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An Inexpensive and Simple Experimental Approach for the Estimation of Solute Import into Groundwater and Subsequent Export Using Inflow/Outflow Data
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作者 Velu Rasiah 《Journal of Water Resource and Protection》 2017年第8期908-930,共23页
In agricultural catchments where groundwater (GW) base flow discharge contributes substantially towards stream flow, the information linking GW inflow/outflow with contaminant import/export is scarce. However, this in... In agricultural catchments where groundwater (GW) base flow discharge contributes substantially towards stream flow, the information linking GW inflow/outflow with contaminant import/export is scarce. However, this information is essential to address aquatic ecosystem health hazard/risk associated with nitrate export and subsequent loading in sensitive surface water bodies (SWB). The objectives of this study were to assess the temporal dynamics of (i) rain water inflow/outflow behaviour in three agricultural catchments in the humid tropics of far-northeast Queensland of Australia, (ii) solute import via inflow and subsequent export in outflow, and (iii) the association between GW inflow/outflow and solute import/export. Approximately 71% of the average seasonal rainfall percolated (inflow) into the porous basaltic regolith of the Johnstone River Catchment (JRC) compared with 44% into the alluvial regolith in the Mulgrave River Catchment (MRC) and 29% into the metamorphic regolith in the Tully River Catchment (TRC), respectively. The outflows from the basaltic, alluvial, and metamorphic regoliths were 56%, 36%, and 55% of the inflows, respectively. The cumulative nitrate import per season was 25 k/ha in the JRC compared with 11 kg/ha in MRC and 34 kg/ha in TRC. The corresponding exports were 24 kg/ha, 8 kg/ha 26 kg/ha in JRC, MRC, and TRC, respectively. The total dissolved solute (TDS) exports were 82%, 77%, 75%, of the corresponding imports in JRC, MRC, and TRC, respectively. Simple correlations indicated that nitrate export was positively correlated with the outflow in each one of the regolith and similar trends were observed between inflow and import. The import/export mass balance for nitrate shows that 73% to 96% of the imports were exported during the same rainy season, suggesting the potential for nitrate associated ecosystem health hazard/risk in sensitive SWB receiving the outflows. 展开更多
关键词 GROUNDWATER inflow/outflow SOLUTE Import/Export Nitrate Total Dissolved SOLUTES (TDS/EC)
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Tailoring the area of hepatic resection using inflow and outflow modulation 被引量:1
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作者 Matteo Donadon Fabio Procopio Guido Torzilli 《World Journal of Gastroenterology》 SCIE CAS 2013年第7期1049-1055,共7页
