiphilic polymerwas utilized to prepare P-IR890 nano-photosensitizer via self-assembly method.Under irradiation with deep NIR light(850 nm,0.5 W/cm^(2),10 min),the dye degradation rate of P-IR890 was less than 5%.However,IR780 was almost completely degraded with the same light output power density and irradiation duration.In addition,P-IR890 could stably generate a large number of ROS and heat at the same time.It was rarely reported that the stable synergistic combination therapy of PDT and PTT could be efficiently performed by a single photosensitizer via irradiation with deep NIR light.P-IR890 exhibited favorable anti-tumor outcomes through apoptosis pathway.Therefore,the P-IR890 could provide a new insight into the design of photosensitizers and new opportunities for synergistic combination therapy of PDT and PTT.展开更多
A miniaturized short-wavelength infrared spectrometer for use with diffuse light was created by combining a thin form factor carbon nanotube composite collimator,a linear variable filter,and an InGaAs photodiode array...A miniaturized short-wavelength infrared spectrometer for use with diffuse light was created by combining a thin form factor carbon nanotube composite collimator,a linear variable filter,and an InGaAs photodiode array.The resulting spectrometer measures 3 mm×4 mm×14 mm and shows a significant improvement in resolution over a spectrometer without the collimator when used with diffuse light.Its small size and high throughput make it ideal for applications such as wearable optical sensing,where light from highly scattering tissue is measured.Plethysmographic measurements on the wrist were demonstrated,showing rapid data collection with diffuse light.展开更多
In view of the difficulties in traditional long-wave infrared imaging spectrometer which is hard to realize a high signal-to-noise ratio and miniaturization as well under the weak remote sensing signal,Offner convex g...In view of the difficulties in traditional long-wave infrared imaging spectrometer which is hard to realize a high signal-to-noise ratio and miniaturization as well under the weak remote sensing signal,Offner convex grating spectrometer and Dyson concave grating spectrometer,both having concentric structure,are designed and analyzed in the band of 8-12 μm. The diffraction angle expressions of the two spectrometers are obtained and the diffraction characteristics are acquired. Both of the spectrometers are designed in Zemax environment under different F-numbers and different grating constants with the same slit,spatial resolution,spectral resolution and detector. The results show that Dyson grating spectrometer possesses the advantages of higher throughput and smaller volume, and Offner grating spectrometer possesses the advantage of more accessible material and the absence of chromatic aberration. The differences between Dyson form and Offner form show that the former is a better choice in the long-wave infrared imaging spectrometer.展开更多
The performance of a portable near-infrared (NIR) spectrometer to determine organic carbon (OC) in marine sediments was evaluated. The NIR reflection spectra of 180 samples in the range 950 - 1650 nm were acquired usi...The performance of a portable near-infrared (NIR) spectrometer to determine organic carbon (OC) in marine sediments was evaluated. The NIR reflection spectra of 180 samples in the range 950 - 1650 nm were acquired using an ultra-compact spectrometer. NIR spectroscopy combined with the partial least squares (PLS) regression and Savitzky-Golay (SG) smoothing was successfully applied to rapid and reagent-free determination of OC. Using the PLS-SG model with 1nd order derivative, 2th polynomial and eleven smoothing points, the root-mean-square errors (RMSEPM) and correlation coefficients (RP,M) of prediction for modeling were 0.073% and 0.894, respectively, the root-mean-square errors (RMSEPV) and correlation coefficients (RP,V) of prediction for validation were 0.075% and 0.883, respectively. Results showed that the small portable NIR instrument achieved well prediction effect for the analysis of OC in marine sediments, which had advantages of rapid, easy to carry and operate suitable for large-scale applications to analyze marine sediments.展开更多
Near-infrared (NIR) spectrometer based on semiconductor lasers can combine light source and splitter into one, which is an important direction for development of miniature instruments. In order to avoid random interfe...Near-infrared (NIR) spectrometer based on semiconductor lasers can combine light source and splitter into one, which is an important direction for development of miniature instruments. In order to avoid random interference caused by inconsistency between light sources, the novel evaluation indicators for global stability of multi-channels spectral system were proposed based on the correlation between dynamic deviation spectra of any two channels. The NIR analysis of moisture for corn powder samples based on the partial least squares combined with Savitzky-Golay (SG) smoothing was taken as an example, and a spectral correction method for enhancing prediction performance of multi-channels spectral system was further provided using above evaluation indicators. The experiment results showed that the global stability evaluation indicators significantly increased after SG smoothing correction. Meanwhile, the root-mean-square errors of prediction for corn moisture reduced from 0.373 to 0.283 (%), and the correlation coefficient between predicted and actual values was improved from 0.702 to 0.855. The above results indicated that by improving global stability indicators, the prediction ability of multi-channels spectral system can be improved. The proposed method provided a valuable reference for designing multi-channels diminutive spectrometer with high prediction performance, which had significance for large-scale application of NIR technology.展开更多
