BACKGROUND The hemoglobin-to-red cell distribution width ratio(HRR)is a recently intro-duced,easily accessible marker that provides insights into inflammation and the tumor vascular microenvironment.It has been sugges...BACKGROUND The hemoglobin-to-red cell distribution width ratio(HRR)is a recently intro-duced,easily accessible marker that provides insights into inflammation and the tumor vascular microenvironment.It has been suggested to have prognostic value for overall survival in various types of cancer,including urothelial carcinoma,lung cancer,and hepatocellular carcinoma.It has not yet been sufficiently invest-igated in colorectal cancers(CRC).AIM To investigate the prognostic significance of the HRR and other inflammation-based hematological markers in patients with metastatic CRC.Additionally,the study evaluated the impact of surgical interventions,particularly metastasectomy,and multiple clinical and laboratory parameters on overall survival.By iden-tifying low-cost,accessible prognostic indicators,this research seeks to support clinicians in optimizing treatment strategies and risk stratification for patients with CRC.METHODS In this retrospective study,patients diagnosed with CRC between January 2020 and December 2024 were analyzed.The impact of HRR in conjunction with inflammatory markers and a total of 22 different clinical and laboratory para-meters on overall survival were evaluated using univariate Cox regression and a multivariate model.Survival curves were visualized using Kaplan-Meier analysis.RESULTS A total of 155 patients with CRC were included in the study.The median age was 60 years,and 61.9%presented with de novo metastasis.In the receiver operating characteristic curve and area under the curve analysis performed to determine the optimal cutoff,the values were found to be 6.10 for carcinoembryonic antigen(CEA)(P=0.036),18.85 for platelet-to-red cell distribution width ratio(P=0.028),and 10.87 for platelet distribution width-to-lymphocyte ratio(P=0.028).For neutrophil-to-lymphocyte ratio,systemic immune-inflammation index(SII),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio,HRR,and carbohydrate antigen 19-9,an optimal cutoff could not be determined using the receiver operating characteristic-area under the curve analysis.Therefore,the median values were adopted as the cutoffs(3.09,835.96,177.50,0.380,0.824,and 21.6,respectively).Univariate analysis identified male gender(P=0.045),being under 65 years of age(P=0.001),history of metastas-ectomy(P=0.001),low serum CEA level(P=0.010),low PLR(P=0.024),low SII(P=0.010),and high HRR(P=0.025)as favorable prognostic factors for overall survival.In the multivariate model,being under 65 years of age[hazard ratio(HR)=1.59,95%confidence interval(CI):1.06-2.39,P=0.025],metastasectomy(HR=0.49,95%CI:0.29-0.85,P=0.011),CEA(HR=1.51,95%CI:1.0-2.28,P=0.048),and PLR(HR=1.63,95%CI:1.09-2.44,P=0.018)emerged as independent prognostic factors for overall survival,whereas gender,SII,and HRR did not retain statistical significance.CONCLUSION In conclusion,low HRR alone was a prognostic indicator.However,when modelled with other inflammatory and clinical parameters,it did not provide a sufficiently strong marker feature.展开更多
BACKGROUND Perioperative blood transfusion is common in gastric cancer surgery,yet its im-pact on postoperative inflammation,stress response,and long-term prognosis remains incompletely understood.AIM To investigate t...BACKGROUND Perioperative blood transfusion is common in gastric cancer surgery,yet its im-pact on postoperative inflammation,stress response,and long-term prognosis remains incompletely understood.AIM To investigate the effect of perioperative blood transfusion on postoperative infla-mmation and stress markers,as well as its correlation with prognosis in patients with gastric cancer undergoing radical gastrectomy.METHODS A retrospective analysis was conducted on 200 patients who underwent gastric cancer surgery,divided into a non-transfusion group(n=108)and a transfusion group(n=92).Baseline characteristics,pathological features,postoperative inflammatory and stress markers,complications,and long-term survival were compared between the two groups.Statistical analyses were performed using t-tests,χ2 tests,and multivariate Cox regression analysis.RESULTS The transfusion group had a lower T-stage distribution and higher intraoperative blood loss than the non-transfusion group(P<0.05).Postoperative inflammatory markers such as white blood cell count,neutrophil/lymphocyte ratio,C-reactive protein,interleukin-6,and stress markers like cortisol and adrenaline were sig-nificantly higher in the transfusion group than in the non-transfusion group(P<0.05).The incidence of postoperative complications was also higher in the transfusion group than in the non-transfusion group.Overall survival(OS)and disease-free survival(DFS)were significantly shorter in the transfusion group(P<0.05)than in the non-transfusion group.Multivariate Cox regression analysis showed that transfusion had a negative impact on OS and DFS.CONCLUSION Perioperative blood transfusion is associated with increased postoperative inflammation,stress reactions,complication rates,and adverse prognosis in patients with gastric cancer.Reducing unnecessary transfusions can improve postoperative recovery and long-term prognosis.展开更多
