Objective:To evaluate the effect of the modified systemic inflammation score(mSIS)on prognosis in patients diagnosed with COVID-19.Methods:In this retrospective cross-sectional study,181 patients were selected and div...Objective:To evaluate the effect of the modified systemic inflammation score(mSIS)on prognosis in patients diagnosed with COVID-19.Methods:In this retrospective cross-sectional study,181 patients were selected and divided into two groups:patients with and without admission to the intensive care unit(ICU).An albumin level of≥4.0 g/dL and lymphocyte-to-monocyte ratio(LMR)of≥3.4 was scored 0,an albumin level of<4.0 g/dL or LMR of<3.4 was scored 1,and an albumin level of<4.0 g/dL and LMR of<3.4 was scored 2.Results:A total of 242 COVID-19 positive patients were initially included in this study.Of these patients,61 were excluded and 181 patients remained.Among the 181 participants,94(51.9%)were female,and the median age was 61(51,75)years.The mSIS scale ranged from 0 to 2.After analysis,the median score was 0(0,0)in the non-ICU group and 2(0,2)in the ICU group(P<0.001).The median white blood cell,lymphocyte counts,and albumin levels were lower in the ICU group(P<0.001,P<0.001,and P<0.001,respectively).In logistic regression analysis lymphocytopenia(OR=5.158,95%CI=1.249-21.304,P=0.023),hypoalbuminemia(OR=49.921,95%CI=1.843-1352.114,P=0.020),AST elevation(OR=3.939,95%CI=1.017-15.261,P=0.047),and mSIS=2(OR=5.853,95%CI=1.338-25.604,P=0.019)were identified as independent predictors of ICU admission.Conclusion:The mSIS can be used as an independent parameter for establishing the intensive care needs of patients with COVID-19.展开更多
Background and aim: Hepatocellular carcinoma (HCC) is one of the leading causes of death in Africa. Many inflammatory scores have been used to predict the prognosis of this disease in various situations. The aim of th...Background and aim: Hepatocellular carcinoma (HCC) is one of the leading causes of death in Africa. Many inflammatory scores have been used to predict the prognosis of this disease in various situations. The aim of this study was to determine the influence of NLR, PLR and SII on the prognosis of advanced HCC in hospitalized patients. Materials and methods: It was a cross-sectional analytical study carried out in the Internal Medicine Department of Bouake University Hospital over a period of 3 years. Results: Out of 96 patients included in the study, we found a significant association between SII and CHILD score ≥ B. We also identified NLR as an independent predictor of hepatic encephalopathy. Conclusion: This study shows the relationship between inflammatory scores and hepatic insufficiency and the possibility of using NLR to predict in-hospital hepatic encephalopathy in patients suffering from advanced HCC.展开更多
Background:The significance of endoscopic evaluation in the diagnosis and management of ulcerative colitis(UC)has been widely recognized.Over the years,scholars have established several endoscopic scores.Herein,we ass...Background:The significance of endoscopic evaluation in the diagnosis and management of ulcerative colitis(UC)has been widely recognized.Over the years,scholars have established several endoscopic scores.Herein,we assessed the clinical application value of the Mayo Endoscopic Subscore(Mayo ES),the Degree of Ulcerative Colitis Burden of Luminal Inflammation(DUBLIN)score,and the Ulcerative Colitis Endoscopic Index of Severity(UCEIS)score in UC patients,by comparing their correlation with disease activity and their predictive potential for treatment response and clinical outcomes.Methods:UC patients hospitalized from September 2015 to September 2019 were retrospectively analysed.We employed Spearman’s rank correlation coefficient to assess the linear association of the assessed endoscopic scores with the clinical parameters.The receiver-operating characteristic curve was applied to evaluate the predictive capabilities of the endoscopic scores for treatment escalation and 1-year readmission.Results:A total of 178 patients were enrolled;most of them(82%)suffered moderate or severe colitis.Among them,48(27%)patients received treatment escalation and 59(33%)were readmitted within 1 year.The DUBLIN and UCEIS scores demonstrated higher correlations with clinical parameters than the Mayo ES.The DUBLIN scores significantly differed between patients with mild,moderate,and severe colitis(all P<0.001).The UCEIS scores demonstrated the best predictabilities for treatment escalation and 1-year readmission with an area under the curve of 0.88 and 0.75,respectively.Compared to the UCEIS and DUBLIN scores,the predictive capabilities of the Mayo ES for treatment escalation(both P<0.001)and 1-year readmission(P<0.001 and P紏0.002,respectively)were lower.The UCEIS scores exhibited a significant difference between the steroid-responsive group and the steroid-dependent or steroid-refractory group(both P<0.001),while no significant differences in the Mayo ES and DUBLIN scores were found among the three groups(both P>0.05).Conclusion:This study demonstrates that both the DUBLIN and UCEIS scores outperform the Mayo ES in assessing disease severity and predicting treatment response and clinical outcomes in UC patients.展开更多
