BACKGROUND Gastric cancer(GC)has a relatively high incidence and mortality rate.Surgery is the primary treatment;however,the survival rate of patients remains low.Therefore,there is an urgent need to identify simple a...BACKGROUND Gastric cancer(GC)has a relatively high incidence and mortality rate.Surgery is the primary treatment;however,the survival rate of patients remains low.Therefore,there is an urgent need to identify simple and feasible prognostic indicators for GC.As an inflammation-related biomarker,the systemic inflammation response index(SIRI),platelet-to-lymphocyte ratio(PLR),and SIRI-PLR can be obtained from routine blood tests.Compared with existing prognostic indicators,which are expensive and rely on complex analyses,SIRI-PLR offers extremely high convenience and cost-effectiveness.AIM To explore the impact of SIRI-PLR on the prognosis of patients with stage I–III GC after surgery and construct a nomogram.METHODS We retrospectively analyzed the clinical and pathological data of patients with GC who underwent radical surgery at The First Affiliated Hospital of Anhui Medical University between January 2014 and December 2017.A total of 1071 patients with clear clinical prognoses were selected.Univariate and multivariate Cox regression analyses were performed to identify independent prognostic factors associated with overall survival in patients with GC,and a nomogram prediction model was constructed.RESULTS Multivariate Cox regression analysis revealed that age,tumor size,T stage,N stage,SIRI-PLR,and carcinoembryonic antigen were independent prognostic factors.The areas under the curve of the nomogram for training and validation sets were 0.821 and 0.848,respectively.Calibration plots and decision curve analyses demonstrated that the nomogram exhibited good predictive performance and clinical utility in training and validation cohorts.CONCLUSION Preoperative SIRI-PLR was significantly associated with the prognosis of patients with stage I–III GC following radical gastrectomy.Our nomogram could serve as an essential tool for clinicians to predict the postoperative prognosis of patients with stage I–III GC.展开更多
Objective Venous thromboembolism is a highly prevalent condition after polytrauma,and recognized as an important factor contributing to poor prognosis.The aim of this study was to investigate the risk factors for lowe...Objective Venous thromboembolism is a highly prevalent condition after polytrauma,and recognized as an important factor contributing to poor prognosis.The aim of this study was to investigate the risk factors for lower extremity deep venous thrombosis(LEDVT)in a severely traumatized population and to evaluate their predictive value for LEDVT.Methods This was a retrospective,single-center observational study.All subjects were severely traumatized patients who were admitted to the Traumatic Intensive Care Unit from January 2021 to May 2024.Based on Doppler ultrasound findings of both lower extremities from the time of injury to 30 days post-injury,patients who developed LEDVT were enrolled in the LEDVT group,and those who did not develop LEDVT were enrolled in the NLEDVT group.Demographic,clinical,and laboratory data were collected upon admission.Multivariable logistic regression analysis was performed to identify risk factors for LEDVT.Receiver operating characteristic(ROC)curve was used to evaluate the overall fit of the final model.Results There were 56 patients enrolled in the LEDVT group and 81 patients in the NLEDVT group.Age,Aggregate Index of Systemic Inflammation(AISI),Systemic Inflammation Response Index(SIRI),ICU length of stay,and albumin were identified as independent risk factors for LEDVT(all P<0.05).The area under their ROC curves were 0.604,0.657,0.694,0.668,and 0.405,respectively.Combined model for early clinical prediction of LEDVT in severely traumatized patients by age,SIRI,AISI,and albumin resulted in an area under the ROC curve of 0.805(95%CI:0.73-0.88,SE=0.037).Conclusion The combination of age,SIRI,AISI,and albumin has a predictive value for LEDVT in severely traumatized patients.展开更多