The performance of hepatic surgery without a parenchyma-sparing strategy carries significant risks for patient survival because of the not negligible occurrence of postoperative liver failure.The key factor of modern ... The performance of hepatic surgery without a parenchyma-sparing strategy carries significant risks for patient survival because of the not negligible occurrence of postoperative liver failure.The key factor of modern hepatic surgery is the use of the intraoperative ultrasound(IOUS),not only to stage the disease,but more importantly to guide resection with the specific aim to maximize the sparing of the functional parenchyma.Whether in patients with hepatocellular carcinoma and underlying liver cirrhosis,or in patients with colorectal liver metastasis,IOUS allows the performance of the so-called "radical but conservative surgery",which is the pivotal factor to offer a chance of cure to an increasing proportion of patients,who until few years ago were considered only for palliative care.Using some new IOUS-guided surgical maneuvers,which are based on the liver inflow and outflow modulations,more precise anatomically subsegmental-and segmentaloriented resections can be effectively performed.The present work describes the rationale and the surgical technique for a precise tailoring of the area of hepatic resection using the most recent attainments in IOUS.Such important technical achievements should be a fundamental part of the surgical armamentarium of the modern liver surgeon. 展开更多
关键词 Hepatic RESECTION INTRAOPERATIVE ultrasound LIVER inflow LIVER outflow RESECTION guidance
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Inflow and outflow permeability tests in a very soft clay under low stresses
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作者 J.W.S.Vargas F.A.B.Danziger +1 位作者 F.R.Lopes T.Lunne 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第8期3270-3283,共14页
In situ inflow and outflow permeability tests with the BAT probe at SarapuíII soft clay test site are presented.A description of the BAT permeability test is provided,discussing its advantages and shortcomings,es... In situ inflow and outflow permeability tests with the BAT probe at SarapuíII soft clay test site are presented.A description of the BAT permeability test is provided,discussing its advantages and shortcomings,especially in the case of very soft clays under low stresses.Pore pressures were monitored during probe installation and were found to be slightly lower than piezocone u2 pore pressures,consistent with the position of the filter.The role of filter tip saturation was investigated after the usual saturation procedure provided an unsatisfactory pore pressure response during probe installation.Results show that the vacuum saturation procedure provides adequate response during installation and increases the reliability of the coefficient of permeability determination in early measurements.Both inflow and outflow tests yielded similar results,indicating that careful execution of the test can lead to good test repeatability regardless of the loading condition.Various sequences of alternated inflow and outflow tests have yielded similar results,indicating that soil reconsolidation and filter clogging were negligible in the tests performed.Data are presented concerning the relationship between index parameters and the in situ coefficient of permeability for SarapuíII clay,which plot outside the range of existing databases. 展开更多
关键词 Permeability test Soft clay BAT probe inflow and outflow tests
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Recent Progress on Outflow/Inflow Problem for Viscous Multi-phase Flow
