BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients oft...BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients often experience bad moods,sleep disorders,and other health issues.Despite recognizing these factors,no studies have examined the correlation between inflammatory factors,lactic acid levels,ASF,mood disturbances,and sleep quality in critically ill patients.We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality,which may inform clinical treatment for septic shock and ASF.AIM To explore the relationship between inflammatory factors,lactic acid levels,the severity of ASF,bad mood,and sleep quality.METHODS The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University,categorized into ASF(n=35)or non-ASF groups(n=115).We compared the peripheral blood inflammatory factors,including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),lactic acid levels,skin mottling score(SMS),modified early warning score(MEWS),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and Pittsburgh sleep quality index(PSQI)scores.Pearson correlation analysis assessed relationships among these variables.RESULTS The ASF group had significantly higher levels of CRP(19.60±4.10 vs 15.30±2.96 mg/mL),IL-6(298.65±48.65 vs 268.66±33.66 pg/L),procalcitonin,lactic acid(8.42±2.32 vs 5.70±1.27 mmol/L),SMS[0(0,1)vs 3(2,3)],MEWS(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),and PSQI scores(14.23±3.94 vs 8.69±2.46)compared with the non-ASF group(all P<0.001).Pearson correlation analysis revealed that IL-6,CRP,TNF-α,and lactic acid were positively correlated with SMS,MEWS,SAS,SDS,and PSQI scores(P<0.05).CONCLUSION Peripheral blood levels of IL-6,CRP,TNF-α,and lactic acid correlate positively with SMS,MEWS,SAS,SDS,and PSQI in critically ill patients with ASF.展开更多
BACKGROUND The incidence of chronic wounds is rising due to an aging population and lifestyle changes in our country.In addition,as the disease spectrum evolves,chronic wounds have become common clinical issues that s...BACKGROUND The incidence of chronic wounds is rising due to an aging population and lifestyle changes in our country.In addition,as the disease spectrum evolves,chronic wounds have become common clinical issues that seriously threaten health and impose significant social and economic burdens.AIM To investigate how depression,anxiety,peripheral blood inflammatory factors,and stress levels affect therapeutic outcomes in patients with chronic wounds.METHODS Retrospectively collected clinical data from 110 patients with chronic wounds treated at Changde Hospital,Xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)between January 2021 and December 2023,categorizing them into effective and ineffective groups based on treatment effects.Differences between both groups were analyzed using univariate analysis,independent risk factors identified via logistic regression,and their predictive value assessed through receiver operating characteristic analysis.RESULTS Following treatment,95 cases were classified as the effective group(cured or improved),while 15 cases with improvement formed the ineffective group.Significant differences between both groups were noted in wound area,infection status,daily bed time,Hamilton Anxiety Rating Scale(HAMA)scores,Hamilton Depression Rating Scale(HAMD)scores,and levels of interleukin-6,tumor necrosis factor-alpha,and superoxide dismutase(P<0.05).Logistic regression analysis identified a wound area≥7 cm^(2),HAMA≥9 scores,and HAMD≥8 scores were independent risk factors for ineffective treatment in patients with chronic wounds(P<0.05).The receiver operating characteristic curve analysis revealed that the area under the curve for ineffective treatment based on wound area,HAMA,and HAMD was 0.767,0.805,and 0.768 respectively.CONCLUSION Wound size,anxiety,and depression are significant factors influencing the therapeutic outcomes in patients with chronic wounds that require careful attention,alongside the development of appropriate strategies.展开更多
This study examines the impact of digital literacy on the levels of depressive symptoms of older adults,utilizing data from the 2022 China Family Panel Studies(CFPS).Factor analysis was used to construct digital liter...This study examines the impact of digital literacy on the levels of depressive symptoms of older adults,utilizing data from the 2022 China Family Panel Studies(CFPS).Factor analysis was used to construct digital literacy indicators,and OLS multiple linear regression modeling was carried out;the results demonstrate that digital literacy exerts a significant negative influence on depressive symptoms in older adults(β=-0.5385,p<0.01),and the findings are robust.Mechanism analysis reveals that digital literacy reduces depressive symptoms by enhancing future confidence(the mediation effect accounts for 18.0%).Heterogeneity analysis also indicates that there are more pronounced depressive symptoms-alleviating effects among male,married,and younger-old adults(aged 60-79)(p<0.01).Policy recommendations include implementing tiered digital literacy education programs with targeted support for vulnerable groups,enriching digital education resources through dedicated digital service platforms for the elderly,and strengthening psychological interventions to boost future confidence for effective depressive symptoms mitigation.展开更多
Under the new development pattern,promoting the balanced development of the regional life service level is the key to attaining the goal of meeting people’s need for an improved life.This study constructed an index s...Under the new development pattern,promoting the balanced development of the regional life service level is the key to attaining the goal of meeting people’s need for an improved life.This study constructed an index system with six dimensions,namely,economic base,innovation drive,living environment,transportation,public services and life security,and explored the balanced characteristics and obstacles of the life service level in the Yangtze River Delta,China in 2020 using the Gini coefficient,the standard deviation ellipse,the global spatial autocorrelation,the equilibrium entropy and the obstacle degree model.Results show that:1)the current overall level of life services in the Yangtze River Delta is in relative equilibrium,and the Gini coefficient of three dimensions,namely,economic base,innovation drive and life security,is relatively low and on the verge of imbalance.2)The spatial pattern of the six dimensions of the overall level of the life service is oriented toward the‘southeast-northwest’direction with significant spatial differentiation and spatial agglomeration.3)At present,most of the cities have a comparative advantage in the coordination of their life services,and the potential of their life service system shows room for further improvement in the future.4)Currently,the quality of economic development,talent concentration,innovation inputs,innovation outputs,basic education,health care,cultural sharing,the living standards of the urban and rural residents and the construction of a transportation system are the main factors constraining the improvement of the level of life services in the Yangtze River Delta.This study attempts to research on the evaluation and measurement of regional life service level in the new era,and provides a reference for the promotion of regional coordination and sustainable development.展开更多
BACKGROUND Acute myeloid leukemia(AML)is a disease in which immature hematopoietic cells accumulate in the bone marrow and continuously expand,inhibiting hematopoiesis.The treatment and prognosis of this disease have ...BACKGROUND Acute myeloid leukemia(AML)is a disease in which immature hematopoietic cells accumulate in the bone marrow and continuously expand,inhibiting hematopoiesis.The treatment and prognosis of this disease have always been unsatisfactory.AIM To investigate the correlation between vascular endothelial growth factor(VEGF)and transforming growth factor-β1(TGFβ1)expression and prognosis in older adults with AML.METHODS This study enrolled 80 patients with AML(AML group),including 36 with complete response(AML-CR),23 with partial response(AML-PR),and 21 with no response(AML-NR).The expression levels of VEGF and TGFβ1 were detected by reverse transcription polymerase chain reaction in bone marrow mononuclear cells isolated from 56 healthy controls.Kaplan-Meier analysis was performed to assess overall survival(OS)and progression-or disease-free survival(DFS).Prognostic risk factors were analyzed using a Cox proportional hazards model.RESULTS The AML group showed a VEGF level of 2.68±0.16.VEGF expression was lower in patients with AML-CR than those with AML-PR or AML-NR(P<0.05).TGFβ1 expression in the AML group was 0.33±0.05.Patients with AML-CR showed a higher TGFβ1 expression than those with AML-PR or AML-NR(P<0.05).VEGF and TGFβ1 expression in patients with AML was significantly correlated with the counts of leukocytes,platelets,hemoglobin,and peripheral blood immature cells(P<0.05);Kaplan-Meier survival analysis revealed that patients with high TGFβ1 expression had better OS and DFS than those with low TGFβ1 expression(P<0.05),whereas patients with low VEGF levels showed better OS and DFS than those with high VEGF levels(P<0.05).VEGF,TGFβ1,and platelet count were identified by the Cox proportional hazards model as independent risk factors for OS(P<0.05),while VEGF,TGFβ1,and white blood cell count were independent risk factors for DFS(P<0.05).CONCLUSION Decreased VEGF expression and increased TGFβ1 expression in patients with AML provide valuable references for determining and individualizing clinical treatment strategies.展开更多