Cytokines play an important role in the pathological process of atherosclerosis(AS),affecting the progression and prognosis of cerebrovascular diseases concerned with AS.Cytokines mainly include C-reactive protein,int...Cytokines play an important role in the pathological process of atherosclerosis(AS),affecting the progression and prognosis of cerebrovascular diseases concerned with AS.Cytokines mainly include C-reactive protein,interleukin,tumor necrosis factor,chemotactic cytokines,matrix metalloproteinases,etc.These These cytokines promote or inhibit the inflammatory response and plaque formation during AS process through different targets and mechanisms.A comprehensive understanding of the cytokines in the occurrence and development of AS is conducive to search for new therapeutic targets and drugs.展开更多
Background:The role of inflammation in the development of gestational diabetes mellitus(GDM)has recently become a focus of research.The systemic immune-inflammation index(SII)and systemic inflammation response index(S...Background:The role of inflammation in the development of gestational diabetes mellitus(GDM)has recently become a focus of research.The systemic immune-inflammation index(SII)and systemic inflammation response index(SIRI),novel indices,reflect the body’s chronic immune-inflammatory state.This study aimed to investigate the associations between the SII or SIRI and GDM.Methods:A prospective birth cohort study was conducted at Beijing Obstetrics and Gynecology Hospital from February 2018 to December 2020,recruiting participants in their first trimester of pregnancy.Baseline SII and SIRI values were derived from routine clinical blood results,calculated as follows:SII=neutrophil(Neut)count×platelet(PLT)count/lymphocyte(Lymph)count,SIRI=Neut count×monocyte(Mono)count/Lymph count,with participants being grouped by quartiles of their SII or SIRI values.Participants were followed up for GDM with a 75-g,2-h oral glucose tolerance test(OGTT)at 24-28 weeks of gestation using the glucose thresholds of the International Association of Diabetes and Pregnancy Study Groups(IADPSG).Logistic regression was used to analyze the odds ratios(ORs)(95%confidence intervals[CIs])for the the associations between SII,SIRI,and the risk of GDM.Results:Among the 28,124 women included in the study,the average age was 31.8±3.8 years,and 15.76%(4432/28,124)developed GDM.Higher SII and SIRI quartiles were correlated with increased GDM rates,with rates ranging from 12.26%(862/7031)in the lowest quartile to 20.10%(1413/7031)in the highest quartile for the SII(P_(trend)<0.001)and 11.92-19.31%for the SIRI(P_(trend)<0.001).The ORs(95%CIs)of the second,third,and fourth SII quartiles were 1.09(0.98-1.21),1.21(1.09-1.34),and 1.39(1.26-1.54),respectively.The SIRI findings paralleled the SII outcomes.For the second through fourth quartiles,the ORs(95%CIs)were 1.24(1.12-1.38),1.41(1.27-1.57),and 1.64(1.48-1.82),respectively.These associations were maintained in subgroup and sensitivity analyses.Conclusion:The SII and SIRI are potential independent risk factors contributing to the onset of GDM.展开更多
Extensive use of avermectin(AVM)in agriculture can seriously contaminate fish in aquaculture.Ferulic acid(FA)is a strong antioxidant sourced from plants and is widely applied in food and medicine,but its protective fu...Extensive use of avermectin(AVM)in agriculture can seriously contaminate fish in aquaculture.Ferulic acid(FA)is a strong antioxidant sourced from plants and is widely applied in food and medicine,but its protective function on the immunological damage caused by AVM is still lacking.In this study,carp were chronically exposed to(1/1096 hr LC_(50))AVM for 30 day(s),with a dietary supplement of FA(400 mg/kg)to assess its effects on carp spleen.The experimental groups(n=10)included:control,AVM-exposed(2.404μg/L),FA+AVM co-treated,and FA alone.Long-term AVM exposure altered spleen tissue,reducing serum complement C3(p<0.01)and immunoglobulin M levels(p<0.001),and increasing proinflammatory tnf-α(p<0.001),il-6(p<0.001),il-1β(p<0.001),and inos mRNA levels,whilst down-regulating the anti-inflammatory tgf-β(p<0.05).Additionally,it disrupted the balance of oxidative stress indicators such asMDA(p<0.001),T-AOC,GSH,and CAT,leading to spleen tissue apoptosis(42.4%).However,the addition of FA reversed these conditions,elevated the anti-inflammatory factor,and improved spleen immune function following chronic exposure to AVMin carp.Moreover,the ability to restore oxidative homeostasis in carp by adjusting the Nrf2/NQO-1 axis protected the health of spleen tissues.This discovery also supports the development of fish feed for aquaculture.展开更多