Background and Objectives:Protein-energy wasting(PEW)is common among maintenance hemodialysis(MHD)patients and is strongly associated with mortality and adverse outcomes.This study aimed to assess the effects of low-p...Background and Objectives:Protein-energy wasting(PEW)is common among maintenance hemodialysis(MHD)patients and is strongly associated with mortality and adverse outcomes.This study aimed to assess the effects of low-protein energy supplements on the nutritional status of MHD patients with PEW.Methods and Study Design:We conducted a prospective randomized controlled trial in 68 MHD patients suffering from PEW.Patients randomized to the intervention group received dietary counseling along with daily low-protein supplements containing 212 kcal of energy and 2.4 g of protein every day for 3 months.The control group received dietary counseling only.Dietary data,nutritional assessments,anthropometric measurements,bioelectrical impedance analysis and blood analysis were collected at baseline and after three months from both groups.Results:Fifty-nine MHD patients completed the study.Patients in the intervention group showed an increase in energy intakes(p<0.001).A significant decrease in the Malnutrition Inflammation Score(MIS)(p<0.001)and Nutrition Risk Screening 2002(p<0.001)were found in the intervention group compared with the control group.Moreover,significant improvements in mid-upper arm circumference(p<0.001),mid-arm muscle circumference(p<0.001),albumin(p=0.003),and prealbumin(p=0.033)were observed in the intervention group compared with the control group.Conclusions:The combination of oral low-protein supplements and dietary counseling for three months was more effective than dietary counseling alone in terms of improving the nutritional status of MHD patients with PEW.展开更多
文摘Objective:To evaluate the effect of the modified systemic inflammation score(mSIS)on prognosis in patients diagnosed with COVID-19.Methods:In this retrospective cross-sectional study,181 patients were selected and divided into two groups:patients with and without admission to the intensive care unit(ICU).An albumin level of≥4.0 g/dL and lymphocyte-to-monocyte ratio(LMR)of≥3.4 was scored 0,an albumin level of<4.0 g/dL or LMR of<3.4 was scored 1,and an albumin level of<4.0 g/dL and LMR of<3.4 was scored 2.Results:A total of 242 COVID-19 positive patients were initially included in this study.Of these patients,61 were excluded and 181 patients remained.Among the 181 participants,94(51.9%)were female,and the median age was 61(51,75)years.The mSIS scale ranged from 0 to 2.After analysis,the median score was 0(0,0)in the non-ICU group and 2(0,2)in the ICU group(P<0.001).The median white blood cell,lymphocyte counts,and albumin levels were lower in the ICU group(P<0.001,P<0.001,and P<0.001,respectively).In logistic regression analysis lymphocytopenia(OR=5.158,95%CI=1.249-21.304,P=0.023),hypoalbuminemia(OR=49.921,95%CI=1.843-1352.114,P=0.020),AST elevation(OR=3.939,95%CI=1.017-15.261,P=0.047),and mSIS=2(OR=5.853,95%CI=1.338-25.604,P=0.019)were identified as independent predictors of ICU admission.Conclusion:The mSIS can be used as an independent parameter for establishing the intensive care needs of patients with COVID-19.
文摘Background and aim: Hepatocellular carcinoma (HCC) is one of the leading causes of death in Africa. Many inflammatory scores have been used to predict the prognosis of this disease in various situations. The aim of this study was to determine the influence of NLR, PLR and SII on the prognosis of advanced HCC in hospitalized patients. Materials and methods: It was a cross-sectional analytical study carried out in the Internal Medicine Department of Bouake University Hospital over a period of 3 years. Results: Out of 96 patients included in the study, we found a significant association between SII and CHILD score ≥ B. We also identified NLR as an independent predictor of hepatic encephalopathy. Conclusion: This study shows the relationship between inflammatory scores and hepatic insufficiency and the possibility of using NLR to predict in-hospital hepatic encephalopathy in patients suffering from advanced HCC.