The research concluded peasants＇ willingness on homestead exiting and influential factors by questionnaire survey and interviewing in two villages with varied levels of economic development in Anhui Province.Comparis...The research concluded peasants＇ willingness on homestead exiting and influential factors by questionnaire survey and interviewing in two villages with varied levels of economic development in Anhui Province.Comparisons were performed on subjective factors and objective factors were explored by Logistic regression.The results showed that both of education background and homestead use have positive correlation with peasants＇ willingness on homestead exit;the number of family members has negative effects on peasants in advanced village but the number of migrant workers or members living in cities has positive effects;the area of homestead has positive effects on peasants in underdeveloped village.Therefore,the emphasis should be varied on homestead exit upon village economy and it is necessary to reinforce homestead exit promotion at improving immigrants＇ reception work,social security,employment,and education.展开更多
This paper focuses on the dynamic variation of groundwater level in Lhasacity. According to the data, the obvious characteristic of the groundwater level of the city is thatit is changing seasonally. Lhasa is divided ...This paper focuses on the dynamic variation of groundwater level in Lhasacity. According to the data, the obvious characteristic of the groundwater level of the city is thatit is changing seasonally. Lhasa is divided into three districts according to hydrogeologicalconditions: the alluvial plain of the Lhasa-river, the alluvial plain of the Doilung-river, and thealluvial fan of inter mountain, which presents a downward trend, a slight upward trend and basicallystabilizing trend over the years individually. The analysis indicates that meteorological andhydrological factors lead to the obvious dynamic change of the groundwater level. However, more andmore human activities and over-exploitation of the groundwater cause the downward trend inthegroundwater level.展开更多
AIM：To detect the impact of insulin-like growth factor-1（IGF-1）and other risk factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clini...AIM：To detect the impact of insulin-like growth factor-1（IGF-1）and other risk factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels.METHODS：The study was conducted with 127 preterm infants.IGF-1 levels in the 1st day of life,1st,2nd,3rd and4th week of life was analyzed.The score was established after logistic regression analysis,considering the impact of each variable on the occurrences of any stage ROP.A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated.RESULTS：Birth weights（BW）,gestational weeks（GW）and the prevalence of breast milk consumption were lower,respiratory distress syndrome（RDS）,bronchopulmonarydysplasia（BPD）and necrotizing enterocolitis（NEC）were more frequent,the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP（P〈0.05）.Initial serum IGF-1 levels tended to be lower in newborns who developed ROP.Logistic regression analysis revealed that low BW（〈1250 g）,presence of intraventricular hemorrhage（IVH）and formula feeding increased the risk of ROP.Afterwards,the scoring system was validated on 107 infants.The negative predictive values of a score less than 4 were 84.3%,74.7%and 79.8%while positive predictive values were 76.3%,65.5%and71.6%respectively.CONCLUSION：In addition to BW〈1250 g and IVH,formula consumption was detected as a risk factor for the development of ROP.Breastfeeding is important for prevention of ROP in preterm infants.展开更多
Background: The aim of the current study was to evaluate the anthropometric and demographic factors and their correlation with type 2 diabetes mellitus (T2DM) in Bangladesh. Methods: One hundred fourteen patients (70 ...Background: The aim of the current study was to evaluate the anthropometric and demographic factors and their correlation with type 2 diabetes mellitus (T2DM) in Bangladesh. Methods: One hundred fourteen patients (70 males and 44 females) between 30 and 75 years of age from various areas of Bangladesh were screened for T2DM. Fasting blood sugar (FBS) was analyzed by using laboratory kits and spectrophotometric technique. Anthropometric and socio-demographic data were collected using a structured questionnaire. Body mass index (BMI) was calculated from weight (kg) and height (m) of the individual respondents. Physical activity was categorized based on activity during daily work. Economic condition is defined by respective family income and education level is categorized into 3 levels: illiterate, 0 - 12 years of education and graduate or above. Results: According to the current study results, half of the patients were from the middle-class family with low physical activity and their age was within the range of 30 - 45 years. The male and female ratio of the study population was 60:40. Most of the patients were found to be obese and educated. Urban populations were more prone to have DM than the rural population. Age, education, the area of residence (urban and rural), physical activity and co-morbid diseases were significantly correlated with T2DM in Bangladesh (P Conclusion: Our study shows that different socio-demographic factors have a significant correlation with T2DM in Bangladesh. Diabetes awareness, early diagnosis, patient education and life-style modification can be initiated to manage T2DM efficiently.展开更多
Objective： The plasma fibrinogen levels had not only been used as an independent prognostic parameter for the patients with non-small cell lung cancer （NSCLC）, but also as a promising biomarker for evaluating the e...Objective： The plasma fibrinogen levels had not only been used as an independent prognostic parameter for the patients with non-small cell lung cancer （NSCLC）, but also as a promising biomarker for evaluating the efficacy of chemotherapy. This study aimed to investigate the correlation between the plasma fibrinogen levels and epidermal growth factor receptor （EGFR） gene mutation and clinical-pathological characteristics of Chinese patients with NSCLC. Methods： In this retrospective study, NSCLC specimens collected from 352 patients between November 2009 and November 2011 were selected to detect EGFR gene mutation with real-time polymerase chain reaction （RT-PCR）. In these specimens, 308 ones were also detected EGFR gene copy number with fluorescence in situ hybridization （FISH）. Coagulation makers were examined prior to the operations. The association between the plasma fibrinogen levels and EGFR gene mutation and clinical-pathological characteristics were analyzed using SPSS 16.0 software. Results： The median pre-operation plasma fibrinogen level was 3.55 g/L （109/352） patients with higher plasma fibrinogen level （〉 4.0 g/L）. The lower plasma fibrinogen levels correlated significantly with EGFR gene mutations （P 〈 0.001）, the similar result was seen in platelet counts （P = 0.026）. A linear correlation was found between the plasma fibrinogen levels and the platelet counts in NSCLC patients （R^2 = 0.209, P 〈 0.001）. Pre-peration plasma fibrinogen levels correlated with gender （P 〈 0.001）, smoking status （P 〈 0.001 ）, and histology （P 〈 0.001 ）. There were significant link between the above clinical-pathological characteristics and EGFR gene mutations. In addition, EGFR gene mutation was correlated with FISH-positive status （P 〈 0.001）. Moreover, both plasma fibrinogen level （P = 0.024） and the EGFR gene copy number （P = 0.040） had significant relationships with the pathological TNM stage. Conclusion： This study showed that a significant relevance between plasma fibrinogen levels and EGFR gene mutations. The plasma fibrinogen level might be as a clinical decision parameter for evaluating the efficacy of anti-EGFR tyrosine kinase inhibitors （TKIs） in NSCLC. The patients of NSCLC had higher indicate have poor benefits from anti-EFGR TKIs. In addition, pre-operation plasma fibrinogen level could be used as an indepedent prognostic biomarker for the patients with NSCLC.展开更多
BACKGROUND Anxiety complicates recovery in esophagectomy patients undergoing esophagectomy,while preoperative depressive symptoms may further delay surgeryassociated malnutrition resolution,highlighting a critical nee...BACKGROUND Anxiety complicates recovery in esophagectomy patients undergoing esophagectomy,while preoperative depressive symptoms may further delay surgeryassociated malnutrition resolution,highlighting a critical need for psychological intervention.AIM To explore the correlation of anxiety and depression with mindfulness levels in patients undergoing esophagectomy for esophageal cancer and analyze associated risk factors.METHODS A total of 120 patients with esophageal cancer,all of whom underwent esophagectomy in The Affiliated Yongchuan Hospital of Chongqing Medical University between September 2022 and September 2024,were enrolled.The hospital anxiety and depression scale(HADS)was utilized to evaluate the anxiety(HADS-anxiety subscale,HADS-A)and depression(HADS-depression subscale,HADS-D)levels of these patients,and the Mindful Attention Awareness Scale(MAAS)was employed to assess their mindfulness levels.The relationships among anxiety,depression,and mindfulness levels were analyzed,and both univariate and multivariate analyses were conducted to identify the risk factors for anxiety and depression in these patients.RESULTS Data revealed that the mean HADS-A score of patients undergoing esophagectomy was(10.43±4.24)points,and 40.00%,35.00%,and 10.83%of the patients had mild,moderate,and severe anxiety,respectively.The mean HADS-D score https://www.wjgnet.com 2 September 19,2025 Volume 15 Issue 9 was(9.20±4.66)points,and 37.50%,23.33%,and 9.17%of the patients had mild,moderate,and severe depression,respectively.Patients with negative or mild anxiety(or depression)exhibited significantly higher MAAS scores than those with moderate or severe anxiety(or depression).The HADS-A and HADS-D scores showed a strong and negative correlation with the MAAS score.Univariate and multivariate analyses demonstrated that sex(P=0.006),age(P=0.017),per capita monthly household income(P=0.005),and educational level(P=0.004)were all independently associated with the exacerbation of anxiety in patients undergoing esophagectomy.Age(P=0.026),living status(P=0.005),per capita monthly household income(P=0.024),educational level(P=0.002),and postoperative complications(P<0.001)were all independently related to the aggravation of depression in such patients.CONCLUSION This study indicated a significant negative correlation among anxiety,depression,and mindfulness levels in patients undergoing esophagectomy.Sex,age,per capita monthly household income,and educational level were risk factors for anxiety in patients undergoing esophagectomy,whereas age,living status,per capita monthly household income,educational level,and postoperative complications were risk factors for depression.展开更多