基金supported by the Science and Technology Project of Guangdong Province, China (Grant No. 2020B010190001)the National Natural Science Foundation of China (Grant No. 12434016)the National Key Research and Development Program of China (Grant No. 2018YFA0306200)。
文摘Infrared(IR) optics have garnered significant attention due to growing demands in advanced optical imaging,communication, detection, and sensing. Among various IR devices, microlenses and microlens arrays offer distinct advantages in integration capability, imaging precision, multifunctionality, and cost-effective manufacturing. We present a novel design of high-resolution achromatic microlens in the mid-IR region. Different from traditional high-refractive-index convex microlenses embedded within a low-index background medium, the current design is a low-index air concave microlens embedded within a high-index silicon medium. The designed air microlens exhibits capabilities in high-resolution imaging(~λ/6) and achromatic performance across the 3–5 μm mid-IR spectrum. The air microlens could be assembled in large-area microlens arrays or as part of multi-lens system.When combined with the HgCdTe detector system placed on the focal plane, the air microlens can find promising applications in high-resolution optical imaging and high-sensitivity photoelectric detection.
文摘This experiment studies on the used infrared spectroscopy to establish technology methods for liquor identification methods, as well as offers the science data for establishment of the fingerprint in white spirit. The results have shown that using near-infrared spectroscopy analysis of liquor has the obvious features such as strong specificity, good reproducibility, simple operation, and finally confirmed that it is an authentic and ideal method for identification in white spirit.
基金supported by the National Natural Science Foundation China(No.42022051,No.U21A2028)Youth Innovation Promotion Association of the Chinese Academy of Sciences(No.Y202089)the HFIPS Director's Fund(No.YZJJ202101,No.BJPY2023A02).
文摘Optical frequency combbased Fourier transform spectroscopy has the features of broad spectral bandwidth,high sensitivity,andmultiplexed trace gas detection,which has valuable application potential in the fields of precision spectroscopy and trace gas detection.Here,we report the development of a mid-infrared Fourier transform spectrometer based on an optical frequency comb combined with a Herriott-type multipass cell.Using this instrument,the broadband absorption spectra of several important molecules,including methane,acetylene,water molecules and nitrous oxide,are measured by near real-time data acquisition in the 2800-3500 cm^(-1)spectral region.The achieved minimum detectable absorption of the instrument is 4.4×10^(-8)cm^(-1)·Hz^(-1/2)per spectral element.Broadband spectra of H_(2)0 are fited using the Voigt profile multispectral fitting technique and the consistency of the concentration inversion is 1%.Our system also enables precise spectroscopic measurements,and it allows the determination of the spectral line positions and upper state constants of N_(2)O in the(0002)-(1000)band,with results in good agreement with those reported by Toth[Appl.Opt.30,5289(1991)].
基金This project was supported by National Natural Science Foundation of China(Grant No.82271629 and 82301790)Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(Grant No.2023R01002)Ningbo Natural Science Foundation(Grant No.2023J054).
文摘The cyanine dyes represented by IR780 can achieve synergistic photodynamic therapy(PDT)and photothermal therapy(PTT)under the stimulation of near-infrared(NIR)light(commonly 808 nm).Unfortunately,the stability of NIR-excited cyanine dyes is not satisfactory.These cyanine dyes can be attacked by self-generated reactive oxygen species(ROS)during PDT processes,resulting in structural damage and rapid degradation,which is fatal for phototherapy.To address this issue,a novel non-cyanine dye(IR890)was elaborately designed and synthesized by our team.The maximum absorption wavelength of IR890 was located in the deep NIR region(ca.890 nm),which was beneficial for further improving tissue penetration depth.Importantly,IR890 exhibited good stability when continuously illuminated by deep NIR light.To improve the hydrophilicity and biocompatibility,the hydrophobic IR890 dye was grafted onto the side chain of hydrophilic polymer(POEGMA-b-PGMA-g-C≡CH)via click chemistry.Then,the synthesized POEGMA-b-PGMA-g-IR890 amphiphilic polymerwas utilized to prepare P-IR890 nano-photosensitizer via self-assembly method.Under irradiation with deep NIR light(850 nm,0.5 W/cm^(2),10 min),the dye degradation rate of P-IR890 was less than 5%.However,IR780 was almost completely degraded with the same light output power density and irradiation duration.In addition,P-IR890 could stably generate a large number of ROS and heat at the same time.It was rarely reported that the stable synergistic combination therapy of PDT and PTT could be efficiently performed by a single photosensitizer via irradiation with deep NIR light.P-IR890 exhibited favorable anti-tumor outcomes through apoptosis pathway.Therefore,the P-IR890 could provide a new insight into the design of photosensitizers and new opportunities for synergistic combination therapy of PDT and PTT.