Objective To explore the predictive value of baseline complete blood count derivative marker levels for the occurrence of the first peritonitis in patients undergoing peritoneal dialysis(PD).Methods This study was a r...Objective To explore the predictive value of baseline complete blood count derivative marker levels for the occurrence of the first peritonitis in patients undergoing peritoneal dialysis(PD).Methods This study was a retrospective cohort study.展开更多
Background:Systemic inflammatory markers are associated with cardiovascular disease.This study aimed to assess the relationship between systemic inflammatory markers and abdominal aortic calcification(AAC).Methods:Dat...Background:Systemic inflammatory markers are associated with cardiovascular disease.This study aimed to assess the relationship between systemic inflammatory markers and abdominal aortic calcification(AAC).Methods:Data were collected from the 2013 to 2014 cycle of the National Health and Nutrition Examination Survey(NHANES).AAC was quantified using the Kauppila scoring system,which is based on dual-energy X-ray absorptiometry.Severe abdominal aortic calcifi-cation(sAAC)was defined as a total AAC score≥6.Multivariate regression models were used to determine the relationships between sys-temic inflammation indicators,AAC scores,and sAAC.Results:Data from 3047 participants were analyzed.After adjusting for multiple covariates,AAC scores increased slightly for every one-unit increase in standardized systemic immune-inflammation index(SII;β=0.13;95%confidence interval[CI]:0.01–0.25,P=0.030).Neutrophil-to-lymphocyte ratio(NLR)was positively correlated with higher AAC scores(β=0.15;95%CI:0.06–0.24,P=0.001)and sAAC(odds ratio[OR]:1.10;95%CI:1.01–1.19,P=0.025).There was no significant correlation between platelet-to-lymphocyte ratio(PLR)and AAC scores(β=−0.0006;95%CI:−0.0018 to 0.0030).Conversely,lymphocyte-to-monocyte ratio(LMR)was positively associated with lower AAC scores(β=−0.14;95%CI:−0.22 to−0.05,P=0.001),with a 12%decrease in the odds of sAAC for every one-unit increase in LMR(OR:0.88;95%CI:0.79–0.97,P=0.013).Conclusion:Correlations between different systemic inflammation markers and AAC varied among the adult population of the United States.NLR was associated with higher AAC scores and an increased incidence of sAAC,whereas LMR had the opposite effect.NLR and LMR have emerged as potential biomarkers forAACrisk,highlighting theirimportance in understanding the inflammatory processes associated withAAC.展开更多
Serum markers of systemic inflammation （SAA （serum amyloid protein A）, CRP （C-reactive protein）, cq-AT （ct l-antitripsin）, Hp （haptoglobin） and F （fibrinogen）） have been studied in 317 patients with pulmon...Serum markers of systemic inflammation （SAA （serum amyloid protein A）, CRP （C-reactive protein）, cq-AT （ct l-antitripsin）, Hp （haptoglobin） and F （fibrinogen）） have been studied in 317 patients with pulmonary tuberculosis. It was established that sensitivity of SAA as an activity marker was higher than of other acute phase reactants, because its levels were increased in 98.8% patients, whereas the level of CRP exceeded the norm in 80.8%, α1-AT--in 59.3%, Hp----in 43.5% and F--in 63.1% cases. The degree of increase of acute phase reactants directly related to the expressiveness of tuberculosis intoxication, the extent of the process in the lung and the quantity of MTB （M. tuberculosis） in sputum. We concluded that SAA was a useful marker of the process activity in patients with pulmonary tuberculosis and its sensitivity was higher than that of other acute phase reactants.展开更多
we critically review the authors’perspective and analyze the relevance of the results obtained in the original article of clinical research by Liu et al.We consider that additional factors associated with colon cance...we critically review the authors’perspective and analyze the relevance of the results obtained in the original article of clinical research by Liu et al.We consider that additional factors associated with colon cancer progression have recently been described in extensive clinical research,and should be included in this analysis to achieve a more accurate prognosis.These factors include inflammation,gut microbiota composition,immune status and nutritional balance,as they influence the post-surgical survival profile of patients with stage II colorectal cancer.We also address the clinical implementation and limitations of these analyses.Evaluation of the patient´s entire context is essential for selection of the most appropriate therapy.展开更多
To the Editor,Mutations in LPIN2,located on the short arm of chromosome 18,can lead to Majeed syndrome,a rare autosomal recessive disorder characterized by fever,chronic relapsing multifocal osteomyelitis,congenital e...To the Editor,Mutations in LPIN2,located on the short arm of chromosome 18,can lead to Majeed syndrome,a rare autosomal recessive disorder characterized by fever,chronic relapsing multifocal osteomyelitis,congenital erythropoietic dysplasia,and markedly elevated markers of blood inflammation.展开更多