Picornaviruses, small positive-stranded RNA viruses, cause a wide range of diseases which is based on their differential tissue and cell type tropisms. This diversity is reflected by the immune responses, both innate ...Picornaviruses, small positive-stranded RNA viruses, cause a wide range of diseases which is based on their differential tissue and cell type tropisms. This diversity is reflected by the immune responses, both innate and adaptive, induced after infection, and the subsequent interactions of the viruses with the immune system. The defense mechanisms of the host and the countermeasures of the virus significantly contribute to the pathogenesis of the infections. Important human pathogens are poliovirus, coxsackievirus, human rhinovirus and hepatitis A virus. These viruses are the beststudied members of the family, and in this review we want to present the major aspects of the reciprocal effects between the immune system and these viruses.展开更多
Obesity is a major contributor to metabolic dysfunction,and its impact on pancreatic health has garnered increasing attention.Macrophages,as key regulators of inflammation and metabolism,play a central role in mediati...Obesity is a major contributor to metabolic dysfunction,and its impact on pancreatic health has garnered increasing attention.Macrophages,as key regulators of inflammation and metabolism,play a central role in mediating obesity-induced pancreatic damage.In obese individuals,excessive lipid accumulation and chronic low-grade inflammation drive the infiltration and polarization of macrophages within the pancreas.These macrophages,particularly the pro-inflammatory Macrophage,pro-inflammatory phenotype(M1)phenotype,secrete cytokines such as C-C motif ligand 2(CCL2)and transforming growth factor beta(TGF-β),which disrupt pancreaticβ-cell function and impair insulin secretion.Conversely,anti-inflammatory Macrophage,anti-inflammatory phenotype(M2)macrophages contribute to tissue repair but may also promote fibrotic changes under prolonged metabolic stress.Pancreatic macrophages are activated under high-fat diet conditions,promoting inflammation and impairingβ-cell function through the SUCLA2-HIF-1αaxis and mechanistic Target of Rapamycin Complex 1(mTORC1)/PD-1 pathway,thereby establishing a self-perpetuating"metabolicimmunosuppressive"vicious cycle.Targeted intervention strategies against macrophages—such as SUCLA2 inhibitors can ameliorate metabolic dysregulation.Meanwhile,exosome-mediated interorgan communication[e.g.,via microRNA-155(miR-155)and miR-30a]offers novel insights for multi-system synergistic therapies.Understanding the mechanisms by which macrophages mediate metabolic dysregulation in the pancreas under obese conditions provides critical insights into the pathogenesis of obesity-related pancreatic disorders.展开更多
BACKGROUND Gastric ulcer(GU),a common gastrointestinal condition,is influenced by multiple factors,particularly inflammatory and immune responses.Complete blood count(CBC)-derived inflammatory biomarkers represent a n...BACKGROUND Gastric ulcer(GU),a common gastrointestinal condition,is influenced by multiple factors,particularly inflammatory and immune responses.Complete blood count(CBC)-derived inflammatory biomarkers represent a novel indicator of systemic inflammation and immune status;however,their association with GU remains unclear.AIM To investigate the association between CBC-derived inflammatory markers and GU.METHODS The study sample included individuals admitted to the Gastroenterology Unit of the Second Affiliated Hospital of Nanchang University from 2023 to 2024.We explored how each CBC-based inflammation indicator correlated with GU occurrence through logistic models,and assessed their predictive ability using receiver operating characteristic curve analysis.Additionally,we applied the least absolute shrinkage and selection operator method along with stepwise regression techniques to determine which inflammatory indicators were most significantly linked to GU.RESULTS Higher levels of log2 neutrophil-to-lymphocyte ratio,log2 monocyte-to-lymphocyte ratio,log2 systemic immuneinflammation index,log2 systemic inflammatory response index(SIRI),and log2 aggregate index of systemic inflammation were significantly associated with increased GU prevalence across all models,while log2 platelet-tolymphocyte ratio was significant only in the fully adjusted model.SIRI demonstrated the highest discriminative ability,with an area under the curve of 0.868.CONCLUSION Hematological indicators derived from CBC tests show a significant correlation with the prevalence of GU.Among them,SIRI demonstrated the most prominent association.These markers could act as practical tools in recognizing individuals more likely to develop GU.展开更多