文摘A miniaturized short-wavelength infrared spectrometer for use with diffuse light was created by combining a thin form factor carbon nanotube composite collimator,a linear variable filter,and an InGaAs photodiode array.The resulting spectrometer measures 3 mm×4 mm×14 mm and shows a significant improvement in resolution over a spectrometer without the collimator when used with diffuse light.Its small size and high throughput make it ideal for applications such as wearable optical sensing,where light from highly scattering tissue is measured.Plethysmographic measurements on the wrist were demonstrated,showing rapid data collection with diffuse light.
基金Sponsored by the National High Technology Research and Development Program of China(863 Program)(Grant No.2013AA03A116)
文摘In view of the difficulties in traditional long-wave infrared imaging spectrometer which is hard to realize a high signal-to-noise ratio and miniaturization as well under the weak remote sensing signal,Offner convex grating spectrometer and Dyson concave grating spectrometer,both having concentric structure,are designed and analyzed in the band of 8-12 μm. The diffraction angle expressions of the two spectrometers are obtained and the diffraction characteristics are acquired. Both of the spectrometers are designed in Zemax environment under different F-numbers and different grating constants with the same slit,spatial resolution,spectral resolution and detector. The results show that Dyson grating spectrometer possesses the advantages of higher throughput and smaller volume, and Offner grating spectrometer possesses the advantage of more accessible material and the absence of chromatic aberration. The differences between Dyson form and Offner form show that the former is a better choice in the long-wave infrared imaging spectrometer.
文摘The performance of a portable near-infrared (NIR) spectrometer to determine organic carbon (OC) in marine sediments was evaluated. The NIR reflection spectra of 180 samples in the range 950 - 1650 nm were acquired using an ultra-compact spectrometer. NIR spectroscopy combined with the partial least squares (PLS) regression and Savitzky-Golay (SG) smoothing was successfully applied to rapid and reagent-free determination of OC. Using the PLS-SG model with 1nd order derivative, 2th polynomial and eleven smoothing points, the root-mean-square errors (RMSEPM) and correlation coefficients (RP,M) of prediction for modeling were 0.073% and 0.894, respectively, the root-mean-square errors (RMSEPV) and correlation coefficients (RP,V) of prediction for validation were 0.075% and 0.883, respectively. Results showed that the small portable NIR instrument achieved well prediction effect for the analysis of OC in marine sediments, which had advantages of rapid, easy to carry and operate suitable for large-scale applications to analyze marine sediments.
文摘Near-infrared (NIR) spectrometer based on semiconductor lasers can combine light source and splitter into one, which is an important direction for development of miniature instruments. In order to avoid random interference caused by inconsistency between light sources, the novel evaluation indicators for global stability of multi-channels spectral system were proposed based on the correlation between dynamic deviation spectra of any two channels. The NIR analysis of moisture for corn powder samples based on the partial least squares combined with Savitzky-Golay (SG) smoothing was taken as an example, and a spectral correction method for enhancing prediction performance of multi-channels spectral system was further provided using above evaluation indicators. The experiment results showed that the global stability evaluation indicators significantly increased after SG smoothing correction. Meanwhile, the root-mean-square errors of prediction for corn moisture reduced from 0.373 to 0.283 (%), and the correlation coefficient between predicted and actual values was improved from 0.702 to 0.855. The above results indicated that by improving global stability indicators, the prediction ability of multi-channels spectral system can be improved. The proposed method provided a valuable reference for designing multi-channels diminutive spectrometer with high prediction performance, which had significance for large-scale application of NIR technology.
