DNA has long been proposed as a molecular-level data storage media with large storage capacity due to its precise sequence structure and modern sequencing techniques. Adenine and cytosine are arbitrarily denoted as th...DNA has long been proposed as a molecular-level data storage media with large storage capacity due to its precise sequence structure and modern sequencing techniques. Adenine and cytosine are arbitrarily denoted as the O-bit, and guanine and thymine as the 1-bit. However, the environmental stability and compatibility of DNA limit its practical applications [1].展开更多
Sequence-defined oligocarbamates were synthesized by orthogonal iterative chemistry on a modified Wang solid support.In this approach,amino alcohol building blocks,containing either primary or secondary amines,were us...Sequence-defined oligocarbamates were synthesized by orthogonal iterative chemistry on a modified Wang solid support.In this approach,amino alcohol building blocks,containing either primary or secondary amines,were used in order to obtain ondemand either a classical urethane motif−NH−CO−O−or a Nsubstituted urethane linkage−NR−CO−O−.Hence,aperiodic carbamate sequences could be easily prepared in this work.Polymers with different monomer sequences and chain-length were synthesized.Characterization by NMR,SEC and ESI-MS indicated formation of near-monodisperse polymers.Furthermore,these informational oligocarbamates were sequenced by MS/MS.Very interestingly,it was found that a fully orthogonal fragmentation of−NH−CO−O−urethane motifs occurs in these macromolecules.展开更多
文摘DNA has long been proposed as a molecular-level data storage media with large storage capacity due to its precise sequence structure and modern sequencing techniques. Adenine and cytosine are arbitrarily denoted as the O-bit, and guanine and thymine as the 1-bit. However, the environmental stability and compatibility of DNA limit its practical applications [1].
基金the CSC Graduate School funded by the French National Research Agency(CSC-IGS ANR-17-EURE-0016)for a PhD fellowship.
文摘Sequence-defined oligocarbamates were synthesized by orthogonal iterative chemistry on a modified Wang solid support.In this approach,amino alcohol building blocks,containing either primary or secondary amines,were used in order to obtain ondemand either a classical urethane motif−NH−CO−O−or a Nsubstituted urethane linkage−NR−CO−O−.Hence,aperiodic carbamate sequences could be easily prepared in this work.Polymers with different monomer sequences and chain-length were synthesized.Characterization by NMR,SEC and ESI-MS indicated formation of near-monodisperse polymers.Furthermore,these informational oligocarbamates were sequenced by MS/MS.Very interestingly,it was found that a fully orthogonal fragmentation of−NH−CO−O−urethane motifs occurs in these macromolecules.