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作者 Fangfang Hao Hai-Liang Li +1 位作者 Luyao Shang Shuang Zhao 《Communications on Applied Mathematics and Computation》 2023年第3期987-1014,共28页
According to the boundary condition with the zero,negative,or positive velocity,the initial boundary problem for compressible multi-phase flow with the Dirichlet-type boundary condition can be classified into three ca... According to the boundary condition with the zero,negative,or positive velocity,the initial boundary problem for compressible multi-phase flow with the Dirichlet-type boundary condition can be classified into three cases:impermeable problem,inflow problem,or outflow problem.In this paper,we review the recent progress on the existence and nonlinear stability of the stationary solution to the outflow/inflow problems for viscous multi-phase flow. 展开更多
关键词 Two-phase flow-outflow/inflow problem Stationary solution-Navier-Stokes equations
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Effect of Inflow and Outflow Angles on the Computational Hemodynamics in Abdominal Aortic Aneurysm
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作者 SHI Zheng-tao LI Zhi-Yong 《Chinese Journal of Biomedical Engineering(English Edition)》 2012年第4期144-150,共7页
To help the clinical screening and diagnosis of abdominal aortic aneurysm(AAA), we evaluated the effect of inflow angle (IA) and outflow bifurcation angle(BA) on the distribution of blood flow and wall shear stress(WS... To help the clinical screening and diagnosis of abdominal aortic aneurysm(AAA), we evaluated the effect of inflow angle (IA) and outflow bifurcation angle(BA) on the distribution of blood flow and wall shear stress(WSS) in an idealized AAA model. A 2D incompressible Newtonian flow is assumed and the computational simulation is performed using finite volume method. The results showed that the largest WSS often located at the proximal and the distal end of the AAA. An increase in IA resulted in an increase in maximum WSS. We also found that WSS was maximal when BA was 90°. IA and BA are two important geometrical factors, they may help AAA risk assessment along with the commonly used AAA diameter. 展开更多
关键词 abdominal aortic aneurysm inflow angle wall shear stress bifurcationangle RUPTURE
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Numerical study on the water inflow and hydraulic pressure of mountain tunnel underpassing a reservoir
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作者 LIU Dongdong SONG Wenjie +3 位作者 WANG Xintong YANG Tao HUANG Bo ZHONG GUO 《中国水利水电科学研究院学报(中英文)》 北大核心 2025年第5期580-589,共10页
Prediction of water inflow into a tunnel is a crucial prerequisite for the waterproof and drainage design of mountain tunnels in water-rich areas.Based on the proposed Baiyun Mountain Tunnel project in Guangzhou,a num... Prediction of water inflow into a tunnel is a crucial prerequisite for the waterproof and drainage design of mountain tunnels in water-rich areas.Based on the proposed Baiyun Mountain Tunnel project in Guangzhou,a numerical percolation model of random fractured rock of a tunnel underpassing a water reservoir is established to study the seepage characteristics of surrounding rock,the law of water inflow,and the change of lining