Objective To investigate the value of BT-H3 in expressed prostatic secretions ( EPS) in differential diagnosis of patients with inflammatory elevation of PSA in t - PSA gray zone ( 4 - 10 ng /ml) . Methods One hundred...Objective To investigate the value of BT-H3 in expressed prostatic secretions ( EPS) in differential diagnosis of patients with inflammatory elevation of PSA in t - PSA gray zone ( 4 - 10 ng /ml) . Methods One hundred and sixteen patients from ages of 19 to 80 years ( mean,40 years) were studied. In the group there展开更多
When lipopolysaccharide(LPS)enters the cell cytosol,it can bind to mouse caspase-11 and human caspase-4/5 and induce self-cleavage of these molecules[1].After self-cutting,caspase-11 assembles into homodimers and clea...When lipopolysaccharide(LPS)enters the cell cytosol,it can bind to mouse caspase-11 and human caspase-4/5 and induce self-cleavage of these molecules[1].After self-cutting,caspase-11 assembles into homodimers and cleaves gasdermin D(GSDMD)[2,3].With the help of the nuclear orphan receptor NUR77[4],non-canonical inflammasomes can also activate the nucleotide-binding and oligomerization domain(NOD)-like receptor(NLR)family pyrin domain containing 3(NLRP3)inflammasome to secrete inflammatory cytokines interleukin-1b(IL-1b).展开更多
文摘Objective To investigate the value of BT-H3 in expressed prostatic secretions ( EPS) in differential diagnosis of patients with inflammatory elevation of PSA in t - PSA gray zone ( 4 - 10 ng /ml) . Methods One hundred and sixteen patients from ages of 19 to 80 years ( mean,40 years) were studied. In the group there
基金supported by the National Natural Science Foundation of China(grant numbers 92369104,82271790,92169113,and 22174003)Beijing Natural Science Foundation(grant number JG23028)+1 种基金the National Key R&D Program of China(grant numbers 2021YFA1300202,2022YFC2302900,and 2022YFA1304500)Fok Ying Tung Education Foundation to P.X.
文摘When lipopolysaccharide(LPS)enters the cell cytosol,it can bind to mouse caspase-11 and human caspase-4/5 and induce self-cleavage of these molecules[1].After self-cutting,caspase-11 assembles into homodimers and cleaves gasdermin D(GSDMD)[2,3].With the help of the nuclear orphan receptor NUR77[4],non-canonical inflammasomes can also activate the nucleotide-binding and oligomerization domain(NOD)-like receptor(NLR)family pyrin domain containing 3(NLRP3)inflammasome to secrete inflammatory cytokines interleukin-1b(IL-1b).