AIM:To evaluate the prevalence of myopia and identify its associated risk factors among children and adolescents in Xi’an,China.METHODS:In a school-based cross-sectional design,students ranging from kindergarten to h...AIM:To evaluate the prevalence of myopia and identify its associated risk factors among children and adolescents in Xi’an,China.METHODS:In a school-based cross-sectional design,students ranging from kindergarten to high school across Xi’an were enrolled.Ophthalmic examinations were performed to assess refractive status via non-cycloplegic refraction.Myopia was defined as SE≤-0.5 D,with stratification into mild(SE:≤-0.5 to>-3.0 D),moderate(SE:≤-3.0 to>-6.0 D),and high myopia(SE≤-6.0 D).Data on potential risk factors such as age,gender,and educational level were obtained through structured questionnaires.RESULTS:The study included 156416 participants,with 81389 boys(52.0%)and 75027 girls(48.0%).The prevalence rates of myopia were 65.67%for boys and 68.83%for girls.Data collection occurred over two consecutive years,2021 and 2022,with 78849 and 77567 participants,respectively.The prevalence of myopia was 67.65%in 2021 and decreased slightly to 66.71%in 2022.The high myopia rates were 3.85%and 3.43%for these years,respectively.Analysis revealed significant risk factors including gender,age,and educational level,with a distinct positive correlation between increased educational level and higher myopia prevalence.Notably,both genders exhibited a significant decrease in moderate myopia over the study period,with reductions of 1.7%and 1.2%.CONCLUSION:This comprehensive study underscores the substantial prevalence of myopia among school-aged children and adolescents in Xi’an,marking it as a significant public health concern.The correlation with higher educational levels suggests the need for targeted interventions aimed at myopia prevention and management.These findings contribute critically to the body of knowledge necessary for formulating effective public health strategies in Xi’an and potentially other similar regions.展开更多
BACKGROUND Gastric cancer(GC)and head and neck squamous cell carcinoma(HNSCC)are common malignancies with high morbidity and mortality rates.Traditional treatments often yield limited efficacy,especially in advanced c...BACKGROUND Gastric cancer(GC)and head and neck squamous cell carcinoma(HNSCC)are common malignancies with high morbidity and mortality rates.Traditional treatments often yield limited efficacy,especially in advanced cases.Recent advancements in immunotherapy,particularly immune checkpoint inhibitors targeting programmed death-ligand 1(PD-L1),have shown promise.However,the expression and interaction of pescadillo ribosomal biogenesis factor 1(PES1)and PD-L1 in these cancers remain unclear.Understanding their roles could provide new insights into tumor biology and improve therapeutic strategies.AIM To investigate the expression levels of PES1 and PD-L1 in tumor tissues of patients with GC and HNSCC.METHODS A total of 58 cases of GC and HNSCC undergoing surgical resection were selected from January 2022 to January 2024.Paraffin specimens of GC and HNSCC tissues were taken from the patients,and the sections were subjected to staining with immunohistochemistry and hematoxylin-eosin staining,and the protein expression of PES1 and PD-L1 was observed microscopically.RESULTS Among 58 GC and HNSCC tissues,30 cases were positive and 28 cases were negative for PES1 expression,and 34 cases were positive and 24 cases were negative for PD-L1 expression.The positive expression rates of PES1 and PDL1 were 51.72% and 58.62%,respectively.PES1 expression was correlated with the TNM stage,lymph node metastasis,and the depth of infiltration(P<0.05),and PD-L1 expression was correlated with the differentiation degree,lymph node metastasis,and infiltration depth(P<0.05).CONCLUSION PES1 and PD-L1 were positively expressed in GC and HNSCC tissues and correlated with clinical features.They may serve as potential biomarkers for immune-targeted therapies.展开更多
Objectives Mu Lao Zu population.Methods A total of 1055 subjects of Mu Lao Zu were studied by a stratified randomized cluster sampling.Blood pressure,body height, body weight,waist circumference and serum lipid and ap...Objectives Mu Lao Zu population.Methods A total of 1055 subjects of Mu Lao Zu were studied by a stratified randomized cluster sampling.Blood pressure,body height, body weight,waist circumference and serum lipid and apolipoprotein(Apo) levels were measured.The data were compared with those in 969 subjects of Han Chinese from the same region.In order to evaluate the association of hyperlipidemia with nine possible riks factors,multivariate logistic regression analysis was also performed in the combined population of Mu Lao Zu and Han,Mu Lao Zu,and Han;respectively. Results The levels of total cholesterol,triglyceride, low-density lipoprotein cholesterol and ApoB in Mu Lao Zu were significantly higher than those in Han(P【0.05-0.001); but the levels of high-density lipoprotein cholesterol,ApoA1 and ApoA1/Apo were significantly lower than those in Han (P【0.001 ).The prevalence of hyperlipidemia and Hypercholesterolemia was also significantly higher in Mu Lao Zu than in Han(53.0%vs.46.1%,P【0.001) and(44.5%vs. 37.5%,P【0.001).There was no difference in the prevalence of hypertriglyceridemia between the both ethnic groups (22.8%vs.19.4%,P】0.05).Hyperlipidemia was positively correlated with age,BMI,and systolic blood pressureMu Lao Zu(P【0.05),whereas it was positively correlated with BMI and hypertension in Han(P【0.05 for each).Conclusions The serum lipid profiles,the prevalence of hyperlipidemia and the risk factors are different between the Mu Lao Zu and Han populations.The differences in serum lipid profiles between the two ethnic groups might result from different dietary habit,life style,as well as genetic factors,in ? To determine the serum lipid levels and their risk factors in the Guangxi.展开更多
Background: Self-efficacy has been identified as an important determinant of youth's behavior change including physical activity(PA) participation. However, the dimensionality check of a PA self-efficacy scale has...Background: Self-efficacy has been identified as an important determinant of youth's behavior change including physical activity(PA) participation. However, the dimensionality check of a PA self-efficacy scale has rarely been conducted in China. The current study aims to examine(1) the unidimensionality of a shortened Chinese version of PA self-efficacy scale(S-PASESC);(2) the measurement invariance of S-PASESC across gender and levels of education;(3) the latent factor mean difference between gender and levels of education;(4) the direct effects of self-efficacy on PA by different gender and education levels; and(5) the comparisons of the direct effects of self-efficacy on PA across gender and education levels.Methods: The participants were 5 th through 11 th grade public school students recruited from 7 cities located in different geographic regions of China. The final data include a total of 3003 participants(49.7% boys) who have completed the scales.Results: Confirmatory factor analysis(CFA) test supported the unidimensionality of S-PASESC. The S-PASESC is invariant across gender and 3 levels of education at both configural, full metric, and full scalar levels. Findings from latent mean comparisons showed that boys reported higher PA self-efficacy than girls. Students' perceived PA self-efficacy tend to decrease from elementary to high school. Finally, self-efficacy positively related to PA by groups of different gender and education levels and the relationship between self-efficacy and PA is stronger among middle school boys than girls.Conclusion: Findings suggest S-PASESC is a valid scale for measuring Chinese students' PA self-efficacy.展开更多