water pressure,considering the local artificial boundary conditions for seepage in large rock mass,.In addition,the influences of rock permeability,fracture aperture,grouting circle thickness,and penetration are analyzed.The results show that:(1)Only fractures with aperture wider than 0.1 mm can play a significant role in water conduction in rocks with the permeability lower than 10^(-11)m^(2);(2)The greater the permeability difference between the fractures and rocks,the more remarkable the effects of fractures on the surrounding rock seepage field and cavern water inflow;(3)The sensitivity of grouting waterproof function to grouting circle thickness,grouting ring penetration,and rock permeability is significantly higher than that of tunnel buried depth and fracture aperture;(4)The lining water head is much more sensitive to the grouting circle thickness and penetration than to the tunnel buried depth;(5)With the grouting range enlarging,the impact of grouting circle permeability on the precipitation pressure role of the grouting ring increases;(6)For the interesting tunnel designed to be built at the depth of 70 m,the grouting circle with the thickness of 0.5 m and permeability of 10-^(14)m^(2)is recommended. 展开更多
关键词 mountain tunnel water inflow into a tunnel lining water pressure grouting circle stochastic fracture networks
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Dynamic prediction of water inflow in mountain tunnels based on non-Darcian flow
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作者 LUO Jianjun WANG Guanqing +3 位作者 ZHANG Ziwei SONG Ye WANG Dengke LI Feilong 《Journal of Mountain Science》 2025年第11期4113-4132,共20页
Water inflow into mountain tunnels exhibits high variability and nonlinear seepage behavior,leading to significant prediction inaccuracies and poor pattern recognition when conventional analytical methods are applied.... Water inflow into mountain tunnels exhibits high variability and nonlinear seepage behavior,leading to significant prediction inaccuracies and poor pattern recognition when conventional analytical methods are applied.This study proposes a dynamic water inflow prediction method specifically designed for mountain tunnels.The method is based on groundwater dynamics theory,employing nonDarcian law as the governing equation and deriving analytical solutions applicable to both confined and phreatic aquifer conditions.The method incorporates spatiotemporal variations along the tunnel alignment,enabling both short-term and long-term dynamic predictions of water inflow.The study examines the nonlinear characteristics of the seepage field during tunnel water inrush.The research findings indicate that the predictive results are consistent with the hypothesized two-stage water inflow pattern,with relative errors for key parameters,such as maximum water inflow,normal water inflow,and duration of water inflow,remaining within 10%.The magnitude of water inflow is positively correlated with the permeability coefficient,head height;it is negatively correlated with the axial distance to the tunnel face and the non-Darcian influence coefficient.Both water inflow and water pressure are subject to non-Darcian effects within a defined influence zone extending approximately 1.3 times the tunnel diameter.Comparisons with established predictive methods,numerical simulations,and data from existing tunnel projects confirm the effectiveness of the proposed method.Moreover,the method was successfully applied to a mountain tunnel in the Tibet Plateau region in southwestern China,where it achieved prediction errors within 3%to 8%,demonstrating high reliability. 展开更多
