Objective:To investigate factors influencing vaccine hesitancy and its effects on SARS-CoV-2 infection in multiple myeloma(MM)patients during the Omicron BA.4/5 subvariant outbreak.Methods:This cross-sectional study w...Objective:To investigate factors influencing vaccine hesitancy and its effects on SARS-CoV-2 infection in multiple myeloma(MM)patients during the Omicron BA.4/5 subvariant outbreak.Methods:This cross-sectional study was conducted in China'Mainland from December 26,2022,to April 20,2023.An expert-developed anonymous online questionnaire was distributed via WeChat mini-program to several groups of 500 MM patients,each comprising of 500 patients.The questionnaire covered demographic characteristics,MM medical attributes,COVID-19 vaccine status,and clinical manifestations of COVID-19.Data were analyzed to assess the impact of vaccination on COVID-19 infection rates and the disease severity among MM patients.Results:Among 508 valid responses from 30 provinces,only 34.1%(n=173)of MM patients reported receiving COVID-19 vaccination,and the proportions were lower among patients who had undergone autologous stem cell transplantation(20.2%vs.48.4%,P<0.001).Vaccine hesitancy was primarily attributed to physician recommendations(52.0%),conflicts with MM treatment(37.8%),and concerns about MM progression(31.3%).Hospitalization due to severe SARS-CoV-2 infections was significantly reduced in the vaccinated group(4.8%vs.12.3%,P=0.038).Conclusions:The lower infection rate in MM patients may be attributed to stringent quarantine measures and self-imposed social restrictions.While vaccination did not directly correlate with fewer SARS-CoV-2 infections,it did afford protection to vulnerable populations.Clinicians are encouraged to recommend vaccines to MM patients to mitigate severe infections and associated mortality during recurrent COVID-19 waves.展开更多
基金funded by the Capital Health Development Scientific Research Fund(Grant No.2022-2-4013)National High-Level Hospital Clinical Research Funding(2022-PUMCH-B-048).
文摘Objective:To investigate factors influencing vaccine hesitancy and its effects on SARS-CoV-2 infection in multiple myeloma(MM)patients during the Omicron BA.4/5 subvariant outbreak.Methods:This cross-sectional study was conducted in China'Mainland from December 26,2022,to April 20,2023.An expert-developed anonymous online questionnaire was distributed via WeChat mini-program to several groups of 500 MM patients,each comprising of 500 patients.The questionnaire covered demographic characteristics,MM medical attributes,COVID-19 vaccine status,and clinical manifestations of COVID-19.Data were analyzed to assess the impact of vaccination on COVID-19 infection rates and the disease severity among MM patients.Results:Among 508 valid responses from 30 provinces,only 34.1%(n=173)of MM patients reported receiving COVID-19 vaccination,and the proportions were lower among patients who had undergone autologous stem cell transplantation(20.2%vs.48.4%,P<0.001).Vaccine hesitancy was primarily attributed to physician recommendations(52.0%),conflicts with MM treatment(37.8%),and concerns about MM progression(31.3%).Hospitalization due to severe SARS-CoV-2 infections was significantly reduced in the vaccinated group(4.8%vs.12.3%,P=0.038).Conclusions:The lower infection rate in MM patients may be attributed to stringent quarantine measures and self-imposed social restrictions.While vaccination did not directly correlate with fewer SARS-CoV-2 infections,it did afford protection to vulnerable populations.Clinicians are encouraged to recommend vaccines to MM patients to mitigate severe infections and associated mortality during recurrent COVID-19 waves.