AIM： To investigate the role of inflammatory and anti-vira genes in the pathogenesis of SARS. METHODS： cDNA microarrays were used to screen the gene expression profiles of peripheral blood mononuclear cells （PBMCs...AIM： To investigate the role of inflammatory and anti-vira genes in the pathogenesis of SARS. METHODS： cDNA microarrays were used to screen the gene expression profiles of peripheral blood mononuclear cells （PBMCs） in two SARS patients （one in the acute severe phase and the other in the convalescent phase） and a healthy donor. In addition, real-time qualitative PCR was also performed to verify the reproducibility of the microarray results. The data were further analyzed. RESULTS： Many inflammatory and anti-viral genes were differentially expressed in SARS patients. Compared to the healthy control or the convalescent case, plenty of pro-inflammatory cytokines such as IL-1, TNF-α, IL-8, and MAPK signaling pathway were significantly upregulated in the acute severe case. However, anti-inflammatory agents such as IL-4 receptor, IL-13 receptor, IL-1Ra, and TNF-α-induced proteins 3 and 6 also increased dramatically in the acute severe case. On the contrary, a lot of IFN-stimulated genes like PKR, GBP-1 and 2, CXCL-10 and 11, and JAK/STAT signal pathway were downregulated in the acute severe case compared to the convalescent case. CONCLUSION： Gene expression in SAPS patients mirrors a host state of inflammation and anti-viral immunity at the transcription level, and understanding of gene expression profiles may make contribution to further studies of the SAPS pathogenesis.展开更多
Background and Objectives:The presence and accumulation of inflammation may exacerbate the development of dyslipidemia.Therefore,this study aimed to explore the relationship between blood inflammatory markers and the ...Background and Objectives:The presence and accumulation of inflammation may exacerbate the development of dyslipidemia.Therefore,this study aimed to explore the relationship between blood inflammatory markers and the dietary inflammatory index(DII)in American adults as well as their association with dyslipidemia.Methods and Study Design:This cross-sectional study included participants with complete data on lipid levels,dietary intake,and blood inflammatory markers.The associations between dyslipidemia and two sets of exposures—blood inflammatory markers and the DII—were analysed using weighted univariate and multivariate logistic regression models.Results:Among the 9,441 participants(2009–2018),6,689(70.9%)had dyslipidemia.展开更多
The aging of alveolar stem cells has been linked to many chronic lung diseases,including pulmonary fibrosis.However,the effects of aging on alveolar stem cells during homeostasis and post-injury alveolar repair have n...The aging of alveolar stem cells has been linked to many chronic lung diseases,including pulmonary fibrosis.However,the effects of aging on alveolar stem cells during homeostasis and post-injury alveolar repair have not been well characterized.Here we conducted a single-cell RNA sequencing(scRNA-seq)analysis of alveolar stem cells of 3-month-old and 12-month-old mice to characterize the aging effect on alveolar stem cells.Our results have shown that the transcriptomes of alveolar stem cells of 3-month-old and 12-month-old mice are not significantly different under the steady condition.However,after a bleomycin-induced lung injury,the alveolar stem cells of 12-month-old mice show enhanced inflammatory responses and decreased lipid metabolism.Our study suggests a close relationship among aging,lipid metabolism,inflammatory responses and chronic lung diseases.展开更多
基金Supported by Key Projects of Anhui Provincial Department of Education,No.2023AH053330.