关键词 Mountain tunnel Non-Darcian law Dynamic inflow prediction Confined water formula Phreatic water formula Tunnel water inflow
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Characteristics of tropical cyclone outflow over the western North Pacific
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作者 Yidan Lin Kekuan Chu Zhe-Min Tan 《Atmospheric and Oceanic Science Letters》 2025年第2期9-15,共7页
This study employs the self-organizing map method to investigate the upper-tropospheric outflow patterns of tropical cyclones(TCs)over the western North Pacific from 1979 to 2019,using the 200 hPa horizontal wind fiel... This study employs the self-organizing map method to investigate the upper-tropospheric outflow patterns of tropical cyclones(TCs)over the western North Pacific from 1979 to 2019,using the 200 hPa horizontal wind fields from the ERA5 reanalysis datasets.According to the number and orientation of TC outflow channels,as well as the wind speed,the outflow patterns are classified into five categories:southwestward single-channel pattern S1(26.1%);northwestward single-channel pattern S2(23.6%);northeastward single-channel pattern S3(23.6%);double-channel outflow pattern D(20.8%);and high latitude outflow pattern H(6.0%).Composite analysis shows that the orientations of the TC outflow channels are aligned with the direction of the environmental vertical wind shear and closely related to the distribution of the environmental inertial instability,upper-level divergence,and inner-core convective activities.TC intensity and intensity changes for different outflow patterns are also significantly different.Patterns S1 and S2 usually appear in the development phase and are thus prone to TC intensification,while patterns S3 and H usually occur in the weakening phase and are thus prone to TC weakening.The double-channel pattern(D)has the largest mean intensity and accounts for more than 60%of super-typhoon samples. 展开更多
关键词 Tropical cyclone outflow INTENSITY Self-organizing map
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EXISTENCE OF LARGE BOUNDARY LAYER SOLUTIONS TO INFLOW PROBLEM OF 1D FULL COMPRESSIBLE NAVIER-STOKES EQUATIONS
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作者 Yi WANG Yongfu YANG Qiuyang YU 《Acta Mathematica Scientia》 2025年第6期2591-2606,共16页
We present the existence/non-existence criteria for large-amplitude boundary layer solutions to the inflow problem of the one-dimensional(1D)full compressible NavierStokes equations on a half line R_+.Instead of the c... We present the existence/non-existence criteria for large-amplitude boundary layer solutions to the inflow problem of the one-dimensional(1D)full compressible NavierStokes equations on a half line R_+.Instead of the classical center manifold approach for the existence of small-amplitude boundary layer solutions in the previous results,the delicate global phase plane analysis,based on the qualitative theory of ODEs,is utilized to obtain the sufficient and necessary conditions for the existence/non-existence of large boundary layer solutions to the half-space inflow problem when the right end state belongs to the supersonic,transonic,and subsonic regions,respectively,which completely answers the existence/nonexistence of boundary layer solutions to the half-space inflow problem of 1D full compressible Navier-Stokes equations. 展开更多
