Inflammation plays an important role in the occurrence and development of disease;dysregulation of inflammatory progression often leads to disease such as tissue sclerosis,cancers,stroke,etc.Optical imaging technology...Inflammation plays an important role in the occurrence and development of disease;dysregulation of inflammatory progression often leads to disease such as tissue sclerosis,cancers,stroke,etc.Optical imaging technology,due to its higher sensitivity and resolution,can provide finer images for the observation of inflammation.Many optical probes have been developed as contrast agents for optical imaging techniques in different diseases.In this review,we summarize the recent advances of optical probe and imaging methods for imaging inflammation in different organs,such as brain,liver,lung,kidney,intestine,etc.Finally,we discuss the opportunities and challenges of optical probes used in the clinic for inflammation monitoring and prospect their future development in disease detection.展开更多
Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-...Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-infrared chemiluminescence(CL)emission and distinctive photodynamic capacity,the H2O2-driven chemiluminescent CNGs are further designed by assembling the polymeric conjugate and CL donors,enabling an in vitro and in vivo ROS bioimaging capability in animal inflammation models and a high-performance therapy for xenograft tumors.Mechanistically,ROS generated in inflammatory sites or tumor microenvironment can trigger the chemically initiated electron exchange luminescence in the chemical reaction of peroxalate and H2O2,enabling in vivo CL imaging.Meanwhile,part of the excited-state electrons will transfer to the ambient H2O or dissolved oxygen and in turn lead to the type I and type II photochemical ROS production of hydroxyl radicals or singlet oxygen,endowing the apoptosis of tumor cells and thus enabling cancer therapy.These results open up a new avenue for the design of multifunctional nanomaterials for bioimaging and antienoplastic agents.展开更多
基金supported by the National Key R&D Program of China(No.2017YFA0701301)the Natural Science Foundation of China No.92163214 and 51690153)the Natural Science Foundation of Jiangsu Province(BK20202002 and BK20210186).
文摘Inflammation plays an important role in the occurrence and development of disease;dysregulation of inflammatory progression often leads to disease such as tissue sclerosis,cancers,stroke,etc.Optical imaging technology,due to its higher sensitivity and resolution,can provide finer images for the observation of inflammation.Many optical probes have been developed as contrast agents for optical imaging techniques in different diseases.In this review,we summarize the recent advances of optical probe and imaging methods for imaging inflammation in different organs,such as brain,liver,lung,kidney,intestine,etc.Finally,we discuss the opportunities and challenges of optical probes used in the clinic for inflammation monitoring and prospect their future development in disease detection.
基金the National Natural Science Foundation of China(Nos.12074348,U2004168,U1904142,and U21A2070)the China Postdoctoral Science Foundation(No.2020M682310)+1 种基金the Natural Science Foundation of Henan Province(No.212300410078)Science and Technology Department of Henan Province(No.182102410010).
文摘Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-infrared chemiluminescence(CL)emission and distinctive photodynamic capacity,the H2O2-driven chemiluminescent CNGs are further designed by assembling the polymeric conjugate and CL donors,enabling an in vitro and in vivo ROS bioimaging capability in animal inflammation models and a high-performance therapy for xenograft tumors.Mechanistically,ROS generated in inflammatory sites or tumor microenvironment can trigger the chemically initiated electron exchange luminescence in the chemical reaction of peroxalate and H2O2,enabling in vivo CL imaging.Meanwhile,part of the excited-state electrons will transfer to the ambient H2O or dissolved oxygen and in turn lead to the type I and type II photochemical ROS production of hydroxyl radicals or singlet oxygen,endowing the apoptosis of tumor cells and thus enabling cancer therapy.These results open up a new avenue for the design of multifunctional nanomaterials for bioimaging and antienoplastic agents.