基金supported by grants from the National Nature Science Foundation of China[grant number 81970461,81800496]the Qingdao Science and Technology Project[grant number 3199].
文摘Background:The significance of endoscopic evaluation in the diagnosis and management of ulcerative colitis(UC)has been widely recognized.Over the years,scholars have established several endoscopic scores.Herein,we assessed the clinical application value of the Mayo Endoscopic Subscore(Mayo ES),the Degree of Ulcerative Colitis Burden of Luminal Inflammation(DUBLIN)score,and the Ulcerative Colitis Endoscopic Index of Severity(UCEIS)score in UC patients,by comparing their correlation with disease activity and their predictive potential for treatment response and clinical outcomes.Methods:UC patients hospitalized from September 2015 to September 2019 were retrospectively analysed.We employed Spearman’s rank correlation coefficient to assess the linear association of the assessed endoscopic scores with the clinical parameters.The receiver-operating characteristic curve was applied to evaluate the predictive capabilities of the endoscopic scores for treatment escalation and 1-year readmission.Results:A total of 178 patients were enrolled;most of them(82%)suffered moderate or severe colitis.Among them,48(27%)patients received treatment escalation and 59(33%)were readmitted within 1 year.The DUBLIN and UCEIS scores demonstrated higher correlations with clinical parameters than the Mayo ES.The DUBLIN scores significantly differed between patients with mild,moderate,and severe colitis(all P<0.001).The UCEIS scores demonstrated the best predictabilities for treatment escalation and 1-year readmission with an area under the curve of 0.88 and 0.75,respectively.Compared to the UCEIS and DUBLIN scores,the predictive capabilities of the Mayo ES for treatment escalation(both P<0.001)and 1-year readmission(P<0.001 and P紏0.002,respectively)were lower.The UCEIS scores exhibited a significant difference between the steroid-responsive group and the steroid-dependent or steroid-refractory group(both P<0.001),while no significant differences in the Mayo ES and DUBLIN scores were found among the three groups(both P>0.05).Conclusion:This study demonstrates that both the DUBLIN and UCEIS scores outperform the Mayo ES in assessing disease severity and predicting treatment response and clinical outcomes in UC patients.
基金supported by the Scientific Research Start Plan of Shunde Hospital,Southern Medical University(SRSP2021003)the Foshan Medical Scientific Research Projects(20230351)+1 种基金the Medical Science and Technology Research Project of Foshan City(2320001006829)the Scientific Research Start Plan of Shunde Hospital,Southern Medical University(CRSP2022010).
文摘Background and Objectives:Protein-energy wasting(PEW)is common among maintenance hemodialysis(MHD)patients and is strongly associated with mortality and adverse outcomes.This study aimed to assess the effects of low-protein energy supplements on the nutritional status of MHD patients with PEW.Methods and Study Design:We conducted a prospective randomized controlled trial in 68 MHD patients suffering from PEW.Patients randomized to the intervention group received dietary counseling along with daily low-protein supplements containing 212 kcal of energy and 2.4 g of protein every day for 3 months.The control group received dietary counseling only.Dietary data,nutritional assessments,anthropometric measurements,bioelectrical impedance analysis and blood analysis were collected at baseline and after three months from both groups.Results:Fifty-nine MHD patients completed the study.Patients in the intervention group showed an increase in energy intakes(p<0.001).A significant decrease in the Malnutrition Inflammation Score(MIS)(p<0.001)and Nutrition Risk Screening 2002(p<0.001)were found in the intervention group compared with the control group.Moreover,significant improvements in mid-upper arm circumference(p<0.001),mid-arm muscle circumference(p<0.001),albumin(p=0.003),and prealbumin(p=0.033)were observed in the intervention group compared with the control group.Conclusions:The combination of oral low-protein supplements and dietary counseling for three months was more effective than dietary counseling alone in terms of improving the nutritional status of MHD patients with PEW.