关键词 compressible Navier-Stokes equations inflow problem large-amplitude boundary layer solutions
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Tissue expanders–an innovative approach in the management of hepatic venous outflow obstruction after liver transplantation:A case report
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作者 Igor Petrovic Klara Brekalo +7 位作者 Ivan Romic Hrvoje Silovski Vibor Sesa Ruzica Galunic Cicak Kresimir Bulic Oliver M Koltay Iva Martina Strajher Anna Mrzljak 《World Journal of Clinical Cases》 2025年第29期112-119,共8页
BACKGROUND Hepatic venous outflow obstruction(HVOO)is a rare but serious complication of liver transplantation,particularly in piggyback liver transplantation techniques where the inferior vena cava(IVC)is preserved.C... BACKGROUND Hepatic venous outflow obstruction(HVOO)is a rare but serious complication of liver transplantation,particularly in piggyback liver transplantation techniques where the inferior vena cava(IVC)is preserved.CASE SUMMARY A transplanted liver patient underwent retransplantation due to hepatic artery thrombosis and subsequently developed HVOO caused by graft compression of the IVC.A novel approach using a retrohepatic tissue expander effectively relieved the IVC compression,restored venous outflow,and stabilized hemodynamics.We discuss this case in the context of current treatment options and advances in HVOO management,from endovascular interventions such as balloon dilation and stenting to innovative surgical solutions such as graft repositioning and retrohepatic implants.CONCLUSION This case shows how important personalized treatments are for managing HVOO and how tissue expanders can be an adjustable and less invasive option. 展开更多
关键词 Liver transplantation Hepatic venous outflow obstruction Tissue expander Vascular complications Case report
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基于LSTM-Transformer模型的突水条件下矿井涌水量预测
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作者 李振华 姜雨菲 +1 位作者 杜锋 王文强 《河南理工大学学报(自然科学版)》 北大核心 2026年第1期77-85,共9页
目的矿井涌水量精准预测对预防矿井水害和保障矿井安全生产具有重要意义,为精准预测矿井涌水量,构建适用于华北型煤田受底板L_(1-4)灰岩含水层和奥陶系灰岩含水层水害威胁的矿井涌水量预测模型。方法以河南某典型矿井的水文监测数据为基... 目的矿井涌水量精准预测对预防矿井水害和保障矿井安全生产具有重要意义,为精准预测矿井涌水量,构建适用于华北型煤田受底板L_(1-4)灰岩含水层和奥陶系灰岩含水层水害威胁的矿井涌水量预测模型。方法以河南某典型矿井的水文监测数据为基础,提出LSTMTransformer模型。利用LSTM捕捉矿井涌水量的动态时序特征,通过Transformer的多头注意力机制分析含水层水位变化和矿井涌水量之间的复杂时序关联,构建水位动态变化驱动下的矿井涌水量精准预测框架。结果结果表明,LSTM-Transformer模型预测精度显著优于LSTM,CNN,Transformer和CNN-LSTM模型的,其均方根误差为20.91 m^(3)/h,平均绝对误差为16.08 m^(3)/h,平均绝对百分比误差为1.12%,且和单因素涌水量预测模型相比,水位-涌水量双因素预测模型预测结果更加稳定。结论LSTM-Transformer模型成功克服传统方法在捕捉复杂水文地质系统中水位-涌水量动态关联上的局限,为矿井涌水量动态预测提供可解释性强、鲁棒性好的解决方案,也为类似地质条件下矿井涌水量预测提供了新方法。 展开更多
关键词 涌水量预测 水位动态响应 LSTM-Transformer耦合模型 时间序列预测 注意力机制 矿井安全生产
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脑血管畸形MR INFLOW法和PC法血管成像探讨 被引量:1