文摘BACKGROUND The hemoglobin-to-red cell distribution width ratio(HRR)is a recently intro-duced,easily accessible marker that provides insights into inflammation and the tumor vascular microenvironment.It has been suggested to have prognostic value for overall survival in various types of cancer,including urothelial carcinoma,lung cancer,and hepatocellular carcinoma.It has not yet been sufficiently invest-igated in colorectal cancers(CRC).AIM To investigate the prognostic significance of the HRR and other inflammation-based hematological markers in patients with metastatic CRC.Additionally,the study evaluated the impact of surgical interventions,particularly metastasectomy,and multiple clinical and laboratory parameters on overall survival.By iden-tifying low-cost,accessible prognostic indicators,this research seeks to support clinicians in optimizing treatment strategies and risk stratification for patients with CRC.METHODS In this retrospective study,patients diagnosed with CRC between January 2020 and December 2024 were analyzed.The impact of HRR in conjunction with inflammatory markers and a total of 22 different clinical and laboratory para-meters on overall survival were evaluated using univariate Cox regression and a multivariate model.Survival curves were visualized using Kaplan-Meier analysis.RESULTS A total of 155 patients with CRC were included in the study.The median age was 60 years,and 61.9%presented with de novo metastasis.In the receiver operating characteristic curve and area under the curve analysis performed to determine the optimal cutoff,the values were found to be 6.10 for carcinoembryonic antigen(CEA)(P=0.036),18.85 for platelet-to-red cell distribution width ratio(P=0.028),and 10.87 for platelet distribution width-to-lymphocyte ratio(P=0.028).For neutrophil-to-lymphocyte ratio,systemic immune-inflammation index(SII),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio,HRR,and carbohydrate antigen 19-9,an optimal cutoff could not be determined using the receiver operating characteristic-area under the curve analysis.Therefore,the median values were adopted as the cutoffs(3.09,835.96,177.50,0.380,0.824,and 21.6,respectively).Univariate analysis identified male gender(P=0.045),being under 65 years of age(P=0.001),history of metastas-ectomy(P=0.001),low serum CEA level(P=0.010),low PLR(P=0.024),low SII(P=0.010),and high HRR(P=0.025)as favorable prognostic factors for overall survival.In the multivariate model,being under 65 years of age[hazard ratio(HR)=1.59,95%confidence interval(CI):1.06-2.39,P=0.025],metastasectomy(HR=0.49,95%CI:0.29-0.85,P=0.011),CEA(HR=1.51,95%CI:1.0-2.28,P=0.048),and PLR(HR=1.63,95%CI:1.09-2.44,P=0.018)emerged as independent prognostic factors for overall survival,whereas gender,SII,and HRR did not retain statistical significance.CONCLUSION In conclusion,low HRR alone was a prognostic indicator.However,when modelled with other inflammatory and clinical parameters,it did not provide a sufficiently strong marker feature.
文摘BACKGROUND Perioperative blood transfusion is common in gastric cancer surgery,yet its im-pact on postoperative inflammation,stress response,and long-term prognosis remains incompletely understood.AIM To investigate the effect of perioperative blood transfusion on postoperative infla-mmation and stress markers,as well as its correlation with prognosis in patients with gastric cancer undergoing radical gastrectomy.METHODS A retrospective analysis was conducted on 200 patients who underwent gastric cancer surgery,divided into a non-transfusion group(n=108)and a transfusion group(n=92).Baseline characteristics,pathological features,postoperative inflammatory and stress markers,complications,and long-term survival were compared between the two groups.Statistical analyses were performed using t-tests,χ2 tests,and multivariate Cox regression analysis.RESULTS The transfusion group had a lower T-stage distribution and higher intraoperative blood loss than the non-transfusion group(P<0.05).Postoperative inflammatory markers such as white blood cell count,neutrophil/lymphocyte ratio,C-reactive protein,interleukin-6,and stress markers like cortisol and adrenaline were sig-nificantly higher in the transfusion group than in the non-transfusion group(P<0.05).The incidence of postoperative complications was also higher in the transfusion group than in the non-transfusion group.Overall survival(OS)and disease-free survival(DFS)were significantly shorter in the transfusion group(P<0.05)than in the non-transfusion group.Multivariate Cox regression analysis showed that transfusion had a negative impact on OS and DFS.CONCLUSION Perioperative blood transfusion is associated with increased postoperative inflammation,stress reactions,complication rates,and adverse prognosis in patients with gastric cancer.Reducing unnecessary transfusions can improve postoperative recovery and long-term prognosis.