文摘BACKGROUND Gastric cancer(GC)has a relatively high incidence and mortality rate.Surgery is the primary treatment;however,the survival rate of patients remains low.Therefore,there is an urgent need to identify simple and feasible prognostic indicators for GC.As an inflammation-related biomarker,the systemic inflammation response index(SIRI),platelet-to-lymphocyte ratio(PLR),and SIRI-PLR can be obtained from routine blood tests.Compared with existing prognostic indicators,which are expensive and rely on complex analyses,SIRI-PLR offers extremely high convenience and cost-effectiveness.AIM To explore the impact of SIRI-PLR on the prognosis of patients with stage I–III GC after surgery and construct a nomogram.METHODS We retrospectively analyzed the clinical and pathological data of patients with GC who underwent radical surgery at The First Affiliated Hospital of Anhui Medical University between January 2014 and December 2017.A total of 1071 patients with clear clinical prognoses were selected.Univariate and multivariate Cox regression analyses were performed to identify independent prognostic factors associated with overall survival in patients with GC,and a nomogram prediction model was constructed.RESULTS Multivariate Cox regression analysis revealed that age,tumor size,T stage,N stage,SIRI-PLR,and carcinoembryonic antigen were independent prognostic factors.The areas under the curve of the nomogram for training and validation sets were 0.821 and 0.848,respectively.Calibration plots and decision curve analyses demonstrated that the nomogram exhibited good predictive performance and clinical utility in training and validation cohorts.CONCLUSION Preoperative SIRI-PLR was significantly associated with the prognosis of patients with stage I–III GC following radical gastrectomy.Our nomogram could serve as an essential tool for clinicians to predict the postoperative prognosis of patients with stage I–III GC.
基金Basic Research Spe-cial Project of Suzhou Science and Technology Bureau(SSD2024050).
文摘Objective Venous thromboembolism is a highly prevalent condition after polytrauma,and recognized as an important factor contributing to poor prognosis.The aim of this study was to investigate the risk factors for lower extremity deep venous thrombosis(LEDVT)in a severely traumatized population and to evaluate their predictive value for LEDVT.Methods This was a retrospective,single-center observational study.All subjects were severely traumatized patients who were admitted to the Traumatic Intensive Care Unit from January 2021 to May 2024.Based on Doppler ultrasound findings of both lower extremities from the time of injury to 30 days post-injury,patients who developed LEDVT were enrolled in the LEDVT group,and those who did not develop LEDVT were enrolled in the NLEDVT group.Demographic,clinical,and laboratory data were collected upon admission.Multivariable logistic regression analysis was performed to identify risk factors for LEDVT.Receiver operating characteristic(ROC)curve was used to evaluate the overall fit of the final model.Results There were 56 patients enrolled in the LEDVT group and 81 patients in the NLEDVT group.Age,Aggregate Index of Systemic Inflammation(AISI),Systemic Inflammation Response Index(SIRI),ICU length of stay,and albumin were identified as independent risk factors for LEDVT(all P<0.05).The area under their ROC curves were 0.604,0.657,0.694,0.668,and 0.405,respectively.Combined model for early clinical prediction of LEDVT in severely traumatized patients by age,SIRI,AISI,and albumin resulted in an area under the ROC curve of 0.805(95%CI:0.73-0.88,SE=0.037).Conclusion The combination of age,SIRI,AISI,and albumin has a predictive value for LEDVT in severely traumatized patients.