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作者 盛元相 付况 +1 位作者 于多 李荣香 《中国临床医学影像杂志》 CAS 1999年第2期122-123,共2页
关键词 脑血管畸形 MR inflow PC法 血管成像
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创新驱动的大学生信息素养教育InFlow模型实证研究 被引量:3
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作者 黎景光 《图书馆论坛》 CSSCI 北大核心 2015年第11期92-99,共8页
文章通过文献分析法解构InFlow信息素养模型八个元素,提出InFlow具有创新能力培养为中心、多角色合作体系和非线性化模块灵活组合三大特征。以暨南大学InFlow模型实证研究为例,分析In Flow模型应用在信息素养教育中的成效和存在的问题... 文章通过文献分析法解构InFlow信息素养模型八个元素,提出InFlow具有创新能力培养为中心、多角色合作体系和非线性化模块灵活组合三大特征。以暨南大学InFlow模型实证研究为例,分析In Flow模型应用在信息素养教育中的成效和存在的问题。在结合案例分析和理论探讨的基础上提出信息素养教育应加强个人反思能力和思维形象化能力的训练,完善信息素养教育多角色合作机制,并通过建立InFlow教学案例数据库构建图书馆信息素养教学的学术圈和协同创新的平台。 展开更多
关键词 inflow 非线性模块 创新能力 反思能力 信息素养教育
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潜水泵站侧向进水前池流态调控措施的数值研究
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作者 徐鹏飞 徐燕 +3 位作者 徐贵颖 王旭 刘景禹 杨帆 《长江科学院院报》 北大核心 2026年第1期76-85,共10页
侧向来流易使前池内水体在变向的过程中产生脱流及回流现象,导致前池流态恶化、严重威胁泵站机组高效稳定运行。采用计算流体动力学(CFD)方法对大寨河泵站的进水建筑物进行了流场计算,并通过物理模型试验对数值计算方法的有效性加以验证... 侧向来流易使前池内水体在变向的过程中产生脱流及回流现象,导致前池流态恶化、严重威胁泵站机组高效稳定运行。采用计算流体动力学(CFD)方法对大寨河泵站的进水建筑物进行了流场计算,并通过物理模型试验对数值计算方法的有效性加以验证,定量和定性对比分析了采取导流格栅、整流坎和各型式导流墙共5种流场调控措施时前池及开敞式进水池的流场特征。结果表明:采用弧形导流墙和直线导流墙相结合的措施时流场调控效果最佳,该方案各潜水泵喇叭管进口面的轴向速度分布均匀度与初设方案相比平均提高了14.8%,速度加权平均角平均提高了9.2°,且采用弧形导流墙和直线导流墙相结合的措施时各机组间轴向速度分布均匀度的极差最小,优选的流场调控方案能为潜水泵站各机组提供较好的入流条件。研究成果可为本工程及类似侧向进水泵站工程提供重要参考。 展开更多
关键词 大寨河泵站 侧向进水前池 流场 调控措施 数值分析
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不同水文时期河流中典型抗生素的分配系数及其在沉积物中的生态风险
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作者 王浩加 李子琼 +5 位作者 郑子帅 李晓宁 高宇昂 杜兆楠 崔建升 张璐璐 《环境科学学报》 北大核心 2026年第1期178-193,共16页
抗生素在水体与沉积物中的分配行为受水体和沉积物理化性质共同调控,然而目前对不同水文时期典型河流中抗生素的分配行为及其生态风险研究相对有限.鉴于此,本研究以白洋淀流域府河、孝义河与白沟引河为研究区,于2023年非汛期(5月)和汛... 抗生素在水体与沉积物中的分配行为受水体和沉积物理化性质共同调控,然而目前对不同水文时期典型河流中抗生素的分配行为及其生态风险研究相对有限.鉴于此,本研究以白洋淀流域府河、孝义河与白沟引河为研究区,于2023年非汛期(5月)和汛期(8月)采集水体及沉积物样品,采用超高效液相色谱串联质谱法(HPLC-MS),分析磺胺类、喹诺酮类、四环素类及大环内酯类等35种抗生素的时空分布特征,计算典型抗生素在水体-沉积物中的分配系数(K_(d))及其在沉积物中的风险熵值(RQ).结果表明:水体和沉积物中分别检出35种和31种抗生素,水体和沉积物抗生素总浓度均值非汛期((34.4±31.2)ng·L^(-1)和(16.0±8.1)ng·g^(-1))高于汛期((21.2±12.6)ng·L^(-1)和(10.7±4.1)ng·g^(-1));其中,喹诺酮类(Quinolones,QNs)为水体与沉积物的主要抗生素(占比51%~73%);3条河流中抗生素K_(d)值范围为9.5~5481 L·kg^(-1),其中,QNs的K_(d)值(217~5481 L·kg^(-1))较高;相关性分析结果表明,K_(d)(TC)与中位粒径DV50呈显著负相关(ρ=-0.80,p<0.01)、K_(d)(NOR)与TP呈显著负相关(ρ=-0.70,p<0.01),而K_(d)(ERY)与水温(TEM)呈显著正相关(ρ=0.70,p<0.01);沉积物中抗生素生态评价结果表明,吡哌酸(Pipemidic Acid,PIP)在孝义河与白沟引河沉积物中呈中风险(RQ=0.34~0.42),其余抗生素风险为低风险(RQ<0.1);联合生态风险结果表明3条河流中抗生素均为中风险.本研究结果揭示了不同水文时期典型入淀河流抗生素的赋存特征、分配行为及其生态风险,为白洋淀流域污染管控提供了重要科学依据. 展开更多
关键词 白洋淀流域 入淀河流 不同水文时期 抗生素 水-沉积物分配系数 生态风险
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基于井筒涌水量的大直径地面管道井透巷结构研究及应用
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作者 查显东 时元玲 +2 位作者 汪志祥 周峰 许波 《煤炭技术》 2026年第1期108-112,共5页
煤矿大直径地面透巷钻井技术,作为瓦斯综合治理、应急救援通道构建、巷道排水通风及物料高效输送的关键工程手段,在现代矿山安全生产中具有重要应用价值。以安徽临涣煤矿大直径地面排水管道井工程为研究对象,提出基于井筒涌水量预测的... 煤矿大直径地面透巷钻井技术,作为瓦斯综合治理、应急救援通道构建、巷道排水通风及物料高效输送的关键工程手段,在现代矿山安全生产中具有重要应用价值。以安徽临涣煤矿大直径地面排水管道井工程为研究对象,提出基于井筒涌水量预测的井身结构优化设计方法。钻井结构设计阶段,采用井筒涌水量预测模型计算涌水量,若井筒预测涌水量小于20 m^(3)/h时,可二开直接透巷,否则,需二开下入套管、固井,再进行三开透巷,防止地下水和岩屑涌入巷道引起灾害。工程实施阶段,采用电测绳法进行井筒水位和涌水量动态监测,保证透巷施工过程安全。 展开更多
关键词 大直径地面钻井 涌水量 透巷
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音猬因子信号通路调控小鼠胚胎心脏流出道的形成与分隔