According to the 2010 China Statistical Yearbook,a total of 12 indicators in the aspects of residents' production,consumption expenditure,and living conditions are selected in order to construct the indicator syst...According to the 2010 China Statistical Yearbook,a total of 12 indicators in the aspects of residents' production,consumption expenditure,and living conditions are selected in order to construct the indicator system of rural development level.Both factor analysis and cluster analysis methods are adopted to compare the current situations of rural development levels in 31 provinces and regions of China.Result of factor analysis shows that the 12 indicators can be classified into 4 factors,such as the income and expenditure factor,the agricultural scale and science and technology factor,the life quality factor,and the agricultural output factor.Moreover,factors affecting the rural development level of China are analyzed.Then,the 31 provinces and regions are divided into 4 categories according to the development levels in rural areas:the first category is Shanghai,Beijing and Zhejiang,which have the highest development level in rural areas;the second category includes Jiangsu,Shandong and Tianjin,which take the 4th to 6th places;the third category is Guangdong,Jilin,Liaoning,Hebei,Fujian,Heilongjiang,Henan,Inner Mongolia,Anhui,Hubei,Hunan and Jiangxi,which rank the 7th-18th;and the fourth category includes Sichuan,Hainan,Ningxia,Shanxi,Guangxi,Shanxi,Xinjiang,Chongqing,Tibet,Yunnan,Gansu,Qinghai and Guizhou,taking the 19th-31st places.展开更多
BACKGROUND Preoperative chemoradiotherapy(CRT)is a standard treatment modality for locally advanced rectal cancer.However,CRT alone cannot improve overall survival.Approximately 20%of patients with CRT-resistant tumor...BACKGROUND Preoperative chemoradiotherapy(CRT)is a standard treatment modality for locally advanced rectal cancer.However,CRT alone cannot improve overall survival.Approximately 20%of patients with CRT-resistant tumors show disease progression.Therefore,predictive factors for treatment response are needed to identify patients who will benefit from CRT.We theorized that the prognosis may vary if patients are classified according to pre-to post-CRT changes in carcinoembryonic antigen(CEA)levels.AIM To identify patients with locally advanced rectal cancer for preoperative chemoradiotherapy based on carcinoembryonic antigen levels.METHODS We retrospectively included locally advanced rectal cancer patients who underwent preoperative CRT and curative resection between 2011 and 2017.Patients were assigned to groups A,B,and C based on pre-and post-CRT serum CEA levels:Both>5;pre>5 and post≤5;and both≤5 ng/mL,respectively.We compared the response to CRT based on changes in serum CEA levels.Receiver operating characteristic curve analysis was performed to determine optimal cutoff for neutrophil–lymphocyte ratio and platelet–lymphocyte ratio.Multivariate logistic regression analysis was used to evaluate the prognostic factors for pathologic complete response(pCR)/good response.RESULTS The cohort comprised 145 patients;of them,27,43,and 65 belonged to groups A,B,and C,respectively,according to changes in serum CEA levels before and after CRT.Pre-(P<0.001)and post-CRT(P<0.001)CEA levels and the ratio of downstaging(P=0.013)were higher in Groups B and C than in Group A.The ratio of pathologic tumor regression grade 0/1 significantly differed among the groups(P=0.003).Group C had the highest number of patients showing pCR(P<0.001).Most patients with pCR showed pre-and post-CRT CEA levels<5 ng/mL(P<0.001,P=0.008).Pre-and post-CRT CEA levels were important risk factors for pCR(OR=18.71;95%CI:4.62–129.51,P<0.001)and good response(OR=5.07;95%CI:1.92–14.83,P=0.002),respectively.Pre-CRT neutrophil–lymphocyte ratio and post-CRT T≥3 stage were also prognostic factors for pCR or good response.CONCLUSION Pre-and post-CRT CEA levels,as well as change in CEA levels,were prognostic markers for treatment response to CRT and may facilitate treatment individualization for rectal cancer.展开更多
In this study, we searched multiple databases for all relevant original articles (1996-2013). To investigate blood lead levels (BLL) and possible risk factors for lead exposure among children in China A total of 388 a...In this study, we searched multiple databases for all relevant original articles (1996-2013). To investigate blood lead levels (BLL) and possible risk factors for lead exposure among children in China A total of 388 articles met our inclusion criteria. The overall geometric mean (GM) BLL was 71 μg/L, and the prevalence of elevated BLL (EBLL, defined as BLL ≥100 μg/L) was 18.48% among children. The prevalence of EBLL remained significantly higher among boys. In children less than 6 years of age, there were significantly increasing trends in both BLL and prevalence of EBLL in an age-dependent manner. The ban on leaded gasoline significantly reduced the BLL as well as EBLL prevalence; however, children whose parents had lower educational levels or were exposed to lead in the workplace had a higher EBLL prevalence. Despite its decline over time, the average BLL among children in China remains higher than the average level most recently reported in the United States. Childhood lead poisoning remains a public health problem in China.展开更多
BACKGROUND Patients with thalamic infarction experience abnormal blockages of multinuc-leated vessels,affecting the body and thereby the thalamus.Most patients with thalamic infarction have an adverse prognosis,which ...BACKGROUND Patients with thalamic infarction experience abnormal blockages of multinuc-leated vessels,affecting the body and thereby the thalamus.Most patients with thalamic infarction have an adverse prognosis,which seriously affects their safety.Therefore,it is essential to analyze the independent risk factors that influence the prognosis of patients with thalamic infarction and develop corresponding preventive measures.AIM To explore the effect of non-high-density lipoprotein cholesterol(non-HDL-C)and Homocysteine(Hcy)levels in cognitive impairment in thalamic infarction.METHODS From March 2019 to March 2022,80 patients with thalamic infarction were divided into a group with cognitive impairment[Montreal Cognitive Assessment(MoCA)score<26;35 patients]and a group with normal cognitive function(MoCA score of 26-30;45 patients)according to the MoCA score.In addition,50 healthy people in the same period were selected as the control group.A correlation between the non-HDL-C and Hcy levels and the MoCA score and receiver operating characteristic curve was observed,and the serum non-HDL-C and Hcy levels were analyzed for the diagnosis of cognitive impairment in patients with thalamic infarction.According to the Modified Rankin Scale(MRS)score,80 patients with thalamic infarction were divided into a good prognosis group(MRS score≤2)and a poor prognosis group(MRS score>2).RESULTS The non-HDL-C and Hcy levels were significantly higher in the group with cognitive impairment than in the group with normal cognitive function(P<0.05).There was no significant difference in the non-HDL-C level between the control group and the group with normal cognitive function(P>0.05).The MoCA scores of the group with cognitive impairment were significantly lower than those of the group with normal cognitive function and the control group(P<0.05).There was a significant difference between the control group and the group with normal cognitive function(P<0.05).The non-HDL-C and Hcy levels were correlated with the MoCA score(P<0.05),cognitive impairment[areas under the curve(AUC)=0.709,95%confidence interval(95%CI):0.599-0.816],the non-HDL-C level,and could predict cognitive impairment in patients with thalamic infarction(AUC=0.738,95%CI:0.618-0.859).Hcy combined with non-HDL-C levels can predict cognitive impairment in patients with thalamic infarction(AUC=0.769,95%CI:0.721-0.895).RESULTS There were 50 patients in the good prognosis group and 30 patients in the poor prognosis group.Compared with the good prognosis group,in the poor prognosis group,the National Institutes of Health Stroke Scale(NIHSS)score,non-HDL-C level,Hcy level,large-area cerebral infarction,atrial fibrillation,and activated partial prothrombin time were statistically significant(P<0.05).The non-HDL-C level,the Hcy level,the NIHSS score,extensive cerebral serum,and atrial fibrillation may all be independent risk factors for poor prognosis in patients with thalamic infarction(P<0.05).CONCLUSION Non-HDL-C and Hcy levels are positively correlated with cognitive impairment in patients with thalamic infarction.Non-HDL-C and Hcy levels can be used in the diagnosis of cognitive impairment in patients with thalamic infarction,and the combined detection effect is better.The main factors affecting the prognosis of patients with thalamic infarction are the non-HDL-C level,the Hcy level,the NIHSS score,large-area cerebral infarction,and atrial fibrillation.Clinically,corresponding preventive measures can be formulated based on the above factors to prevent poor prognosis and reduce mortality.展开更多
Water level variations have caused numerous dam slope collapse disasters around the world,illustrating the large influence of water level fluctuations on dam slopes.The required indoor tests were conducted and a numer...Water level variations have caused numerous dam slope collapse disasters around the world,illustrating the large influence of water level fluctuations on dam slopes.The required indoor tests were conducted and a numerical model of an actual earth-filled dam was constructed to investigate the influences of the water level fluctuation rate and the hysteresis of the soil-water characteristic curve(SWCC)on the stability of the upstream dam slope.The results revealed that the free surface in the dam body for the desorption SWCC during water level fluctuations was higher than that for the adsorption SWCC,which would be more evident at higher water levels.The safety factor of the upstream dam slope initially decreased and then increased for the most dangerous water level as the water level rose and fell.The water level fluctuation rate mainly influenced the initial section of the safety factor variation curve,while the SWCC hysteresis mainly affected the minimum safety factor of the water level fluctuations.The desorption SWCC is suggested for engineering design.Furthermore,a quick prediction method is proposed to estimate the safety factor of upstream dam slopes with identical structures.展开更多