基金National Natural Foundation(No.81873117)Subproject of Threeyear Planning for Traditional Chinese Medicine of Shanghai(2018-2020)[No.ZY(2018-2020)-CCCX-2002-04]。
文摘Cytokines play an important role in the pathological process of atherosclerosis(AS),affecting the progression and prognosis of cerebrovascular diseases concerned with AS.Cytokines mainly include C-reactive protein,interleukin,tumor necrosis factor,chemotactic cytokines,matrix metalloproteinases,etc.These These cytokines promote or inhibit the inflammatory response and plaque formation during AS process through different targets and mechanisms.A comprehensive understanding of the cytokines in the occurrence and development of AS is conducive to search for new therapeutic targets and drugs.
基金supported by the Capital’s Funds for Health Improvement and Research(No.2024-2G-2118)the National Key Research and Development Program of China(No.2016YFC1000100)+2 种基金the Leading Talents in the Construction Project of High Level Public Health Technical Talents in Beijing(No.20221003)the“Green Seedling”Youth Program by the Beijing Hospitals Authority(No.QML20231402)the Young Elite Scientist Sponsorship Program by the Beijing Association for Science and Technology(No.BYESS2022200).
文摘Background:The role of inflammation in the development of gestational diabetes mellitus(GDM)has recently become a focus of research.The systemic immune-inflammation index(SII)and systemic inflammation response index(SIRI),novel indices,reflect the body’s chronic immune-inflammatory state.This study aimed to investigate the associations between the SII or SIRI and GDM.Methods:A prospective birth cohort study was conducted at Beijing Obstetrics and Gynecology Hospital from February 2018 to December 2020,recruiting participants in their first trimester of pregnancy.Baseline SII and SIRI values were derived from routine clinical blood results,calculated as follows:SII=neutrophil(Neut)count×platelet(PLT)count/lymphocyte(Lymph)count,SIRI=Neut count×monocyte(Mono)count/Lymph count,with participants being grouped by quartiles of their SII or SIRI values.Participants were followed up for GDM with a 75-g,2-h oral glucose tolerance test(OGTT)at 24-28 weeks of gestation using the glucose thresholds of the International Association of Diabetes and Pregnancy Study Groups(IADPSG).Logistic regression was used to analyze the odds ratios(ORs)(95%confidence intervals[CIs])for the the associations between SII,SIRI,and the risk of GDM.Results:Among the 28,124 women included in the study,the average age was 31.8±3.8 years,and 15.76%(4432/28,124)developed GDM.Higher SII and SIRI quartiles were correlated with increased GDM rates,with rates ranging from 12.26%(862/7031)in the lowest quartile to 20.10%(1413/7031)in the highest quartile for the SII(P_(trend)<0.001)and 11.92-19.31%for the SIRI(P_(trend)<0.001).The ORs(95%CIs)of the second,third,and fourth SII quartiles were 1.09(0.98-1.21),1.21(1.09-1.34),and 1.39(1.26-1.54),respectively.The SIRI findings paralleled the SII outcomes.For the second through fourth quartiles,the ORs(95%CIs)were 1.24(1.12-1.38),1.41(1.27-1.57),and 1.64(1.48-1.82),respectively.These associations were maintained in subgroup and sensitivity analyses.Conclusion:The SII and SIRI are potential independent risk factors contributing to the onset of GDM.
基金supported by the National Natural Science Foundation of China(No.81773968)the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
文摘Extensive use of avermectin(AVM)in agriculture can seriously contaminate fish in aquaculture.Ferulic acid(FA)is a strong antioxidant sourced from plants and is widely applied in food and medicine,but its protective function on the immunological damage caused by AVM is still lacking.In this study,carp were chronically exposed to(1/1096 hr LC_(50))AVM for 30 day(s),with a dietary supplement of FA(400 mg/kg)to assess its effects on carp spleen.The experimental groups(n=10)included:control,AVM-exposed(2.404μg/L),FA+AVM co-treated,and FA alone.Long-term AVM exposure altered spleen tissue,reducing serum complement C3(p<0.01)and immunoglobulin M levels(p<0.001),and increasing proinflammatory tnf-α(p<0.001),il-6(p<0.001),il-1β(p<0.001),and inos mRNA levels,whilst down-regulating the anti-inflammatory tgf-β(p<0.05).Additionally,it disrupted the balance of oxidative stress indicators such asMDA(p<0.001),T-AOC,GSH,and CAT,leading to spleen tissue apoptosis(42.4%).However,the addition of FA reversed these conditions,elevated the anti-inflammatory factor,and improved spleen immune function following chronic exposure to AVMin carp.Moreover,the ability to restore oxidative homeostasis in carp by adjusting the Nrf2/NQO-1 axis protected the health of spleen tissues.This discovery also supports the development of fish feed for aquaculture.