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作者 姚凯宁 闫玉楠 +4 位作者 周祎凡 师亮 曹锡梅 Zeeshan Rahim 杨艳萍 《中国组织工程研究》 北大核心 2026年第16期4077-4087,共11页
背景:第二生心区及心脏神经嵴共同参与流出道的形成与分隔,但音猬因子信号通路在该过程中调控作用的确切机制尚未明确。目的:探究第二生心区形成过程中音猬因子信号通路各组分的调控作用,确认音猬因子信号通路在流出道形成与分隔过程中... 背景:第二生心区及心脏神经嵴共同参与流出道的形成与分隔,但音猬因子信号通路在该过程中调控作用的确切机制尚未明确。目的:探究第二生心区形成过程中音猬因子信号通路各组分的调控作用,确认音猬因子信号通路在流出道形成与分隔过程中的调控作用。方法:从妊娠ICR小鼠中获取胚龄10-15 d小鼠胚胎作为实验材料,经石蜡包埋后制备连续切片样本,通过免疫组化染色、免疫荧光双染实验观察胰岛素基因增强结合蛋白1、音猬因子、Ptch1、Ptch2、Smoothened、Gli3及骨形态发生蛋白2的时空表达模式;剥离10.5 d胚龄小鼠胚胎的前肠与相邻间充质,通过蛋白印迹分析与免疫共沉淀实验探究音猬因子信号通路与骨形态发生蛋白和第二生心区细胞与心脏神经嵴细胞之间的关系。结果与结论:①在胚龄10-11.5 d小鼠胚胎中,音猬因子与Gli3的表达见于咽内胚层,而Ptch1、Ptch2与Smoothened表达与呼吸内胚层的发生相偶联;呼吸内胚层形成导致胰岛素基因增强结合蛋白1阳性第二生心区祖细胞增多并参与流出道的发育。音猬因子信号通路各组分未在鳃弓核心间充质表达,但出现于心包腔背侧壁。②在流出道心内膜垫形成与融合过程中,Ptch1、Ptch2与Smoothened表达于心肌,Gli3表达于心肌与心内膜垫的间充质细胞、主动脉与肺动脉干管壁。③在胚龄胚龄10.5-11 d小鼠胚胎中,胰岛素基因增强结合蛋白1和骨形态发生蛋白2的共表达分布于前肠内胚层及第二生心区;沿弓动脉分布的激活增强子结合蛋白2α阳性心脏神经嵴细胞同时表达Gli3或骨形态发生蛋白2,免疫共沉淀显示激活增强子结合蛋白2α与Gli3或骨形态发生蛋白2存在相互作用。④结果表明,音猬因子信号通路参与第二生心区发育,并且在第二生心区不同亚群的形成、迁移与分化过程中发挥不同作用;音猬因子信号通路在流出道心内膜垫形成与融合过程中持续产生作用;Gli3、骨形态发生蛋白2共同调节心脏神经嵴细胞的迁移。 展开更多
关键词 心脏流出道 第二生心区 心脏神经嵴 音猬因子信号通路 骨形态发生蛋白2 激活增强子结合蛋白2α
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基于耕地动态变化视角下的耕地空间布局优化研究
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作者 朱传广 朱文文 朱宏雁 《国土与自然资源研究》 2026年第2期32-36,共5页
新形势下国家对于耕地保护工作愈发重视,耕地动态管理、总量管控的模式也开始实施。在此背景下,把握区域内耕地动态变化规律,并结合变化规律研究耕地空间布局优化策略,完成耕地总量管控目标,成为当前耕地保护工作的研究重点。文章基于... 新形势下国家对于耕地保护工作愈发重视,耕地动态管理、总量管控的模式也开始实施。在此背景下,把握区域内耕地动态变化规律,并结合变化规律研究耕地空间布局优化策略,完成耕地总量管控目标,成为当前耕地保护工作的研究重点。文章基于第三次国土调查数据和2020-2024年国土变更调查数据,从时间和空间角度分析耕地动态变化规律,并结合规律预测区域内耕地流出和流入情况,优化区域内耕地空间布局,以期对区域内耕地保护工作提供重点方向和政策建议。 展开更多
关键词 耕地 耕地保护 耕地流出 耕地流入 耕地布局优化
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基于流入血管空间占有(VASO)MRI灌注技术在脑胶质瘤定性诊断与术前分级中的应用研究
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作者 陈超凡 杨胜娇 +2 位作者 肖静 邹雅琪 王伟 《罕少疾病杂志》 2026年第1期15-17,共3页
目的探讨基于流入血管空间占有(iVASO)-MRI灌注技术(MRI)在脑胶质瘤的定性及术前分级诊断中的价值。方法回顾性选取2021年1月至2024年1月我院收治的50例脑胶质瘤或单发脑转移瘤患者的临床资料,均于术前行iVASO-MRI扫描检查,分析iVASO-MR... 目的探讨基于流入血管空间占有(iVASO)-MRI灌注技术(MRI)在脑胶质瘤的定性及术前分级诊断中的价值。方法回顾性选取2021年1月至2024年1月我院收治的50例脑胶质瘤或单发脑转移瘤患者的临床资料,均于术前行iVASO-MRI扫描检查,分析iVASO-MRI灌注成像,对于脑胶质瘤患者,进行脑血容量(CBVa)值的比较,包括肿瘤实质区、瘤周水肿区以及对侧健康白质区。同时计算所有患者肿瘤实质区和瘤周水肿区的脑血容量比值,得到相对脑血容量(rCBVa),通过采用ROC曲线评估rCBVa值在诊断不同级别的脑胶质瘤以及不同性质的脑瘤方面的价值。结果脑胶质瘤患者的肿瘤实质区和瘤周水肿区所示CBVa值明显高于对侧健康白质区,且肿瘤实质区CBVa值高于瘤周水肿区(P<0.05);高级别脑胶质瘤患者肿瘤实质区和瘤周水肿区的rCBVa值均明显高于低级别脑胶质瘤患者,也高于单发脑转移瘤的患者(P<0.05);ROC曲线分析显示,诊断不同级别脑胶质瘤以及不同性质脑瘤rCBVa值的AUC分别为90.11%、91.03%;阈值分别是3.203、3.181,敏感度是85.40%、86.12%,特异度是89.12%、88.79%。结论由iVASO-MRI所获取的rCBVa值在脑胶质瘤中对不同性质诊断及术前分级评估具有重要的参考价值。 展开更多
关键词 流入血管空间灌注成像(VASO) 磁共振成像 小动脉血容量(CBVa) 脑胶质瘤 定性诊断
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基于PSO-BP神经网络矿井涌水量预测模型
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作者 李启兴 张宇 +1 位作者 乔秀杰 闫国成 《煤》 2026年第1期94-99,共6页
矿井涌水量的准确预测对矿山建设及煤层安全高效回采意义重大。文章以某华北型煤田煤矿为研究对象,该矿主要受石炭-二叠系砂岩裂隙含水层影响。研究采用时间序列分析方法、BP和PSO-BP神经网络模型构建多模型预测体系。通过聚类分析发现... 矿井涌水量的准确预测对矿山建设及煤层安全高效回采意义重大。文章以某华北型煤田煤矿为研究对象,该矿主要受石炭-二叠系砂岩裂隙含水层影响。研究采用时间序列分析方法、BP和PSO-BP神经网络模型构建多模型预测体系。通过聚类分析发现,该矿涌水量受季节性影响小,进而将其视为整体研究。时间序列模型预测结果表明,该模型有一定预测能力,但存在弊端。引入PSO-BP方法优化模型,对比BP神经网络等模型,结果显示PSO-BP神经网络预测模型准确性最高(R^(2)=0.9924,RMSE值为0.08219),为矿井涌水量精准预测、灾害预警及煤矿安全生产提供了有效方法和理论支撑。 展开更多
关键词 涌水量预测 时间序列模型 PSO-BP
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