文摘BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients often experience bad moods,sleep disorders,and other health issues.Despite recognizing these factors,no studies have examined the correlation between inflammatory factors,lactic acid levels,ASF,mood disturbances,and sleep quality in critically ill patients.We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality,which may inform clinical treatment for septic shock and ASF.AIM To explore the relationship between inflammatory factors,lactic acid levels,the severity of ASF,bad mood,and sleep quality.METHODS The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University,categorized into ASF(n=35)or non-ASF groups(n=115).We compared the peripheral blood inflammatory factors,including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),lactic acid levels,skin mottling score(SMS),modified early warning score(MEWS),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and Pittsburgh sleep quality index(PSQI)scores.Pearson correlation analysis assessed relationships among these variables.RESULTS The ASF group had significantly higher levels of CRP(19.60±4.10 vs 15.30±2.96 mg/mL),IL-6(298.65±48.65 vs 268.66±33.66 pg/L),procalcitonin,lactic acid(8.42±2.32 vs 5.70±1.27 mmol/L),SMS[0(0,1)vs 3(2,3)],MEWS(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),and PSQI scores(14.23±3.94 vs 8.69±2.46)compared with the non-ASF group(all P<0.001).Pearson correlation analysis revealed that IL-6,CRP,TNF-α,and lactic acid were positively correlated with SMS,MEWS,SAS,SDS,and PSQI scores(P<0.05).CONCLUSION Peripheral blood levels of IL-6,CRP,TNF-α,and lactic acid correlate positively with SMS,MEWS,SAS,SDS,and PSQI in critically ill patients with ASF.
文摘BACKGROUND The incidence of chronic wounds is rising due to an aging population and lifestyle changes in our country.In addition,as the disease spectrum evolves,chronic wounds have become common clinical issues that seriously threaten health and impose significant social and economic burdens.AIM To investigate how depression,anxiety,peripheral blood inflammatory factors,and stress levels affect therapeutic outcomes in patients with chronic wounds.METHODS Retrospectively collected clinical data from 110 patients with chronic wounds treated at Changde Hospital,Xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)between January 2021 and December 2023,categorizing them into effective and ineffective groups based on treatment effects.Differences between both groups were analyzed using univariate analysis,independent risk factors identified via logistic regression,and their predictive value assessed through receiver operating characteristic analysis.RESULTS Following treatment,95 cases were classified as the effective group(cured or improved),while 15 cases with improvement formed the ineffective group.Significant differences between both groups were noted in wound area,infection status,daily bed time,Hamilton Anxiety Rating Scale(HAMA)scores,Hamilton Depression Rating Scale(HAMD)scores,and levels of interleukin-6,tumor necrosis factor-alpha,and superoxide dismutase(P<0.05).Logistic regression analysis identified a wound area≥7 cm^(2),HAMA≥9 scores,and HAMD≥8 scores were independent risk factors for ineffective treatment in patients with chronic wounds(P<0.05).The receiver operating characteristic curve analysis revealed that the area under the curve for ineffective treatment based on wound area,HAMA,and HAMD was 0.767,0.805,and 0.768 respectively.CONCLUSION Wound size,anxiety,and depression are significant factors influencing the therapeutic outcomes in patients with chronic wounds that require careful attention,alongside the development of appropriate strategies.
基金Research on the Implementation Path and Optimization of Labor Relations Consultation under the Platform Economy(ID:2024CSH048)a youth project of the National Social Science Fund of China.
文摘This study examines the impact of digital literacy on the levels of depressive symptoms of older adults,utilizing data from the 2022 China Family Panel Studies(CFPS).Factor analysis was used to construct digital literacy indicators,and OLS multiple linear regression modeling was carried out;the results demonstrate that digital literacy exerts a significant negative influence on depressive symptoms in older adults(β=-0.5385,p<0.01),and the findings are robust.Mechanism analysis reveals that digital literacy reduces depressive symptoms by enhancing future confidence(the mediation effect accounts for 18.0%).Heterogeneity analysis also indicates that there are more pronounced depressive symptoms-alleviating effects among male,married,and younger-old adults(aged 60-79)(p<0.01).Policy recommendations include implementing tiered digital literacy education programs with targeted support for vulnerable groups,enriching digital education resources through dedicated digital service platforms for the elderly,and strengthening psychological interventions to boost future confidence for effective depressive symptoms mitigation.
基金Under the auspices of National Natural Science Foundation of China(No.42371185)。
文摘Under the new development pattern,promoting the balanced development of the regional life service level is the key to attaining the goal of meeting people’s need for an improved life.This study constructed an index system with six dimensions,namely,economic base,innovation drive,living environment,transportation,public services and life security,and explored the balanced characteristics and obstacles of the life service level in the Yangtze River Delta,China in 2020 using the Gini coefficient,the standard deviation ellipse,the global spatial autocorrelation,the equilibrium entropy and the obstacle degree model.Results show that:1)the current overall level of life services in the Yangtze River Delta is in relative equilibrium,and the Gini coefficient of three dimensions,namely,economic base,innovation drive and life security,is relatively low and on the verge of imbalance.2)The spatial pattern of the six dimensions of the overall level of the life service is oriented toward the‘southeast-northwest’direction with significant spatial differentiation and spatial agglomeration.3)At present,most of the cities have a comparative advantage in the coordination of their life services,and the potential of their life service system shows room for further improvement in the future.4)Currently,the quality of economic development,talent concentration,innovation inputs,innovation outputs,basic education,health care,cultural sharing,the living standards of the urban and rural residents and the construction of a transportation system are the main factors constraining the improvement of the level of life services in the Yangtze River Delta.This study attempts to research on the evaluation and measurement of regional life service level in the new era,and provides a reference for the promotion of regional coordination and sustainable development.
基金the Ethic Committee of Suzhou Hospital of Anhui Medical University(Approval No.C2024003).
文摘BACKGROUND Acute myeloid leukemia(AML)is a disease in which immature hematopoietic cells accumulate in the bone marrow and continuously expand,inhibiting hematopoiesis.The treatment and prognosis of this disease have always been unsatisfactory.AIM To investigate the correlation between vascular endothelial growth factor(VEGF)and transforming growth factor-β1(TGFβ1)expression and prognosis in older adults with AML.METHODS This study enrolled 80 patients with AML(AML group),including 36 with complete response(AML-CR),23 with partial response(AML-PR),and 21 with no response(AML-NR).The expression levels of VEGF and TGFβ1 were detected by reverse transcription polymerase chain reaction in bone marrow mononuclear cells isolated from 56 healthy controls.Kaplan-Meier analysis was performed to assess overall survival(OS)and progression-or disease-free survival(DFS).Prognostic risk factors were analyzed using a Cox proportional hazards model.RESULTS The AML group showed a VEGF level of 2.68±0.16.VEGF expression was lower in patients with AML-CR than those with AML-PR or AML-NR(P<0.05).TGFβ1 expression in the AML group was 0.33±0.05.Patients with AML-CR showed a higher TGFβ1 expression than those with AML-PR or AML-NR(P<0.05).VEGF and TGFβ1 expression in patients with AML was significantly correlated with the counts of leukocytes,platelets,hemoglobin,and peripheral blood immature cells(P<0.05);Kaplan-Meier survival analysis revealed that patients with high TGFβ1 expression had better OS and DFS than those with low TGFβ1 expression(P<0.05),whereas patients with low VEGF levels showed better OS and DFS than those with high VEGF levels(P<0.05).VEGF,TGFβ1,and platelet count were identified by the Cox proportional hazards model as independent risk factors for OS(P<0.05),while VEGF,TGFβ1,and white blood cell count were independent risk factors for DFS(P<0.05).CONCLUSION Decreased VEGF expression and increased TGFβ1 expression in patients with AML provide valuable references for determining and individualizing clinical treatment strategies.