基金Supported by The Tonjes-Vagt-Stiftung,Bremen,Germany.
文摘Picornaviruses, small positive-stranded RNA viruses, cause a wide range of diseases which is based on their differential tissue and cell type tropisms. This diversity is reflected by the immune responses, both innate and adaptive, induced after infection, and the subsequent interactions of the viruses with the immune system. The defense mechanisms of the host and the countermeasures of the virus significantly contribute to the pathogenesis of the infections. Important human pathogens are poliovirus, coxsackievirus, human rhinovirus and hepatitis A virus. These viruses are the beststudied members of the family, and in this review we want to present the major aspects of the reciprocal effects between the immune system and these viruses.
基金Supported by National Natural Science Foundation of China Youth Science Fund Project,No.82305376the Young Talent Support Program of the China Association for Acupuncture-Moxibustion,No.2024-2026ZGZJXH-QNRC005+1 种基金the 2024 Jiangsu Provincial Young Scientific and Technological Talent Support Program,No.JSTJ-2024-380the 2025 Jiangsu Science and Technology Think Tank Program Project,No.JSKX0125035。
文摘Obesity is a major contributor to metabolic dysfunction,and its impact on pancreatic health has garnered increasing attention.Macrophages,as key regulators of inflammation and metabolism,play a central role in mediating obesity-induced pancreatic damage.In obese individuals,excessive lipid accumulation and chronic low-grade inflammation drive the infiltration and polarization of macrophages within the pancreas.These macrophages,particularly the pro-inflammatory Macrophage,pro-inflammatory phenotype(M1)phenotype,secrete cytokines such as C-C motif ligand 2(CCL2)and transforming growth factor beta(TGF-β),which disrupt pancreaticβ-cell function and impair insulin secretion.Conversely,anti-inflammatory Macrophage,anti-inflammatory phenotype(M2)macrophages contribute to tissue repair but may also promote fibrotic changes under prolonged metabolic stress.Pancreatic macrophages are activated under high-fat diet conditions,promoting inflammation and impairingβ-cell function through the SUCLA2-HIF-1αaxis and mechanistic Target of Rapamycin Complex 1(mTORC1)/PD-1 pathway,thereby establishing a self-perpetuating"metabolicimmunosuppressive"vicious cycle.Targeted intervention strategies against macrophages—such as SUCLA2 inhibitors can ameliorate metabolic dysregulation.Meanwhile,exosome-mediated interorgan communication[e.g.,via microRNA-155(miR-155)and miR-30a]offers novel insights for multi-system synergistic therapies.Understanding the mechanisms by which macrophages mediate metabolic dysregulation in the pancreas under obese conditions provides critical insights into the pathogenesis of obesity-related pancreatic disorders.