文摘Objective To explore the predictive value of baseline complete blood count derivative marker levels for the occurrence of the first peritonitis in patients undergoing peritoneal dialysis(PD).Methods This study was a retrospective cohort study.
基金supported by the Taishan Young Scholar Program of Shandong Province(grant number tsqn202306349)ECCM Program of Clinical Research Center of Shandong University(grant number 2021SDUCRCA001).
文摘Background:Systemic inflammatory markers are associated with cardiovascular disease.This study aimed to assess the relationship between systemic inflammatory markers and abdominal aortic calcification(AAC).Methods:Data were collected from the 2013 to 2014 cycle of the National Health and Nutrition Examination Survey(NHANES).AAC was quantified using the Kauppila scoring system,which is based on dual-energy X-ray absorptiometry.Severe abdominal aortic calcifi-cation(sAAC)was defined as a total AAC score≥6.Multivariate regression models were used to determine the relationships between sys-temic inflammation indicators,AAC scores,and sAAC.Results:Data from 3047 participants were analyzed.After adjusting for multiple covariates,AAC scores increased slightly for every one-unit increase in standardized systemic immune-inflammation index(SII;β=0.13;95%confidence interval[CI]:0.01–0.25,P=0.030).Neutrophil-to-lymphocyte ratio(NLR)was positively correlated with higher AAC scores(β=0.15;95%CI:0.06–0.24,P=0.001)and sAAC(odds ratio[OR]:1.10;95%CI:1.01–1.19,P=0.025).There was no significant correlation between platelet-to-lymphocyte ratio(PLR)and AAC scores(β=−0.0006;95%CI:−0.0018 to 0.0030).Conversely,lymphocyte-to-monocyte ratio(LMR)was positively associated with lower AAC scores(β=−0.14;95%CI:−0.22 to−0.05,P=0.001),with a 12%decrease in the odds of sAAC for every one-unit increase in LMR(OR:0.88;95%CI:0.79–0.97,P=0.013).Conclusion:Correlations between different systemic inflammation markers and AAC varied among the adult population of the United States.NLR was associated with higher AAC scores and an increased incidence of sAAC,whereas LMR had the opposite effect.NLR and LMR have emerged as potential biomarkers forAACrisk,highlighting theirimportance in understanding the inflammatory processes associated withAAC.
文摘Serum markers of systemic inflammation （SAA （serum amyloid protein A）, CRP （C-reactive protein）, cq-AT （ct l-antitripsin）, Hp （haptoglobin） and F （fibrinogen）） have been studied in 317 patients with pulmonary tuberculosis. It was established that sensitivity of SAA as an activity marker was higher than of other acute phase reactants, because its levels were increased in 98.8% patients, whereas the level of CRP exceeded the norm in 80.8%, α1-AT--in 59.3%, Hp----in 43.5% and F--in 63.1% cases. The degree of increase of acute phase reactants directly related to the expressiveness of tuberculosis intoxication, the extent of the process in the lung and the quantity of MTB （M. tuberculosis） in sputum. We concluded that SAA was a useful marker of the process activity in patients with pulmonary tuberculosis and its sensitivity was higher than that of other acute phase reactants.
基金Supported by Consejo Nacional de Investigaciones Científicas y Técnicas,No.PIP11220200103061COAgencia Nacional de promoción Científica y Tecnológica,No.PICT-2020-SERIEA-03440Universidad Nacional del Sur,No.PGI 24/B303 and No.PGI 24/ZB01.
文摘we critically review the authors’perspective and analyze the relevance of the results obtained in the original article of clinical research by Liu et al.We consider that additional factors associated with colon cancer progression have recently been described in extensive clinical research,and should be included in this analysis to achieve a more accurate prognosis.These factors include inflammation,gut microbiota composition,immune status and nutritional balance,as they influence the post-surgical survival profile of patients with stage II colorectal cancer.We also address the clinical implementation and limitations of these analyses.Evaluation of the patient´s entire context is essential for selection of the most appropriate therapy.
文摘To the Editor,Mutations in LPIN2,located on the short arm of chromosome 18,can lead to Majeed syndrome,a rare autosomal recessive disorder characterized by fever,chronic relapsing multifocal osteomyelitis,congenital erythropoietic dysplasia,and markedly elevated markers of blood inflammation.