文摘The research concluded peasants＇ willingness on homestead exiting and influential factors by questionnaire survey and interviewing in two villages with varied levels of economic development in Anhui Province.Comparisons were performed on subjective factors and objective factors were explored by Logistic regression.The results showed that both of education background and homestead use have positive correlation with peasants＇ willingness on homestead exit;the number of family members has negative effects on peasants in advanced village but the number of migrant workers or members living in cities has positive effects;the area of homestead has positive effects on peasants in underdeveloped village.Therefore,the emphasis should be varied on homestead exit upon village economy and it is necessary to reinforce homestead exit promotion at improving immigrants＇ reception work,social security,employment,and education.
文摘This paper focuses on the dynamic variation of groundwater level in Lhasacity. According to the data, the obvious characteristic of the groundwater level of the city is thatit is changing seasonally. Lhasa is divided into three districts according to hydrogeologicalconditions: the alluvial plain of the Lhasa-river, the alluvial plain of the Doilung-river, and thealluvial fan of inter mountain, which presents a downward trend, a slight upward trend and basicallystabilizing trend over the years individually. The analysis indicates that meteorological andhydrological factors lead to the obvious dynamic change of the groundwater level. However, more andmore human activities and over-exploitation of the groundwater cause the downward trend inthegroundwater level.
文摘AIM：To detect the impact of insulin-like growth factor-1（IGF-1）and other risk factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels.METHODS：The study was conducted with 127 preterm infants.IGF-1 levels in the 1st day of life,1st,2nd,3rd and4th week of life was analyzed.The score was established after logistic regression analysis,considering the impact of each variable on the occurrences of any stage ROP.A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated.RESULTS：Birth weights（BW）,gestational weeks（GW）and the prevalence of breast milk consumption were lower,respiratory distress syndrome（RDS）,bronchopulmonarydysplasia（BPD）and necrotizing enterocolitis（NEC）were more frequent,the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP（P〈0.05）.Initial serum IGF-1 levels tended to be lower in newborns who developed ROP.Logistic regression analysis revealed that low BW（〈1250 g）,presence of intraventricular hemorrhage（IVH）and formula feeding increased the risk of ROP.Afterwards,the scoring system was validated on 107 infants.The negative predictive values of a score less than 4 were 84.3%,74.7%and 79.8%while positive predictive values were 76.3%,65.5%and71.6%respectively.CONCLUSION：In addition to BW〈1250 g and IVH,formula consumption was detected as a risk factor for the development of ROP.Breastfeeding is important for prevention of ROP in preterm infants.
文摘Background: The aim of the current study was to evaluate the anthropometric and demographic factors and their correlation with type 2 diabetes mellitus (T2DM) in Bangladesh. Methods: One hundred fourteen patients (70 males and 44 females) between 30 and 75 years of age from various areas of Bangladesh were screened for T2DM. Fasting blood sugar (FBS) was analyzed by using laboratory kits and spectrophotometric technique. Anthropometric and socio-demographic data were collected using a structured questionnaire. Body mass index (BMI) was calculated from weight (kg) and height (m) of the individual respondents. Physical activity was categorized based on activity during daily work. Economic condition is defined by respective family income and education level is categorized into 3 levels: illiterate, 0 - 12 years of education and graduate or above. Results: According to the current study results, half of the patients were from the middle-class family with low physical activity and their age was within the range of 30 - 45 years. The male and female ratio of the study population was 60:40. Most of the patients were found to be obese and educated. Urban populations were more prone to have DM than the rural population. Age, education, the area of residence (urban and rural), physical activity and co-morbid diseases were significantly correlated with T2DM in Bangladesh (P Conclusion: Our study shows that different socio-demographic factors have a significant correlation with T2DM in Bangladesh. Diabetes awareness, early diagnosis, patient education and life-style modification can be initiated to manage T2DM efficiently.
基金Supported by a grant from the Ministry of Science and Technology ofChina(No.2012AA021502)
文摘Objective： The plasma fibrinogen levels had not only been used as an independent prognostic parameter for the patients with non-small cell lung cancer （NSCLC）, but also as a promising biomarker for evaluating the efficacy of chemotherapy. This study aimed to investigate the correlation between the plasma fibrinogen levels and epidermal growth factor receptor （EGFR） gene mutation and clinical-pathological characteristics of Chinese patients with NSCLC. Methods： In this retrospective study, NSCLC specimens collected from 352 patients between November 2009 and November 2011 were selected to detect EGFR gene mutation with real-time polymerase chain reaction （RT-PCR）. In these specimens, 308 ones were also detected EGFR gene copy number with fluorescence in situ hybridization （FISH）. Coagulation makers were examined prior to the operations. The association between the plasma fibrinogen levels and EGFR gene mutation and clinical-pathological characteristics were analyzed using SPSS 16.0 software. Results： The median pre-operation plasma fibrinogen level was 3.55 g/L （109/352） patients with higher plasma fibrinogen level （〉 4.0 g/L）. The lower plasma fibrinogen levels correlated significantly with EGFR gene mutations （P 〈 0.001）, the similar result was seen in platelet counts （P = 0.026）. A linear correlation was found between the plasma fibrinogen levels and the platelet counts in NSCLC patients （R^2 = 0.209, P 〈 0.001）. Pre-peration plasma fibrinogen levels correlated with gender （P 〈 0.001）, smoking status （P 〈 0.001 ）, and histology （P 〈 0.001 ）. There were significant link between the above clinical-pathological characteristics and EGFR gene mutations. In addition, EGFR gene mutation was correlated with FISH-positive status （P 〈 0.001）. Moreover, both plasma fibrinogen level （P = 0.024） and the EGFR gene copy number （P = 0.040） had significant relationships with the pathological TNM stage. Conclusion： This study showed that a significant relevance between plasma fibrinogen levels and EGFR gene mutations. The plasma fibrinogen level might be as a clinical decision parameter for evaluating the efficacy of anti-EGFR tyrosine kinase inhibitors （TKIs） in NSCLC. The patients of NSCLC had higher indicate have poor benefits from anti-EFGR TKIs. In addition, pre-operation plasma fibrinogen level could be used as an indepedent prognostic biomarker for the patients with NSCLC.
基金Supported by Yongchuan District Natural Science Foundation,No.2022yc-jckx20050。
文摘BACKGROUND Anxiety complicates recovery in esophagectomy patients undergoing esophagectomy,while preoperative depressive symptoms may further delay surgeryassociated malnutrition resolution,highlighting a critical need for psychological intervention.AIM To explore the correlation of anxiety and depression with mindfulness levels in patients undergoing esophagectomy for esophageal cancer and analyze associated risk factors.METHODS A total of 120 patients with esophageal cancer,all of whom underwent esophagectomy in The Affiliated Yongchuan Hospital of Chongqing Medical University between September 2022 and September 2024,were enrolled.The hospital anxiety and depression scale(HADS)was utilized to evaluate the anxiety(HADS-anxiety subscale,HADS-A)and depression(HADS-depression subscale,HADS-D)levels of these patients,and the Mindful Attention Awareness Scale(MAAS)was employed to assess their mindfulness levels.The relationships among anxiety,depression,and mindfulness levels were analyzed,and both univariate and multivariate analyses were conducted to identify the risk factors for anxiety and depression in these patients.RESULTS Data revealed that the mean HADS-A score of patients undergoing esophagectomy was(10.43±4.24)points,and 40.00%,35.00%,and 10.83%of the patients had mild,moderate,and severe anxiety,respectively.The mean HADS-D score https://www.wjgnet.com 2 September 19,2025 Volume 15 Issue 9 was(9.20±4.66)points,and 37.50%,23.33%,and 9.17%of the patients had mild,moderate,and severe depression,respectively.Patients with negative or mild anxiety(or depression)exhibited significantly higher MAAS scores than those with moderate or severe anxiety(or depression).The HADS-A and HADS-D scores showed a strong and negative correlation with the MAAS score.Univariate and multivariate analyses demonstrated that sex(P=0.006),age(P=0.017),per capita monthly household income(P=0.005),and educational level(P=0.004)were all independently associated with the exacerbation of anxiety in patients undergoing esophagectomy.Age(P=0.026),living status(P=0.005),per capita monthly household income(P=0.024),educational level(P=0.002),and postoperative complications(P<0.001)were all independently related to the aggravation of depression in such patients.CONCLUSION This study indicated a significant negative correlation among anxiety,depression,and mindfulness levels in patients undergoing esophagectomy.Sex,age,per capita monthly household income,and educational level were risk factors for anxiety in patients undergoing esophagectomy,whereas age,living status,per capita monthly household income,educational level,and postoperative complications were risk factors for depression.