文摘BACKGROUND Gastric ulcer(GU),a common gastrointestinal condition,is influenced by multiple factors,particularly inflammatory and immune responses.Complete blood count(CBC)-derived inflammatory biomarkers represent a novel indicator of systemic inflammation and immune status;however,their association with GU remains unclear.AIM To investigate the association between CBC-derived inflammatory markers and GU.METHODS The study sample included individuals admitted to the Gastroenterology Unit of the Second Affiliated Hospital of Nanchang University from 2023 to 2024.We explored how each CBC-based inflammation indicator correlated with GU occurrence through logistic models,and assessed their predictive ability using receiver operating characteristic curve analysis.Additionally,we applied the least absolute shrinkage and selection operator method along with stepwise regression techniques to determine which inflammatory indicators were most significantly linked to GU.RESULTS Higher levels of log2 neutrophil-to-lymphocyte ratio,log2 monocyte-to-lymphocyte ratio,log2 systemic immuneinflammation index,log2 systemic inflammatory response index(SIRI),and log2 aggregate index of systemic inflammation were significantly associated with increased GU prevalence across all models,while log2 platelet-tolymphocyte ratio was significant only in the fully adjusted model.SIRI demonstrated the highest discriminative ability,with an area under the curve of 0.868.CONCLUSION Hematological indicators derived from CBC tests show a significant correlation with the prevalence of GU.Among them,SIRI demonstrated the most prominent association.These markers could act as practical tools in recognizing individuals more likely to develop GU.
基金Supported by the Grants From Shanghai Commission of Science and TechnologyShanghai Bureau of Health, No. 024Y32the grants from the Sino-German Center for Research Promotion, No.GZNr. 239(202/12)
文摘AIM： To investigate the role of inflammatory and anti-vira genes in the pathogenesis of SARS. METHODS： cDNA microarrays were used to screen the gene expression profiles of peripheral blood mononuclear cells （PBMCs） in two SARS patients （one in the acute severe phase and the other in the convalescent phase） and a healthy donor. In addition, real-time qualitative PCR was also performed to verify the reproducibility of the microarray results. The data were further analyzed. RESULTS： Many inflammatory and anti-viral genes were differentially expressed in SARS patients. Compared to the healthy control or the convalescent case, plenty of pro-inflammatory cytokines such as IL-1, TNF-α, IL-8, and MAPK signaling pathway were significantly upregulated in the acute severe case. However, anti-inflammatory agents such as IL-4 receptor, IL-13 receptor, IL-1Ra, and TNF-α-induced proteins 3 and 6 also increased dramatically in the acute severe case. On the contrary, a lot of IFN-stimulated genes like PKR, GBP-1 and 2, CXCL-10 and 11, and JAK/STAT signal pathway were downregulated in the acute severe case compared to the convalescent case. CONCLUSION： Gene expression in SAPS patients mirrors a host state of inflammation and anti-viral immunity at the transcription level, and understanding of gene expression profiles may make contribution to further studies of the SAPS pathogenesis.
基金the National Center for Health Statistics for this public resource.
文摘Background and Objectives:The presence and accumulation of inflammation may exacerbate the development of dyslipidemia.Therefore,this study aimed to explore the relationship between blood inflammatory markers and the dietary inflammatory index(DII)in American adults as well as their association with dyslipidemia.Methods and Study Design:This cross-sectional study included participants with complete data on lipid levels,dietary intake,and blood inflammatory markers.The associations between dyslipidemia and two sets of exposures—blood inflammatory markers and the DII—were analysed using weighted univariate and multivariate logistic regression models.Results:Among the 9,441 participants(2009–2018),6,689(70.9%)had dyslipidemia.
基金supported by the National Natural Science Foundation of China(81430001 and 81870056)Beijing Major Science and Technology Projects(Z171100000417003 to N.T.)
文摘The aging of alveolar stem cells has been linked to many chronic lung diseases,including pulmonary fibrosis.However,the effects of aging on alveolar stem cells during homeostasis and post-injury alveolar repair have not been well characterized.Here we conducted a single-cell RNA sequencing(scRNA-seq)analysis of alveolar stem cells of 3-month-old and 12-month-old mice to characterize the aging effect on alveolar stem cells.Our results have shown that the transcriptomes of alveolar stem cells of 3-month-old and 12-month-old mice are not significantly different under the steady condition.However,after a bleomycin-induced lung injury,the alveolar stem cells of 12-month-old mice show enhanced inflammatory responses and decreased lipid metabolism.Our study suggests a close relationship among aging,lipid metabolism,inflammatory responses and chronic lung diseases.