基金Supported by Key R&D Plan of Shaanxi Province:Key Industrial Innovation Chain(Cluster)-Social Development Field(No.2022ZDLSF03-10)the 2025 Youth Training Project of the Xi’an Municipal Health Commission(No.2025qn05)+1 种基金Xi’an Medical Research-Discipline Capacity Building Project(No.23YXYJ0002)Research Incubation Fund of Xi’an People’s Hospital(Xi’an Fourth Hospital)(No.LH-13).
文摘AIM:To evaluate the prevalence of myopia and identify its associated risk factors among children and adolescents in Xi’an,China.METHODS:In a school-based cross-sectional design,students ranging from kindergarten to high school across Xi’an were enrolled.Ophthalmic examinations were performed to assess refractive status via non-cycloplegic refraction.Myopia was defined as SE≤-0.5 D,with stratification into mild(SE:≤-0.5 to>-3.0 D),moderate(SE:≤-3.0 to>-6.0 D),and high myopia(SE≤-6.0 D).Data on potential risk factors such as age,gender,and educational level were obtained through structured questionnaires.RESULTS:The study included 156416 participants,with 81389 boys(52.0%)and 75027 girls(48.0%).The prevalence rates of myopia were 65.67%for boys and 68.83%for girls.Data collection occurred over two consecutive years,2021 and 2022,with 78849 and 77567 participants,respectively.The prevalence of myopia was 67.65%in 2021 and decreased slightly to 66.71%in 2022.The high myopia rates were 3.85%and 3.43%for these years,respectively.Analysis revealed significant risk factors including gender,age,and educational level,with a distinct positive correlation between increased educational level and higher myopia prevalence.Notably,both genders exhibited a significant decrease in moderate myopia over the study period,with reductions of 1.7%and 1.2%.CONCLUSION:This comprehensive study underscores the substantial prevalence of myopia among school-aged children and adolescents in Xi’an,marking it as a significant public health concern.The correlation with higher educational levels suggests the need for targeted interventions aimed at myopia prevention and management.These findings contribute critically to the body of knowledge necessary for formulating effective public health strategies in Xi’an and potentially other similar regions.
文摘BACKGROUND Gastric cancer(GC)and head and neck squamous cell carcinoma(HNSCC)are common malignancies with high morbidity and mortality rates.Traditional treatments often yield limited efficacy,especially in advanced cases.Recent advancements in immunotherapy,particularly immune checkpoint inhibitors targeting programmed death-ligand 1(PD-L1),have shown promise.However,the expression and interaction of pescadillo ribosomal biogenesis factor 1(PES1)and PD-L1 in these cancers remain unclear.Understanding their roles could provide new insights into tumor biology and improve therapeutic strategies.AIM To investigate the expression levels of PES1 and PD-L1 in tumor tissues of patients with GC and HNSCC.METHODS A total of 58 cases of GC and HNSCC undergoing surgical resection were selected from January 2022 to January 2024.Paraffin specimens of GC and HNSCC tissues were taken from the patients,and the sections were subjected to staining with immunohistochemistry and hematoxylin-eosin staining,and the protein expression of PES1 and PD-L1 was observed microscopically.RESULTS Among 58 GC and HNSCC tissues,30 cases were positive and 28 cases were negative for PES1 expression,and 34 cases were positive and 24 cases were negative for PD-L1 expression.The positive expression rates of PES1 and PDL1 were 51.72% and 58.62%,respectively.PES1 expression was correlated with the TNM stage,lymph node metastasis,and the depth of infiltration(P<0.05),and PD-L1 expression was correlated with the differentiation degree,lymph node metastasis,and infiltration depth(P<0.05).CONCLUSION PES1 and PD-L1 were positively expressed in GC and HNSCC tissues and correlated with clinical features.They may serve as potential biomarkers for immune-targeted therapies.
文摘Objectives Mu Lao Zu population.Methods A total of 1055 subjects of Mu Lao Zu were studied by a stratified randomized cluster sampling.Blood pressure,body height, body weight,waist circumference and serum lipid and apolipoprotein(Apo) levels were measured.The data were compared with those in 969 subjects of Han Chinese from the same region.In order to evaluate the association of hyperlipidemia with nine possible riks factors,multivariate logistic regression analysis was also performed in the combined population of Mu Lao Zu and Han,Mu Lao Zu,and Han;respectively. Results The levels of total cholesterol,triglyceride, low-density lipoprotein cholesterol and ApoB in Mu Lao Zu were significantly higher than those in Han(P【0.05-0.001); but the levels of high-density lipoprotein cholesterol,ApoA1 and ApoA1/Apo were significantly lower than those in Han (P【0.001 ).The prevalence of hyperlipidemia and Hypercholesterolemia was also significantly higher in Mu Lao Zu than in Han(53.0%vs.46.1%,P【0.001) and(44.5%vs. 37.5%,P【0.001).There was no difference in the prevalence of hypertriglyceridemia between the both ethnic groups (22.8%vs.19.4%,P】0.05).Hyperlipidemia was positively correlated with age,BMI,and systolic blood pressureMu Lao Zu(P【0.05),whereas it was positively correlated with BMI and hypertension in Han(P【0.05 for each).Conclusions The serum lipid profiles,the prevalence of hyperlipidemia and the risk factors are different between the Mu Lao Zu and Han populations.The differences in serum lipid profiles between the two ethnic groups might result from different dietary habit,life style,as well as genetic factors,in ? To determine the serum lipid levels and their risk factors in the Guangxi.
基金supported by a grant from the National Social Science Foundation of China (No. 13CTY031)
文摘Background: Self-efficacy has been identified as an important determinant of youth's behavior change including physical activity(PA) participation. However, the dimensionality check of a PA self-efficacy scale has rarely been conducted in China. The current study aims to examine(1) the unidimensionality of a shortened Chinese version of PA self-efficacy scale(S-PASESC);(2) the measurement invariance of S-PASESC across gender and levels of education;(3) the latent factor mean difference between gender and levels of education;(4) the direct effects of self-efficacy on PA by different gender and education levels; and(5) the comparisons of the direct effects of self-efficacy on PA across gender and education levels.Methods: The participants were 5 th through 11 th grade public school students recruited from 7 cities located in different geographic regions of China. The final data include a total of 3003 participants(49.7% boys) who have completed the scales.Results: Confirmatory factor analysis(CFA) test supported the unidimensionality of S-PASESC. The S-PASESC is invariant across gender and 3 levels of education at both configural, full metric, and full scalar levels. Findings from latent mean comparisons showed that boys reported higher PA self-efficacy than girls. Students' perceived PA self-efficacy tend to decrease from elementary to high school. Finally, self-efficacy positively related to PA by groups of different gender and education levels and the relationship between self-efficacy and PA is stronger among middle school boys than girls.Conclusion: Findings suggest S-PASESC is a valid scale for measuring Chinese students' PA self-efficacy.
文摘According to the 2010 China Statistical Yearbook,a total of 12 indicators in the aspects of residents' production,consumption expenditure,and living conditions are selected in order to construct the indicator system of rural development level.Both factor analysis and cluster analysis methods are adopted to compare the current situations of rural development levels in 31 provinces and regions of China.Result of factor analysis shows that the 12 indicators can be classified into 4 factors,such as the income and expenditure factor,the agricultural scale and science and technology factor,the life quality factor,and the agricultural output factor.Moreover,factors affecting the rural development level of China are analyzed.Then,the 31 provinces and regions are divided into 4 categories according to the development levels in rural areas:the first category is Shanghai,Beijing and Zhejiang,which have the highest development level in rural areas;the second category includes Jiangsu,Shandong and Tianjin,which take the 4th to 6th places;the third category is Guangdong,Jilin,Liaoning,Hebei,Fujian,Heilongjiang,Henan,Inner Mongolia,Anhui,Hubei,Hunan and Jiangxi,which rank the 7th-18th;and the fourth category includes Sichuan,Hainan,Ningxia,Shanxi,Guangxi,Shanxi,Xinjiang,Chongqing,Tibet,Yunnan,Gansu,Qinghai and Guizhou,taking the 19th-31st places.
文摘BACKGROUND Preoperative chemoradiotherapy(CRT)is a standard treatment modality for locally advanced rectal cancer.However,CRT alone cannot improve overall survival.Approximately 20%of patients with CRT-resistant tumors show disease progression.Therefore,predictive factors for treatment response are needed to identify patients who will benefit from CRT.We theorized that the prognosis may vary if patients are classified according to pre-to post-CRT changes in carcinoembryonic antigen(CEA)levels.AIM To identify patients with locally advanced rectal cancer for preoperative chemoradiotherapy based on carcinoembryonic antigen levels.METHODS We retrospectively included locally advanced rectal cancer patients who underwent preoperative CRT and curative resection between 2011 and 2017.Patients were assigned to groups A,B,and C based on pre-and post-CRT serum CEA levels:Both>5;pre>5 and post≤5;and both≤5 ng/mL,respectively.We compared the response to CRT based on changes in serum CEA levels.Receiver operating characteristic curve analysis was performed to determine optimal cutoff for neutrophil–lymphocyte ratio and platelet–lymphocyte ratio.Multivariate logistic regression analysis was used to evaluate the prognostic factors for pathologic complete response(pCR)/good response.RESULTS The cohort comprised 145 patients;of them,27,43,and 65 belonged to groups A,B,and C,respectively,according to changes in serum CEA levels before and after CRT.Pre-(P<0.001)and post-CRT(P<0.001)CEA levels and the ratio of downstaging(P=0.013)were higher in Groups B and C than in Group A.The ratio of pathologic tumor regression grade 0/1 significantly differed among the groups(P=0.003).Group C had the highest number of patients showing pCR(P<0.001).Most patients with pCR showed pre-and post-CRT CEA levels<5 ng/mL(P<0.001,P=0.008).Pre-and post-CRT CEA levels were important risk factors for pCR(OR=18.71;95%CI:4.62–129.51,P<0.001)and good response(OR=5.07;95%CI:1.92–14.83,P=0.002),respectively.Pre-CRT neutrophil–lymphocyte ratio and post-CRT T≥3 stage were also prognostic factors for pCR or good response.CONCLUSION Pre-and post-CRT CEA levels,as well as change in CEA levels,were prognostic markers for treatment response to CRT and may facilitate treatment individualization for rectal cancer.
基金supported by The National Natural Science Foundation of China(No.81172628)the Fundamental Research Funds for the Central Universities(No.2014305020201)
文摘In this study, we searched multiple databases for all relevant original articles (1996-2013). To investigate blood lead levels (BLL) and possible risk factors for lead exposure among children in China A total of 388 articles met our inclusion criteria. The overall geometric mean (GM) BLL was 71 μg/L, and the prevalence of elevated BLL (EBLL, defined as BLL ≥100 μg/L) was 18.48% among children. The prevalence of EBLL remained significantly higher among boys. In children less than 6 years of age, there were significantly increasing trends in both BLL and prevalence of EBLL in an age-dependent manner. The ban on leaded gasoline significantly reduced the BLL as well as EBLL prevalence; however, children whose parents had lower educational levels or were exposed to lead in the workplace had a higher EBLL prevalence. Despite its decline over time, the average BLL among children in China remains higher than the average level most recently reported in the United States. Childhood lead poisoning remains a public health problem in China.
基金The study was reviewed and approved by the Institutional Review Board of Chaohu Hospital Affiliated to AnhuiMedical University,Approval No.KYXM-202208-011.
文摘BACKGROUND Patients with thalamic infarction experience abnormal blockages of multinuc-leated vessels,affecting the body and thereby the thalamus.Most patients with thalamic infarction have an adverse prognosis,which seriously affects their safety.Therefore,it is essential to analyze the independent risk factors that influence the prognosis of patients with thalamic infarction and develop corresponding preventive measures.AIM To explore the effect of non-high-density lipoprotein cholesterol(non-HDL-C)and Homocysteine(Hcy)levels in cognitive impairment in thalamic infarction.METHODS From March 2019 to March 2022,80 patients with thalamic infarction were divided into a group with cognitive impairment[Montreal Cognitive Assessment(MoCA)score<26;35 patients]and a group with normal cognitive function(MoCA score of 26-30;45 patients)according to the MoCA score.In addition,50 healthy people in the same period were selected as the control group.A correlation between the non-HDL-C and Hcy levels and the MoCA score and receiver operating characteristic curve was observed,and the serum non-HDL-C and Hcy levels were analyzed for the diagnosis of cognitive impairment in patients with thalamic infarction.According to the Modified Rankin Scale(MRS)score,80 patients with thalamic infarction were divided into a good prognosis group(MRS score≤2)and a poor prognosis group(MRS score>2).RESULTS The non-HDL-C and Hcy levels were significantly higher in the group with cognitive impairment than in the group with normal cognitive function(P<0.05).There was no significant difference in the non-HDL-C level between the control group and the group with normal cognitive function(P>0.05).The MoCA scores of the group with cognitive impairment were significantly lower than those of the group with normal cognitive function and the control group(P<0.05).There was a significant difference between the control group and the group with normal cognitive function(P<0.05).The non-HDL-C and Hcy levels were correlated with the MoCA score(P<0.05),cognitive impairment[areas under the curve(AUC)=0.709,95%confidence interval(95%CI):0.599-0.816],the non-HDL-C level,and could predict cognitive impairment in patients with thalamic infarction(AUC=0.738,95%CI:0.618-0.859).Hcy combined with non-HDL-C levels can predict cognitive impairment in patients with thalamic infarction(AUC=0.769,95%CI:0.721-0.895).RESULTS There were 50 patients in the good prognosis group and 30 patients in the poor prognosis group.Compared with the good prognosis group,in the poor prognosis group,the National Institutes of Health Stroke Scale(NIHSS)score,non-HDL-C level,Hcy level,large-area cerebral infarction,atrial fibrillation,and activated partial prothrombin time were statistically significant(P<0.05).The non-HDL-C level,the Hcy level,the NIHSS score,extensive cerebral serum,and atrial fibrillation may all be independent risk factors for poor prognosis in patients with thalamic infarction(P<0.05).CONCLUSION Non-HDL-C and Hcy levels are positively correlated with cognitive impairment in patients with thalamic infarction.Non-HDL-C and Hcy levels can be used in the diagnosis of cognitive impairment in patients with thalamic infarction,and the combined detection effect is better.The main factors affecting the prognosis of patients with thalamic infarction are the non-HDL-C level,the Hcy level,the NIHSS score,large-area cerebral infarction,and atrial fibrillation.Clinically,corresponding preventive measures can be formulated based on the above factors to prevent poor prognosis and reduce mortality.
基金funded by the Key R&D Program of Science and Technology Bureau of Shangluo City(Grant No.2020-Z-0111)Scientific Research Program of Science and Technology Department of Shaanxi Province(Grant No.2021JQ-844).
文摘Water level variations have caused numerous dam slope collapse disasters around the world,illustrating the large influence of water level fluctuations on dam slopes.The required indoor tests were conducted and a numerical model of an actual earth-filled dam was constructed to investigate the influences of the water level fluctuation rate and the hysteresis of the soil-water characteristic curve(SWCC)on the stability of the upstream dam slope.The results revealed that the free surface in the dam body for the desorption SWCC during water level fluctuations was higher than that for the adsorption SWCC,which would be more evident at higher water levels.The safety factor of the upstream dam slope initially decreased and then increased for the most dangerous water level as the water level rose and fell.The water level fluctuation rate mainly influenced the initial section of the safety factor variation curve,while the SWCC hysteresis mainly affected the minimum safety factor of the water level fluctuations.The desorption SWCC is suggested for engineering design.Furthermore,a quick prediction method is proposed to estimate the safety factor of upstream dam slopes with identical structures.
